W G Hill

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc Prediction of multi-locus inbreeding coefficients and relation to linkage disequilibrium in random mating populations
    William G Hill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JT, UK
    Theor Popul Biol 72:179-85. 2007
  2. pmc Quantitative genetics in the genomics era
    William G Hill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JT, UK
    Curr Genomics 13:196-206. 2012
  3. pmc Identification of pedigree relationship from genome sharing
    William G Hill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, United Kingdom
    G3 (Bethesda) 3:1553-71. 2013
  4. pmc On estimation of genetic variance within families using genome-wide identity-by-descent sharing
    William G Hill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Genet Sel Evol 45:32. 2013
  5. doi request reprint Variation in actual relationship among descendants of inbred individuals
    W G Hill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Genet Res (Camb) 94:267-74. 2012
  6. pmc On the pleiotropic structure of the genotype-phenotype map and the evolvability of complex organisms
    William G Hill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, United Kingdom
    Genetics 190:1131-7. 2012
  7. pmc Inheritance of fertility in broiler chickens
    Anna Wolc
    Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Wolynska 33, 60 637 Poznan, Poland
    Genet Sel Evol 41:47. 2009
  8. doi request reprint Can more be learned from selection experiments of value in animal breeding programmes? Or is it time for an obituary?
    W G Hill
    Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK
    J Anim Breed Genet 128:87-94. 2011
  9. doi request reprint Parentage identification using single nucleotide polymorphism genotypes: application to product tracing
    W G Hill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    J Anim Sci 86:2508-17. 2008
  10. ncbi request reprint Effects on phenotypic variability of directional selection arising through genetic differences in residual variability
    William G Hill
    Institute of Cell, Animal and Population Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JT, UK
    Genet Res 83:121-32. 2004

Detail Information

Publications65

  1. pmc Prediction of multi-locus inbreeding coefficients and relation to linkage disequilibrium in random mating populations
    William G Hill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JT, UK
    Theor Popul Biol 72:179-85. 2007
    ..The results can be applied to predict multi-locus identity in, for example, gene mapping...
  2. pmc Quantitative genetics in the genomics era
    William G Hill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JT, UK
    Curr Genomics 13:196-206. 2012
    ....
  3. pmc Identification of pedigree relationship from genome sharing
    William G Hill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, United Kingdom
    G3 (Bethesda) 3:1553-71. 2013
    ..Two relationships with the same R can be distinguished only if R is high, e.g., half-sibs and uncle-nephew, with probability of correct assignment being approximately 5/6. ..
  4. pmc On estimation of genetic variance within families using genome-wide identity-by-descent sharing
    William G Hill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Genet Sel Evol 45:32. 2013
    ..In livestock and plants much larger families can be obtained, and simulation has shown sampling variances are then much smaller...
  5. doi request reprint Variation in actual relationship among descendants of inbred individuals
    W G Hill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Genet Res (Camb) 94:267-74. 2012
    ..For descendants of full-sibs, the variation is reduced in later generations, but for descendants of half-sibs, it is increased...
  6. pmc On the pleiotropic structure of the genotype-phenotype map and the evolvability of complex organisms
    William G Hill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, United Kingdom
    Genetics 190:1131-7. 2012
    ..We demonstrate that these highly pleiotropic models can give results similar to those obtained in analyses of experimental data and that conclusions on limits to evolvability through pleiotropy are not robust...
  7. pmc Inheritance of fertility in broiler chickens
    Anna Wolc
    Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Wolynska 33, 60 637 Poznan, Poland
    Genet Sel Evol 41:47. 2009
    ..The fertility of a chicken's egg is a trait which depends on both the hen that lays the egg and on her mate. It is also known that fertility of an individual changes over the laying period...
  8. doi request reprint Can more be learned from selection experiments of value in animal breeding programmes? Or is it time for an obituary?
    W G Hill
    Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK
    J Anim Breed Genet 128:87-94. 2011
    ....
  9. doi request reprint Parentage identification using single nucleotide polymorphism genotypes: application to product tracing
    W G Hill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    J Anim Sci 86:2508-17. 2008
    ..This appears to be a straightforward and potentially effective means of product tracing...
  10. ncbi request reprint Effects on phenotypic variability of directional selection arising through genetic differences in residual variability
    William G Hill
    Institute of Cell, Animal and Population Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JT, UK
    Genet Res 83:121-32. 2004
    ..The evidence for and implications of such variability in variance are discussed...
  11. ncbi request reprint Moment estimation of population diversity and genetic distance from data on recessive markers
    W G Hill
    Institute of Cell, Animal and Population Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Mol Ecol 13:895-908. 2004
    ..Approximate sampling errors of the estimates are given. Methods are extended to estimate genetic distances and their sampling errors. The AFLP data from samples of breeds of pig are used for illustration...
  12. pmc Understanding and using quantitative genetic variation
    William G Hill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Philos Trans R Soc Lond B Biol Sci 365:73-85. 2010
    ..Methods based on summary statistics and predictions rather than at the individual gene level seem likely to prevail for some time yet...
  13. pmc Data and theory point to mainly additive genetic variance for complex traits
    William G Hill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Genet 4:e1000008. 2008
    ..We conclude that interactions at the level of genes are not likely to generate much interaction at the level of variance...
  14. doi request reprint Genetic analysis of environmental variation
    William G Hill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Genet Res (Camb) 92:381-95. 2010
    ..We also evaluate the opportunities for reducing VE in breeding programmes. Although empirical and theoretical studies have increased our understanding of genetic control of environmental variance, many issues remain unresolved...
  15. pmc D. S. Falconer and Introduction to quantitative genetics
    William G Hill
    School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 167:1529-36. 2004
  16. pmc Variation in actual relationship as a consequence of Mendelian sampling and linkage
    W G Hill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Genet Res (Camb) 93:47-64. 2011
    ....
  17. ncbi request reprint Genetics. A century of corn selection
    William G Hill
    School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, UK
    Science 307:683-4. 2005
  18. ncbi request reprint Mutation and conflicts between artificial and natural selection for quantitative traits
    W G Hill
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Scotland
    Genetica 102:171-81. 1998
    ..Results from long-term selection experiments in mice in this laboratory are described and related to the theoretical analyses with the aim of reconciling the evidence for substantial standing variation with the low rate of response...
  19. pmc Selection with recurrent backcrossing to develop congenic lines for quantitative trait loci analysis
    W G Hill
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Scotland, United Kingdom
    Genetics 148:1341-52. 1998
    ..Analytical formulas are given for one or two loci, and simulation is used for more. It is shown that the method could have substantial discriminating ability and thus potential practical value...
  20. pmc Prediction of multilocus identity-by-descent
    William G Hill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, W Mains Road, Edinburgh, United Kingdom
    Genetics 176:2307-15. 2007
    ..The results can be applied to detection of quantitative trait loci (QTL) by computing the probability of IBD at candidate loci in terms of identity-by-state at neighboring markers...
  21. pmc Estimating quantitative genetic parameters using sibships reconstructed from marker data
    S C Thomas
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 155:1961-72. 2000
    ..Extensions to these techniques allow reconstruction of half sibships when some or all of the maternal genotypes are known...
  22. ncbi request reprint Mapping quantitative trait loci for body weight on the X chromosome in mice. I. Analysis of a reciprocal F2 population
    K A Rance
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Scotland, UK
    Genet Res 70:117-24. 1997
    ..Dominance effects in the females were found to be non-significant. No significant X-linked effect on carcass fat percentage was detected, but a single X-linked QTL appears to explain almost the entire X-linked body weight effect...
  23. ncbi request reprint Genotype and diet effects on energy balance in the first three lactations of dairy cows
    M P Coffey
    Scottish Agricultural College, West Mains Road, Edinburgh EH9 3JG, UK
    J Dairy Sci 87:4318-26. 2004
    ..Cows use body lipid to support lactation over 3 lactations and the profile of that use varies according to genotype and diet...
  24. ncbi request reprint Estimating variance components in natural populations using inferred relationships
    S C Thomas
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, U K
    Heredity (Edinb) 84:427-36. 2000
    ..The modified form shows less bias in its estimates of heritability than the likelihood technique originally proposed...
  25. ncbi request reprint Effects of leptin administration on long-term selected fat mice
    L Bunger
    Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
    Genet Res 69:215-25. 1997
    ..7-6.4%) and CU (2-15%) animals. While sensitivity to leptin remains in the fat line, response appears to vary among animals at the dose level used...
  26. pmc Effect of selection against deleterious mutations on the decline in heterozygosity at neutral loci in closely inbreeding populations
    J Wang
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 153:1475-89. 1999
    ..The simulations results are in general compatible with empirical observations...
  27. ncbi request reprint A link function approach to model heterogeneity of residual variances over time in lactation curve analyses
    F Jaffrezic
    Institute of Cell Animal and Population Biology, University of Edinburgh, UK
    J Dairy Sci 83:1089-93. 2000
    ..In this model, only a few parameters need to be estimated, and the residual variance is then a continuous function of time. The analysis of a sample data set illustrates this methodology...
  28. ncbi request reprint Inbred lines of mice derived from long-term growth selected lines: unique resources for mapping growth genes
    L Bunger
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JT, UK
    Mamm Genome 12:678-86. 2001
    ..Litter size, food intake, and fat content also differ substantially. These inbred extreme selected lines are a uniquely valuable resource for QTL or gene mapping, candidate gene identification, and elucidation of epistatic effects...
  29. ncbi request reprint The effect of testosterone in mice divergently selected on fat content or body weight
    I M Hastings
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Scotland, UK
    Genet Res 70:135-41. 1997
    ..It is therefore concluded that testosterone metabolism has not contributed disproportionately to the response to artificial selection in spite of its known effects on growth and body composition...
  30. ncbi request reprint Effects of thyroid hormone deficiency on mice selected for increased and decreased body weight and fatness
    L Bunger
    Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
    Genet Res 72:39-53. 1998
    ..The interactions between the effects of the transgene and of the lit gene and the genetic background were, nevertheless, relatively small and therefore these results support a polygenic model of selection response...
  31. ncbi request reprint Genetic parameters for a heavy female turkey line: impact of simultaneous selection for body weight and total egg number
    A Kranis
    Division of Genetics and Genomics, Roslin Institute Edinburgh, Scotland, UK
    Br Poult Sci 47:685-93. 2006
    ..8. Thus, in order to avoid continued selection for body weight reducing egg production to a point where natural selection offsets selection gains, alternative selection strategies should be considered...
  32. ncbi request reprint Dynamics of inbreeding depression due to deleterious mutations in small populations: mutation parameters and inbreeding rate
    J Wang
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Scotland, UK
    Genet Res 74:165-78. 1999
    ..The simulation results and their implications are discussed in the context of biological conservation and tests for purging...
  33. ncbi request reprint Role of growth hormone in the genetic change of mice divergently selected for body weight and fatness
    L Bunger
    Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
    Genet Res 74:351-60. 1999
    ..The interactions between the effects of the lit gene and the genetic background were, however, relatively small compared with these main effects and again indicate that other systems contributed most of the selection response...
  34. ncbi request reprint Competition can maintain genetic but not environmental variance in the presence of stabilizing selection
    Xu sheng Zhang
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    Evolution 61:1532-45. 2007
    ..If the magnitude of the environmental variance is not under genetic control, there is a complementary relationship between the levels of environmental and genetic variance such that the level of phenotypic variance is little affected...
  35. doi request reprint Mutation-selection balance for environmental variance
    Xu sheng Zhang
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    Am Nat 171:394-9. 2008
    ..This conclusion is not robust for small populations because some mutants may become fixed, which indicates that other selective forces must be involved, such as an intrinsic cost of homogeneity...
  36. doi request reprint Change and maintenance of variation in quantitative traits in the context of the Price equation
    Xu sheng Zhang
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Theor Popul Biol 77:14-22. 2010
    ..In this study, we use the Price equation to derive many such well-known results for the dynamics and equilibria of variances in a straightforward way and to develop them further...
  37. pmc The population genetics of mutations: good, bad and indifferent
    Laurence Loewe
    Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JT, UK
    Philos Trans R Soc Lond B Biol Sci 365:1153-67. 2010
    ..important, why do we age, which genetic processes can generate new species or drive endangered species to extinction, and how should policy on levels of potentially harmful mutagens introduced into the environment by humans be determined?..
  38. pmc The anomalous effects of biased mutation revisited: mean-optimum deviation and apparent directional selection under stabilizing selection
    Xu sheng Zhang
    Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 179:1135-41. 2008
    ..We show by simulation that genetic drift, leptokurtosis of mutational effects, and pleiotropy can increase the mean-optimum deviation greatly, however, and that the apparent directional selection thereby caused can be substantial...
  39. ncbi request reprint Multivariate stabilizing selection and pleiotropy in the maintenance of quantitative genetic variation
    Xu sheng Zhang
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    Evolution 57:1761-75. 2003
    ....
  40. pmc Redistribution of gene frequency and changes of genetic variation following a bottleneck in population size
    Xu sheng Zhang
    Institute of Cell, Animal and Population Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 167:1475-92. 2004
    ....
  41. pmc Predictions of patterns of response to artificial selection in lines derived from natural populations
    Xu sheng Zhang
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 169:411-25. 2005
    ..Comparison with data from laboratory selection experiments shows that, overall, the analysis did not provide clear support for the joint-effect model or a clear case for rejection...
  42. pmc Influence of dominance, leptokurtosis and pleiotropy of deleterious mutations on quantitative genetic variation at mutation-selection balance
    Xu sheng Zhang
    Institute of Cell, Animal and Population Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, United Kingdom
    Genetics 166:597-610. 2004
    ..Thus considerations of dominance coefficients of mutations lend further support to our previous conclusion that mutation-selection balance is a plausible mechanism of the maintenance of the genetic variance in natural populations...
  43. ncbi request reprint Long-term divergent selection on fatness in mice indicates a regulation system independent of leptin production and reception
    Lutz Bunger
    Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
    FASEB J 17:85-7. 2003
    ....
  44. ncbi request reprint Evolution of the environmental component of the phenotypic variance: stabilizing selection in changing environments and the cost of homogeneity
    Xu sheng Zhang
    Institute of Evolutionary Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    Evolution 59:1237-44. 2005
    ..It is shown that a small homogeneity cost is enough to maintain the observed levels of environmental variance, whereas a large amount of temporal variation in the optimal phenotype and the strength of selection would be necessary...
  45. pmc Joint effects of pleiotropic selection and stabilizing selection on the maintenance of quantitative genetic variation at mutation-selection balance
    Xu sheng Zhang
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 162:459-71. 2002
    ..This finding provides some promise that a high heritability can be explained under strong total stabilizing selection for what are regarded as typical values of mutation and selection parameters...
  46. ncbi request reprint Sibship reconstruction in hierarchical population structures using Markov chain Monte Carlo techniques
    Stuart C Thomas
    Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
    Genet Res 79:227-34. 2002
    ..Estimates of variance component are biased, with the direction and magnitude of bias being dependent upon the underlying errors made during pedigree reconstruction...
  47. pmc Pleiotropic model of maintenance of quantitative genetic variation at mutation-selection balance
    Xu sheng Zhang
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 161:419-33. 2002
    ....
  48. ncbi request reprint Leptin levels in lines of mice developed by long-term divergent selection on fat content
    L Bunger
    Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
    Genet Res 73:37-44. 1999
    ..Correlations between leptin level and fat amount were high (over 0.86) in fed or fasted animals of the F line, indicative of leptin resistance...
  49. pmc Introduction. Evolutionary dynamics of wild populations: the use of long-term pedigree data
    L E B Kruuk
    Insitute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, UK
    Proc Biol Sci 275:593-6. 2008
    ..We discuss here common themes, specific problems and pointers for future research...
  50. pmc Genetic heterogeneity of residual variance in broiler chickens
    Suzanne J Rowe
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JT, UK
    Genet Sel Evol 38:617-35. 2006
    ....
  51. ncbi request reprint Marker-assisted introgression of the Compact mutant myostatin allele MstnCmpt-dl1Abc into a mouse line with extreme growth effects on body composition and muscularity
    Lutz Bunger
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, UK
    Genet Res 84:161-73. 2004
    ..This line, when congenic, will be a useful resource in gene expression studies and for finding modifying genes...
  52. pmc Bottleneck effect on genetic variance. A theoretical investigation of the role of dominance
    J Wang
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, Scotland
    Genetics 150:435-47. 1998
    ..This article suggests that dominance is the main cause for increased genetic variances for fitness components and fitness-related traits after bottlenecks observed in various experiments...
  53. ncbi request reprint Genetic evaluations of dairy bulls for daughter energy balance profiles using linear type scores and body condition score analyzed using random regression
    M P Coffey
    Animal Biology Division, Scottish Agricultural College, West Mains Road, Edinburgh EH9 3JG, UK
    J Dairy Sci 86:2205-12. 2003
    ..Breeding values for energy balance can be calculated from single observations of BCS and linear type traits on daughters of a sire; data that can routinely be collected in national conformation assessment schemes...
  54. pmc Marker-assisted selection to increase effective population size by reducing Mendelian segregation variance
    J Wang
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 154:475-89. 2000
    ..The assumptions made in developing the theory and methods and the applications of MAS in conservation are discussed...
  55. ncbi request reprint On the use of double haploids for detecting QTL in outbred populations
    V A Martinez
    Institute of Cell, Animal and Population Biology, University of Edinburgh, King s Buildings, Edinburgh EH9 3JT, UK
    Heredity (Edinb) 88:423-31. 2002
    ....
  56. ncbi request reprint Population dynamics of Plasmodium falciparum in an unstable malaria area of eastern Sudan
    H A Babiker
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Scotland, UK
    Parasitology 120:105-11. 2000
    ..A higher frequency of inbreeding was estimated among the parasites that survived the dry season compared to the wet season...
  57. ncbi request reprint Prediction of effects of genetic drift on variance components under a general model of epistasis
    William G Hill
    Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JT, UK
    Theor Popul Biol 70:56-62. 2006
    ..We also discuss the effects of population bottlenecks on covariances among relatives...
  58. pmc Estimation of recombination rate and detection of recombination hotspots from dense single-nucleotide polymorphism trio data
    Peter M Visscher
    Genetics 173:2415-7. 2006
  59. doi request reprint Heritability in the genomics era--concepts and misconceptions
    Peter M Visscher
    Queensland Institute of Medical Research, Royal Brisbane Hospital Post Office, Brisbane 4029, Queensland, Australia
    Nat Rev Genet 9:255-66. 2008
    ..Recent reports of substantial heritability for gene expression and new estimation methods using marker data highlight the relevance of heritability in the genomics era...
  60. pmc Measures of human population structure show heterogeneity among genomic regions
    Bruce S Weir
    Program in Statistical Genetics, Department of Statistics, North Carolina State University, Raleigh, North Carolina 27695 7566, USA
    Genome Res 15:1468-76. 2005
    ..Furthermore, it may be that the best indications of selection will come from population-specific F(ST) values rather than the usually reported population-average values...
  61. pmc Selection for uniformity in livestock by exploiting genetic heterogeneity of residual variance
    Han A Mulder
    Animal Breeding and Genomics Centre, Wageningen University, 6700 AH Wageningen, The Netherlands
    Genet Sel Evol 40:37-59. 2008
    ..Genetic improvement of uniformity is particularly interesting for traits where the current population mean is near an intermediate optimum...
  62. ncbi request reprint Structured antedependence models for genetic analysis of repeated measures on multiple quantitative traits
    Florence Jaffrezic
    INRA Quantitative and Applied Genetics, 78352 Jouy en Josas, France
    Genet Res 82:55-65. 2003
    ..These models offer a substantial flexibility for the correlation structure, even in the case of complex non-stationary patterns, and perform better than multivariate random regression models, with fewer parameters...
  63. ncbi request reprint The variance of the variance - genetic analysis of environmental variability
    William G Hill
    J Anim Breed Genet 124:49. 2007
  64. pmc Genome partitioning of genetic variation for height from 11,214 sibling pairs
    Peter M Visscher
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia
    Am J Hum Genet 81:1104-10. 2007
    ....
  65. ncbi request reprint Non-parametric exploratory analysis of the covariance structure for genetic analysis of repeated measures and other function-value traits
    Florence Jaffrezic
    INRA Quantitative and Applied Genetics, 78352 Jouy en Josas, France
    Genet Res 80:47-53. 2002
    ..This paper presents a generalization of their approach to genetic analyses. The methodology is applied to daily records for milk production in dairy cattle and data on age-specific fertility in Drosophila...