A V Hill

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. pmc Evolution, revolution and heresy in the genetics of infectious disease susceptibility
    Adrian V S Hill
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Philos Trans R Soc Lond B Biol Sci 367:840-9. 2012
  2. pmc Thick blood film examination for Plasmodium falciparum malaria has reduced sensitivity and underestimates parasite density
    Philip Bejon
    Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Oxford, OX3 7LJ, UK
    Malar J 5:104. 2006
  3. ncbi request reprint Aspects of genetic susceptibility to human infectious diseases
    Adrian V S Hill
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom
    Annu Rev Genet 40:469-86. 2006
  4. ncbi request reprint Pre-erythrocytic malaria vaccines: towards greater efficacy
    Adrian V S Hill
    Centre for Clinical Vaccinology and Tropical Medicine, and The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Nat Rev Immunol 6:21-32. 2006
  5. ncbi request reprint The immunogenetics of human infectious diseases
    A V Hill
    Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom
    Annu Rev Immunol 16:593-617. 1998
  6. ncbi request reprint Immunogenetics and genomics
    A V Hill
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Lancet 357:2037-41. 2001
  7. ncbi request reprint The genomics and genetics of human infectious disease susceptibility
    A V Hill
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom
    Annu Rev Genomics Hum Genet 2:373-400. 2001
  8. ncbi request reprint Enhanced immunogenicity for CD8+ T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara
    J Schneider
    Institute of Molecular Medicine, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, UK
    Nat Med 4:397-402. 1998
  9. ncbi request reprint Immunogenicities of intravenous and intramuscular administrations of modified vaccinia virus Ankara-based multi-CTL epitope vaccine for human immunodeficiency virus type 1 in mice
    T Hanke
    Molecular Immunology Group, Institute of Molecular Medicine, University of Oxford, The John Radcliffe, UK
    J Gen Virol 79:83-90. 1998
  10. ncbi request reprint Identification of frequently recognized dimorphic T-cell epitopes in plasmodium falciparum merozoite surface protein-1 in West and East Africans: lack of correlation of immune recognition and allelic prevalence
    E A Lee
    Institute of Molecular Medicine, Nuffield Department Medicine, University of Oxford, John Radcliffe Hospital, United Kingdom
    Am J Trop Med Hyg 64:194-203. 2001

Collaborators

Detail Information

Publications128 found, 100 shown here

  1. pmc Evolution, revolution and heresy in the genetics of infectious disease susceptibility
    Adrian V S Hill
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Philos Trans R Soc Lond B Biol Sci 367:840-9. 2012
    ....
  2. pmc Thick blood film examination for Plasmodium falciparum malaria has reduced sensitivity and underestimates parasite density
    Philip Bejon
    Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Oxford, OX3 7LJ, UK
    Malar J 5:104. 2006
    ..Thick blood films are routinely used to diagnose Plasmodium falciparum malaria. Here, they were used to diagnose volunteers exposed to experimental malaria challenge...
  3. ncbi request reprint Aspects of genetic susceptibility to human infectious diseases
    Adrian V S Hill
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom
    Annu Rev Genet 40:469-86. 2006
    ..However, the great majority of susceptibility loci remain to be identified and the advent of large-scale genome-wide association scans offers a new approach to defining many of these...
  4. ncbi request reprint Pre-erythrocytic malaria vaccines: towards greater efficacy
    Adrian V S Hill
    Centre for Clinical Vaccinology and Tropical Medicine, and The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Nat Rev Immunol 6:21-32. 2006
    ..This Review focuses on the potential immunological basis for the encouraging partial protection induced by these vaccines, and it considers ways for developing more effective malaria vaccines...
  5. ncbi request reprint The immunogenetics of human infectious diseases
    A V Hill
    Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom
    Annu Rev Immunol 16:593-617. 1998
    ..It is likely that susceptibility to most microorganisms is determined by a large number of polymorphic genes, and identification of these should provide insights into protective and pathogenic mechanisms in infectious diseases...
  6. ncbi request reprint Immunogenetics and genomics
    A V Hill
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Lancet 357:2037-41. 2001
    ..This new era of immunogenomics promises to provide key insights into disease pathogenesis and identify multiple molecular targets for intervention strategies...
  7. ncbi request reprint The genomics and genetics of human infectious disease susceptibility
    A V Hill
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom
    Annu Rev Genomics Hum Genet 2:373-400. 2001
    ..These studies indicate a highly polygenic basis for susceptibility to many common infectious diseases, with some emerging examples of interaction between variants of specific polymorphic host and pathogen genes...
  8. ncbi request reprint Enhanced immunogenicity for CD8+ T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara
    J Schneider
    Institute of Molecular Medicine, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, UK
    Nat Med 4:397-402. 1998
    ..DNA priming followed by MVA boosting may provide a general immunization regime for induction of high levels of CD8+ T cells...
  9. ncbi request reprint Immunogenicities of intravenous and intramuscular administrations of modified vaccinia virus Ankara-based multi-CTL epitope vaccine for human immunodeficiency virus type 1 in mice
    T Hanke
    Molecular Immunology Group, Institute of Molecular Medicine, University of Oxford, The John Radcliffe, UK
    J Gen Virol 79:83-90. 1998
    ..Also, the correct processing and presentation of some HLA-restricted epitopes in human cells was confirmed...
  10. ncbi request reprint Identification of frequently recognized dimorphic T-cell epitopes in plasmodium falciparum merozoite surface protein-1 in West and East Africans: lack of correlation of immune recognition and allelic prevalence
    E A Lee
    Institute of Molecular Medicine, Nuffield Department Medicine, University of Oxford, John Radcliffe Hospital, United Kingdom
    Am J Trop Med Hyg 64:194-203. 2001
    ..Further analysis of the mechanisms determining this response pattern may be required if vaccines are to overcome this allelic reactivity bias in malaria-exposed populations...
  11. ncbi request reprint Altered peptide ligands narrow the repertoire of cellular immune responses by interfering with T-cell priming
    M Plebanski
    Institute of Molecular Medicine, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, UK
    Nat Med 5:565-71. 1999
    ..Reshaping of the T-cell repertoire by such immune interference during naive T-cell induction may provide a general mechanism for observed patterns of immunodominance and persistence by many polymorphic pathogens...
  12. ncbi request reprint Gene gun intradermal DNA immunization followed by boosting with modified vaccinia virus Ankara: enhanced CD8+ T cell immunogenicity and protective efficacy in the influenza and malaria models
    P Degano
    PowderJect Pharmaceuticals plc, 4 Robert Robinson Avenue, The Oxford Science Park, Oxford, UK
    Vaccine 18:623-32. 1999
    ..In the DNA/MVA regime, equally high CD8+ T cell responses and levels of protection are achieved using ten times less DNA when delivered with a gene gun compared to intramuscular injection...
  13. ncbi request reprint Interleukin 10-mediated immunosuppression by a variant CD4 T cell epitope of Plasmodium falciparum
    M Plebanski
    Institute of Molecular Medicine, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, United Kingdom
    Immunity 10:651-60. 1999
    ..This mechanism may contribute to the low levels of T cell responses observed to this pathogen in malaria-endemic areas...
  14. pmc Enhanced T cell-mediated protection against malaria in human challenges by using the recombinant poxviruses FP9 and modified vaccinia virus Ankara
    Daniel P Webster
    Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital, Old Road, Oxford OX3 7LJ, UK
    Proc Natl Acad Sci U S A 102:4836-41. 2005
    ....
  15. ncbi request reprint Severe malarial anemia and cerebral malaria are associated with different tumor necrosis factor promoter alleles
    W McGuire
    Department of Paediatrics, John Radcliffe Hospital, Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom
    J Infect Dis 179:287-90. 1999
    ..5 (P<.001) after stratification for HLA type. These findings suggest that severe malarial anemia and cerebral malaria are influenced by separate genetic factors situated near the TNF gene...
  16. ncbi request reprint Assessment of the interleukin 1 gene cluster and other candidate gene polymorphisms in host susceptibility to tuberculosis
    R Bellamy
    Wellcome Trust Centre for Human Genetics, Oxford University, UK
    Tuber Lung Dis 79:83-9. 1998
    ..A study of tuberculosis cases and healthy blood donor controls from the Western Region of The Gambia, West Africa...
  17. pmc Multifunctional, high-level cytokine-producing Th1 cells in the lung, but not spleen, correlate with protection against Mycobacterium tuberculosis aerosol challenge in mice
    Emily K Forbes
    The Jenner Institute, University of Oxford, Headington, Oxford, United Kingdom
    J Immunol 181:4955-64. 2008
    ..Successful immunization regimes appear to induce Ag-specific cells with abundant intracellular cytokine staining...
  18. ncbi request reprint Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans
    Samuel J McConkey
    Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    Nat Med 9:729-35. 2003
    ..Such heterologous prime-boost immunization approaches may provide a basis for preventative and therapeutic vaccination in humans...
  19. ncbi request reprint Enhanced CD8+ T cell immune responses and protection elicited against Plasmodium berghei malaria by prime boost immunization regimens using a novel attenuated fowlpox virus
    Richard J Anderson
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    J Immunol 172:3094-100. 2004
    ..berghei and was more immunogenic and protective than DNA/MVA prime/boost immunization. However, further improvement was not achieved by sequential (triple) immunization with a DNA vaccine, FP9, and MVA...
  20. ncbi request reprint Rapid detection of Mycobacterium tuberculosis infection by enumeration of antigen-specific T cells
    A Lalvani
    Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    Am J Respir Crit Care Med 163:824-8. 2001
    ..tuberculosis infection and BCG vaccination. This capability may facilitate tuberculosis control in nonendemic regions...
  21. ncbi request reprint Association of vitamin D receptor genotype with leprosy type
    S Roy
    Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdon
    J Infect Dis 179:187-91. 1999
    ..This study suggests that the VDR polymorphism may influence susceptibility to some diseases by affecting the type and the strength of the host immune response...
  22. ncbi request reprint Induction of CD8+ T cells using heterologous prime-boost immunisation strategies
    J Schneider
    Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, UK
    Immunol Rev 170:29-38. 1999
    ..Possible mechanisms explaining why heterologous prime-boost strategies, in particular boosting with replication-impaired recombinant poxviruses, are so effective are discussed...
  23. ncbi request reprint Differential immunogenicity of various heterologous prime-boost vaccine regimens using DNA and viral vectors in healthy volunteers
    Jenni M Vuola
    Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, UK
    J Immunol 174:449-55. 2005
    ..This difference may be of importance for the protective efficacy of these vaccination approaches against various diseases...
  24. ncbi request reprint Use of complete eluted peptide sequence data from HLA-DR and -DQ molecules to predict T cell epitopes, and the influence of the nonbinding terminal regions of ligands in epitope selection
    A J Godkin
    Molecular Immunology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    J Immunol 161:850-8. 1998
    ..Thus, the use of complete eluted peptide sequence data offers a powerful approach to the prediction of HLA-DQ and -DR peptide ligands and T cell epitopes...
  25. pmc Cytotoxic T-lymphocyte epitopes for HLA-B53 and other HLA types in the malaria vaccine candidate liver-stage antigen 3
    M Aidoo
    Molecular Immunology Group, Institute of Molecular Medicine, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    Infect Immun 68:227-32. 2000
    ..These findings emphasize the diversity of P. falciparum antigens recognized by CD8(+) T cells in humans and support the inclusion of components from several antigens in new CTL-inducing vaccines against malaria...
  26. ncbi request reprint Novel protein and poxvirus-based vaccine combinations for simultaneous induction of humoral and cell-mediated immunity
    Claire L Hutchings
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    J Immunol 175:599-606. 2005
    ....
  27. ncbi request reprint Direct processing and presentation of antigen from malaria sporozoites by professional antigen-presenting cells in the induction of CD8 T-cell responses
    Magdalena Plebanski
    Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, UK
    Immunol Cell Biol 83:307-12. 2005
    ..The induction of sporozoite-specific CD8 T-cell responses without the need for liver stage infection identifies a potentially important mechanism in the development of pre-erythrocytic immunity...
  28. ncbi request reprint Cellular reactivity to the p. Falciparum protein trap in adult kenyans: novel epitopes, complex cytokine patterns, and the impact of natural antigenic variation
    Katie L Flanagan
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom
    Am J Trop Med Hyg 74:367-75. 2006
    ..They further define polymorphic variants able to boost specific Th1, Th2, and possibly Tr1 reactivity...
  29. ncbi request reprint Enumeration of T cells specific for RD1-encoded antigens suggests a high prevalence of latent Mycobacterium tuberculosis infection in healthy urban Indians
    A Lalvani
    Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    J Infect Dis 183:469-77. 2001
    ..In contrast, of 40 mostly BCG-vaccinated, United Kingdom-resident healthy adults, none responded to either antigen. This study suggests an 80% prevalence of latent M. tuberculosis infection in urban India...
  30. ncbi request reprint Calculation of liver-to-blood inocula, parasite growth rates, and preerythrocytic vaccine efficacy, from serial quantitative polymerase chain reaction studies of volunteers challenged with malaria sporozoites
    Philip Bejon
    Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Oxford, United Kingdom
    J Infect Dis 191:619-26. 2005
    ..Forty-eight-hour growth rates in blood from control subjects were not different from those in blood from any vaccination group (mean, 14.4-fold [95% confidence interval, 11-19-fold])...
  31. pmc Safety, immunogenicity, and efficacy of prime-boost immunization with recombinant poxvirus FP9 and modified vaccinia virus Ankara encoding the full-length Plasmodium falciparum circumsporozoite protein
    Michael Walther
    Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, United Kingdom
    Infect Immun 74:2706-16. 2006
    ..Vaccines containing this antigen proved safe and induced modest immune responses but showed no evidence of efficacy in a sporozoite challenge...
  32. ncbi request reprint Enhanced contact tracing and spatial tracking of Mycobacterium tuberculosis infection by enumeration of antigen-specific T cells
    A Lalvani
    Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Lancet 357:2017-21. 2001
    ..With an enzyme-linked immunospot (ELISPOT) assay for interferon gamma, we have identified ESAT-6-specific T cells as an accurate marker of M tuberculosis infection...
  33. ncbi request reprint Ex vivo interferon-gamma immune response to thrombospondin-related adhesive protein in coastal Kenyans: longevity and risk of Plasmodium falciparum infection
    Katie L Flanagan
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom
    Am J Trop Med Hyg 68:421-30. 2003
    ..This study provides important information regarding natural reactivity to a key malaria antigen...
  34. ncbi request reprint A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria
    J C Knight
    Molecular Infectious Diseases Group, Institute of Molecular Medicine, Oxford, UK
    Nat Genet 22:145-50. 1999
    ....
  35. ncbi request reprint Absence of an association between intercellular adhesion molecule 1, complement receptor 1 and interleukin 1 receptor antagonist gene polymorphisms and severe malaria in a West African population
    R Bellamy
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    Trans R Soc Trop Med Hyg 92:312-6. 1998
    ..This suggests that there may be heterogeneity in genetic susceptibility to this condition between these 2 African populations...
  36. ncbi request reprint In vivo antigen challenge in celiac disease identifies a single transglutaminase-modified peptide as the dominant A-gliadin T-cell epitope
    R P Anderson
    Institute of Molecular Medicine, Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK
    Nat Med 6:337-42. 2000
    ..Discovery of this dominant epitope may allow development of antigen-specific immunotherapy for CD...
  37. pmc Rapid effector function in CD8+ memory T cells
    A Lalvani
    Molecular Immunology Group, Institute of Molecular Medicine, Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    J Exp Med 186:859-65. 1997
    ..The phenotype of these cells, which persist at a low frequency long after recovery from an acute viral infection, suggests that they play a role in protective immunological memory...
  38. ncbi request reprint Dimorphic Plasmodium falciparum merozoite surface protein-1 epitopes turn off memory T cells and interfere with T cell priming
    Edwin A M Lee
    Molecular Immunology Group, Weatherall Institute of Molecular Medicine, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Eur J Immunol 36:1168-78. 2006
    ....
  39. pmc Safety and immunogenicity of boosting BCG vaccinated subjects with BCG: comparison with boosting with a new TB vaccine, MVA85A
    Kathryn T Whelan
    Jenner Institute, University of Oxford, Churchill Hospital, Oxford, United Kingdom
    PLoS ONE 4:e5934. 2009
    ....
  40. pmc Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence
    Angela J Frodsham
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Proc Natl Acad Sci U S A 103:9148-53. 2006
    ..0003), and in vitro assays support functional roles for these variants in receptor signaling...
  41. pmc Genetic regulation of acquired immune responses to antigens of Mycobacterium tuberculosis: a study of twins in West Africa
    A Jepson
    Wellcome Trust Centre for Human Genetics, Headington, Oxford, United Kingdom
    Infect Immun 69:3989-94. 2001
    ..Such findings have implications for vaccine development...
  42. pmc Enhanced immunogenicity of CD4(+) t-cell responses and protective efficacy of a DNA-modified vaccinia virus Ankara prime-boost vaccination regimen for murine tuberculosis
    H McShane
    Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    Infect Immun 69:681-6. 2001
    ....
  43. ncbi request reprint HIV in Africa (Communication arising): chemokine-receptor genes and AIDS risk
    Patricia A Ramaley
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Nature 417:140. 2002
    ..This gene may therefore not be subject to rapid evolutionary change as a result of the HIV epidemic in Africa...
  44. pmc A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis
    Chiea C Khor
    The Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Nat Genet 39:523-8. 2007
    ..6 x 10(-8)). We found that the Mal S180L variant attenuated TLR2 signal transduction...
  45. ncbi request reprint Dendritic cells infected by recombinant modified vaccinia virus Ankara retain immunogenicity in vivo despite in vitro dysfunction
    Shahriar Behboudi
    Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Headington, Oxford OX3 9DU, UK
    Vaccine 22:4326-31. 2004
    ..These data indicate that despite the ability of poxviruses to impair DC maturation in vivo, the important ability of MVA to boost CD8 T-cell response in vivo is mediated at the level of the infected dendritic cells...
  46. pmc Boosting BCG with recombinant modified vaccinia ankara expressing antigen 85A: different boosting intervals and implications for efficacy trials
    Ansar A Pathan
    Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom
    PLoS ONE 2:e1052. 2007
    ....
  47. pmc Correlation of memory T cell responses against TRAP with protection from clinical malaria, and CD4 CD25 high T cells with susceptibility in Kenyans
    Stephen M Todryk
    Centre for Clinical Vaccinology and Tropical Medicine, Oxford University, Churchill Hospital, Oxford, United Kingdom
    PLoS ONE 3:e2027. 2008
    ....
  48. ncbi request reprint Allelic association between the NRAMP1 gene and susceptibility to tuberculosis in Guinea-Conakry
    A C Cervino
    Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Ann Hum Genet 64:507-12. 2000
    ..Our results therefore confirm, using a family-based approach on a newly studied population, the previously reported association between this polymorphism and tuberculosis in a population-based study of West Africans...
  49. pmc Genetic susceptibility to tuberculosis in Africans: a genome-wide scan
    R Bellamy
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Proc Natl Acad Sci U S A 97:8005-9. 2000
    ..An X chromosome susceptibility gene may contribute to the excess of males with tuberculosis observed in many different populations...
  50. ncbi request reprint A prime-boost immunisation regimen using DNA followed by recombinant modified vaccinia virus Ankara induces strong cellular immune responses against the Plasmodium falciparum TRAP antigen in chimpanzees
    J Schneider
    Molecular Immunology Group, Institute of Molecular Medicine, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, OX3 9DU, Oxford, UK
    Vaccine 19:4595-602. 2001
    ..The high immunogenicity of this prime-boost regimen in chimpanzees supports further assessment of this delivery strategy for the induction of protection against P. falciparum malaria in humans...
  51. pmc Comparison of tests for association and linkage in incomplete families
    A C Cervino
    The Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom
    Am J Hum Genet 67:120-32. 2000
    ..Under various dominant models, SIBASSOC/STDT was slightly more powerful than TRANSMIT. Misclassification of the disease status of healthy sibs, as well as the discarding of incomplete families, resulted in a consistent loss of power...
  52. pmc CISH and susceptibility to infectious diseases
    Chiea C Khor
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    N Engl J Med 362:2092-101. 2010
    ..The interleukin-2-mediated immune response is critical for host defense against infectious pathogens. Cytokine-inducible SRC homology 2 (SH2) domain protein (CISH), a suppressor of cytokine signaling, controls interleukin-2 signaling...
  53. ncbi request reprint Quantitative association tests of immune responses to antigens of Mycobacterium tuberculosis: a study of twins in West Africa
    Amanda Wiart
    Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom
    Twin Res 7:578-88. 2004
    ..These results yield a greater understanding of the genetic mechanisms that underlie the immune responses in tuberculosis and have implications for the design of therapeutic interventions...
  54. ncbi request reprint Durable human memory T cells quantifiable by cultured enzyme-linked immunospot assays are induced by heterologous prime boost immunization and correlate with protection against malaria
    Sheila M Keating
    Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Medicine, Churchill Hospital, Oxford, United Kingdom
    J Immunol 175:5675-80. 2005
    ..This cultured assay identifies long-lasting protective T cell responses and therefore offers an attractive option for assessments of vaccine immunogenicity...
  55. ncbi request reprint Quantitative real-time polymerase chain reaction for malaria diagnosis and its use in malaria vaccine clinical trials
    Laura Andrews
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Am J Trop Med Hyg 73:191-8. 2005
    ..This PCR method has so far been used to follow 137 vaccinee and control volunteers in Phase IIa trials in Oxford and on 220 volunteer samples during a Phase IIb field trial in The Gambia...
  56. doi request reprint Comparing human T cell and NK cell responses in viral-based malaria vaccine trials
    Tamara K Berthoud
    Centre for Clinical Vaccinology and Tropical Medicine, Oxford University, Churchill Hospital, Oxford, UK
    Vaccine 28:21-7. 2009
    ..In conclusion, measuring antigen-specific T cells is more meaningful than NK cells in these vaccination regimens...
  57. ncbi request reprint MBL genotype and risk of invasive pneumococcal disease: a case-control study
    Suchismita Roy
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Lancet 359:1569-73. 2002
    ..We did a case-control study in the UK to assess whether these mutant genotypes were associated with invasive pneumococcal disease...
  58. ncbi request reprint Fine mapping of a putative tuberculosis-susceptibility locus on chromosome 15q11-13 in African families
    Alessandra C L Cervino
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Hum Mol Genet 11:1599-603. 2002
    ..002). These fine-mapping data suggest that UBE3A or a closely flanking gene may be a tuberculosis-susceptibility locus...
  59. ncbi request reprint Association of NRAMP1 polymorphism with leprosy type but not susceptibility to leprosy per se in west Africans
    S J Meisner
    Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom
    Am J Trop Med Hyg 65:733-5. 2001
    ..Thus, variation in or near the NRAMP1 gene may exert an influence on the clinical presentation of leprosy, possibly by influencing cellular immune response type...
  60. ncbi request reprint Unique T cell effector functions elicited by Plasmodium falciparum epitopes in malaria-exposed Africans tested by three T cell assays
    K L Flanagan
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom
    J Immunol 167:4729-37. 2001
    ..The data suggest that natural immunity to malaria is a complex function of T cell subgroups with different effector functions and has important implications for future studies of natural T cell immunity...
  61. ncbi request reprint Naturally processed HLA class II peptides reveal highly conserved immunogenic flanking region sequence preferences that reflect antigen processing rather than peptide-MHC interactions
    A J Godkin
    Nuffield Department of Medicine, Molecular Immunology Group, Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    J Immunol 166:6720-7. 2001
    ..Recognition of these allele-transcending patterns in the PFRs may prove useful in epitope identification and vaccine design...
  62. pmc The relationship between human effector and memory T cells measured by ex vivo and cultured ELISPOT following recent and distal priming
    Stephen M Todryk
    Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, University of Oxford, Oxford, UK
    Immunology 128:83-91. 2009
    ..This study highlights differences between CD4(+) and CD8(+) effector and memory T cells, and the more complex phenotype of CD4(+) T cells...
  63. pmc Mapping of a novel susceptibility locus suggests a role for MC3R and CTSZ in human tuberculosis
    Graham S Cooke
    Wellcome Trust Centre for Human Genetics, University of Oxford, Churchill Hospital, Headington, Oxford, United Kingdom
    Am J Respir Crit Care Med 178:203-7. 2008
    ..Tuberculosis remains a major cause of morbidity and mortality in the developing world. A better understanding of the mechanisms of disease protection could allow novel strategies to disease management and control...
  64. ncbi request reprint Large-scale candidate gene study of tuberculosis susceptibility in the Karonga district of northern Malawi
    Jodene Fitness
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Am J Trop Med Hyg 71:341-9. 2004
    ..Genetic susceptibility to TB in Africans appears polygenic. The relevant genes and variants may vary significantly between populations, and may be affected by HIV infection status...
  65. doi request reprint Multiple functions of human T cells generated by experimental malaria challenge
    Stephen M Todryk
    Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK
    Eur J Immunol 39:3042-51. 2009
    ..This study shows that malaria infection elicits specific Th1 and Th2 effector cells, but concomitant weak central memory and regulatory activity, which may help to explain the short-lived immunity observed...
  66. ncbi request reprint A CD4(+) T-cell immune response to a conserved epitope in the circumsporozoite protein correlates with protection from natural Plasmodium falciparum infection and disease
    William H H Reece
    Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Nat Med 10:406-10. 2004
    ..These findings provide direct evidence for a protective role for CD4(+) T cells in humans, and a precise target for the design of improved vaccines against P. falciparum...
  67. pmc MIG (CXCL9) is a more sensitive measure than IFN-gamma of vaccine induced T-cell responses in volunteers receiving investigated malaria vaccines
    Tamara K Berthoud
    University of Oxford, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, OX3 7LJ, UK
    J Immunol Methods 340:33-41. 2009
    ..Measurement of MIG alongside IFN-gamma may provide a fuller picture of Th1 type responses post-vaccination...
  68. ncbi request reprint Effective induction of HIV-specific CTL by multi-epitope using gene gun in a combined vaccination regime
    T Hanke
    Molecular Immunology Group, Institute of Molecular Medicine, University of Oxford, The John Radcliffe Hospital, Headington, UK
    Vaccine 17:589-96. 1999
    ..Thus particular sequences of routes or vaccine vehicles rather than simple prime-boost delivery of a single vaccine is critical for an effective elicitation of CTL...
  69. ncbi request reprint Protection from Plasmodium berghei infection by priming and boosting T cells to a single class I-restricted epitope with recombinant carriers suitable for human use
    M Plebanski
    Institute of Molecular Medicine, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, GB
    Eur J Immunol 28:4345-55. 1998
    ..Thus, the novel recombinant Ty/MVA prime/boost combination with these constructs provides a safe alternative for evaluation for human vaccination against P. falciparum malaria...
  70. pmc 1,25-Dihydroxyvitamin D3 induces nitric oxide synthase and suppresses growth of Mycobacterium tuberculosis in a human macrophage-like cell line
    K A Rockett
    Molecular Infectious Disease Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    Infect Immun 66:5314-21. 1998
    ....
  71. pmc Extended follow-up following a phase 2b randomized trial of the candidate malaria vaccines FP9 ME-TRAP and MVA ME-TRAP among children in Kenya
    Philip Bejon
    Kenya Medical Research Institute, Centre for Geographical Medicine Research Coast, Kilifi, Kenya
    PLoS ONE 2:e707. 2007
    ..5, 95% CI 1.0-2.3). Although the study was unblinded, another nine months follow-up was planned to monitor the incidence of malaria and other serious adverse events...
  72. pmc Mannose-binding lectin genotypes: lack of association with susceptibility to thoracic empyema
    Stephen J Chapman
    The Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    BMC Med Genet 11:5. 2010
    ..The possible role of MBL genotypic deficiency in susceptibility to thoracic empyema has not previously been reported...
  73. ncbi request reprint Prime-boost vectored malaria vaccines: progress and prospects
    Adrian V S Hill
    The Jenner Institute, University of Oxford, Oxford, UK
    Hum Vaccin 6:78-83. 2010
    ..These viral vectors now provide a major option for inclusion in a high efficacy multi-stage malaria vaccine that should achieve deployable levels of efficacy in endemic settings...
  74. doi request reprint Expression of tak1 and tram induces synergistic pro-inflammatory signalling and adjuvants DNA vaccines
    Karen Colbjørn Larsen
    The Jenner Institute, University of Oxford, Oxford OX3 7DQ, United Kingdom
    Vaccine 27:5589-98. 2009
    ..These results indicate that optimal immunogenicity may require activation of distinct innate immune signalling pathways. Thus this strategy offers a novel route to the discovery of a new generation of adjuvants...
  75. pmc Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in Mycobacterium tuberculosis-infected individuals
    Clare R Sander
    Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, University of Oxford, Oxford OX3 7LJ, UK
    Am J Respir Crit Care Med 179:724-33. 2009
    ..An effective new tuberculosis (TB) vaccine regimen must be safe in individuals with latent TB infection (LTBI) and is a priority for global health care...
  76. pmc Boosting BCG vaccination with MVA85A down-regulates the immunoregulatory cytokine TGF-beta1
    Helen A Fletcher
    Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK
    Vaccine 26:5269-75. 2008
    ..This apparent ability to counteract regulatory T cell effects suggests a potential use of MVA85A as an adjuvant for less immunogenic vaccines...
  77. doi request reprint A comparison of IFNgamma detection methods used in tuberculosis vaccine trials
    Natalie E R Beveridge
    Jenner Institute, Old Road Campus Research Building, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7DQ, UK
    Tuberculosis (Edinb) 88:631-40. 2008
    ..Future tuberculosis vaccine trials and immunology studies should ideally include a combination of ex vivo and cultured assays to ensure a thorough and multifaceted evaluation of the immune response is achieved...
  78. pmc Effective induction of high-titer antibodies by viral vector vaccines
    Simon J Draper
    The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford OX3 7DQ, UK
    Nat Med 14:819-21. 2008
    ..Antibodies induced against a blood-stage malaria antigen by this viral vector platform are highly effective against Plasmodium yoelii parasites in mice and against Plasmodium falciparum in vitro...
  79. pmc Evidence of blood stage efficacy with a virosomal malaria vaccine in a phase IIa clinical trial
    Fiona M Thompson
    Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Oxford, United Kingdom
    PLoS ONE 3:e1493. 2008
    ..This trial was the first to combine two existing vaccination strategies to produce a vaccine that induces immune responses to both the pre-erythrocytic and blood stages of the P. falciparum life cycle...
  80. pmc CD209 genetic polymorphism and tuberculosis disease
    Fredrik O Vannberg
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS ONE 3:e1388. 2008
    ..The present study investigates the role of the CD209 -336A/G variant in susceptibility to tuberculosis in a large sample of individuals from sub-Saharan Africa...
  81. pmc Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional Mycobacterium tuberculosis-specific CD4+ memory T lymphocyte populations
    Natalie E R Beveridge
    Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, UK
    Eur J Immunol 37:3089-100. 2007
    ..Overall, these data strongly support the use of MVA85A in humans as a boosting agent to expand polyfunctional M.tb-specific CD4(+) T cells capable of significant secondary responses...
  82. pmc Combination of protein and viral vaccines induces potent cellular and humoral immune responses and enhanced protection from murine malaria challenge
    Claire L Hutchings
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Infect Immun 75:5819-26. 2007
    ....
  83. pmc Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    Eleftheria Zeggini
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    Science 316:1336-41. 2007
    ..The regions identified underscore the importance of pathways influencing pancreatic beta cell development and function in the etiology of type 2 diabetes...
  84. ncbi request reprint Functional polymorphisms in the FCN2 gene are not associated with invasive pneumococcal disease
    Stephen J Chapman
    The Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Mol Immunol 44:3267-70. 2007
    ..Although we are unable to exclude small effects of FCN2 genetic variation on susceptibility to IPD, the result suggests that L-ficolin may not be critical for host defence against pneumococcal infection...
  85. ncbi request reprint Synergistic DNA-MVA prime-boost vaccination regimes for malaria and tuberculosis
    Sarah C Gilbert
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Vaccine 24:4554-61. 2006
    ..In this review we summarise the safety, immunogenicity and efficacy results from these malaria and tuberculosis vaccine clinical trials...
  86. ncbi request reprint Boosting BCG with MVA85A: the first candidate subunit vaccine for tuberculosis in clinical trials
    Helen McShane
    Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK
    Tuberculosis (Edinb) 85:47-52. 2005
    ..MVA85A is now in clinical trials in the UK and Africa and the design of these trials, including the ethical and regulatory issues are discussed...
  87. pmc Inverse associations of human leukocyte antigen and malaria parasite types in two West African populations
    Karen Young
    Wellcome Trust Centre for Human Genetics, Oxford University, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Infect Immun 73:953-5. 2005
    ..e., the malaria parasite, and a major biological mechanism are well defined. We show that this surprising result fits well with the predictions of a mathematical model describing the population genetics and dynamics of this interaction...
  88. ncbi request reprint Prime-boost strategies for malaria vaccine development
    Susanna J Dunachie
    Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital, Old Road, Oxford OX3 7LJ, UK
    J Exp Biol 206:3771-9. 2003
    ..The prime-boost approach represents an encouraging step towards establishing an effective preventative vaccine to one of the world's greatest killers...
  89. pmc Protective immunity against Mycobacterium tuberculosis induced by dendritic cells pulsed with both CD8(+)- and CD4(+)-T-cell epitopes from antigen 85A
    Helen McShane
    Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    Infect Immun 70:1623-6. 2002
    ....
  90. ncbi request reprint Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans
    Helen McShane
    Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    Nat Med 10:1240-4. 2004
    ..Boosting vaccinations with MVA85A could offer a practical and efficient strategy for enhancing and prolonging antimycobacterial immunity in tuberculosis-endemic areas...
  91. ncbi request reprint Association of genetic variants of the chemokine receptor CCR5 and its ligands, RANTES and MCP-2, with outcome of HCV infection
    Simon Hellier
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Hepatology 38:1468-76. 2003
    ..018, OR: 2.29, 95% CI: 1.14-4.58). In conclusion, our study suggests a possible role of the polymorphisms CCR5-delta32, RANTES -403, and MCP-2 Q46K in the outcome of HCV infection...
  92. ncbi request reprint Interleukin-1 gene cluster polymorphisms and susceptibility to clinical malaria in a Gambian case-control study
    Andrew J Walley
    Wellcome Trust Centre for Human Genetics, Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, UK
    Eur J Hum Genet 12:132-8. 2004
    ..Haplotypes constructed using the SNPHAP programme were not associated with any of the malaria phenotypes investigated. In summary, if IL1 variants are involved in malaria susceptibility in the Gambia at all, then the effects are small...
  93. pmc A Plasmodium falciparum candidate vaccine based on a six-antigen polyprotein encoded by recombinant poxviruses
    Eric Prieur
    Weatherall Institute of Molecular Medicine and Cellular Immunology, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    Proc Natl Acad Sci U S A 101:290-5. 2004
    ..The use of polyprotein constructs in nonreplicating poxviruses should broaden the target antigen range of vaccine-induced immunity and increase the number of potential epitopes available for immunogenetically diverse human populations...
  94. ncbi request reprint Enhanced immunogenicity and protective efficacy against Mycobacterium tuberculosis of bacille Calmette-Guérin vaccine using mucosal administration and boosting with a recombinant modified vaccinia virus Ankara
    Nilu P Goonetilleke
    Nuffield Department of Clinical Medicine, Oxford University, John Radcliffe Hospital, Oxford, United Kingdom
    J Immunol 171:1602-9. 2003
    ..These findings support further evaluation of mucosally targeted prime-boost vaccination approaches for tuberculosis...
  95. ncbi request reprint A clinical trial of prime-boost immunisation with the candidate malaria vaccines RTS,S/AS02A and MVA-CS
    Susanna J Dunachie
    Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK
    Vaccine 24:2850-9. 2006
    ..Protection against 3D7 Plasmodium falciparum sporozoite challenge 4 weeks after the final vaccination was equal for both regimens at 33% (95% C.I. 4.3-77.7%), with one subject remaining fully protected on rechallenge at 5 months...
  96. ncbi request reprint Haptoglobin genotypes are not associated with resistance to severe malaria in The Gambia
    Christophe Aucan
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
    Trans R Soc Trop Med Hyg 96:327-8. 2002
    ..No significant association was found between severe malaria and either haptoglobin genotypes or phenotypes. The advantages of using a deoxyribonucleic acid-based haptoglobin typing method are discussed...
  97. ncbi request reprint Association of Fcgamma receptor IIa (CD32) polymorphism with severe malaria in West Africa
    Graham S Cooke
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Am J Trop Med Hyg 69:565-8. 2003
    ..This is the first evidence for an association between CD32 polymorphism and severe malaria and provides an example of balancing selective pressures from different infectious diseases operating at the same genetic locus...
  98. ncbi request reprint A region of chromosome 20 is linked to leprosy susceptibility in a South Indian population
    Kerrie Tosh
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    J Infect Dis 186:1190-3. 2002
    ..021), which suggests that a locus controlling susceptibility lies close to this marker...
  99. ncbi request reprint Genetics of susceptibility to human infectious disease
    G S Cooke
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Nat Rev Genet 2:967-77. 2001
    ..As part of this effort, developments in genetics have allowed a more systematic study of the impact that the human genome and infectious disease have on each other...
  100. ncbi request reprint A major susceptibility locus for leprosy in India maps to chromosome 10p13
    M R Siddiqui
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Genet 27:439-41. 2001
    ..Thus, despite the polygenic nature of infectious disease susceptibility, some major, non-HLA-linked loci exist that may be mapped through obtainable numbers of affected sibling pairs...
  101. ncbi request reprint Strong HLA class I--restricted T cell responses in dengue hemorrhagic fever: a double-edged sword?
    H Loke
    Nuffield Department of Medicine, John Radcliffe Hospital and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    J Infect Dis 184:1369-73. 2001
    ..The potentially pathogenic role of serotype-cross-reactive CD8 T cells poses yet another obstacle to successful dengue vaccine development...