Julian P T Higgins

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Planning future studies based on the conditional power of a meta-analysis
    Verena Roloff
    MRC Biostatistics Unit, Cambridge, U K
    Stat Med 32:11-24. 2013
  2. pmc Imputation methods for missing outcome data in meta-analysis of clinical trials
    Julian P T Higgins
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge, UK
    Clin Trials 5:225-39. 2008
  3. pmc Meta-analysis of skewed data: combining results reported on log-transformed or raw scales
    Julian P T Higgins
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    Stat Med 27:6072-92. 2008
  4. doi request reprint Commentary: Heterogeneity in meta-analysis should be expected and appropriately quantified
    Julian P T Higgins
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 0SR, UK
    Int J Epidemiol 37:1158-60. 2008
  5. ncbi request reprint Meta-analysis of continuous outcome data from individual patients
    J P Higgins
    MRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge CB2 2SR, U K
    Stat Med 20:2219-41. 2001
  6. ncbi request reprint Controlling the risk of spurious findings from meta-regression
    Julian P T Higgins
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, U K
    Stat Med 23:1663-82. 2004
  7. pmc Measuring inconsistency in meta-analyses
    Julian P T Higgins
    MRC Biostatistics Unit, Institute of Public Health, Cambridge CB2 2SR
    BMJ 327:557-60. 2003
  8. pmc Sequential methods for random-effects meta-analysis
    Julian P T Higgins
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 0SR, U K
    Stat Med 30:903-21. 2011
  9. ncbi request reprint Quantifying heterogeneity in a meta-analysis
    Julian P T Higgins
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK
    Stat Med 21:1539-58. 2002
  10. ncbi request reprint Allowing for uncertainty due to missing data in meta-analysis--part 2: hierarchical models
    Ian R White
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    Stat Med 27:728-45. 2008

Collaborators

Detail Information

Publications50

  1. pmc Planning future studies based on the conditional power of a meta-analysis
    Verena Roloff
    MRC Biostatistics Unit, Cambridge, U K
    Stat Med 32:11-24. 2013
    ..We demonstrate that if heterogeneity is anticipated, it might not be possible for a single study to reach the desirable power no matter how large it is...
  2. pmc Imputation methods for missing outcome data in meta-analysis of clinical trials
    Julian P T Higgins
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge, UK
    Clin Trials 5:225-39. 2008
    ..An intention-to-treat analysis should take account of all randomized participants even if they have missing observations...
  3. pmc Meta-analysis of skewed data: combining results reported on log-transformed or raw scales
    Julian P T Higgins
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    Stat Med 27:6072-92. 2008
    ..An assumption can be made that the standard deviations in the two groups are equal. This increases precision of the estimates, but if incorrect can lead to very misleading results...
  4. doi request reprint Commentary: Heterogeneity in meta-analysis should be expected and appropriately quantified
    Julian P T Higgins
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 0SR, UK
    Int J Epidemiol 37:1158-60. 2008
  5. ncbi request reprint Meta-analysis of continuous outcome data from individual patients
    J P Higgins
    MRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge CB2 2SR, U K
    Stat Med 20:2219-41. 2001
    ..Relative merits of the three software packages for such meta-analyses are discussed, as are the assessment of model assumptions and extensions to incorporate more than two treatments...
  6. ncbi request reprint Controlling the risk of spurious findings from meta-regression
    Julian P T Higgins
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, U K
    Stat Med 23:1663-82. 2004
    ..The permutation test appropriately tempers the statistical significance of meta-regression findings. We recommend its use before a statistically significant relationship is claimed from a standard meta-regression analysis...
  7. pmc Measuring inconsistency in meta-analyses
    Julian P T Higgins
    MRC Biostatistics Unit, Institute of Public Health, Cambridge CB2 2SR
    BMJ 327:557-60. 2003
  8. pmc Sequential methods for random-effects meta-analysis
    Julian P T Higgins
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 0SR, U K
    Stat Med 30:903-21. 2011
    ..We illustrate the method using an example in the treatment of bleeding peptic ulcers...
  9. ncbi request reprint Quantifying heterogeneity in a meta-analysis
    Julian P T Higgins
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK
    Stat Med 21:1539-58. 2002
    ..One or both should be presented in published meta-analyses in preference to the test for heterogeneity...
  10. ncbi request reprint Allowing for uncertainty due to missing data in meta-analysis--part 2: hierarchical models
    Ian R White
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    Stat Med 27:728-45. 2008
    ..By applying the method in three different data sets, we show that it is possible to appropriately capture the extra uncertainty due to missing data, and we discuss in what circumstances it is possible to learn about the IMOR...
  11. ncbi request reprint How should meta-regression analyses be undertaken and interpreted?
    Simon G Thompson
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK
    Stat Med 21:1559-73. 2002
    ..The examples considered in this paper show the tension between the scientific rationale for using meta-regression and the difficult interpretative problems to which such analyses are prone...
  12. ncbi request reprint Treating individuals 4: can meta-analysis help target interventions at individuals most likely to benefit?
    Simon G Thompson
    MRC Biostatistics Unit, Institute of Public Health, Cambridge CB2 2 sR, UK
    Lancet 365:341-6. 2005
    ..Also, although meta-analyses generally summarise an intervention's effect as a relative risk reduction, the groups of patients with the greatest absolute risk reduction have the most to gain...
  13. ncbi request reprint Bayesian synthesis of epidemiological evidence with different combinations of exposure groups: application to a gene-gene-environment interaction
    Georgia Salanti
    MRC Biostatistics Unit, Cambridge, U K
    Stat Med 25:4147-63. 2006
    ..The methodology is implemented in an original meta-analysis of studies relating the risk of bladder cancer to two N-acetyltransferase genes, NAT1 and NAT2, and smoking status...
  14. ncbi request reprint Allowing for uncertainty due to missing data in meta-analysis--part 1: two-stage methods
    Ian R White
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    Stat Med 27:711-27. 2008
    ..We illustrate the methods using a meta-analysis on psychiatric interventions in deliberate self-harm...
  15. ncbi request reprint Bayesian multivariate meta-analysis with multiple outcomes
    Yinghui Wei
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge, CB2 0SR, UK
    Stat Med 32:2911-34. 2013
    ..We illustrate the methods with an example data set from the Cochrane Database of Systematic Reviews...
  16. pmc Online genetic databases informing human genome epidemiology
    Angela J Frodsham
    Public Health Genetics Unit, Strangeways Research Laboratory, Cambridge, UK
    BMC Med Res Methodol 7:31. 2007
    ..A first port of call for most such reviews is a search of MEDLINE. We examined whether this could be usefully supplemented by identifying databases on the World Wide Web that contain genetic epidemiological information...
  17. ncbi request reprint Bayesian meta-analysis and meta-regression for gene-disease associations and deviations from Hardy-Weinberg equilibrium
    Georgia Salanti
    MRC Biostatistics Unit, Cambridge, UK
    Stat Med 26:553-67. 2007
    ..The proposed hierarchical models allow the synthesis of data across gene-disease association studies with appropriate consideration of HWE issues...
  18. ncbi request reprint Meta-analysis of individual patient data from randomized trials: a review of methods used in practice
    Mark C Simmonds
    MRC Biostatistics Unit, Robinson Way, Cambridge, UK
    Clin Trials 2:209-17. 2005
    ..Meta-analyses based on individual patient data (IPD) are regarded as the gold standard for systematic reviews. However, the methods used for analysing and presenting results from IPD meta-analyses have received little discussion...
  19. pmc Five glutathione s-transferase gene variants in 23,452 cases of lung cancer and 30,397 controls: meta-analysis of 130 studies
    Zheng Ye
    Department of Public Health and Primary Care, University of Cambridge, Strangeways Site, Cambridge, United Kingdom
    PLoS Med 3:e91. 2006
    ..It has been suggested that polymorphisms in the GST genes are risk factors for lung cancer, but a large number of studies have reported apparently conflicting results...
  20. ncbi request reprint Challenges in the use of literature-based meta-analysis to examine gene-environment interactions
    Luigi Palla
    Institute of Metabolic Science, Cambridge University Hospital Foundation Trust, United Kingdom
    Am J Epidemiol 171:1225-32. 2010
    ..This issue may ultimately only be resolvable by the de novo establishment of large single or multicenter cohorts using comparable methods...
  21. pmc Long-term interleukin-6 levels and subsequent risk of coronary heart disease: two new prospective studies and a systematic review
    John Danesh
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
    PLoS Med 5:e78. 2008
    ..We updated a systematic review to put the new findings in context...
  22. ncbi request reprint Relative and absolute risk of colorectal cancer for individuals with a family history: a meta-analysis
    Adam S Butterworth
    Public Health Genetics Unit, Cambridge Genetics Knowledge Park, Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN, UK
    Eur J Cancer 42:216-27. 2006
    ..8 to 4.0) with at least one affected relative or 6.9% (95% CI 4.5 to 10.4) with two or more. Accurate absolute risk estimates show how cancer risks vary over time, particularly by pattern of family history and age of individual at-risk...
  23. ncbi request reprint Obstacles and opportunities in meta-analysis of genetic association studies
    Georgia Salanti
    MRC Biostatistics Unit, Cambridge, UK
    Genet Med 7:13-20. 2005
    ..We believe that systematic review and meta-analysis has an important role to play in understanding genetic association studies and should help us to separate the wheat from the chaff...
  24. ncbi request reprint Tools for assessing quality and susceptibility to bias in observational studies in epidemiology: a systematic review and annotated bibliography
    Simon Sanderson
    Primary Care Genetics, General Practice and Primary Care Research Unit, University of Cambridge and Public Health Genetics Unit, Strangeways Research Labs, Worts Causeway, Cambridge, UK
    Int J Epidemiol 36:666-76. 2007
    ..Tools for assessing quality in clinical trials are well-described but much less attention has been given to similar tools for observational epidemiological studies...
  25. pmc The association between the peroxisome proliferator-activated receptor-gamma2 (PPARG2) Pro12Ala gene variant and type 2 diabetes mellitus: a HuGE review and meta-analysis
    Hebe N Gouda
    Department of Public Health and Primary Care, University ofCambridge, Cambridge CB2 0SR, UK
    Am J Epidemiol 171:645-55. 2010
    ..Work on PPARG Pro12Ala should now focus on the observed heterogeneity in the magnitude of the association between populations. Further investigations into gene-gene and gene-environment interactions may prove enlightening...
  26. ncbi request reprint A design-by-treatment interaction model for network meta-analysis with random inconsistency effects
    Dan Jackson
    MRC Biostatistics Unit, Cambridge, U K
    Stat Med 33:3639-54. 2014
    ..We derive R and I(2) statistics to quantify the impact of the between-study heterogeneity and the inconsistency. We apply our model to two examples. © 2014 The Authors. Statistics in Medicine published by John Wiley & Sons, Ltd. ..
  27. pmc The impact of study size on meta-analyses: examination of underpowered studies in Cochrane reviews
    Rebecca M Turner
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, United Kingdom
    PLoS ONE 8:e59202. 2013
    ..We examine the distribution of power available in studies within meta-analyses published in Cochrane reviews, and investigate the impact of underpowered studies on meta-analysis results...
  28. pmc Estimating within-study covariances in multivariate meta-analysis with multiple outcomes
    Yinghui Wei
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 0SR, UK
    Stat Med 32:1191-205. 2013
    ..An application to a meta-analysis of treatments for stroke illustrates the use of the approximated covariance in multivariate meta-analysis with correlated outcomes...
  29. ncbi request reprint A case study of multiple-treatments meta-analysis demonstrates that covariates should be considered
    Georgia Salanti
    MRC Biostatistics Unit, Cambridge, UK
    J Clin Epidemiol 62:857-64. 2009
    ....
  30. pmc Non-invasive prenatal diagnostic test accuracy for fetal sex using cell-free DNA a review and meta-analysis
    Caroline F Wright
    PHG Foundation, 2 Worts Causeway, Cambridge, UK
    BMC Res Notes 5:476. 2012
    ..We applied a sensitive search of multiple bibliographic databases including PubMed (MEDLINE), EMBASE, the Cochrane library and Web of Science...
  31. pmc Two-stage meta-analysis of survival data from individual participants using percentile ratios
    Jessica K Barrett
    MRC Biostatistics Unit, Cambridge, UK
    Stat Med 31:4296-308. 2012
    ..We describe a novel two-stage method for the meta-analysis of percentile ratios that avoids distributional assumptions at the study level...
  32. pmc Characteristics of meta-analyses and their component studies in the Cochrane Database of Systematic Reviews: a cross-sectional, descriptive analysis
    Jonathan Davey
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    BMC Med Res Methodol 11:160. 2011
    ..The characteristics of these reviews and the meta-analyses and individual studies they contain provide insights into the nature of healthcare research and important context for the development of relevant statistical and other methods...
  33. ncbi request reprint Being sceptical about meta-analyses: a Bayesian perspective on magnesium trials in myocardial infarction
    Julian P T Higgins
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    Int J Epidemiol 31:96-104. 2002
    ....
  34. doi request reprint Array CGH in patients with learning disability (mental retardation) and congenital anomalies: updated systematic review and meta-analysis of 19 studies and 13,926 subjects
    Gurdeep S Sagoo
    MRC Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom
    Genet Med 11:139-46. 2009
    ..However, given that this technology also identifies false positives at a similar rate to causal variants, caution in clinical practice should be advised...
  35. ncbi request reprint Meta-analysis of genetic association studies under different inheritance models using data reported as merged genotypes
    Georgia Salanti
    Clinical and Molecular Epidemiology Unit, University of Ioannina School of Medicine, Ioannina, Greece
    Stat Med 27:764-77. 2008
    ....
  36. ncbi request reprint Meta-analysis in occupational epidemiology: a review of practice
    Damien M McElvenny
    Public and Environmental Health Research Unit, London School of Hygiene and Tropical Medicine, London, UK
    Occup Med (Lond) 54:336-44. 2004
    ..To describe past practice in meta-analyses found in occupational epidemiology, identifying the major issues that should be considered by researchers planning a meta-analysis in this setting...
  37. ncbi request reprint Seven haemostatic gene polymorphisms in coronary disease: meta-analysis of 66,155 cases and 91,307 controls
    Zheng Ye
    Department of Public Health and Primary Care, University of Cambridge, Strangeways Site, Wort s Causeway, Cambridge CB1 8RN, UK
    Lancet 367:651-8. 2006
    ..We did meta-analyses on seven such haemostatic genetic variants for which the available evidence on each comprises at least 5000 coronary disease cases and at least 5000 controls...
  38. ncbi request reprint A road map for efficient and reliable human genome epidemiology
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, and Biomedical Research Institute, Foundation for Research and Technology Hellas, Ioannina 45110, Greece
    Nat Genet 38:3-5. 2006
    ..Systematic reviews will be expanded to include more meta-analyses of individual-level data and prospective meta-analyses. Field synopses will offer regularly updated overviews...
  39. ncbi request reprint Assessment of cumulative evidence on genetic associations: interim guidelines
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Int J Epidemiol 37:120-32. 2008
    ..Future empirical research and consensus development are needed to develop an integrated model for combining epidemiological and biological evidence in the rapidly evolving field of investigation of genetic factors...
  40. ncbi request reprint Meta-analyses involving cross-over trials: methodological issues
    Diana R Elbourne
    Medical Statistics Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Int J Epidemiol 31:140-9. 2002
    ..This paper concentrates on RCTs of a different design-two-period, two-treatment cross-over trials...
  41. ncbi request reprint Turning the pump handle: evolving methods for integrating the evidence on gene-disease association
    Julian P T Higgins
    Am J Epidemiol 166:863-6. 2007
  42. ncbi request reprint Systematic review of controlled trials on the effectiveness of fluoride gels for the prevention of dental caries in children
    Valeria C C Marinho
    Systematic Reviews Training Unit, Institute of Child Health, London
    J Dent Educ 67:448-58. 2003
    ..2 D(M)FS/year, or an NNT of twenty-four (95 percent CI, 18 to 36) based on an increment of 0.2 D(M)FS/year. However, further work is needed to identify and quantify potential harmful effects of fluoride gels...
  43. ncbi request reprint Relative efficacy of differential methods of dietary advice: a systematic review
    Rachel L Thompson
    Institute of Human Nutrition, University of Southampton, Southampton, UK
    Am J Clin Nutr 77:1052S-1057S. 2003
    ..Dietary advice to lower blood cholesterol may be given by a variety of means. The relative efficacy of the different methods is unknown...
  44. ncbi request reprint The emergence of networks in human genome epidemiology: challenges and opportunities
    Daniela Seminara
    Epidemiology and Genetics Research Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, NIH, EPN Bldg, Rm 5142, MSC 7393, 6130 Executive Blvd, Bethesda, MD 20892, USA
    Epidemiology 18:1-8. 2007
  45. ncbi request reprint Response to paper by Lang A, Edwards N, and Fleiszer A
    Sally Green
    Monash University, Australasian Cochrane Centre, Melbourne, Australia
    J Clin Epidemiol 60:598-9. 2007
  46. ncbi request reprint A network of investigator networks in human genome epidemiology
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Am J Epidemiol 162:302-4. 2005
    ....
  47. ncbi request reprint Evaluation of networks of randomized trials
    Georgia Salanti
    Clinical and Molecular Epidemiology Unit and Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Greece
    Stat Methods Med Res 17:279-301. 2008
    ..Finally, we discuss the implications of inconsistency, network geometry and asymmetry in informing the planning of future trials...
  48. pmc Risks and benefits of omega 3 fats for mortality, cardiovascular disease, and cancer: systematic review
    Lee Hooper
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich NR4 7TJ
    BMJ 332:752-60. 2006
    ..To review systematically the evidence for an effect of long chain and shorter chain omega 3 fatty acids on total mortality, cardiovascular events, and cancer...