R S Heyderman

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. ncbi request reprint Early management of suspected bacterial meningitis and meningococcal septicaemia in immunocompetent adults--second edition
    R S Heyderman
    Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
    J Infect 50:373-4. 2005
  2. ncbi request reprint Neutrophil response to Neisseria meningitidis: inhibition of adhesion molecule expression and phagocytosis by recombinant bactericidal/permeability-increasing protein (rBPI21)
    R S Heyderman
    Division of Microbiology, Departments of Pathology and Microbiology, School of Medical Sciences, University of Bristol, University Walk, Bristol, United Kingdom BS8 1TD
    J Infect Dis 179:1288-92. 1999
  3. ncbi request reprint Is immune cell activation the missing link in the pathogenesis of post-diarrhoeal HUS?
    R S Heyderman
    Dept of Pathology and Microbiology, School of Medical Sciences, University of Bristol, BS8 1TD, Bristol, UK
    Trends Microbiol 9:262-6. 2001
  4. ncbi request reprint Early management of suspected bacterial meningitis and meningococcal septicaemia in adults
    R S Heyderman
    Department of Pathalogy and Microbiology, School of Medical Sciences, University of Bristol, UK
    J Infect 46:75-7. 2003
  5. ncbi request reprint Mucosal immunity and optimizing protection with meningococcal serogroup B vaccines
    Robert S Heyderman
    Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
    Trends Microbiol 14:120-4. 2006
  6. pmc The incidence and mortality for meningococcal disease associated with area deprivation: an ecological study of hospital episode statistics
    R S Heyderman
    Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, University Walk, UK
    Arch Dis Child 89:1064-8. 2004
  7. ncbi request reprint Quality of in-hospital care for adults with acute bacterial meningitis: a national retrospective survey
    A B Gjini
    Social Medicine Department, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, UK
    QJM 99:761-9. 2006
  8. doi request reprint Polysaccharide-protein conjugate vaccination induces antibody production but not sustained B-cell memory in the human nasopharyngeal mucosa
    E T Clarke
    School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK
    Mucosal Immunol 6:288-96. 2013
  9. doi request reprint IgA1 antibodies specific for outer membrane protein PorA modulate the interaction between Neisseria meningitidis and the epithelium
    R E Horton
    Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, Bristol, UK
    Microb Pathog 46:253-60. 2009
  10. pmc Changing epidemiology of bacterial meningitis among adults in England and Wales 1991-2002
    A B Gjini
    Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, UK
    Epidemiol Infect 134:567-9. 2006

Detail Information

Publications26

  1. ncbi request reprint Early management of suspected bacterial meningitis and meningococcal septicaemia in immunocompetent adults--second edition
    R S Heyderman
    Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
    J Infect 50:373-4. 2005
    ....
  2. ncbi request reprint Neutrophil response to Neisseria meningitidis: inhibition of adhesion molecule expression and phagocytosis by recombinant bactericidal/permeability-increasing protein (rBPI21)
    R S Heyderman
    Division of Microbiology, Departments of Pathology and Microbiology, School of Medical Sciences, University of Bristol, University Walk, Bristol, United Kingdom BS8 1TD
    J Infect Dis 179:1288-92. 1999
    ..meningitidis. The effect of rBPI21 was reversed by excess E. coli LPS or FMLP. It is proposed that PMNL priming by N. meningitidis results in an exaggerated activation and phagocytosis response to the organism...
  3. ncbi request reprint Is immune cell activation the missing link in the pathogenesis of post-diarrhoeal HUS?
    R S Heyderman
    Dept of Pathology and Microbiology, School of Medical Sciences, University of Bristol, BS8 1TD, Bristol, UK
    Trends Microbiol 9:262-6. 2001
    ..Validation of this hypothesis could lead to a targeted anti-inflammatory approach aimed at modulating immune cell function in HUS...
  4. ncbi request reprint Early management of suspected bacterial meningitis and meningococcal septicaemia in adults
    R S Heyderman
    Department of Pathalogy and Microbiology, School of Medical Sciences, University of Bristol, UK
    J Infect 46:75-7. 2003
  5. ncbi request reprint Mucosal immunity and optimizing protection with meningococcal serogroup B vaccines
    Robert S Heyderman
    Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
    Trends Microbiol 14:120-4. 2006
    ..Thus, mucosal immunization before a systemic booster vaccination could provide the solution and reduce the necessity for multiple injections to achieve immunity...
  6. pmc The incidence and mortality for meningococcal disease associated with area deprivation: an ecological study of hospital episode statistics
    R S Heyderman
    Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, University Walk, UK
    Arch Dis Child 89:1064-8. 2004
    ..To determine whether incidence, mortality, and case fatality for meningococcal disease (MD) differs by area deprivation, and if this has changed over time...
  7. ncbi request reprint Quality of in-hospital care for adults with acute bacterial meningitis: a national retrospective survey
    A B Gjini
    Social Medicine Department, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, UK
    QJM 99:761-9. 2006
    ..In contrast to paediatric practice, data from industrialized countries with regard to current hospital management practice are lacking...
  8. doi request reprint Polysaccharide-protein conjugate vaccination induces antibody production but not sustained B-cell memory in the human nasopharyngeal mucosa
    E T Clarke
    School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK
    Mucosal Immunol 6:288-96. 2013
    ..It would also be expected to boost local mucosal immunity, thus extending herd protection. Strategies to generate PS-specific B(MEM) in the mucosa warrant further investigation...
  9. doi request reprint IgA1 antibodies specific for outer membrane protein PorA modulate the interaction between Neisseria meningitidis and the epithelium
    R E Horton
    Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, Bristol, UK
    Microb Pathog 46:253-60. 2009
    ..Together these data suggest the presence of a specific epithelial IgA receptor that could influence the effect of both naturally acquired and vaccine induced IgA antibodies at the epithelial surface...
  10. pmc Changing epidemiology of bacterial meningitis among adults in England and Wales 1991-2002
    A B Gjini
    Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, UK
    Epidemiol Infect 134:567-9. 2006
    ..Improvements in clinical management, childhood vaccination programmes and the re-emergence of tuberculosis are likely to be drivers of these changes...
  11. pmc Major histocompatibility complex class I expression in human tonsillar and laryngeal epithelium
    C G L Hobbs
    Clinical Sciences at South Bristol, Division of Veterinary Pathology, Immunity and Infection, University of Bristol, Bristol, UK
    Clin Exp Immunol 145:365-71. 2006
    ..This may affect immunosurveillance directed at viral and tumour-related epitopes in the upper airway...
  12. ncbi request reprint Interactions of meningococci with endothelium
    R S Heyderman
    Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, UK
    Methods Mol Med 67:649-61. 2001
    ..For this reason, our work has focused on understanding the cellular and molecular consequences of meningococcalendothelial interactions...
  13. pmc Influence of age and carriage status on salivary IgA to Neisseria meningitidis
    R E Horton
    Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, and Health Protection Agency, Bristol, UK
    Epidemiol Infect 133:883-9. 2005
    ..1 (95% CI 1.1-18) and OR 3.8 (95% CI 0.96-16) for reference strains B:1:P1.14 and B:4:P1.5,4 respectively. These data implicate IgA as a factor in host defence from meningococcal invasion, although the precise mechanisms remain uncertain...
  14. ncbi request reprint Human papillomavirus and head and neck cancer: a systematic review and meta-analysis
    C G L Hobbs
    Clinical Science at South Bristol, University of Bristol, Bristol, UK
    Clin Otolaryngol 31:259-66. 2006
    ..However, the method of viral detection may be an important source of heterogeneity. Resolution of this issue will require further studies using both methods, examining associations separately in different sites...
  15. ncbi request reprint Parenteral influenza vaccination influences mucosal and systemic T cell-mediated immunity in healthy adults
    Terry Guthrie
    Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, United Kingdom
    J Infect Dis 190:1927-35. 2004
    ..Our data indicate that parenteral influenza vaccination influences both mucosal and systemic naturally acquired T cell immunity...
  16. doi request reprint Mucosal immunity in healthy adults after parenteral vaccination with outer-membrane vesicles from Neisseria meningitidis serogroup B
    Victoria Davenport
    Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
    J Infect Dis 198:731-40. 2008
    ..This natural immunity is associated with mucosal and systemic T cell memory. Whether parenteral Neisseria meningitidis serogroup B (MenB) vaccination influences natural mucosal immunity is unknown...
  17. ncbi request reprint Regulation of Th-1 T cell-dominated immunity to Neisseria meningitidis within the human mucosa
    Victoria Davenport
    Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, University Walk, Bristol, UK
    Cell Microbiol 9:1050-61. 2007
    ....
  18. pmc Immunoglobulin G subclass response to a meningococcal quadrivalent polysaccharide-diphtheria toxoid conjugate vaccine
    Helen Findlow
    Vaccine Evaluation Unit, Health Protection Agency North West, P O Box 209, Clinical Sciences Building, Manchester Royal Infirmary, Manchester, M13 9WZ, United Kingdom
    Clin Vaccine Immunol 13:507-10. 2006
    ..Further studies on IgG subclasses following meningococcal polysaccharide and conjugate vaccination are needed...
  19. ncbi request reprint Evidence for naturally acquired T cell-mediated mucosal immunity to Neisseria meningitidis
    Victoria Davenport
    Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
    J Immunol 171:4263-70. 2003
    ..This mucosal cellular immunity can be present in the absence of serum bactericidal Abs, a classical marker of protective immunity...
  20. pmc Management of diagnostic uncertainty in children with possible meningitis: a qualitative study
    Cathy A Brennan
    Department of Pathology and Microbiology Division of Primary Health Care, University of Bristol
    Br J Gen Pract 53:626-31. 2003
    ..Neisseria meningitidis serogroup B is the most common cause of bacterial meningitis in children and young adults. Early recognition and prompt intervention with antibiotics are thought to be key to preventing serious complications...
  21. pmc IFN-gamma amplifies NFkappaB-dependent Neisseria meningitidis invasion of epithelial cells via specific upregulation of CEA-related cell adhesion molecule 1
    Natalie J Griffiths
    Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, UK
    Cell Microbiol 9:2968-83. 2007
    ..The data imply that cell-surface remodelling by virally induced cytokines could be one factor that increases host susceptibility to bacterial infection...
  22. ncbi request reprint Tonsil T cell immunity to human papillomavirus in the absence of detectable virus in healthy adults
    Christopher G L Hobbs
    Department of Otolaryngology and Head and Neck Surgery, Birmingham Heartlands Hospital, Birmingham, UK
    Laryngoscope 118:459-63. 2008
    ..Human papillomavirus (HPV) is known to infect the epithelium of the upper aerodigestive tract; however, major questions regarding prevalence and persistence of infection, and their relation to local immune response, remain unanswered...
  23. doi request reprint Epidemics of invasive Salmonella enterica serovar enteritidis and S. enterica Serovar typhimurium infection associated with multidrug resistance among adults and children in Malawi
    Melita A Gordon
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi
    Clin Infect Dis 46:963-9. 2008
    ..Nontyphoidal salmonellae (NTS) have become the most common cause of bacteremia in tropical Africa, particularly among susceptible children and HIV-infected adults...
  24. ncbi request reprint Critical determinants of the interactions of capsule-expressing Neisseria meningitidis with host cells: the role of receptor density in increased cellular targeting via the outer membrane Opa proteins
    Christopher J Bradley
    Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, UK
    Cell Microbiol 7:1490-503. 2005
    ..Thus the data also suggest a novel rationale for the epidemiological observations that individuals with prior infectious/inflammatory conditions carry a high risk of invasive meningococcal disease...
  25. ncbi request reprint Capture-recapture analysis and pneumococcal meningitis estimates in England
    Ardiana Gjini
    Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
    Emerg Infect Dis 10:87-93. 2004
    ..The estimated case-fatality rate was 24% [95% CI 21% to 26%]. These estimates indicate that a cost-benefit analysis of adult pneumococcal vaccination programs is required...
  26. ncbi request reprint Clinical management of urinary tract infection in women: a prospective cohort study
    Tom Fahey
    Tayside Centre for General Practice, University of Dundee, Kirsty Semple Way, Dundee DD2 4AD, UK
    Fam Pract 20:1-6. 2003
    ..It is unclear how symptoms of urinary tract infection (UTI) influence clinical management in terms of diagnostic testing and treatment with antibiotics...