J E Hewitt

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. ncbi A family history of DUX4: phylogenetic analysis of DUXA, B, C and Duxbl reveals the ancestral DUX gene
    Andreas Leidenroth
    Centre for Genetics and Genomics, School of Biology, The University of Nottingham, Queens Medical Centre, Nottingham NG7 2UH, UK
    BMC Evol Biol 10:364. 2010
  2. ncbi Glycomarkers for muscular dystrophy
    Jane E Hewitt
    Centre for Genetics and Genomics, School of Biology, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Biochem Soc Trans 39:336-9. 2011
  3. ncbi Abnormal glycosylation of dystroglycan in human genetic disease
    Jane E Hewitt
    Institute of Genetics, School of Biology, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Biochim Biophys Acta 1792:853-61. 2009
  4. ncbi Glycosylation defects in inherited muscle disease
    J E Hewitt
    Institute of Genetics, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, United Kingdom
    Cell Mol Life Sci 60:251-8. 2003
  5. ncbi Mutant glycosyltransferase and altered glycosylation of alpha-dystroglycan in the myodystrophy mouse
    P K Grewal
    Institute of Genetics, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Nat Genet 28:151-4. 2001
  6. ncbi Intron loss in the SART1 genes of Fugu rubripes and Tetraodon nigroviridis
    D J Bolland
    Institute of Genetics, Queen s Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK
    Gene 271:43-9. 2001
  7. ncbi The murine urea transporter genes Slc14a1 and Slc14a2 occur in tandem on chromosome 18
    R A Fenton
    School of Biological Science, University of Manchester, UK
    Cytogenet Cell Genet 87:95-6. 1999
  8. ncbi Nucleotide sequence of the partially deleted D4Z4 locus in a patient with FSHD identifies a putative gene within each 3.3 kb element
    J Gabriels
    Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium
    Gene 236:25-32. 1999
  9. ncbi FRG1, a gene in the FSH muscular dystrophy region on human chromosome 4q35, is highly conserved in vertebrates and invertebrates
    P K Grewal
    School of Biological Sciences, The University of Manchester, 3 239 Stopford Building, Oxford Rd, Manchester M13 9PT, UK
    Gene 216:13-9. 1998
  10. ncbi High-resolution mapping of mouse chromosome 8 identifies an evolutionary chromosomal breakpoint
    P K Grewal
    School of Biological Sciences, The University of Manchester, 3 239 Stopford Building, Oxford Rd, Manchester M13 9PT, UK
    Mamm Genome 9:603-7. 1998

Collaborators

  • P K Grewal
  • R E Bittner
  • Andreas Leidenroth
  • D J Bolland
  • J Gabriels
  • R A Fenton
  • G W Padberg
  • R R Frants
  • J C van Deutekom
  • M C Beckers
  • A Howorth
  • C A Cottingham
  • H Ding
  • A De Vriese
  • S Plaisance
  • A Belayew
  • S M van der Maarel
  • D Collen
  • C P Smith
  • T J Wright
  • S Romberg
  • M van Geel
  • H G Dauwerse
  • R J Lemmers
  • M H Hofker

Detail Information

Publications12

  1. ncbi A family history of DUX4: phylogenetic analysis of DUXA, B, C and Duxbl reveals the ancestral DUX gene
    Andreas Leidenroth
    Centre for Genetics and Genomics, School of Biology, The University of Nottingham, Queens Medical Centre, Nottingham NG7 2UH, UK
    BMC Evol Biol 10:364. 2010
    ..Here, we investigate the evolutionary history of this multi-member double-homeobox gene family in eutherian mammals...
  2. ncbi Glycomarkers for muscular dystrophy
    Jane E Hewitt
    Centre for Genetics and Genomics, School of Biology, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Biochem Soc Trans 39:336-9. 2011
    ..Genetic heterogeneity indicates that other genes are involved in this pathway. Identification of these additional genes would increase our understanding of this specific and essential glycosylation pathway...
  3. ncbi Abnormal glycosylation of dystroglycan in human genetic disease
    Jane E Hewitt
    Institute of Genetics, School of Biology, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Biochim Biophys Acta 1792:853-61. 2009
    ....
  4. ncbi Glycosylation defects in inherited muscle disease
    J E Hewitt
    Institute of Genetics, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, United Kingdom
    Cell Mol Life Sci 60:251-8. 2003
    ..Recent data have shown that there is altered glycosylation of the protein and that this reduces its ability to bind to extracellular matrix ligands such as laminin and agrin...
  5. ncbi Mutant glycosyltransferase and altered glycosylation of alpha-dystroglycan in the myodystrophy mouse
    P K Grewal
    Institute of Genetics, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Nat Genet 28:151-4. 2001
    ..We speculate that abnormal post-translational modification of alpha-dystroglycan may contribute to the myd phenotype...
  6. ncbi Intron loss in the SART1 genes of Fugu rubripes and Tetraodon nigroviridis
    D J Bolland
    Institute of Genetics, Queen s Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK
    Gene 271:43-9. 2001
    ..The Fugu and Tetraodon SART1 genes encode putative proteins of 772 and 774 aa, respectively, each having 65% amino acid identity to human SART1. Leucine zipper and basic motifs are conserved in the predicted Fugu and Tetraodon proteins...
  7. ncbi The murine urea transporter genes Slc14a1 and Slc14a2 occur in tandem on chromosome 18
    R A Fenton
    School of Biological Science, University of Manchester, UK
    Cytogenet Cell Genet 87:95-6. 1999
  8. ncbi Nucleotide sequence of the partially deleted D4Z4 locus in a patient with FSHD identifies a putative gene within each 3.3 kb element
    J Gabriels
    Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium
    Gene 236:25-32. 1999
    ..In conclusion, we propose that each of the 3.3kb elements in the partially deleted D4Z4 locus could include a DUX4 gene encoding a double homeodomain protein...
  9. ncbi FRG1, a gene in the FSH muscular dystrophy region on human chromosome 4q35, is highly conserved in vertebrates and invertebrates
    P K Grewal
    School of Biological Sciences, The University of Manchester, 3 239 Stopford Building, Oxford Rd, Manchester M13 9PT, UK
    Gene 216:13-9. 1998
    ..We have also identified FRG1 homologues in two nematodes; Caenorhabditis elegans and Brugia malayi. The FRG1 protein is highly conserved and contains a lipocalin sequence motif, suggesting it may function as a transport protein...
  10. ncbi High-resolution mapping of mouse chromosome 8 identifies an evolutionary chromosomal breakpoint
    P K Grewal
    School of Biological Sciences, The University of Manchester, 3 239 Stopford Building, Oxford Rd, Manchester M13 9PT, UK
    Mamm Genome 9:603-7. 1998
    ..Thus, this YAC spans an evolutionary chromosomal breakpoint. As well as providing clues about chromosomal evolution, this map of the FSHD syntenic mouse region should prove invaluable in the isolation of candidate genes for this disease...
  11. ncbi The mouse homolog of FRG1, a candidate gene for FSHD, maps proximal to the myodystrophy mutation on chromosome 8
    P K Grewal
    School of Biological Sciences, The University of Manchester, 3 239 Stopford Building, Oxford Road, Manchester, M13 9PT, UK
    Mamm Genome 8:394-8. 1997
    ..Using a cross segregating the myd mutation and the European Collaborative Interspecific Backcross, we showed that Frg1 maps proximal to the myd locus and to the Clc3 and Ant1 genes...
  12. ncbi Identification of the first gene (FRG1) from the FSHD region on human chromosome 4q35
    J C van Deutekom
    MGC Department of Human Genetics, Leiden University, The Netherlands
    Hum Mol Genet 5:581-90. 1996
    ..No evidence for PEV mediated repression of allelic transcription was obtained in these tissues. However, detection of PEV in FSHD patients may require analysis of more specific cell types at particular developmental stages...