Martin Hewison

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. ncbi request reprint Synthesis of 1,25-dihydroxyvitamin D(3) by human endothelial cells is regulated by inflammatory cytokines: a novel autocrine determinant of vascular cell adhesion
    Daniel Zehnder
    Division of Medical Sciences, The University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK
    J Am Soc Nephrol 13:621-9. 2002
  2. ncbi request reprint Vitamin D and barrier function: a novel role for extra-renal 1 alpha-hydroxylase
    Martin Hewison
    Division of Medical Sciences, Institute of Clinical Research, The University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
    Mol Cell Endocrinol 215:31-8. 2004
  3. ncbi request reprint Vitamin D-mediated hypercalcemia in lymphoma: evidence for hormone production by tumor-adjacent macrophages
    Martin Hewison
    Division of Medical Sciences, University of Birmingham, Birmingham, United Kingdom
    J Bone Miner Res 18:579-82. 2003
  4. ncbi request reprint Extra-renal 25-hydroxyvitamin D3-1alpha-hydroxylase in human health and disease
    Martin Hewison
    Burns and Allen Research Institute, Division of Endocrinology, Cedars Sinai Medical Center and David Geffen School of Medicine at UCLA, Los Angeles, CA 90048, USA
    J Steroid Biochem Mol Biol 103:316-21. 2007
  5. ncbi request reprint 11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response
    Jeremy W Tomlinson
    Endocrinology, Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, B15 2TH, UK
    Endocr Rev 25:831-66. 2004
  6. ncbi request reprint Alternative splicing of vitamin D-24-hydroxylase: a novel mechanism for the regulation of extrarenal 1,25-dihydroxyvitamin D synthesis
    Songyang Ren
    Department of Medicine, Division of Endocrinology, Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Biol Chem 280:20604-11. 2005
  7. ncbi request reprint Glucocorticoid-induced apoptosis in human decidua: a novel role for 11beta-hydroxysteroid dehydrogenase in late gestation
    Junny Chan
    Division of Reproduction and Child Health, Department of Fetal Medicine, Birmingham Women s Hospital, University of Birmingham, Birmingham B15 2TH, UK
    J Endocrinol 195:7-15. 2007
  8. ncbi request reprint Effects of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on cytokine production by human decidual cells
    Katie N Evans
    Division of Medical Sciences, Institute of Biomedical Research, The University of Birmingham, Birmingham, B15 2TT, United Kingdom
    Biol Reprod 75:816-22. 2006
  9. ncbi request reprint Expression of 11beta-hydroxysteroid dehydrogenase type 1 permits regulation of glucocorticoid bioavailability by human dendritic cells
    Lisa Freeman
    Department of Hematology, University of Birmingham, Birmingham, United Kingdom
    Blood 106:2042-9. 2005
  10. pmc 1alpha-hydroxylase and innate immune responses to 25-hydroxyvitamin D in colonic cell lines
    Venu Lagishetty
    Department of Orthopaedic Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Steroid Biochem Mol Biol 121:228-33. 2010

Detail Information

Publications76

  1. ncbi request reprint Synthesis of 1,25-dihydroxyvitamin D(3) by human endothelial cells is regulated by inflammatory cytokines: a novel autocrine determinant of vascular cell adhesion
    Daniel Zehnder
    Division of Medical Sciences, The University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK
    J Am Soc Nephrol 13:621-9. 2002
    ..The rapid induction of endothelial 1alpha-OHase activity by inflammatory cytokines suggests a novel autocrine/paracrine role for the enzyme, possibly as a modulator of endothelial cell adhesion...
  2. ncbi request reprint Vitamin D and barrier function: a novel role for extra-renal 1 alpha-hydroxylase
    Martin Hewison
    Division of Medical Sciences, Institute of Clinical Research, The University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
    Mol Cell Endocrinol 215:31-8. 2004
    ....
  3. ncbi request reprint Vitamin D-mediated hypercalcemia in lymphoma: evidence for hormone production by tumor-adjacent macrophages
    Martin Hewison
    Division of Medical Sciences, University of Birmingham, Birmingham, United Kingdom
    J Bone Miner Res 18:579-82. 2003
    ..Based on this case study, we propose that the abnormal synthesis of 1,25(OH)2D3 associated with some lymphomas is because of paracrine regulation of tumor-associated macrophages...
  4. ncbi request reprint Extra-renal 25-hydroxyvitamin D3-1alpha-hydroxylase in human health and disease
    Martin Hewison
    Burns and Allen Research Institute, Division of Endocrinology, Cedars Sinai Medical Center and David Geffen School of Medicine at UCLA, Los Angeles, CA 90048, USA
    J Steroid Biochem Mol Biol 103:316-21. 2007
    ..Data suggest that local synthesis of 1,25(OH)(2)D(3) may be a preferred mode of response to antigenic challenge in many tissues...
  5. ncbi request reprint 11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response
    Jeremy W Tomlinson
    Endocrinology, Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, B15 2TH, UK
    Endocr Rev 25:831-66. 2004
    ..Therapeutic inhibition of 11beta-HSD1 reductase activity in patients with obesity and the metabolic syndrome, as well as in glaucoma and osteoporosis, remains an exciting prospect...
  6. ncbi request reprint Alternative splicing of vitamin D-24-hydroxylase: a novel mechanism for the regulation of extrarenal 1,25-dihydroxyvitamin D synthesis
    Songyang Ren
    Department of Medicine, Division of Endocrinology, Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Biol Chem 280:20604-11. 2005
    ..We theorize that expression of the CYP24-SV may contribute to the extracellular accumulation of 1,25(OH)(2)D in human health and disease...
  7. ncbi request reprint Glucocorticoid-induced apoptosis in human decidua: a novel role for 11beta-hydroxysteroid dehydrogenase in late gestation
    Junny Chan
    Division of Reproduction and Child Health, Department of Fetal Medicine, Birmingham Women s Hospital, University of Birmingham, Birmingham B15 2TH, UK
    J Endocrinol 195:7-15. 2007
    ..These data show that autocrine metabolism of glucocorticoids is an important facet of the feto-placental unit in late gestation and we propose that a possible effect of this is to stimulate programmed cell death in human decidua...
  8. ncbi request reprint Effects of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on cytokine production by human decidual cells
    Katie N Evans
    Division of Medical Sciences, Institute of Biomedical Research, The University of Birmingham, Birmingham, B15 2TT, United Kingdom
    Biol Reprod 75:816-22. 2006
    ....
  9. ncbi request reprint Expression of 11beta-hydroxysteroid dehydrogenase type 1 permits regulation of glucocorticoid bioavailability by human dendritic cells
    Lisa Freeman
    Department of Hematology, University of Birmingham, Birmingham, United Kingdom
    Blood 106:2042-9. 2005
    ..In conclusion, prereceptor regulation of endogenous GCs appears to be an important determinant of DC function and represents a potential target for therapeutic manipulation...
  10. pmc 1alpha-hydroxylase and innate immune responses to 25-hydroxyvitamin D in colonic cell lines
    Venu Lagishetty
    Department of Orthopaedic Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Steroid Biochem Mol Biol 121:228-33. 2010
    ..Thus, in common with other barrier sites such as the skin or placenta, colonic epithelial cells may require specific factors to initiate intracrine responses to vitamin D...
  11. ncbi request reprint Increased expression of mineralocorticoid effector mechanisms in kidney biopsies of patients with heavy proteinuria
    Marcus Quinkler
    Division of Medical Sciences, University of Birmingham, Birmingham B15 2TT, UK
    Circulation 112:1435-43. 2005
    ..There is also experimental evidence that aldosterone contributes to the development of nephrosclerosis and renal fibrosis in rodent models, but little is known of its role in clinical renal disease...
  12. pmc Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages
    Mario Fabri
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles UCLA, Los Angeles, CA 90095, USA
    Sci Transl Med 3:104ra102. 2011
    ..The present findings underscore the importance of adequate amounts of vitamin D in all human populations for sustaining both innate and acquired immunity against infection...
  13. pmc Vitamin D deficiency in mice impairs colonic antibacterial activity and predisposes to colitis
    Venu Lagishetty
    Room 410D, Orthopaedic Hospital Research Center, University of California Los Angeles, Los Angeles, California 90095, USA
    Endocrinology 151:2423-32. 2010
    ..This may be a pivotal mechanism linking vitamin D status with IBD in humans...
  14. pmc Control of estradiol-directed gene transactivation by an intracellular estrogen-binding protein and an estrogen response element-binding protein
    Hong Chen
    Division of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Mol Endocrinol 22:559-69. 2008
    ..This appears to involve a physical association between the two proteins to form a complex that is able to interact with both E(2) and ERalpha in cytosolic and nuclear compartments...
  15. pmc T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism
    Kristina Edfeldt
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:22593-8. 2010
    ....
  16. pmc Altered endocrine and autocrine metabolism of vitamin D in a mouse model of gastrointestinal inflammation
    Nancy Liu
    Department of Orthopaedic Surgery, David Geffen School of Medicine, UCLA, 615 Charles E Young Drive South, Los Angeles, California 90095, USA
    Endocrinology 149:4799-808. 2008
    ..These data indicate that both local and endocrine synthesis of 1,25(OH)2D3 affect colitis in DSS-treated mice. Lack of Cyp27b1 exacerbates disease in this model, suggesting that similar effects may occur with vitamin D deficiency...
  17. ncbi request reprint Differential regulation of vitamin D receptor and its ligand in human monocyte-derived dendritic cells
    Martin Hewison
    Department of Medical Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom
    J Immunol 170:5382-90. 2003
    ..In conclusion, differential regulation of endogenous 1 alpha 25(OH)(2)D(3) ligand and its nuclear receptor appear to be important regulators of DC biology and represent potential targets for the manipulation of DC function...
  18. pmc 1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3
    Louisa E Jeffery
    Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, Institute of Biomedical Research, University of Birmingham Medical School, Birmingham, United Kingdom
    J Immunol 183:5458-67. 2009
    ..Our results suggest that 1,25(OH)(2)D(3) and IL-2 have direct synergistic effects on activated T cells, acting as potent anti-inflammatory agents and physiologic inducers of adaptive regulatory T cells...
  19. pmc Vitamin D and the immune system: new perspectives on an old theme
    Martin Hewison
    Department of Orthopaedic Surgery, Molecular Biology Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Endocrinol Metab Clin North Am 39:365-79, table of contents. 2010
    ..This article describes some of the recent developments with respect to vitamin D and the immune system, and possible clinical implications...
  20. ncbi request reprint Vitamin D in defense of the human immune response
    John S Adams
    Division of Endocrinology, Diabetes and Metabolism, Burns and Allen Research Institute, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Room B 131, Los Angeles, CA 90048, USA
    Ann N Y Acad Sci 1117:94-105. 2007
    ....
  21. ncbi request reprint Substrate and enzyme trafficking as a means of regulating 1,25-dihydroxyvitamin D synthesis and action: the human innate immune response
    John S Adams
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Bone Miner Res 22:V20-4. 2007
    ..In this review, we use vitamin D-directed events in the human innate immune response to Mycobacterium tuberculosis as a physiologically relevant model system in which to highlight the importance of these intracellular traffic patterns...
  22. doi request reprint Vitamin D and the regulation of placental inflammation
    Nancy Q Liu
    Orthopaedic Hospital Research Center, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Immunol 186:5968-74. 2011
    ..These data indicate that fetal (trophoblastic) vitamin D plays a pivotal role in controlling placental inflammation. In humans, this may be a key factor in placental responses to infection and associated adverse outcomes of pregnancy...
  23. ncbi request reprint 11beta-hydroxysteroid dehydrogenase type 1 activity predicts the effects of glucocorticoids on bone
    Mark S Cooper
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, United Kingdom
    J Clin Endocrinol Metab 88:3874-7. 2003
    ..Measures of 11beta-HSD1 activity may predict individual susceptibility to glucocorticoid-induced osteoporosis, and these data should facilitate the development of bone-sparing glucocorticoids...
  24. ncbi request reprint Late-onset apparent mineralocorticoid excess caused by novel compound heterozygous mutations in the HSD11B2 gene
    Gareth G Lavery
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, B15 2TH, UK
    Hypertension 42:123-9. 2003
    ..These genetic and biochemical data emphasize the heterogeneous nature of AME and the effects that heterozygosity at the HSD11B2 locus can have on blood pressure in later life...
  25. pmc Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses
    Rosane M B Teles
    Division of Dermatology, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
    Science 339:1448-53. 2013
    ....
  26. ncbi request reprint Identification of VDR-responsive gene signatures in breast cancer cells
    Kelly Towsend
    Institute of Biomedical Research, Endocrinology and Metabolism, Medical School, University of Birmingham Edgbaston, Birmingham, UK
    Oncology 71:111-23. 2006
    ....
  27. ncbi request reprint Androgen receptor-mediated regulation of the alpha-subunit of the epithelial sodium channel in human kidney
    Marcus Quinkler
    Division of Medical Sciences, University of Birmingham, Birmingham, B15 2TT, UK
    Hypertension 46:787-98. 2005
    ..These data show that alphaENaC expression is directly regulated by androgens in vitro and in vivo and highlight a potential mechanism explaining the reported gender differences in blood pressure...
  28. ncbi request reprint Functional characterization of heterogeneous nuclear ribonuclear protein C1/C2 in vitamin D resistance: a novel response element-binding protein
    Hong Chen
    Division of Endocrinology, Diabetes and Metabolism, Burns and Allen Research Institute, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, California 90048, USA
    J Biol Chem 281:39114-20. 2006
    ..In particular, chromatin immunoprecipitation data suggest that, in addition to its RNA-processing functions, hnRNP C1/C2 may be a key determinant of the temporal patterns of VDRE occupancy...
  29. pmc Differential expression, function and response to inflammatory stimuli of 11beta-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation
    Rowan S Hardy
    Division of Medical Sciences, Institute of Biomedical Research, The University of Birmingham Medical School, Birmingham, UK
    Arthritis Res Ther 8:R108. 2006
    ....
  30. ncbi request reprint Expression of renal 11beta-hydroxysteroid dehydrogenase type 2 is decreased in patients with impaired renal function
    Marcus Quinkler
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, UK
    Eur J Endocrinol 153:291-9. 2005
    ..To date, these studies have relied upon urinary cortisol (F) metabolite levels as surrogate markers of renal 11beta-HSD2 activity...
  31. ncbi request reprint Autocrine metabolism of vitamin D in normal and malignant breast tissue
    Kelly Townsend
    Division of Medical Sciences, Institute of Biomedical Research, Endocrinology and Metabolism, University of Birmingham, Birmingham, United Kingdom
    Clin Cancer Res 11:3579-86. 2005
    ..The aim of this study was to investigate the significance of this in breast cancer...
  32. pmc Increased expression of 25-hydroxyvitamin D-1alpha-hydroxylase in dysgerminomas: a novel form of humoral hypercalcemia of malignancy
    Katie N Evans
    Division of Medical Sciences, Institute of Biomedical Research, The University of Birmingham, Birmingham, United Kingdom
    Am J Pathol 165:807-13. 2004
    ..We further postulate that this autocrine/paracrine action of 1alpha-hydroxylase may lead to increased circulating levels of 1,25(OH)2D3 and a form of HHM which is distinct from that seen with PTHrP-secreting tumors...
  33. pmc Down-regulation of vitamin D receptor in mammospheres: implications for vitamin D resistance in breast cancer and potential for combination therapy
    Shehla Pervin
    Department of Internal Medicine, Charles Drew University of Medicine and Science, Los Angeles, CA, USA
    PLoS ONE 8:e53287. 2013
    ..Our findings therefore, suggest that combination therapy using 1,25D with drugs specifically targeting key survival pathways in MCSCs warrant testing in prospective clinical trial for treatment of aggressive breast cancer...
  34. doi request reprint Dietary vitamin D restriction in pregnant female mice is associated with maternal hypertension and altered placental and fetal development
    Nancy Q Liu
    Orthopaedic Hospital Research Center, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Endocrinology 154:2270-80. 2013
    ..These data provide further evidence that low vitamin D status may predispose pregnant women to dysregulated placental development and elevated blood pressure. ..
  35. pmc Vitamin D-binding protein directs monocyte responses to 25-hydroxy- and 1,25-dihydroxyvitamin D
    Rene F Chun
    Orthopaedic Hospital Research Center, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Clin Endocrinol Metab 95:3368-76. 2010
    ..Both vitamin D metabolites circulate bound to vitamin D-binding protein (DBP), but the effect of this on induction of monocyte cathelicidin remains unclear...
  36. ncbi request reprint Biological actions of extra-renal 25-hydroxyvitamin D-1alpha-hydroxylase and implications for chemoprevention and treatment
    Kelly Townsend
    Division of Medical Sciences, Institute of Biomedical Research, The University of Birmingham, Birmingham B15 2TH, UK
    J Steroid Biochem Mol Biol 97:103-9. 2005
    ..The role of 1alpha-hydroxylase in protection against cancer is likely to be more complicated and may involve anti-tumor immune responses...
  37. ncbi request reprint Vitamin D and placental-decidual function
    Katie N Evans
    Division of Medical Sciences, Institute of Biomedical Research, The University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TH, United Kingdom
    J Soc Gynecol Investig 11:263-71. 2004
    ..In particular, we describe how induction of the vitamin D-activating enzyme 1alpha-hydroxylase in early gestation might provide a mechanism by which environmental or dietary vitamin D can influence fetal-placental development...
  38. ncbi request reprint Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response
    Philip T Liu
    Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Science 311:1770-3. 2006
    ..These data support a link between TLRs and vitamin D-mediated innate immunity and suggest that differences in ability of human populations to produce vitamin D may contribute to susceptibility to microbial infection...
  39. ncbi request reprint 11Beta-hydroxysteroid dehydrogenase type 1 in differentiating omental human preadipocytes: from de-activation to generation of cortisol
    Iwona J Bujalska
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
    Endocr Res 28:449-61. 2002
    ..The differences in set-point of 11beta-HSD1 activity between OM and SC human adipose tissue may be an important factor in the pathogenesis of visceral obesity...
  40. pmc Fibroblast growth factor 23 inhibits extrarenal synthesis of 1,25-dihydroxyvitamin D in human monocytes
    Justine Bacchetta
    UCLA Orthopaedic Hospital, Department of Orthopaedic Surgery, Orthopedic Hospital Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
    J Bone Miner Res 28:46-55. 2013
    ..Elevated expression of FGF23 may therefore play a crucial role in defining immune responses to vitamin D and this, in turn, may be a key determinant of infection in patients with chronic kidney disease (CKD)...
  41. doi request reprint Vitamin D and immune function: an overview
    Martin Hewison
    UCLA and Orthopaedic Hospital Department of Orthopaedic Surgery and the Orthopaedic Hospital Research Center, David Geffen School of Medicine at UCLA, 615 Charles E Young, Los Angeles, CA 90095, USA
    Proc Nutr Soc 71:50-61. 2012
    ..Collectively these observations suggest that vitamin D is a key factor linking innate and adaptive immunity, and both of these functions may be compromised under conditions of vitamin D insufficiency...
  42. ncbi request reprint 19-Nor-1,25(OH)2D2 (a novel, noncalcemic vitamin D analogue), combined with arsenic trioxide, has potent antitumor activity against myeloid leukemia
    Takashi Kumagai
    Division of Hematology Oncology, University of California at Los Angeles School of Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Cancer Res 65:2488-97. 2005
    ..The combination of both of these Food and Drug Administration-approved drugs should be considered for treatment of all-trans retinoic acid-resistant APL patients as well as those with other types of AML...
  43. ncbi request reprint An Hsp27-related, dominant-negative-acting intracellular estradiol-binding protein
    Hong Chen
    Division of Endocrinology, Diabetes, and Metabolism, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, California 90048, USA
    J Biol Chem 279:29944-51. 2004
    ..In summary, by inhibiting the ERalpha-E2 interaction, IEBP acts to squelch ERalpha-directed ERE-regulated transactivation and promote estrogen resistance in NWP cells...
  44. pmc Divergence of macrophage phagocytic and antimicrobial programs in leprosy
    Dennis Montoya
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Host Microbe 6:343-53. 2009
    ..These data indicate that macrophage programs for phagocytosis and antimicrobial responses are distinct and differentially regulated in innate immunity to bacterial infections...
  45. pmc Estradiol and tamoxifen mediate rescue of the dominant-negative effects of estrogen response element-binding protein in vivo and in vitro
    Hong Chen
    Division of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Endocrinology 150:2429-35. 2009
    ..These data highlight the importance of ERE-BP as an attenuator of normal ERalpha signaling in vivo and further suggest that ERE-BP is a novel target for modulation by selective estrogen receptor modulators...
  46. ncbi request reprint Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency
    Nicole Draper
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK
    Nat Genet 34:434-9. 2003
    ..CRD defines a new ER-specific redox potential and establishes H6PDH as a potential factor in the pathogenesis of PCOS...
  47. pmc Inflammatory regulation of glucocorticoid metabolism in mesenchymal stromal cells
    Mohammad M Ahasan
    Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham and Queen Elizabeth Hospital, Edgbaston, Birmingham, UK
    Arthritis Rheum 64:2404-13. 2012
    ..Additionally, GCs act synergistically with proinflammatory cytokines to further increase enzyme expression. The present study was undertaken to investigate the mechanisms underlying this regulation...
  48. pmc Vitamin D metabolism and innate immunity
    Venu Lagishetty
    Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Mol Cell Endocrinol 347:97-105. 2011
    ..The following review describes some of the key developments in innate immune responses to vitamin D with particular emphasis on the role of key metabolic enzyme as determinants of localized immune activity of vitamin D...
  49. ncbi request reprint Adenosine 5'-triphosphate-dependent vitamin D sterol binding to heat shock protein-70 chaperones
    Rene Chun
    Burns and Allen Research Institute and Division of Endocrinology, Diabetes, and Metabolism, Cedars Sinai Medical Center, David Geffen School of Medicine at University of California, Los Angeles, 90048, USA
    Endocrinology 146:5540-4. 2005
    ....
  50. pmc Hormone response element binding proteins: novel regulators of vitamin D and estrogen signaling
    Thomas S Lisse
    Department of Orthopaedic Surgery and Molecular Biology Institute, David Geffen School of Medicine at UCLA, 615 Charles E Young Drive South, Los Angeles, CA 90095, USA
    Steroids 76:331-9. 2011
    ..In addition the review also describes other molecules that are known to influence nuclear receptor signaling through interaction with hormone response elements...
  51. pmc The ontogeny of 25-hydroxyvitamin D(3) 1alpha-hydroxylase expression in human placenta and decidua
    Daniel Zehnder
    Division of Medical Sciences, The University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK
    Am J Pathol 161:105-14. 2002
    ..These spatiotemporal data emphasize the potential importance of 1alpha-OHase during early fetoplacental life and, in particular, suggest an autocrine/paracrine immunomodulatory function for the enzyme...
  52. pmc Update in vitamin D
    John S Adams
    UCLA Orthopaedic Hospital Research Center, 615 Charles Young Drive South, Room 410E, Los Angeles, California 90095 7358, USA
    J Clin Endocrinol Metab 95:471-8. 2010
    ....
  53. pmc Vitamin D deficiency modulates Graves' hyperthyroidism induced in BALB/c mice by thyrotropin receptor immunization
    Alexander Misharin
    Autoimmune Disease Unit, Cedars Sinai Research Institute and University of California Los Angeles, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Endocrinology 150:1051-60. 2009
    ..thyroid function. Our present studies provide evidence that an environmental factor, vitamin D, has only minor effects on induced immunity to the TSHR but directly affects thyroid function in mice...
  54. pmc Back to the future: a new look at 'old' vitamin D
    Rene F Chun
    Department of Orthopaedic Surgery, David Geffen School of Medicine, UCLA, 615 Charles E Young Drive South, Los Angeles, California 90095, USA
    J Endocrinol 198:261-9. 2008
    ..In the following review, we provide a fresh perspective on vitamin D signaling in non-classical target cells such as macrophages by highlighting novel factors associated with the transport and action of this pluripotent secosteroid...
  55. doi request reprint Vitamin D and immune function: autocrine, paracrine or endocrine?
    Martin Hewison
    UCLA and Orthopaedic Hospital Department of Orthopaedic Surgery and Orthopaedic Hospital Research Center, David Geffen School of Medicine at UCLA, 615 Charles E Young Drive South, Los Angeles, CA 90095, USA
    Scand J Clin Lab Invest Suppl 243:92-102. 2012
    ..The current review will discuss this by comparing the intracrine, paracrine and endocrine metabolic systems that influence the interaction between vitamin D and the immune system...
  56. doi request reprint Antibacterial effects of vitamin D
    Martin Hewison
    Department of Orthopaedic Surgery, Room 410D, Orthopaedic Hospital Research Center, 615 Charles E Young Drive South, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA
    Nat Rev Endocrinol 7:337-45. 2011
    ....
  57. pmc Immunomodulation by vitamin D: implications for TB
    Rene F Chun
    Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, 615 Charles E Young Drive South, Los Angeles, CA 90095, USA
    Expert Rev Clin Pharmacol 4:583-91. 2011
    ..The overall aim will be to provide a fresh perspective on the potential benefits of vitamin D supplementation in the prevention and treatment of TB...
  58. doi request reprint An update on vitamin D and human immunity
    Martin Hewison
    Department of Orthopaedic Surgery and Molecular Biology Institute, David Geffen School of Medicine at UCLA, 615 Charles E Young Drive South, Los Angeles, CA 90095, USA
    Clin Endocrinol (Oxf) 76:315-25. 2012
    ..The current review summarizes these developments, with specific reference to the newly identified effects of vitamin D on the immune system, but also highlights the challenges in translating these observations to clinical practice...
  59. ncbi request reprint Hormones and immune function: implications of aging
    Wiebke Arlt
    Division of Medical Sciences, Institute of Biomedical Research, The Medical School, University of Birmingham, B15 2TT, UK
    Aging Cell 3:209-16. 2004
    ..As a step in this direction, the present review summarizes established facts on the physiology of secretion and function of hormones that, in most cases, decline with aging and that are likely to affect the immune system...
  60. ncbi request reprint Association studies between the HSD11B2 gene (encoding human 11beta-hydroxysteroid dehydrogenase type 2), type 1 diabetes mellitus and diabetic nephropathy
    Gareth G Lavery
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK
    Eur J Endocrinol 146:553-8. 2002
    ..A microsatellite marker within the HSD11B2 gene associates with salt sensitivity and hypertension--phenotypes characterising diabetic nephropathy. Here, we evaluate the HSD11B2 gene as a susceptibility locus for diabetic nephropathy...
  61. ncbi request reprint Vitamin D and innate immunity
    Martin Hewison
    University of California, Los Angeles, David Geffen School of Medicine, Department of Orthopedic Surgery, 615 Charles E Young Drive South, Los Angeles, CA 90095, USA
    Curr Opin Investig Drugs 9:485-90. 2008
    ..This new facet of 'non-classical' roles of vitamin D action is discussed in this review...
  62. doi request reprint 1alpha,25-dihydroxyvitamin D3 interacts with curcuminoids to stimulate amyloid-beta clearance by macrophages of Alzheimer's disease patients
    Ava Masoumi
    Department of Orthopaedic Surgery, UCLA School of Medicine, Los Angeles, CA 90095 7358, USA
    J Alzheimers Dis 17:703-17. 2009
    ..Human macrophages are a new paradigm for testing immune therapies for AD...
  63. ncbi request reprint Response element binding proteins and intracellular vitamin D binding proteins: novel regulators of vitamin D trafficking, action and metabolism
    John S Adams
    The Burns and Allen Research Institute, Cedars Sinai Medical Center, UCLA School of Medicine, B131, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, USA
    J Steroid Biochem Mol Biol 89:461-5. 2004
    ..Our ongoing studies indicate directly or indirectly through a series of protein interactions that the IDBPs interact with hydroxylated vitamin D metabolites and facilitate their intracellular targeting...
  64. pmc Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity
    John S Adams
    Department of Endocrinology, Diabetes and Metabolism, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
    Nat Clin Pract Endocrinol Metab 4:80-90. 2008
    ..Specific examples of this will be detailed in the current Review, with particular emphasis on the immunomodulatory properties of vitamin D...
  65. ncbi request reprint The aldo-keto reductase AKR1C3 is a novel suppressor of cell differentiation that provides a plausible target for the non-cyclooxygenase-dependent antineoplastic actions of nonsteroidal anti-inflammatory drugs
    Julian C Desmond
    Division of Medical Sciences, University of Birmingham, Birmingham, B15 2TH United Kingdom
    Cancer Res 63:505-12. 2003
    ..In addition, these observations identify AKR1C3 as plausible target for the non-cyclooxygenase-dependent antineoplastic actions of NSAIDs...
  66. ncbi request reprint Serum- and glucocorticoid-regulated kinase isoform-1 and epithelial sodium channel subunits in human ocular ciliary epithelium
    Saaeha Rauz
    Academic Unit of Ophthalmology, Division of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom
    Invest Ophthalmol Vis Sci 44:1643-51. 2003
    ..Sodium transport across the human ocular nonpigmented and pigmented ciliary epithelial bilayer (NPE-PE) is essential for aqueous humor production, but the expression of SGK1 and ENaC subunits remain to be defined...
  67. doi request reprint Vitamin D and innate and adaptive immunity
    Martin Hewison
    Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Vitam Horm 86:23-62. 2011
    ..Finally, the review will consider the role of immunomodulatory vitamin D in human health, with specific emphasis on infectious and autoimmune disease...
  68. pmc Vitamin D and the intracrinology of innate immunity
    Martin Hewison
    Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Mol Cell Endocrinol 321:103-11. 2010
    ..The current review details these new developments with specific reference to the metabolic and signaling mechanisms associated with innate immune regulation by vitamin D and implications for human disease...
  69. pmc Heterogeneous nuclear ribonucleoprotein (hnRNP) binding to hormone response elements: a cause of vitamin D resistance
    Hong Chen
    Burns and Allen Research Institute and the Division of Endocrinology, Diabetes, and Metabolism, 8700 Beverly Boulevard, Room B 131, Los Angeles, CA 90048, USA
    Proc Natl Acad Sci U S A 100:6109-14. 2003
    ..That this protein is a member of the hnRNP family capable of interacting with double-stranded DNA highlights a potentially important new component of the complex machinery required for steroid hormone signal transduction...
  70. ncbi request reprint Osteoblastic 11beta-hydroxysteroid dehydrogenase type 1 activity increases with age and glucocorticoid exposure
    Mark S Cooper
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, United Kingdom
    J Bone Miner Res 17:979-86. 2002
    ..These studies indicate that activation of glucocorticoids at an autocrine level within bone is likely to play an important role in the age-related decrease in bone formation and increased risk of glucocorticoid-induced osteoporosis...
  71. ncbi request reprint Vitamin D-mediated hypercalcemia in slack skin disease: evidence for involvement of extrarenal 25-hydroxyvitamin D 1alpha-hydroxylase
    Helen Karakelides
    Department of Endocrinology, Metabolism and Nutrition, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    J Bone Miner Res 21:1496-9. 2006
    ..Immunolocalization of 1alpha-OH in skin showed simultaneous dysregulation in epithelial and granulomatous cells...
  72. ncbi request reprint 25-hydroxyvitamin D(3)-1alpha-hydroxylase expression in normal and pathological parathyroid glands
    Ulrika Segersten
    Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    J Clin Endocrinol Metab 87:2967-72. 2002
    ..The findings imply that in addition to feedback control by circulating 1,25(OH)(2)D(3) levels, parathyroid cells may also be influenced by local 1alpha -hydroxylase activity with possible growth regulatory and differentiating effects...
  73. ncbi request reprint Cross-sectional analysis of abnormalities of mineral homeostasis, vitamin D and parathyroid hormone in a cohort of pre-dialysis patients. The chronic renal impairment in Birmingham (CRIB) study
    Daniel Zehnder
    Department of Nephrology, University Hospital Coventry and Warwickshire NHS Trust, Coventry, UK
    Nephron Clin Pract 107:c109-16. 2007
    ..However, it is unclear at what stage of chronic kidney disease (CKD) these abnormalities develop...
  74. ncbi request reprint Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain
    Darryl W Eyles
    Queensland Centre for Schizophrenia Research, The Park Centre for Mental Health, Wacol, QLD 4076, Australia
    J Chem Neuroanat 29:21-30. 2005
    ..The widespread distribution of 1alpha-OHase and the VDR suggests that Vitamin D may have autocrine/paracrine properties in the human brain...
  75. ncbi request reprint Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in pancreatic islets
    Rosemary Bland
    Department of Biological Sciences, Biomedical Research Institute, The University of Warwick, Coventry CV4 7AL, UK
    J Steroid Biochem Mol Biol 89:121-5. 2004
    ..Therefore, we would postulate that local production of 1alpha,25(OH)(2)D(3) maybe an important autocrine link between Vitamin D status and pancreatic function...
  76. ncbi request reprint Mechanisms of decreased Vitamin D 1alpha-hydroxylase activity in prostate cancer cells
    Jian Feng Ma
    Department of Urology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Cell Endocrinol 221:67-74. 2004
    ..We conclude that diminished 1alpha(OH)ase activity in prostate cancer cell lines is through decreased gene expression, whereas decreased activity in primary cultures and tissues is post-translational...