I Hers

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. ncbi The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity
    I Hers
    Department of Biochemistry, School of Medical Sciences, University of Bristol, UK
    FEBS Lett 460:433-6. 1999
  2. ncbi Insulin-like growth factor-1 potentiates platelet activation via the IRS/PI3Kalpha pathway
    Ingeborg Hers
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, UK
    Blood 110:4243-52. 2007
  3. ncbi Identification of p122RhoGAP (deleted in liver cancer-1) Serine 322 as a substrate for protein kinase B and ribosomal S6 kinase in insulin-stimulated cells
    Ingeborg Hers
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Biol Chem 281:4762-70. 2006
  4. ncbi Mechanism of feedback regulation of insulin receptor substrate-1 phosphorylation in primary adipocytes
    Ingeborg Hers
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Biochem J 388:713-20. 2005
  5. ncbi Reciprocal feedback regulation of insulin receptor and insulin receptor substrate tyrosine phosphorylation by phosphoinositide 3-kinase in primary adipocytes
    Ingeborg Hers
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Biochem J 368:875-84. 2002
  6. ncbi Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles
    Daniel C Berwick
    Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk, Bristol, BS8 1TD, UK
    J Cell Sci 117:5985-93. 2004
  7. ncbi Insulin/IGF-1 hybrid receptor expression on human platelets: consequences for the effect of insulin on platelet function
    R W Hunter
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, UK
    J Thromb Haemost 7:2123-30. 2009
  8. ncbi Protein kinase C-mediated phosphorylation and activation of PDE3A regulate cAMP levels in human platelets
    Roger W Hunter
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    J Biol Chem 284:12339-48. 2009
  9. ncbi The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes
    Daniel C Berwick
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Biol Chem 277:33895-900. 2002
  10. ncbi PKC-interacting proteins: from function to pharmacology
    Alastair W Poole
    Department of Pharmacology, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    Trends Pharmacol Sci 25:528-35. 2004

Collaborators

Detail Information

Publications13

  1. ncbi The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity
    I Hers
    Department of Biochemistry, School of Medical Sciences, University of Bristol, UK
    FEBS Lett 460:433-6. 1999
    ..We propose that bisindolylmaleimide I and IX can directly inhibit GSK-3, and that this may explain some of the previously reported insulin-like effects on glycogen synthase activity...
  2. ncbi Insulin-like growth factor-1 potentiates platelet activation via the IRS/PI3Kalpha pathway
    Ingeborg Hers
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, UK
    Blood 110:4243-52. 2007
    ..These results demonstrate that IGF-1 activates the IGF receptor/IRS/PI3K/PKB pathway, and that PI3Kalpha is essential for the potentiatory effect of IGF-1 on platelet responses...
  3. ncbi Identification of p122RhoGAP (deleted in liver cancer-1) Serine 322 as a substrate for protein kinase B and ribosomal S6 kinase in insulin-stimulated cells
    Ingeborg Hers
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Biol Chem 281:4762-70. 2006
    ..These results demonstrate that p122RhoGAP Ser-322 acts as an integrator of signal transduction in a manner dependent on the cellular context...
  4. ncbi Mechanism of feedback regulation of insulin receptor substrate-1 phosphorylation in primary adipocytes
    Ingeborg Hers
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Biochem J 388:713-20. 2005
    ....
  5. ncbi Reciprocal feedback regulation of insulin receptor and insulin receptor substrate tyrosine phosphorylation by phosphoinositide 3-kinase in primary adipocytes
    Ingeborg Hers
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Biochem J 368:875-84. 2002
    ....
  6. ncbi Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles
    Daniel C Berwick
    Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk, Bristol, BS8 1TD, UK
    J Cell Sci 117:5985-93. 2004
    ....
  7. ncbi Insulin/IGF-1 hybrid receptor expression on human platelets: consequences for the effect of insulin on platelet function
    R W Hunter
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, UK
    J Thromb Haemost 7:2123-30. 2009
    ..This study investigated the possibility that platelets express hybrid receptors, which may affect insulin action on platelet function...
  8. ncbi Protein kinase C-mediated phosphorylation and activation of PDE3A regulate cAMP levels in human platelets
    Roger W Hunter
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    J Biol Chem 284:12339-48. 2009
    ....
  9. ncbi The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes
    Daniel C Berwick
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Biol Chem 277:33895-900. 2002
    ..Taken together, these results demonstrate that serine 454 of ATP-citrate lyase is a novel and major in vivo substrate for protein kinase B...
  10. ncbi PKC-interacting proteins: from function to pharmacology
    Alastair W Poole
    Department of Pharmacology, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    Trends Pharmacol Sci 25:528-35. 2004
    ..In this article, we review recent work on C-KIPs and the implications for pharmacological and therapeutic development...
  11. ncbi The PKB inhibitor Akti-1/2 potentiates PAR-1-mediated platelet function independently of its ability to block PKB
    R W Hunter
    Department of Biochemistry, School of Medicine Sciences, University of Bristol, Bristol, UK
    J Thromb Haemost 6:1923-32. 2008
    ..Recently, a selective, non-ATP-competitive PKB inhibitor, Akti-1/2 has been reported, but the efficacy and specificity against PKB activation in platelet function is unknown...
  12. ncbi Regulation of small GTP-binding proteins by insulin
    G I Welsh
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 ITD, UK
    Biochem Soc Trans 34:209-12. 2006
    ..We review recent evidence that this may be the case, and place specific emphasis on the role of these pathways in insulin-stimulated glucose uptake...
  13. ncbi Understanding the therapeutic action of recombinant factor VIIa in platelet disorders
    Ingeborg Hers
    Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
    Platelets 19:571-81. 2008
    ..This review summarizes the clinical and experimental evidence supporting a potentiating effect of FVIIa on platelet activation and discusses the likely mechanism of action...