I Hers

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. pmc Dual regulation of glycogen synthase kinase 3 (GSK3)α/β by protein kinase C (PKC)α and Akt promotes thrombin-mediated integrin αIIbβ3 activation and granule secretion in platelets
    Samantha F Moore
    School of Physiology and Pharmacology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Biol Chem 288:3918-28. 2013
  2. pmc mTORC2 protein complex-mediated Akt (Protein Kinase B) Serine 473 Phosphorylation is not required for Akt1 activity in human platelets [corrected]
    Samantha F Moore
    School of Physiology and Pharmacology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Biol Chem 286:24553-60. 2011
  3. ncbi request reprint The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity
    I Hers
    Department of Biochemistry, School of Medical Sciences, University of Bristol, UK
    FEBS Lett 460:433-6. 1999
  4. ncbi request reprint Insulin-like growth factor-1 potentiates platelet activation via the IRS/PI3Kalpha pathway
    Ingeborg Hers
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, UK
    Blood 110:4243-52. 2007
  5. ncbi request reprint Identification of p122RhoGAP (deleted in liver cancer-1) Serine 322 as a substrate for protein kinase B and ribosomal S6 kinase in insulin-stimulated cells
    Ingeborg Hers
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Biol Chem 281:4762-70. 2006
  6. pmc Mechanism of feedback regulation of insulin receptor substrate-1 phosphorylation in primary adipocytes
    Ingeborg Hers
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Biochem J 388:713-20. 2005
  7. pmc Reciprocal feedback regulation of insulin receptor and insulin receptor substrate tyrosine phosphorylation by phosphoinositide 3-kinase in primary adipocytes
    Ingeborg Hers
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Biochem J 368:875-84. 2002
  8. doi request reprint Insulin/IGF-1 hybrid receptor expression on human platelets: consequences for the effect of insulin on platelet function
    R W Hunter
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, UK
    J Thromb Haemost 7:2123-30. 2009
  9. ncbi request reprint Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles
    Daniel C Berwick
    Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk, Bristol, BS8 1TD, UK
    J Cell Sci 117:5985-93. 2004
  10. pmc Protein kinase C-mediated phosphorylation and activation of PDE3A regulate cAMP levels in human platelets
    Roger W Hunter
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    J Biol Chem 284:12339-48. 2009

Collaborators

Detail Information

Publications18

  1. pmc Dual regulation of glycogen synthase kinase 3 (GSK3)α/β by protein kinase C (PKC)α and Akt promotes thrombin-mediated integrin αIIbβ3 activation and granule secretion in platelets
    Samantha F Moore
    School of Physiology and Pharmacology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Biol Chem 288:3918-28. 2013
    ..Together, these results demonstrate that PKCα and Akt modulate platelet function by phosphorylating and inhibiting GSK3α/β, thereby relieving the negative effect of GSK3α/β on thrombin-mediated platelet activation...
  2. pmc mTORC2 protein complex-mediated Akt (Protein Kinase B) Serine 473 Phosphorylation is not required for Akt1 activity in human platelets [corrected]
    Samantha F Moore
    School of Physiology and Pharmacology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Biol Chem 286:24553-60. 2011
    ..Together, these results demonstrate that mTORC2 is the kinase that phosphorylates Akt Ser(473) in human platelets but that this phosphorylation is dispensable for Thr(308) phosphorylation and Akt1 activity...
  3. ncbi request reprint The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity
    I Hers
    Department of Biochemistry, School of Medical Sciences, University of Bristol, UK
    FEBS Lett 460:433-6. 1999
    ..We propose that bisindolylmaleimide I and IX can directly inhibit GSK-3, and that this may explain some of the previously reported insulin-like effects on glycogen synthase activity...
  4. ncbi request reprint Insulin-like growth factor-1 potentiates platelet activation via the IRS/PI3Kalpha pathway
    Ingeborg Hers
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, UK
    Blood 110:4243-52. 2007
    ..These results demonstrate that IGF-1 activates the IGF receptor/IRS/PI3K/PKB pathway, and that PI3Kalpha is essential for the potentiatory effect of IGF-1 on platelet responses...
  5. ncbi request reprint Identification of p122RhoGAP (deleted in liver cancer-1) Serine 322 as a substrate for protein kinase B and ribosomal S6 kinase in insulin-stimulated cells
    Ingeborg Hers
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Biol Chem 281:4762-70. 2006
    ..These results demonstrate that p122RhoGAP Ser-322 acts as an integrator of signal transduction in a manner dependent on the cellular context...
  6. pmc Mechanism of feedback regulation of insulin receptor substrate-1 phosphorylation in primary adipocytes
    Ingeborg Hers
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Biochem J 388:713-20. 2005
    ....
  7. pmc Reciprocal feedback regulation of insulin receptor and insulin receptor substrate tyrosine phosphorylation by phosphoinositide 3-kinase in primary adipocytes
    Ingeborg Hers
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Biochem J 368:875-84. 2002
    ....
  8. doi request reprint Insulin/IGF-1 hybrid receptor expression on human platelets: consequences for the effect of insulin on platelet function
    R W Hunter
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, UK
    J Thromb Haemost 7:2123-30. 2009
    ..This study investigated the possibility that platelets express hybrid receptors, which may affect insulin action on platelet function...
  9. ncbi request reprint Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles
    Daniel C Berwick
    Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk, Bristol, BS8 1TD, UK
    J Cell Sci 117:5985-93. 2004
    ....
  10. pmc Protein kinase C-mediated phosphorylation and activation of PDE3A regulate cAMP levels in human platelets
    Roger W Hunter
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    J Biol Chem 284:12339-48. 2009
    ....
  11. ncbi request reprint Regulation of small GTP-binding proteins by insulin
    G I Welsh
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 ITD, UK
    Biochem Soc Trans 34:209-12. 2006
    ..We review recent evidence that this may be the case, and place specific emphasis on the role of these pathways in insulin-stimulated glucose uptake...
  12. ncbi request reprint The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes
    Daniel C Berwick
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Biol Chem 277:33895-900. 2002
    ..Taken together, these results demonstrate that serine 454 of ATP-citrate lyase is a novel and major in vivo substrate for protein kinase B...
  13. doi request reprint The PKB inhibitor Akti-1/2 potentiates PAR-1-mediated platelet function independently of its ability to block PKB
    R W Hunter
    Department of Biochemistry, School of Medicine Sciences, University of Bristol, Bristol, UK
    J Thromb Haemost 6:1923-32. 2008
    ..Recently, a selective, non-ATP-competitive PKB inhibitor, Akti-1/2 has been reported, but the efficacy and specificity against PKB activation in platelet function is unknown...
  14. ncbi request reprint PKC-interacting proteins: from function to pharmacology
    Alastair W Poole
    Department of Pharmacology, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    Trends Pharmacol Sci 25:528-35. 2004
    ..In this article, we review recent work on C-KIPs and the implications for pharmacological and therapeutic development...
  15. ncbi request reprint Protein kinase C and P2Y12 take center stage in thrombin-mediated activation of mammalian target of rapamycin complex 1 in human platelets
    S F Moore
    School of Physiology and Pharmacology, Medical Sciences Building, University of Bristol, Bristol, UK
    J Thromb Haemost 12:748-60. 2014
    ..Despite an important role of mTORC1 in platelet function, little is known about how it is regulated. The objective of this study was to determine the signaling pathways that regulate mTORC1 in human platelets...
  16. ncbi request reprint Role of protein kinase B in insulin-regulated glucose uptake
    G I Welsh
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 ITD, UK
    Biochem Soc Trans 33:346-9. 2005
    ..This paper addresses these important questions by reviewing recent progress in the field...
  17. doi request reprint Insulin-like growth factor-II is produced by, signals to and is an important survival factor for the mature podocyte in man and mouse
    L J Hale
    Academic and Children s Renal Unit, University of Bristol, Learning and Research, Southmead Hospital, Bristol, BS10 5NB, UK
    J Pathol 230:95-106. 2013
    ..Collectively, this work reveals the fundamental importance of IGF-II in the mature podocyte for glomerular health across mammalian species...
  18. doi request reprint Understanding the therapeutic action of recombinant factor VIIa in platelet disorders
    Ingeborg Hers
    Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
    Platelets 19:571-81. 2008
    ..This review summarizes the clinical and experimental evidence supporting a potentiating effect of FVIIa on platelet activation and discusses the likely mechanism of action...