Research Topics
| K HerholzSummaryAffiliation: University of Manchester Country: UK Publications
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Detail Information
Publications
Brain tumorsKarl Herholz
School of Cancer and enabling Sciences, The University of Manchester, Wolfson Molecular Imaging Centre, Manchester, England
Semin Nucl Med 42:356-70. 2012....- Use of FDG PET as an imaging biomarker in clinical trials of Alzheimer's diseaseKarl Herholz
The University of Manchester, Wolfson Molecular Imaging Centre, 27 Palatine Road, Manchester, UK
Biomark Med 6:431-9. 2012.... - Cerebral glucose metabolism in preclinical and prodromal Alzheimer's diseaseKarl Herholz
University of Manchester, 27 Palatine Road, Manchester, M20 3LJ, UK
Expert Rev Neurother 10:1667-73. 2010..Frontal and temporoparietal metabolic impairment is closely related to progression of disease in longitudinal studies, and multicenter studies suggest its utility as an outcome parameter to increase the efficiency of therapeutic trials... - Clinical amyloid imaging in Alzheimer's diseaseKarl Herholz
Wolfson Molecular Imaging Centre, School of Cancer and enabling Sciences, University of Manchester, Manchester, UK
Lancet Neurol 10:667-70. 2011..Ultimately, these tracers will hopefully clarify the pathophysiological role of amyloid in AD and contribute to development of new treatments... - Perfusion SPECT and FDG-PETKarl Herholz
Wolfson Molecular Imaging Centre, University of Manchester, Manchester, UK
Int Psychogeriatr 23:S25-31. 2011.... - Evaluation of a calibrated (18)F-FDG PET score as a biomarker for progression in Alzheimer disease and mild cognitive impairmentKarl Herholz
Wolfson Molecular Imaging Centre, School of Cancer and enabling Sciences, University of Manchester, Manchester, UK
J Nucl Med 52:1218-26. 2011..PET using (18)F-FDG provides objective information about the impairment of synaptic function and could, with appropriate standardization, qualify as a biomarker... - Acetylcholine esterase activity in mild cognitive impairment and Alzheimer's diseaseKarl Herholz
Wolfson Molecular Imaging Centre, Clinical Neuroscience, University of Manchester, 27 Palatine Road, Manchester, UK
Eur J Nucl Med Mol Imaging 35:S25-9. 2008..Impairment of cholinergic neurotransmission is a well-established fact in Alzheimer's disease (AD), but there is controversy about its relevance at the early stages of the disease and in mild cognitive impairment (MCI)... - Positron emission tomography imaging in dementiaK Herholz
Wolfson Molecular Imaging Centre, University of Manchester, Manchester, UK
Br J Radiol 80:S160-7. 2007.... - Deficits of the cholinergic system in early ADKarl Herholz
University of Manchester, United Kingdom
Neuropsychologia 46:1642-7. 2008..The relation of these findings to neuronal function and post-mortem findings is being discussed... 
Metabolic and molecular imaging in neuro-oncologyKarl Herholz
Wolfson Molecular Imaging Centre, University of Manchester, Oxford Road, Manchester, UK
Lancet Neurol 6:711-24. 2007..Functional and metabolic imaging can improve the planning and monitoring of radiation and chemotherapy and contribute to the development of new therapies...- Cognitive dysfunction and emotional-behavioural changes in MS: the potential of positron emission tomographyKarl Herholz
University of Manchester, Wolfson Molecular Imaging Centre, 27 Palatine Road, Manchester M20 3LJ, UK
J Neurol Sci 245:9-13. 2006..Other tracers offer a broad spectrum of measuring local physiological functions and pathophysiological processes, but some of them are still limited to experimental animal research... - Cerebral acetylcholine esterase activity in mild cognitive impairmentKarl Herholz
Department of Neurology, University of Cologne, Koln, Germany
Neuroreport 16:1431-4. 2005..These results suggest that low cortical acetylcholine esterase activity may be an indicator of impending dementia in patients with mild cognitive impairment... - Dementia in Parkinson disease: functional imaging of cholinergic and dopaminergic pathwaysR Hilker
Department of Neurology, University of Cologne, Cologne, Germany
Neurology 65:1716-22. 2005..To assess neurochemical deficits in patients with Parkinson disease (PD) associated dementia (PDD) in vivo... - Activation PET as an instrument to determine therapeutic efficacy in Alzheimer's diseaseW D Heiss
Max Planck Institut für neurologische Forschung and Neurologische Universitätsklinik, Koln, Germany
Ann N Y Acad Sci 695:327-31. 1993.... - In vivo study of acetylcholine esterase in basal forebrain, amygdala, and cortex in mild to moderate Alzheimer diseaseK Herholz
Department of Neurology, University Cologne, and Max Planck Institute for Neurological Research, Cologne, Germany
Neuroimage 21:136-43. 2004..The results support the concept that neocortical and amygdaloid functional changes of the cholinergic system are an early and leading event in AD, rather than the consequence of neurodegeneration of basal nuclei... - Propentofylline enhances cerebral metabolic response to auditory memory stimulation in Alzheimer's diseaseR Mielke
Max Planck Institut für Neurologische Forschung und Universitätsklinik für Neurologie, Koln, Germany
J Neurol Sci 154:76-82. 1998..02). The placebo group showed a significantly decline in the MMSE score (P = 0.02) while there was no change in the treatment group. This suggests a protective role for propentofylline in slowing the progression of AD... - 11C-methionine and 18F-2-fluorodeoxyglucose positron emission tomography: a tool for diagnosis of cerebral glioma and monitoring after brachytherapy with 125I seedsJ Voges
Department of Stereotactic and Functional Neurosurgery, University of Cologne, Germany
Stereotact Funct Neurosurg 69:129-35. 1997..In conclusion, 11C-methionine PET may improve tumor delineation and, following brachytherapy, provides more information on the therapeutic effects than FDG... - Impairment of neocortical metabolism predicts progression in Alzheimer's diseaseK Herholz
Max Planck Institut für neurologische Forschung, Koln, Germany
Dement Geriatr Cogn Disord 10:494-504. 1999..In patients with mild cognitive deficits at entry, the risk of deterioration was up to 4.7 times higher if the metabolism was severely impaired than with mild or absent metabolic impairment. Copyrightz1999S.KargerAG, Basel.. - Robustness of correlations between PCA of FDG-PET scans and biological variables in healthy and demented subjectsP J Markiewicz
School of Cancer and Imaging Sciences at the University of Manchester, Wolfson, Molecular Imaging Centre, Manchester, England
Neuroimage 56:782-7. 2011.... - Imaging of acetylcholine esterase activity in brainstem nuclei involved in regulation of sleep and wakefulnessC Eggers
Department of Neurology, University of Cologne, Cologne, Germany
Eur J Neurol 14:690-3. 2007..This approach may be helpful to investigate the interaction of various nuclei in the complex network regulating sleep and wakefulness in representative patient groups with documented sleep disturbance... 
Verification of predicted robustness and accuracy of multivariate analysisP J Markiewicz
School of Cancer and enabling Sciences, University of Manchester MAHSC, Wolfson Molecular Imaging Centre, Manchester, England, UK
Neuroimage 56:1382-5. 2011..Also, it is shown that the type of PET scanner and image reconstruction method has an impact on such analysis and affects the accuracy of the verification sample...- Anosognosia in very mild Alzheimer's disease but not in mild cognitive impairmentE Kalbe
Department of Neurology, University Hospital, and Max Planck Institute for Neurological Research, Cologne, Germany
Dement Geriatr Cogn Disord 19:349-56. 2005..To study awareness of cognitive dysfunction in patients with very mild Alzheimer's disease (AD) and subjects with mild cognitive impairment (MCI)... - Imaging in gene therapy of patients with gliomaA H Jacobs
Max Planck Institute for Neurological Research, Center of Molecular Medicine ZMMK, Department of Neurology, University of Cologne, Cologne, Germany
J Neurooncol 65:291-305. 2003.... - Disease progression continues in patients with advanced Parkinson's disease and effective subthalamic nucleus stimulationR Hilker
Department of Neurology, University Hospital, Joseph Stelzmann Strasse 9, 50924 Cologne, Germany
J Neurol Neurosurg Psychiatry 76:1217-21. 2005..Deep brain stimulation of the STN (STN DBS), in its role as a highly effective treatment of severe PD motor complications, has been thought to inhibit STN hyperactivity and therefore decrease progression of PD... - Imaging in gliomaK Herholz
Wolfson Molecular Imaging Centre, University of Manchester, Manchester, UK
Ann Oncol 19:vii207-8. 2008 - Positron emission tomographic analysis of the nigrostriatal dopaminergic system in familial parkinsonism associated with mutations in the parkin geneR Hilker
Department of Neurology, Medical University of Cologne, Germany
Ann Neurol 49:367-76. 2001..These data indicate a preclinical disease process in these subjects... - Robustness of multivariate image analysis assessed by resampling techniques and applied to FDG-PET scans of patients with Alzheimer's diseaseP J Markiewicz
Research School of Translational Medicine, University of Manchester, Wolfson Molecular Imaging Centre, Manchester, UK
Neuroimage 46:472-85. 2009.... - Quantitative evaluation of white matter tract DTI parameter changes in gliomas using nonlinear registrationP Miller
Wolfson Molecular Imaging Centre, University of Manchester, Manchester M20 3LJ, UK
Neuroimage 60:2309-15. 2012..We show that the classification of tract segments was consistent with disruption, oedema or compression. The results suggest that this method could be used to detect changes in eloquent white matter tracts in individual patients... - Novel neuroimaging findings in a patient with cerebral Whipple's disease: a magnetic resonance imaging and positron emission tomography studyN Galldiks
Department of Neurology, Max Planck-Institute for Neurological Research, Cologne, Germany
J Neuroimaging 14:372-6. 2004.... - Prefrontal cortex dysfunction and depression in atypical parkinsonian syndromesBirgit Herting
Department of Neurology, Technische Universitat Dresden, Germany
Mov Disord 22:490-7. 2007..The findings of this pilot study support the hypothesis that depressive symptoms in MSA and PSP are associated with prefrontal dysfunction... - Nonlinear progression of Parkinson disease as determined by serial positron emission tomographic imaging of striatal fluorodopa F 18 activityRuediger Hilker
Department of Neurology, University of Cologne, Cologne, Germany
Arch Neurol 62:378-82. 2005..The investigation of disease progression provides important information on the dynamics of cell death in Parkinson disease (PD)... - Evaluation of primary brain tumors using 11C-methionine PET with reference to a normal methionine uptake mapDavid J Coope
Wolfson Molecular Imaging Centre, The University of Manchester, Manchester, United Kingdom
J Nucl Med 48:1971-80. 2007.... - Biodistribution, pharmacokinetics and metabolism of interleukin-1 receptor antagonist (IL-1RA) using [¹⁸F]-IL1RA and PET imaging in ratsC Cawthorne
Wolfson Molecular Imaging Centre, University of Manchester, Manchester, UK
Br J Pharmacol 162:659-72. 2011..Here we illustrate the potential of PET imaging in a preclinical study of the biodistribution and metabolism of ¹⁸F-labelled IL-1 receptor antagonist ([¹⁸F]IL-1RA) using a novel [¹⁸F]-radiolabelling technique... - Disturbance and recovery of language function: correlates in PET activation studiesW D Heiss
Max Planck Institute for Neurological Research, University of Cologne, Gleueler Strasse 50, 50931, Cologne, Germany
Neuroimage 20:S42-9. 2003.... - Molecular and functional imaging technology for the development of efficient treatment strategies for gliomasA H Jacobs
Max Planck Institute for Neurological Research, Center of Molecular Medicine ZMMK, University of Cologne, Cologne, Germany
Technol Cancer Res Treat 1:187-204. 2002..Here, we review the main principles of PET imaging and its key roles in neurooncology research... - Cortical acetylcholine esterase activity and ApoE4-genotype in Alzheimer diseaseCarsten Eggers
Department of Neurology, University of Cologne, Germany
Neurosci Lett 408:46-50. 2006..041, p<0.05) in the ApoE4 negative group only. These results indicate that cortical AChE activity is relatively well preserved in ApoE4 carriers, either by preservation of its cellular expression or as AChE activity in amyloid plaques... - [11C]-L-methionine positron emission tomography in the management of children and young adults with brain tumorsNorbert Galldiks
Department of Neurology, University of Cologne, Kerpener Str 62, 50924 Cologne, Germany
J Neurooncol 96:231-9. 2010..02). MET-PET might be a useful tool to differentiate tumorous from non-tumorous lesions in children and young adults when a decision for further therapy is difficult or impossible from routine structural imaging procedures alone... - Positron emission tomography in clinical neurologyKarl Herholz
Department of Neurology, University Cologne, Koln, Germany
Mol Imaging Biol 6:239-69. 2004..Techniques for presurgical localization of eloquent cortex and monitoring of therapy are presented... - Neuroimaging-guided rTMS of the left inferior frontal gyrus interferes with repetition primingAlexander Thiel
Department of Neurology, University of Cologne, Germany
Neuroimage 25:815-23. 2005.... - From the left to the right: How the brain compensates progressive loss of language functionAlexander Thiel
Department of Neurology, University of Cologne, Germany
Brain Lang 98:57-65. 2006..It can thus be concluded that time is the factor which determines successful integration of the right hemisphere into the language network for compensation of lost left hemisphere language function... - PET studies in dementiaKarl Herholz
Neurologische Universitatsklinik, Max Planck Institut für neurologische Forschung, Koln, Germany
Ann Nucl Med 17:79-89. 2003..In LBD there is also impairment of dopamine synthesis, similar to Parkinson disease... - Use of 11C-methionine PET to monitor the effects of temozolomide chemotherapy in malignant gliomasNorbert Galldiks
Department of Neurology, University of Cologne, Cologne, Germany
Eur J Nucl Med Mol Imaging 33:516-24. 2006..A reduction in MET uptake during TMZ treatment predicts a favourable clinical outcome. Molecular imaging of amino acid uptake by MET-PET offers a new method of measurement of the biological activity of recurrent glioma... - Essential language function of the right hemisphere in brain tumor patientsAlexander Thiel
Department of Neurology, University of Cologne, Cologne, Germany
Ann Neurol 57:128-31. 2005..Those patients with lowest dominance were also susceptible to right-sided TMS proving relevant language function of the right IFG... - Crossed cerebellar diaschisis in acute human stroke: a PET study of serial changes and response to supratentorial reperfusionJan Sobesky
Max Planck Institute for Neurological Research, University of Cologne, Cologne, Germany
J Cereb Blood Flow Metab 25:1685-91. 2005.... - Direct comparison of spatially normalized PET and SPECT scans in Alzheimer's diseaseKarl Herholz
Neurologische Universitatsklinik, Koln, Germany
J Nucl Med 43:21-6. 2002..We therefore used statistical parametric mapping to detect and compare abnormal brain areas objectively and quantitatively... - Age and ApoE genotype interaction in Alzheimer's disease: an FDG-PET studyLisa Mosconi
Department of Clinical Pathophysiology, Nuclear Medicine Unit, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
Psychiatry Res 130:141-51. 2004..These results indicate that age-related regional rCMRglu decreases within the frontal and anterior cingulate areas may be more severe in AD patients carrying the ApoE4 allele... - Neural correlates of anosognosia for cognitive impairment in Alzheimer's diseaseEric Salmon
Cyclotron Research Centre, University of Liege, Liege, Belgium
Hum Brain Mapp 27:588-97. 2006.... - Functional interactions of the entorhinal cortex: an 18F-FDG PET study on normal aging and Alzheimer's diseaseLisa Mosconi
Department of Clinical Pathophysiology, Nuclear Medicine Unit, University of Florence, Italy
J Nucl Med 45:382-92. 2004.... - Efficient principal component analysis for multivariate 3D voxel-based mapping of brain functional imaging data sets as applied to FDG-PET and normal agingGerhard Zuendorf
Neurological Clinic and Max Planck Institute for Neurological Research, University Cologne, Gleueler Strasse 50, 50931 Cologne, Germany
Hum Brain Mapp 18:13-21. 2003..Thus, our method showed that the effect of aging on brain metabolism has at least two independent dimensions. This method should have widespread applications in multivariate analysis of brain functional images... - Metabolic rates in small brain nuclei determined by high-resolution PETWolf Dieter Heiss
Max Planck Institute for Neurological Research, 50931 Koln, Germany
J Nucl Med 45:1811-5. 2004..2 mm at sufficient efficiency and permitted the quantification of tracer concentrations in small volumes... - Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementiasLisa Mosconi
Center for Brain Health, New York University School of Medicine, New York, New York 10016, USA
J Nucl Med 49:390-8. 2008.... - Delineation of brain tumor extent with [11C]L-methionine positron emission tomography: local comparison with stereotactic histopathologyLutz W Kracht
Max-Planck-Institute for Neurological Research, Cologne, Germany
Clin Cancer Res 10:7163-70. 2004..High [11C]MET uptake in infiltrating tumor of astrocytoma WHO grade 2 reflects high activity in this tumor compartment. Molecular imaging, with [11C]MET, will guide improved management of patients with brain tumors... - 18F-fluoro-L-thymidine and 11C-methylmethionine as markers of increased transport and proliferation in brain tumorsAndreas H Jacobs
Laboratory for Gene Therapy and Molecular Imaging, Max Planck Institute for Neurological Research, Cologne, Germany
J Nucl Med 46:1948-58. 2005..Additionally, the longer half-life might permit differentiation between transport and intracellular phosphorylation... - Decomposition of metabolic brain clusters in the frontal variant of frontotemporal dementiaEric Salmon
Cyclotron Research Centre, University of Liege, B30 Sart Tilman, 4000 Liege, Belgium
Neuroimage 30:871-8. 2006..The study provides original data-driven arguments for metabolic involvement of separate brain clusters in the rostral limbic system, corresponding to pathological poles differentially affected in each FTD patient... - 18FDG PET in vascular dementia: differentiation from Alzheimer's disease using voxel-based multivariate analysisNacer Kerrouche
INSERM U320, University of Caen, Caen, France
J Cereb Blood Flow Metab 26:1213-21. 2006..By maximizing the separation between groups, this method extracted a metabolic pattern that efficiently differentiated VaD and AD... - Heterogeneity of brain glucose metabolism in mild cognitive impairment and clinical progression to Alzheimer diseaseDavide Anchisi
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele, Milan, Italy
Arch Neurol 62:1728-33. 2005..CONCLUSION: These data provide evidence for clinical and functional heterogeneity among subjects with aMCI and suggest that 18FDG-PET findings combined with memory scores may be useful in predicting short-term conversion to AD... - Orbitofrontal dysfunction related to both apathy and disinhibition in frontotemporal dementiaFrederic Peters
Cyclotron Research Center, University of Liege, Liege, Belgium
Dement Geriatr Cogn Disord 21:373-9. 2006.... - Reduced glucose metabolism in temporo-parietal cortices of women with borderline personality disorderClaudia Lange
Department of Psychiatry and Psychotherapy, , von-Siebold-Str. 5, , Germany
Psychiatry Res 139:115-26. 2005..Decreased resting metabolic rate of these regions may reflect dissociative symptoms and possibly also identity disturbances and interpersonal difficulties of individuals with BPD... - Cortical flattening applied to high-resolution 18F-FDG PETJohannes C Klein
Max Planck Institute for Neurological Research, Cologne, Germany
J Nucl Med 49:44-9. 2008..This type of registration has been demonstrated to provide better matching of congruent cortical structures than volume methods and, thus, offers a potentially more robust way of analyzing PET data... - Imaging in neurooncologyAndreas H Jacobs
Max Planck Institute for Neurological Research, Cologne, Germany
NeuroRx 2:333-47. 2005..In summary, imaging in patients with brain tumors plays a central role in the management of the disease and in the development of improved imaging-guided therapies... - Regional cerebral metabolism in early Alzheimer's disease with clinically significant apathy or depressionVjera A Holthoff
Department of Psychiatry and Psychotherapy, Dresden University of Technology, Germany
Biol Psychiatry 57:412-21. 2005..CONCLUSIONS: These findings support the notion that different functional circuits underlie apathy and depression in early AD... - Predominant ventromedial frontopolar metabolic impairment in frontotemporal dementiaEric Salmon
The Cyclotron Research Center, University of Liege, 4000 Liege, Belgium
Neuroimage 20:435-40. 2003.... - Fast and robust registration of PET and MR images of human brainJiri Cizek
Max Planck Institute for Neurological Research, 50931 Cologne, Germany
Neuroimage 22:434-42. 2004..Registration progress is presented on the fly on a fusion of images and enables visual checking during a registration... - [Different patterns of regional brain activation during emotional stimulation in alexithymics in comparison with normal controls]Michael Huber
Institut und Poliklinik für Psychosomatik und Psychotherapie der Universität zu Köln, Germany
Psychother Psychosom Med Psychol 52:469-78. 2002..This study was designed to determine patterns of regional brain activation during emotional stimulation in alexithymics as compared with normal controls... - Subthalamic nucleus stimulation restores glucose metabolism in associative and limbic cortices and in cerebellum: evidence from a FDG-PET study in advanced Parkinson's diseaseRuediger Hilker
Departments of Neurology and dagger Stereotaxy and Functional Neurosurgery, University Hospital, Cologne, Germany
J Cereb Blood Flow Metab 24:7-16. 2004..These data suggest an activating effect of DBS upon its target structures and confirm a central role of the STN in motor as well as associative, limbic, and cerebellar basal ganglia circuits...