J Herbert

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Strain differences in proliferation of progenitor cells in the dentate gyrus of the adult rat and the response to fluoxetine are dependent on corticosterone
    S Alahmed
    Department of Physiology, Development and Neuroscience, and Cambridge Centre for Brain Repair, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    Neuroscience 157:677-82. 2008
  2. pmc Raised circulating corticosterone inhibits neuronal differentiation of progenitor cells in the adult hippocampus
    E Y H Wong
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    Neuroscience 137:83-92. 2006
  3. pmc The roles of BDNF, pCREB and Wnt3a in the latent period preceding activation of progenitor cell mitosis in the adult dentate gyrus by fluoxetine
    Scarlett B Pinnock
    Department of Physiology, Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 5:e13652. 2010
  4. pmc Cell origin and culture history determine successful integration of neural precursor transplants into the dentate gyrus of the adult rat
    Xia Chen
    Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 6:e17072. 2011
  5. pmc Novel control by the CA3 region of the hippocampus on neurogenesis in the dentate gyrus of the adult rat
    Jian Xin Liu
    Institute of Neurobiology, School of Medicine of Xi an Jiaotong University, Xi an, PR China
    PLoS ONE 6:e17562. 2011
  6. doi request reprint Cortisol and depression: three questions for psychiatry
    J Herbert
    Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, UK
    Psychol Med 43:449-69. 2013
  7. pmc Interaction between the BDNF gene Val/66/Met polymorphism and morning cortisol levels as a predictor of depression in adult women
    J Herbert
    Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0SP, UK
    Br J Psychiatry 201:313-9. 2012
  8. pmc Profiles of family-focused adverse experiences through childhood and early adolescence: the ROOTS project a community investigation of adolescent mental health
    Valerie J Dunn
    Developmental and Life course Research Group, Department of Psychiatry, University of Cambridge, Cambridge, UK
    BMC Psychiatry 11:109. 2011
  9. ncbi request reprint Do corticosteroids damage the brain?
    J Herbert
    Department of Physiology, Development and Neuroscience, and Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, UK
    J Neuroendocrinol 18:393-411. 2006
  10. pmc Synergistic effects of dehydroepiandrosterone and fluoxetine on proliferation of progenitor cells in the dentate gyrus of the adult male rat
    S B Pinnock
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK
    Neuroscience 158:1644-51. 2009

Collaborators

Detail Information

Publications30

  1. pmc Strain differences in proliferation of progenitor cells in the dentate gyrus of the adult rat and the response to fluoxetine are dependent on corticosterone
    S Alahmed
    Department of Physiology, Development and Neuroscience, and Cambridge Centre for Brain Repair, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    Neuroscience 157:677-82. 2008
    ....
  2. pmc Raised circulating corticosterone inhibits neuronal differentiation of progenitor cells in the adult hippocampus
    E Y H Wong
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    Neuroscience 137:83-92. 2006
    ..Raised corticosterone significantly reduced neuronal production while adrenalectomy resulted in significantly higher number of neurons in the adult male rat hippocampus...
  3. pmc The roles of BDNF, pCREB and Wnt3a in the latent period preceding activation of progenitor cell mitosis in the adult dentate gyrus by fluoxetine
    Scarlett B Pinnock
    Department of Physiology, Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 5:e13652. 2010
    ..These results shed new light on the action of fluoxetine on neurogenesis in the adult dentate gyrus, and have both clinical and experimental interest...
  4. pmc Cell origin and culture history determine successful integration of neural precursor transplants into the dentate gyrus of the adult rat
    Xia Chen
    Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 6:e17072. 2011
    ..These findings may be of therapeutic interest for cell replacement therapy in treating the damaged hippocampus...
  5. pmc Novel control by the CA3 region of the hippocampus on neurogenesis in the dentate gyrus of the adult rat
    Jian Xin Liu
    Institute of Neurobiology, School of Medicine of Xi an Jiaotong University, Xi an, PR China
    PLoS ONE 6:e17562. 2011
    ..These results show that CA3 has a hitherto unsuspected role in regulating neurogenesis in the dentate gyrus of the adult rat...
  6. doi request reprint Cortisol and depression: three questions for psychiatry
    J Herbert
    Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, UK
    Psychol Med 43:449-69. 2013
    ..Does this suggest new avenues for studying MDD or its clinical management?..
  7. pmc Interaction between the BDNF gene Val/66/Met polymorphism and morning cortisol levels as a predictor of depression in adult women
    J Herbert
    Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0SP, UK
    Br J Psychiatry 201:313-9. 2012
    ..Much less is known about how they interact with individual differences in cortisol, although these also represent a risk for major depression...
  8. pmc Profiles of family-focused adverse experiences through childhood and early adolescence: the ROOTS project a community investigation of adolescent mental health
    Valerie J Dunn
    Developmental and Life course Research Group, Department of Psychiatry, University of Cambridge, Cambridge, UK
    BMC Psychiatry 11:109. 2011
    ..Adverse family experiences in early life are associated with subsequent psychopathology. This study adds to the growing body of work exploring the nature and associations between adverse experiences over the childhood years...
  9. ncbi request reprint Do corticosteroids damage the brain?
    J Herbert
    Department of Physiology, Development and Neuroscience, and Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, UK
    J Neuroendocrinol 18:393-411. 2006
    ..In this review, we are principally concerned with excess or disturbed patterns of circulating corticosteroids in the longer or shorter term, and the effects they have on the brain...
  10. pmc Synergistic effects of dehydroepiandrosterone and fluoxetine on proliferation of progenitor cells in the dentate gyrus of the adult male rat
    S B Pinnock
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK
    Neuroscience 158:1644-51. 2009
    ..Since altered neurogenesis has been linked to the onset or recovery from depression, one consequence of these results is to suggest DHEA as a useful adjunct therapy for depression...
  11. ncbi request reprint The role of 5-HT1A receptors in the proliferation and survival of progenitor cells in the dentate gyrus of the adult hippocampus and their regulation by corticoids
    G J Huang
    Department of Anatomy and Cambridge Centre for Brain Repair, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    Neuroscience 135:803-13. 2005
    ..5-HT1A mRNA expression was not altered in the hippocampus by adrenalectomy. Thus, the effect of adrenalectomy on cell proliferation and survival is not 5-HT1A dependent, despite the interaction between 5-HT1A and corticosterone...
  12. ncbi request reprint Corticosterone modulates autonomic responses and adaptation of central immediate-early gene expression to repeated restraint stress
    J Stamp
    Anatomy Department, University of Cambridge, Downing Street, CB2 3DY, Cambridge, UK
    Neuroscience 107:465-79. 2001
    ..In particular, there are distinctions between Fos and Fos-b both in the way they adapt to repeated restraint stress, and the effect corticosterone has on this adaptive process...
  13. ncbi request reprint Psychosocial and endocrine features of chronic first-episode major depression in 8-16 year olds
    I M Goodyer
    Developmental Psychiatry Section, Department of Psychiatry, University of Cambridge, Cambridge CB2 2AH, UK
    Biol Psychiatry 50:351-7. 2001
    ....
  14. pmc Corticosterone differentially modulates expression of corticotropin releasing factor and arginine vasopressin mRNA in the hypothalamic paraventricular nucleus following either acute or repeated restraint stress
    S B Pinnock
    Department of Anatomy, University of Cambridge, Cambridge CB2 3DY UK
    Eur J Neurosci 13:576-84. 2001
    ....
  15. pmc 17Beta-oestradiol modulates glucocorticoid, neural and behavioural adaptations to repeated restraint stress in female rats
    P Lunga
    Department of Anatomy, University of Cambridge, Cambridge, UK
    J Neuroendocrinol 16:776-85. 2004
    ..The present study presents novel data showing that the HPA axis remains reactive to repeated stress in 17beta-oestradiol-treated ovariectomized rats, but stress-induced anxiety behaviour is reduced...
  16. ncbi request reprint Glucocorticoid enhances the neurotoxic actions of quinolinic acid in the striatum in a cell-specific manner
    L Y Ngai
    Department of Anatomy and Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, UK
    J Neuroendocrinol 17:424-34. 2005
    ..These results show that corticosterone has a selective neuroendangering action within the striatum, but there is no evidence for a protective action of glucocorticoids at lower doses...
  17. ncbi request reprint Salivary cortisol and DHEA: association with measures of cognition and well-being in normal older men, and effects of three months of DHEA supplementation
    J K van Niekerk
    Department of Psychiatry, University of Cambridge, Box 189, Addenbrooke's Hospital, CB2 2QQ, Cambridge, UK
    Psychoneuroendocrinology 26:591-612. 2001
    ....
  18. ncbi request reprint Dehydroepiandrosterone (DHEA) stimulates neurogenesis in the hippocampus of the rat, promotes survival of newly formed neurons and prevents corticosterone-induced suppression
    K K Karishma
    Department of Anatomy, University of Cambridge, Cambridge, CB2 3DY, UK
    Eur J Neurosci 16:445-53. 2002
    ....
  19. doi request reprint Rhythmic expression of per1 in the dentate gyrus is suppressed by corticosterone: implications for neurogenesis
    M J Gilhooley
    Department of Physiology, Development and Neuroscience, University of Cambridge, UK
    Neurosci Lett 489:177-81. 2011
    ..These results are related to the previous finding that clamping the corticosterone rhythm also prevents the stimulating action of fluoxetine and other controlling agents on the mitotic activity of the progenitor cells...
  20. ncbi request reprint Dehydroepiandrosterone antagonizes the neurotoxic effects of corticosterone and translocation of stress-activated protein kinase 3 in hippocampal primary cultures
    V G Kimonides
    Department of Anatomy, Physiology and MRC Cambridge Centre for Brain Repair, University of Cambridge
    Neuroscience 89:429-36. 1999
    ..This protective action may involve stress-activated protein kinase 3-related intracellular pathways, though direct evidence for this has still to be obtained...
  21. ncbi request reprint The effects of corticosterone and dehydroepiandrosterone on neurotrophic factor mRNA expression in primary hippocampal and astrocyte cultures
    E M Gubba
    Department of Anatomy, and Cambridge Centre for Brain Repair, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    Brain Res Mol Brain Res 127:48-59. 2004
    ....
  22. ncbi request reprint Disrupted daily activity/rest cycles in relation to daily cortisol rhythms of home-dwelling patients with early Alzheimer's dementia
    C F Hatfield
    Department of Anatomy, Cambridge University, Cambridge, UK
    Brain 127:1061-74. 2004
    ..Further characterization of this pathology will facilitate more effective management of sleep patterns in home-dwelling demented patients...
  23. ncbi request reprint Adaptation in patterns of c-fos expression in the brain associated with exposure to either single or repeated social stress in male rats
    M Martinez
    Department of Anatomy, and MRC Cambridge Centre for Brain Repair, University of Cambridge, UK
    Eur J Neurosci 10:20-33. 1998
    ..As in our previous studies of repeated restraint, modulation in the expression of c-fos following repeated stress is highly regionally specific, suggesting that differential neural processing is involved in adaptation to social stress...
  24. ncbi request reprint Differential effects of excitotoxic basolateral and corticomedial lesions of the amygdala on the behavioural and endocrine responses to either sexual or aggression-promoting stimuli in the male rat
    A McGregor
    Department of Anatomy, University of Cambridge, U K
    Brain Res 574:9-20. 1992
    ....
  25. doi request reprint Age-related changes in plasma dehydroepiandrosterone levels in adults with Down's syndrome and the risk of dementia
    J Landt
    Cambridge Intellectual and Developmental Disabilities Research Group, CIDDRG, Department of Psychiatry, University of Cambridge, Cambridge, UK
    J Neuroendocrinol 23:450-5. 2011
    ..Those with DS and evidence of dementia have lower DHEA concentrations than those with DS (controlling for age) but without dementia...
  26. ncbi request reprint Possible role of cortisol and dehydroepiandrosterone in human development and psychopathology
    I M Goodyer
    Developmental Psychiatry Section, Department of Psychiatry, University of Cambridge, UK
    Br J Psychiatry 179:243-9. 2001
    ..DHEA and gonadal steroids may modulate the actions of cortisol. CONCLUSIONS: Steroid hormones contribute to shaping behavioural function during early development and act as risk factors for psychopathology...
  27. pmc Endogenous steroids and financial risk taking on a London trading floor
    J M Coates
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, United Kingdom
    Proc Natl Acad Sci U S A 105:6167-72. 2008
    ....
  28. ncbi request reprint Does the amygdala modulate adaptation to repeated stress?
    R N Carter
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    Neuroscience 126:9-19. 2004
    ....
  29. ncbi request reprint Psychoendocrine antecedents of persistent first-episode major depression in adolescents: a community-based longitudinal enquiry
    I M Goodyer
    Developmental Psychiatry Section, Department of Psychiatry, University of Cambridge
    Psychol Med 33:601-10. 2003
    ....
  30. ncbi request reprint Transthyretin: a choroid plexus-specific transport protein in human brain. The 1986 S. Weir Mitchell award
    J Herbert
    Neurology 36:900-11. 1986
    ..Whether this function differs from its established plasma transport functions is presently unknown...