Research Topics
Genomes and Genes | J HerbertSummaryAffiliation: University of Cambridge Country: UK Publications
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Publications
Cortisol and depression: three questions for psychiatryJ Herbert
Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, UK
Psychol Med 43:449-69. 2013..Does this suggest new avenues for studying MDD or its clinical management?..
Interaction between the BDNF gene Val/66/Met polymorphism and morning cortisol levels as a predictor of depression in adult womenJ Herbert
Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0SP, UK
Br J Psychiatry 201:313-9. 2012..Much less is known about how they interact with individual differences in cortisol, although these also represent a risk for major depression...- Profiles of family-focused adverse experiences through childhood and early adolescence: the ROOTS project a community investigation of adolescent mental healthValerie J Dunn
Developmental and Life course Research Group, Department of Psychiatry, University of Cambridge, Cambridge, UK
BMC Psychiatry 11:109. 2011..Adverse family experiences in early life are associated with subsequent psychopathology. This study adds to the growing body of work exploring the nature and associations between adverse experiences over the childhood years... 
Do corticosteroids damage the brain?J Herbert
Department of Physiology, Development and Neuroscience, and Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, UK
J Neuroendocrinol 18:393-411. 2006..In this review, we are principally concerned with excess or disturbed patterns of circulating corticosteroids in the longer or shorter term, and the effects they have on the brain...- Strain differences in proliferation of progenitor cells in the dentate gyrus of the adult rat and the response to fluoxetine are dependent on corticosteroneS Alahmed
Department of Physiology, Development and Neuroscience, and Cambridge Centre for Brain Repair, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
Neuroscience 157:677-82. 2008.... - Psychosocial and endocrine features of chronic first-episode major depression in 8-16 year oldsI M Goodyer
Developmental Psychiatry Section, Department of Psychiatry, University of Cambridge, Cambridge CB2 2AH, UK
Biol Psychiatry 50:351-7. 2001.... - Synergistic effects of dehydroepiandrosterone and fluoxetine on proliferation of progenitor cells in the dentate gyrus of the adult male ratS B Pinnock
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK
Neuroscience 158:1644-51. 2009..Since altered neurogenesis has been linked to the onset or recovery from depression, one consequence of these results is to suggest DHEA as a useful adjunct therapy for depression... - Corticosterone modulates autonomic responses and adaptation of central immediate-early gene expression to repeated restraint stressJ Stamp
Anatomy Department, University of Cambridge, Downing Street, CB2 3DY, Cambridge, UK
Neuroscience 107:465-79. 2001..In particular, there are distinctions between Fos and Fos-b both in the way they adapt to repeated restraint stress, and the effect corticosterone has on this adaptive process... - Rhythmic expression of per1 in the dentate gyrus is suppressed by corticosterone: implications for neurogenesisM J Gilhooley
Department of Physiology, Development and Neuroscience, University of Cambridge, UK
Neurosci Lett 489:177-81. 2011..These results are related to the previous finding that clamping the corticosterone rhythm also prevents the stimulating action of fluoxetine and other controlling agents on the mitotic activity of the progenitor cells... - Salivary cortisol and DHEA: association with measures of cognition and well-being in normal older men, and effects of three months of DHEA supplementationJ K van Niekerk
Department of Psychiatry, University of Cambridge, Box 189, Addenbrooke's Hospital, CB2 2QQ, Cambridge, UK
Psychoneuroendocrinology 26:591-612. 2001.... - Adaptation in patterns of c-fos expression in the brain associated with exposure to either single or repeated social stress in male ratsM Martinez
Department of Anatomy, and MRC Cambridge Centre for Brain Repair, University of Cambridge, UK
Eur J Neurosci 10:20-33. 1998..As in our previous studies of repeated restraint, modulation in the expression of c-fos following repeated stress is highly regionally specific, suggesting that differential neural processing is involved in adaptation to social stress... - The role of 5-HT1A receptors in the proliferation and survival of progenitor cells in the dentate gyrus of the adult hippocampus and their regulation by corticoidsG J Huang
Department of Anatomy and Cambridge Centre for Brain Repair, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
Neuroscience 135:803-13. 2005..5-HT1A mRNA expression was not altered in the hippocampus by adrenalectomy. Thus, the effect of adrenalectomy on cell proliferation and survival is not 5-HT1A dependent, despite the interaction between 5-HT1A and corticosterone... - Raised circulating corticosterone inhibits neuronal differentiation of progenitor cells in the adult hippocampusE Y H Wong
Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
Neuroscience 137:83-92. 2006..Raised corticosterone significantly reduced neuronal production while adrenalectomy resulted in significantly higher number of neurons in the adult male rat hippocampus... - Dehydroepiandrosterone (DHEA) stimulates neurogenesis in the hippocampus of the rat, promotes survival of newly formed neurons and prevents corticosterone-induced suppressionK K Karishma
Department of Anatomy, University of Cambridge, Cambridge, CB2 3DY, UK
Eur J Neurosci 16:445-53. 2002.... - Endogenous steroids and financial risk taking on a London trading floorJ M Coates
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, United Kingdom
Proc Natl Acad Sci U S A 105:6167-72. 2008.... - Age-related changes in plasma dehydroepiandrosterone levels in adults with Down's syndrome and the risk of dementiaJ Landt
Cambridge Intellectual and Developmental Disabilities Research Group, CIDDRG, Department of Psychiatry, University of Cambridge, Cambridge, UK
J Neuroendocrinol 23:450-5. 2011..Those with DS and evidence of dementia have lower DHEA concentrations than those with DS (controlling for age) but without dementia... - Glucocorticoid enhances the neurotoxic actions of quinolinic acid in the striatum in a cell-specific mannerL-Y Ngai
Department of Anatomy and Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, UK
J Neuroendocrinol 17:424-34. 2005..These results show that corticosterone has a selective neuroendangering action within the striatum, but there is no evidence for a protective action of glucocorticoids at lower doses... - Disrupted daily activity/rest cycles in relation to daily cortisol rhythms of home-dwelling patients with early Alzheimer's dementiaC F Hatfield
Department of Anatomy, Cambridge University, Cambridge, UK
Brain 127:1061-74. 2004..Further characterization of this pathology will facilitate more effective management of sleep patterns in home-dwelling demented patients... - Possible role of cortisol and dehydroepiandrosterone in human development and psychopathologyI M Goodyer
Developmental Psychiatry Section, Department of Psychiatry, University of Cambridge, UK
Br J Psychiatry 179:243-9. 2001..DHEA and gonadal steroids may modulate the actions of cortisol. CONCLUSIONS: Steroid hormones contribute to shaping behavioural function during early development and act as risk factors for psychopathology... - 17Beta-oestradiol modulates glucocorticoid, neural and behavioural adaptations to repeated restraint stress in female ratsP Lunga
Department of Anatomy, University of Cambridge, Cambridge, UK
J Neuroendocrinol 16:776-85. 2004..The present study presents novel data showing that the HPA axis remains reactive to repeated stress in 17beta-oestradiol-treated ovariectomized rats, but stress-induced anxiety behaviour is reduced... - The effects of corticosterone and dehydroepiandrosterone on neurotrophic factor mRNA expression in primary hippocampal and astrocyte culturesE M Gubba
Department of Anatomy, and Cambridge Centre for Brain Repair, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
Brain Res Mol Brain Res 127:48-59. 2004.... - Psychoendocrine antecedents of persistent first-episode major depression in adolescents: a community-based longitudinal enquiryI M Goodyer
Developmental Psychiatry Section, Department of Psychiatry, University of Cambridge
Psychol Med 33:601-10. 2003..CONCLUSIONS: In community adolescents at high risk for psychiatric disorder persistent major depression may be distinguished from sporadic forms by the 08.00 h salivary cortisol/DHEA ratio prior to onset... - Corticosterone differentially modulates expression of corticotropin releasing factor and arginine vasopressin mRNA in the hypothalamic paraventricular nucleus following either acute or repeated restraint stressS B Pinnock
Department of Anatomy, University of Cambridge, Cambridge CB2 3DY UK
Eur J Neurosci 13:576-84. 2001.... - Transthyretin: a choroid plexus-specific transport protein in human brain. The 1986 S. Weir Mitchell awardJ Herbert
Neurology 36:900-11. 1986..Whether this function differs from its established plasma transport functions is presently unknown...