Research Topics
Genomes and GenesSpecies | S M D HenleySummaryAffiliation: University College London Country: UK Publications
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Detail Information
Publications
Whole-brain atrophy as a measure of progression in premanifest and early Huntington's diseaseSusie M D Henley
Dementia Research Centre, Institute of Neurology, National Hospital for Neurology and Neurosurgery, University College London, Queen Square, London, United Kingdom
Mov Disord 24:932-6. 2009..Higher atrophy rates were associated with longer CAG repeat length. MRI-based measures of whole-brain atrophy may have potential as a measure of progression in HD...
Defective emotion recognition in early HD is neuropsychologically and anatomically genericSusie M D Henley
Dementia Research Centre, Institute of Neurology, University College London, UK
Neuropsychologia 46:2152-60. 2008..Even in early HD there is a wide-ranging impairment in recognition of negative emotions denoting 'threat'. Our findings implicate a generic fronto-subcortical network in the pathogenesis of these emotion recognition deficits...
Relationship between CAG repeat length and brain volume in premanifest and early Huntington's diseaseSusie M D Henley
Dementia Research Centre, Institute of Neurology, University College, London, UK
J Neurol 256:203-12. 2009..Overall we have demonstrated that increased CAG repeat length is associated with atrophy in extra-striatal as well as striatal regions, which has implications for the monitoring of disease-modifying therapies in the condition...
Onset and progression of pathologic atrophy in Huntington disease: a longitudinal MR imaging studyN Z Hobbs
Dementia Research Centre and Department of Neurodegenerative Disease, Institute of Neurology, University College London, Queen Square, London, UK
AJNR Am J Neuroradiol 31:1036-41. 2010..This may prove useful in assessing disease-modifying treatments. We investigated how caudate and global volumes change as HD progresses from premanifest to early disease...
Pitfalls in the use of voxel-based morphometry as a biomarker: examples from huntington diseaseS M D Henley
Dementia Research Centre, Department of Neurodegenerative Disease, Institute of Neurology, University College London, United Kingdom
AJNR Am J Neuroradiol 31:711-9. 2010....
Increased rate of whole-brain atrophy over 6 months in early Huntington diseaseS M D Henley
Dementia Research Centre, Institute of Neurology, University College London, London, UK
Neurology 67:694-6. 2006..10 [0.88]%/year; controls, 0.26 [0.54]%/year). The measurement of cerebral change over short time periods (e.g., 6 months) may be relevant for trials designed to assess effects on neurodegeneration or atrophy...
Biomarkers for neurodegenerative diseasesSusie M D Henley
Dementia Research Centre, Institute of Neurology, University College London, London, UK
Curr Opin Neurol 18:698-705. 2005..This review summarizes the field of biomarker research in the major neurodegenerative diseases...
Extensive and temporally ungraded retrograde amnesia in encephalitis associated with antibodies to voltage-gated potassium channelsDennis Chan
Department of Neurology, Royal Sussex County Hospital, Brighton, United Kingdom
Arch Neurol 64:404-10. 2007..Magnetic resonance imaging reveals abnormal signal predominantly restricted to the mediotemporal lobes...
Ten simple rules for reporting voxel-based morphometry studiesGerard R Ridgway
Centre for Medical Image Computing, University College London, UK
Neuroimage 40:1429-35. 2008..This editorial suggests core principles that should be followed and information that should be included when reporting a VBM study in order to make it transparent, replicable and useful...
