J Henley

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. ncbi request reprint Proteins involved in the synaptic organization of AMPA (alpha-amino-3-hydroxy-5-methylisoxazolepropionate) receptors
    J Henley
    MRC Centre for Synaptic Plasticity, Anatomy Department, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Biochem Soc Trans 29:485-8. 2001
  2. pmc Proteins interactions implicated in AMPA receptor trafficking: a clear destination and an improving route map
    Jeremy M Henley
    Department of Anatomy, MRC Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, BS81TD, Bristol, UK
    Neurosci Res 45:243-54. 2003
  3. pmc Differential redistribution of native AMPA receptor complexes following LTD induction in acute hippocampal slices
    David Holman
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Neuropharmacology 52:92-9. 2007
  4. pmc Ultrastructural localisation and differential agonist-induced regulation of AMPA and kainate receptors present at the presynaptic active zone and postsynaptic density
    Marco Feligioni
    Department of Anatomy, MRC Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, Bristol, UK
    J Neurochem 99:549-60. 2006
  5. pmc Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP
    Hélène Hirbec
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University Walk, University of Bristol, Bristol BS8 1TD, United Kingdom
    Neuron 37:625-38. 2003
  6. pmc Activity-dependent endocytic sorting of kainate receptors to recycling or degradation pathways
    Stephane Martin
    Department of Anatomy, MRC Centre for Synaptic Plasticity, School of Medical Sciences, University Walk, University of Bristol, Bristol, UK
    EMBO J 23:4749-59. 2004
  7. pmc Removal of AMPA receptors (AMPARs) from synapses is preceded by transient endocytosis of extrasynaptic AMPARs
    Michael C Ashby
    Medical Research Council, Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 24:5172-6. 2004
  8. pmc Acetylcholinesterase promotes neurite elongation, synapse formation, and surface expression of AMPA receptors in hippocampal neurones
    Silvia Olivera
    MRC Centre for Synaptic Plasticity, Anatomy Department, School of Medical Sciences, University of Bristol, University Walk, UK
    Mol Cell Neurosci 23:96-106. 2003
  9. ncbi request reprint Proteins involved in the trafficking and functional synaptic expression of AMPA and KA receptors
    Sarah A De La Rue
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University Walk, University of Bristol, Bristol, BS8 1TD, UK
    ScientificWorldJournal 2:461-82. 2002
  10. pmc Characterization of the intracellular transport of GluR1 and GluR2 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits in hippocampal neurons
    Pavel V Perestenko
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom
    J Biol Chem 278:43525-32. 2003

Collaborators

  • Kumlesh K Dev
  • David Holman
  • Guido Meyer
  • Graham L Collingridge
  • Hélène Hirbec
  • Marco Feligioni
  • John T R Isaac
  • S Nakanishi
  • J G Hanley
  • Marian Joels
  • Steven P Braithwaite
  • Olof Wiegert
  • M W Brown
  • M Zhou
  • Morgan H Sheng
  • J M Fritschy
  • Stephane Martin
  • Atsushi Nishimune
  • Sriharsha Kantamneni
  • Tristan Bouschet
  • Helena Cimarosti
  • Kevin A Wilkinson
  • Michael C Ashby
  • Frédéric Jaskolski
  • Sonia A L Corrêa
  • Claire L Palmer
  • Silvia Olivera
  • Kwangwook Cho
  • Sarah A De La Rue
  • Jihoon Jo
  • Kristin Baer
  • Henry G S Martin
  • Mohamed T Ghorbel
  • Lucy Cotton
  • Akira Terashima
  • Daniel Rodriguez-Ithurralde
  • Pavel V Perestenko
  • Yasuko Nakamura
  • Belen Mayo-Martin
  • Harmen J Krugers
  • Myrrhe van Spronsen
  • David Jane
  • Casper C Hoogenraad
  • Camilla Lindberg
  • Jamie L Weiss
  • Lars C B Rønn
  • Emma L Jenkins
  • Yunkyung Park
  • William Fraser
  • Simon Ogden
  • Myung Jong Kim
  • Gi Hoon Son
  • Seok Heon
  • Signe F Bomholt
  • Dubravka Göckeritz-Dujmovic
  • Venkateswarlu Kanamarlapudi
  • Thomas Bürli
  • Andreas Wiesner
  • Stuart Mundell
  • Christian Fuhrer
  • Martijn Moransard
  • Ngoc Nga Vinh
  • Kyung Hye Huh
  • Jack R Mellor
  • Mark I Rees
  • Susanne Erb-Vögtli
  • Gina K Hodgkinson
  • Susie R Maier
  • George Banting
  • Viktor I Korolchuk
  • Kevin G Becker
  • Marie Toward
  • Peter G R Hastie
  • Stephen A Burbidge
  • Wonil Lim
  • Shahid Zaman
  • G Scott Ralph
  • Richard Munton
  • Fabrice Duprat
  • Stephen Fitzjohn
  • Kyoko Ibaraki
  • James Uney
  • Zafar I Bashir
  • Joanna C Francis

Detail Information

Publications45

  1. ncbi request reprint Proteins involved in the synaptic organization of AMPA (alpha-amino-3-hydroxy-5-methylisoxazolepropionate) receptors
    J Henley
    MRC Centre for Synaptic Plasticity, Anatomy Department, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Biochem Soc Trans 29:485-8. 2001
    ..Here I present an overview of some of the main interacting proteins, and describe what we know about how these may fit into cellular pathways that control AMPA receptor targeting, trafficking and functional expression...
  2. pmc Proteins interactions implicated in AMPA receptor trafficking: a clear destination and an improving route map
    Jeremy M Henley
    Department of Anatomy, MRC Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, BS81TD, Bristol, UK
    Neurosci Res 45:243-54. 2003
    ..This review highlights recent developments in the field...
  3. pmc Differential redistribution of native AMPA receptor complexes following LTD induction in acute hippocampal slices
    David Holman
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Neuropharmacology 52:92-9. 2007
    ....
  4. pmc Ultrastructural localisation and differential agonist-induced regulation of AMPA and kainate receptors present at the presynaptic active zone and postsynaptic density
    Marco Feligioni
    Department of Anatomy, MRC Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, Bristol, UK
    J Neurochem 99:549-60. 2006
    ..NMDA treatment did not evoke changes in GluR3 localisation. Our results demonstrate that presynaptic and postsynaptic subunits are regulated in opposite directions by AMPA and NMDA stimulation...
  5. pmc Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP
    Hélène Hirbec
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University Walk, University of Bristol, Bristol BS8 1TD, United Kingdom
    Neuron 37:625-38. 2003
    ....
  6. pmc Activity-dependent endocytic sorting of kainate receptors to recycling or degradation pathways
    Stephane Martin
    Department of Anatomy, MRC Centre for Synaptic Plasticity, School of Medical Sciences, University Walk, University of Bristol, Bristol, UK
    EMBO J 23:4749-59. 2004
    ..These results demonstrate that GluR6-containing KARs are subject to activity-dependent endocytic sorting, a process that provides a mechanism for both rapid and chronic changes in the number of functional receptors...
  7. pmc Removal of AMPA receptors (AMPARs) from synapses is preceded by transient endocytosis of extrasynaptic AMPARs
    Michael C Ashby
    Medical Research Council, Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 24:5172-6. 2004
    ..We show that synaptic and extrasynaptic AMPARs respond very differently to NMDA receptor activation; there is a rapid internalization of extrasynaptic AMPARs that precedes the delayed removal of synaptic AMPARs...
  8. pmc Acetylcholinesterase promotes neurite elongation, synapse formation, and surface expression of AMPA receptors in hippocampal neurones
    Silvia Olivera
    MRC Centre for Synaptic Plasticity, Anatomy Department, School of Medical Sciences, University of Bristol, University Walk, UK
    Mol Cell Neurosci 23:96-106. 2003
    ..These results indicate that AChE is necessary for normal dendrite and axon formation in hippocampal neurones and suggest that it may also play a role in excitatory synapse development, plasticity, and remodelling...
  9. ncbi request reprint Proteins involved in the trafficking and functional synaptic expression of AMPA and KA receptors
    Sarah A De La Rue
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University Walk, University of Bristol, Bristol, BS8 1TD, UK
    ScientificWorldJournal 2:461-82. 2002
    ..The aim of this review is to present an overview of the major interacting proteins and suggest how they may fit into the hierarchical series of events controlling the trafficking of AMPARs and KARs...
  10. pmc Characterization of the intracellular transport of GluR1 and GluR2 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits in hippocampal neurons
    Pavel V Perestenko
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom
    J Biol Chem 278:43525-32. 2003
    ..Furthermore, the transport of both subunits is activity-independent, suggesting that the regulated delivery of AMPARs to the vicinity of synapses is not a mechanism that is involved in processes such as synaptic plasticity...
  11. pmc A novel method for monitoring the cell surface expression of heteromeric protein complexes in dispersed neurons and acute hippocampal slices
    David Holman
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    J Neurosci Methods 160:302-8. 2007
    ..Finally, we discuss how this method can be adapted to monitor the cell surface expression of other heteromeric protein complexes...
  12. pmc PICK1 is a calcium-sensor for NMDA-induced AMPA receptor trafficking
    Jonathan G Hanley
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol, UK
    EMBO J 24:3266-78. 2005
    ..This work reveals a novel postsynaptic Ca2+-binding protein that provides a direct mechanistic link between NMDAR-mediated Ca2+ influx and AMPAR endocytosis...
  13. pmc GISP: a novel brain-specific protein that promotes surface expression and function of GABA(B) receptors
    Sriharsha Kantamneni
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol, UK
    J Neurochem 100:1003-17. 2007
    ..These results suggest that GISP is involved in the forward trafficking and stabilization of functional GABA(B)Rs...
  14. ncbi request reprint Syntenin is involved in the developmental regulation of neuronal membrane architecture
    Hélène Hirbec
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University Walk, University of Bristol, Bristol, BS8 1TD, UK
    Mol Cell Neurosci 28:737-46. 2005
    ..These results are consistent with the involvement of syntenin in controlling membrane organization and suggest that by interaction with kainate receptors it may play a role in determining the formation and maturation of synapses...
  15. ncbi request reprint Lateral diffusion drives constitutive exchange of AMPA receptors at dendritic spines and is regulated by spine morphology
    Michael C Ashby
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Medical School, Bristol BS8 1TD, United Kingdom
    J Neurosci 26:7046-55. 2006
    ....
  16. ncbi request reprint Increased protein SUMOylation following focal cerebral ischemia
    Helena Cimarosti
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University Walk, University of Bristol, Bristol BS8 1TD, UK
    Neuropharmacology 54:280-9. 2008
    ..These results suggest that posttranslational modification by SUMO and down-regulation of AMPARs and KARs may play important roles in the pathophysiological response to ischemia...
  17. pmc Bidirectional regulation of kainate receptor surface expression in hippocampal neurons
    Stephane Martin
    Department of Anatomy, Medical Research Council Centre for Synaptic Plasticity, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom
    J Biol Chem 283:36435-40. 2008
    ..This process may provide a mechanism for hippocampal neurons to differentially adapt their physiological responses to changes in synaptic activation and extrasynaptic glutamate concentration...
  18. pmc Regulation of kainate receptors by protein kinase C and metabotropic glutamate receptors
    Kwangwook Cho
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, UK
    J Physiol 548:723-30. 2003
    ....
  19. pmc Corticosterone alters AMPAR mobility and facilitates bidirectional synaptic plasticity
    Stephane Martin
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol, United Kingdom
    PLoS ONE 4:e4714. 2009
    ..In this study we investigate the relationship between corticosterone and AMPA receptors which play a critical role in activity-dependent plasticity and hippocampal-dependent learning...
  20. pmc Ischaemia differentially regulates GABA(B) receptor subunits in organotypic hippocampal slice cultures
    Helena Cimarosti
    Department of Anatomy, MRC Centre for Synaptic Plasticity, School of Medical Sciences, University Walk, University of Bristol, Bristol, UK
    Neuropharmacology 56:1088-96. 2009
    ..However, because GABA(B2) is required for functional surface expression, down-regulation of this subunit removes an important inhibitory feedback mechanism under pathological conditions...
  21. pmc Metabotropic glutamate receptor-mediated LTD involves two interacting Ca(2+) sensors, NCS-1 and PICK1
    Jihoon Jo
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Faculty of Medicine and Dentistry, University of Bristol, Bristol, UK
    Neuron 60:1095-111. 2008
    ..Furthermore, the NCS-1-PICK1 association is stimulated by activation of mGluRs, but not NMDARs, and introduction of a PICK1 BAR domain fusion protein specifically blocks mGluR-LTD. Thus, NCS-1 plays a distinct role in mGluR-LTD...
  22. pmc The molecular pharmacology and cell biology of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors
    Claire L Palmer
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, Bristol University, Bristol, UK
    Pharmacol Rev 57:253-77. 2005
    ..As a result, there has been considerable progress in this field, and the aim of this review is to provide an account of the current state of knowledge...
  23. pmc SUMOylation regulates kainate-receptor-mediated synaptic transmission
    Stephane Martin
    MRC Centre for Synaptic Plasticity, Anatomy Department, University Walk, University of Bristol, Bristol, BS8 1TD, UK
    Nature 447:321-5. 2007
    ..These data reveal a previously unsuspected role for SUMO in the regulation of synaptic function...
  24. pmc Retaining synaptic AMPARs
    Frédéric Jaskolski
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Neuron 55:825-7. 2007
    ..In this issue of Neuron, Lu et al. show that correct synaptic EZ positioning requires links between the GTPase dynamin-3 and the Homer/Shank complex...
  25. pmc Regulation of calcium-sensing-receptor trafficking and cell-surface expression by GPCRs and RAMPs
    Tristan Bouschet
    Department of Anatomy, Medical Research Council Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, University Walk, Bristol, UK
    Trends Pharmacol Sci 29:633-9. 2008
    ....
  26. pmc GISP binding to TSG101 increases GABA receptor stability by down-regulating ESCRT-mediated lysosomal degradation
    Sriharsha Kantamneni
    Department of Anatomy, MRC Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, Bristol, UK
    J Neurochem 107:86-95. 2008
    ..These data suggest that GISP can function as a negative regulator of TSG101-dependent lysosomal degradation of transmembrane proteins in neurons to promote receptor stability...
  27. pmc Novel putative targets of N-ethylmaleimide sensitive fusion protein (NSF) and alpha/beta soluble NSF attachment proteins (SNAPs) include the Pak-binding nucleotide exchange factor betaPIX
    Henry G S Martin
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Cell Biochem 99:1203-15. 2006
    ..In summary, our results support the evolving view that NSF has numerous targets in addition to conventional SNARE complexes...
  28. pmc Regulation of synaptic strength and AMPA receptor subunit composition by PICK1
    Akira Terashima
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 24:5381-90. 2004
    ..These findings suggest that PICK1 acts to downregulate the GluR2 content of AMPARs at hippocampal CA1 synapses, thereby increasing synaptic strength at resting membrane potentials...
  29. pmc The PDZ domain of PICK1 differentially accepts protein kinase C-alpha and GluR2 as interacting ligands
    Kumlesh K Dev
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, UK
    J Biol Chem 279:41393-7. 2004
    ..Taken together, it appears that the PDZ domain of PICK1 is less sensitive to mutations for PKCalpha when compared with GluR2 binding. These results suggest that the PDZ domain of PICK1 has distinct PKCalpha and GluR2 binding subsite(s)...
  30. pmc Development of GABAB subunits and functional GABAB receptors in rat cultured hippocampal neurons
    Sonia A L Corrêa
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, University Walk, Bristol BS 1TD, UK
    Neuropharmacology 47:475-84. 2004
    ..These results provide an important developmental baseline for future studies aimed at investigating, for example, the trafficking and functional regulation of these receptors...
  31. pmc Profile of changes in gene expression in cultured hippocampal neurones evoked by the GABAB receptor agonist baclofen
    Mohamed T Ghorbel
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
    Physiol Genomics 22:93-8. 2005
    ....
  32. pmc Hippocalcin functions as a calcium sensor in hippocampal LTD
    Claire L Palmer
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, United Kingdom
    Neuron 47:487-94. 2005
    ..These data indicate that the AP2-hippocalcin complex acts as a Ca(2+) sensor that couples NMDAR-dependent activation to regulated endocytosis of AMPARs during LTD...
  33. pmc Receptor-activity-modifying proteins are required for forward trafficking of the calcium-sensing receptor to the plasma membrane
    Tristan Bouschet
    Department of Anatomy, Medical Research Council Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, University Walk, Bristol, BS8 1TD, UK
    J Cell Sci 118:4709-20. 2005
    ....
  34. pmc Protein SUMOylation modulates calcium influx and glutamate release from presynaptic terminals
    Marco Feligioni
    Department of Anatomy, MRC Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, Bristol, UK
    Eur J Neurosci 29:1348-56. 2009
    ..These results demonstrate that, in addition to postsynaptic effects, protein SUMOylation acts to modulate neurotransmitter release and thereby regulate synaptic function...
  35. pmc Picking out the details of cerebellar LTD
    Jonathan G Hanley
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, United Kingdom
    Neuron 49:778-80. 2006
    ..In this issue of Neuron, Steinberg et al. provide firm evidence that PICK 1 and the C terminus of GluR2 are central to this process by analyzing three different transgenic mice...
  36. pmc Investigating the mechanisms underlying neuronal death in ischemia using in vitro oxygen-glucose deprivation: potential involvement of protein SUMOylation
    Helena Cimarosti
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University Walk, University of Bristol, Bristol, UK
    Neuroscientist 14:626-36. 2008
    ....
  37. pmc Dynamin-dependent membrane drift recruits AMPA receptors to dendritic spines
    Frédéric Jaskolski
    Department of Anatomy and Physiology, Medical Research Council Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Biol Chem 284:12491-503. 2009
    ..These results provide a novel mechanistic explanation of how AMPARs and other membrane proteins are recruited to spines by synaptic activity...
  38. pmc Emerging extranuclear roles of protein SUMOylation in neuronal function and dysfunction
    Stephane Martin
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, University Walk, Bristol, BS8 1TD, UK
    Nat Rev Neurosci 8:948-59. 2007
    ....
  39. ncbi request reprint The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs
    Hélène Hirbec
    Department of Anatomy, Medical Research Council Centre of Synaptic Plasticity, Medical School, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Biol Chem 277:15221-4. 2002
    ..These data also suggest that the structural determinants involved in PDZ interactions are more complex than originally envisaged...
  40. pmc GISP increases neurotransmitter receptor stability by down-regulating ESCRT-mediated lysosomal degradation
    Sriharsha Kantamneni
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Neurosci Lett 452:106-10. 2009
    ..These data suggest that GISP acts as a negative regulator of TSG101-dependent lysosomal degradation and plays an important role in determining the availability of neurotransmitter receptors...
  41. ncbi request reprint It's green outside: tracking cell surface proteins with pH-sensitive GFP
    Michael C Ashby
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Trends Neurosci 27:257-61. 2004
    ..g. pHluorins). These proteins hold considerable promise for the relatively non-invasive monitoring of events such as exocytosis, endocytosis and protein surface expression in living neurons with high spatial and temporal resolution...
  42. pmc The calcium-sensing receptor changes cell shape via a beta-arrestin-1 ARNO ARF6 ELMO protein network
    Tristan Bouschet
    Department of Anatomy, MRC Centre for Synaptic Plasticity, University of Bristol, University Walk, Bristol, BS8 1TD, UK
    J Cell Sci 120:2489-97. 2007
    ....
  43. pmc Targets and consequences of protein SUMOylation in neurons
    Kevin A Wilkinson
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, University Walk, Bristol, UK
    Brain Res Rev 64:195-212. 2010
    ..Here we review the current understanding of the targets and consequences of protein SUMOylation in the brain and examine its established and potential involvement in a wide range of neurological and neurodegenerative diseases...
  44. pmc AMPA receptor potentiation by acetylcholinesterase is age-dependently upregulated at synaptogenesis sites of the rat brain
    Silvia Olivera
    Molecular Neuroscience Unit, Instituto de Investigaciones Biologicas Clemente Estable, Av Italia 3318, 11600, Montevideo, Uruguay
    Int J Dev Neurosci 21:49-61. 2003
    ..It might also contribute to AChE-mediated neurotoxicity, as postulated in Alzheimer's disease and other CNS disorders...
  45. pmc PICK1 interacts with alpha7 neuronal nicotinic acetylcholine receptors and controls their clustering
    Kristin Baer
    Department of Neurochemistry, Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Mol Cell Neurosci 35:339-55. 2007
    ..These data show that PICK1 negatively regulates surface clustering of alpha7 nAChRs on hippocampal interneurons, which may be important in inhibitory functions of alpha7 in the hippocampus...