Research Topics
| J HenleySummaryAffiliation: University of Bristol Country: UK Publications
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Publications
Proteins involved in the synaptic organization of AMPA (alpha-amino-3-hydroxy-5-methylisoxazolepropionate) receptorsJ Henley
MRC Centre for Synaptic Plasticity, Anatomy Department, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
Biochem Soc Trans 29:485-8. 2001..Here I present an overview of some of the main interacting proteins, and describe what we know about how these may fit into cellular pathways that control AMPA receptor targeting, trafficking and functional expression...
Proteins interactions implicated in AMPA receptor trafficking: a clear destination and an improving route mapJeremy M Henley
Department of Anatomy, MRC Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, BS81TD, Bristol, UK
Neurosci Res 45:243-54. 2003..This review highlights recent developments in the field...- Differential redistribution of native AMPA receptor complexes following LTD induction in acute hippocampal slicesDavid Holman
MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
Neuropharmacology 52:92-9. 2007.... - Ultrastructural localisation and differential agonist-induced regulation of AMPA and kainate receptors present at the presynaptic active zone and postsynaptic densityMarco Feligioni
Department of Anatomy, MRC Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, Bristol, UK
J Neurochem 99:549-60. 2006..NMDA treatment did not evoke changes in GluR3 localisation. Our results demonstrate that presynaptic and postsynaptic subunits are regulated in opposite directions by AMPA and NMDA stimulation... - Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIPHélène Hirbec
MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University Walk, University of Bristol, Bristol BS8 1TD, United Kingdom
Neuron 37:625-38. 2003.... - Activity-dependent endocytic sorting of kainate receptors to recycling or degradation pathwaysStephane Martin
Department of Anatomy, MRC Centre for Synaptic Plasticity, School of Medical Sciences, University Walk, University of Bristol, Bristol, UK
EMBO J 23:4749-59. 2004..These results demonstrate that GluR6-containing KARs are subject to activity-dependent endocytic sorting, a process that provides a mechanism for both rapid and chronic changes in the number of functional receptors... - Removal of AMPA receptors (AMPARs) from synapses is preceded by transient endocytosis of extrasynaptic AMPARsMichael C Ashby
Medical Research Council, Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
J Neurosci 24:5172-6. 2004..We show that synaptic and extrasynaptic AMPARs respond very differently to NMDA receptor activation; there is a rapid internalization of extrasynaptic AMPARs that precedes the delayed removal of synaptic AMPARs... - Acetylcholinesterase promotes neurite elongation, synapse formation, and surface expression of AMPA receptors in hippocampal neuronesSilvia Olivera
MRC Centre for Synaptic Plasticity, Anatomy Department, School of Medical Sciences, University of Bristol, University Walk, UK
Mol Cell Neurosci 23:96-106. 2003..These results indicate that AChE is necessary for normal dendrite and axon formation in hippocampal neurones and suggest that it may also play a role in excitatory synapse development, plasticity, and remodelling... - Proteins involved in the trafficking and functional synaptic expression of AMPA and KA receptorsSarah A De La Rue
MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University Walk, University of Bristol, Bristol, BS8 1TD, UK
ScientificWorldJournal 2:461-82. 2002..The aim of this review is to present an overview of the major interacting proteins and suggest how they may fit into the hierarchical series of events controlling the trafficking of AMPARs and KARs... - Characterization of the intracellular transport of GluR1 and GluR2 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits in hippocampal neuronsPavel V Perestenko
Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom
J Biol Chem 278:43525-32. 2003..Furthermore, the transport of both subunits is activity-independent, suggesting that the regulated delivery of AMPARs to the vicinity of synapses is not a mechanism that is involved in processes such as synaptic plasticity... - A novel method for monitoring the cell surface expression of heteromeric protein complexes in dispersed neurons and acute hippocampal slicesDavid Holman
MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
J Neurosci Methods 160:302-8. 2007..Finally, we discuss how this method can be adapted to monitor the cell surface expression of other heteromeric protein complexes... - PICK1 is a calcium-sensor for NMDA-induced AMPA receptor traffickingJonathan G Hanley
MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol, UK
EMBO J 24:3266-78. 2005..This work reveals a novel postsynaptic Ca2+-binding protein that provides a direct mechanistic link between NMDAR-mediated Ca2+ influx and AMPAR endocytosis... - GISP: a novel brain-specific protein that promotes surface expression and function of GABA(B) receptorsSriharsha Kantamneni
MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol, UK
J Neurochem 100:1003-17. 2007..These results suggest that GISP is involved in the forward trafficking and stabilization of functional GABA(B)Rs... - Syntenin is involved in the developmental regulation of neuronal membrane architectureHélène Hirbec
MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University Walk, University of Bristol, Bristol, BS8 1TD, UK
Mol Cell Neurosci 28:737-46. 2005..These results are consistent with the involvement of syntenin in controlling membrane organization and suggest that by interaction with kainate receptors it may play a role in determining the formation and maturation of synapses... - Lateral diffusion drives constitutive exchange of AMPA receptors at dendritic spines and is regulated by spine morphologyMichael C Ashby
Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Medical School, Bristol BS8 1TD, United Kingdom
J Neurosci 26:7046-55. 2006.... - Increased protein SUMOylation following focal cerebral ischemiaHelena Cimarosti
MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University Walk, University of Bristol, Bristol BS8 1TD, UK
Neuropharmacology 54:280-9. 2008..These results suggest that posttranslational modification by SUMO and down-regulation of AMPARs and KARs may play important roles in the pathophysiological response to ischemia... - Bidirectional regulation of kainate receptor surface expression in hippocampal neuronsStephane Martin
Department of Anatomy, Medical Research Council Centre for Synaptic Plasticity, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom
J Biol Chem 283:36435-40. 2008..This process may provide a mechanism for hippocampal neurons to differentially adapt their physiological responses to changes in synaptic activation and extrasynaptic glutamate concentration... - Regulation of kainate receptors by protein kinase C and metabotropic glutamate receptorsKwangwook Cho
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, UK
J Physiol 548:723-30. 2003.... - Corticosterone alters AMPAR mobility and facilitates bidirectional synaptic plasticityStephane Martin
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol, United Kingdom
PLoS ONE 4:e4714. 2009..In this study we investigate the relationship between corticosterone and AMPA receptors which play a critical role in activity-dependent plasticity and hippocampal-dependent learning... - Ischaemia differentially regulates GABA(B) receptor subunits in organotypic hippocampal slice culturesHelena Cimarosti
Department of Anatomy, MRC Centre for Synaptic Plasticity, School of Medical Sciences, University Walk, University of Bristol, Bristol, UK
Neuropharmacology 56:1088-96. 2009..However, because GABA(B2) is required for functional surface expression, down-regulation of this subunit removes an important inhibitory feedback mechanism under pathological conditions... - Metabotropic glutamate receptor-mediated LTD involves two interacting Ca(2+) sensors, NCS-1 and PICK1Jihoon Jo
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Faculty of Medicine and Dentistry, University of Bristol, Bristol, UK
Neuron 60:1095-111. 2008..Furthermore, the NCS-1-PICK1 association is stimulated by activation of mGluRs, but not NMDARs, and introduction of a PICK1 BAR domain fusion protein specifically blocks mGluR-LTD. Thus, NCS-1 plays a distinct role in mGluR-LTD... - The molecular pharmacology and cell biology of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptorsClaire L Palmer
Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, Bristol University, Bristol, UK
Pharmacol Rev 57:253-77. 2005..As a result, there has been considerable progress in this field, and the aim of this review is to provide an account of the current state of knowledge... - SUMOylation regulates kainate-receptor-mediated synaptic transmissionStephane Martin
MRC Centre for Synaptic Plasticity, Anatomy Department, University Walk, University of Bristol, Bristol, BS8 1TD, UK
Nature 447:321-5. 2007..These data reveal a previously unsuspected role for SUMO in the regulation of synaptic function... - Retaining synaptic AMPARsFrédéric Jaskolski
MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
Neuron 55:825-7. 2007..In this issue of Neuron, Lu et al. show that correct synaptic EZ positioning requires links between the GTPase dynamin-3 and the Homer/Shank complex... - Regulation of calcium-sensing-receptor trafficking and cell-surface expression by GPCRs and RAMPsTristan Bouschet
Department of Anatomy, Medical Research Council Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, University Walk, Bristol, UK
Trends Pharmacol Sci 29:633-9. 2008.... - GISP binding to TSG101 increases GABA receptor stability by down-regulating ESCRT-mediated lysosomal degradationSriharsha Kantamneni
Department of Anatomy, MRC Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, Bristol, UK
J Neurochem 107:86-95. 2008..These data suggest that GISP can function as a negative regulator of TSG101-dependent lysosomal degradation of transmembrane proteins in neurons to promote receptor stability... - Novel putative targets of N-ethylmaleimide sensitive fusion protein (NSF) and alpha/beta soluble NSF attachment proteins (SNAPs) include the Pak-binding nucleotide exchange factor betaPIXHenry G S Martin
Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom
J Cell Biochem 99:1203-15. 2006..In summary, our results support the evolving view that NSF has numerous targets in addition to conventional SNARE complexes... - Regulation of synaptic strength and AMPA receptor subunit composition by PICK1Akira Terashima
Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom
J Neurosci 24:5381-90. 2004..These findings suggest that PICK1 acts to downregulate the GluR2 content of AMPARs at hippocampal CA1 synapses, thereby increasing synaptic strength at resting membrane potentials... - The PDZ domain of PICK1 differentially accepts protein kinase C-alpha and GluR2 as interacting ligandsKumlesh K Dev
Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, UK
J Biol Chem 279:41393-7. 2004..Taken together, it appears that the PDZ domain of PICK1 is less sensitive to mutations for PKCalpha when compared with GluR2 binding. These results suggest that the PDZ domain of PICK1 has distinct PKCalpha and GluR2 binding subsite(s)... - Development of GABAB subunits and functional GABAB receptors in rat cultured hippocampal neuronsSonia A L Corrêa
MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, University Walk, Bristol BS 1TD, UK
Neuropharmacology 47:475-84. 2004..These results provide an important developmental baseline for future studies aimed at investigating, for example, the trafficking and functional regulation of these receptors... - Profile of changes in gene expression in cultured hippocampal neurones evoked by the GABAB receptor agonist baclofenMohamed T Ghorbel
Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
Physiol Genomics 22:93-8. 2005.... - Hippocalcin functions as a calcium sensor in hippocampal LTDClaire L Palmer
MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, United Kingdom
Neuron 47:487-94. 2005..These data indicate that the AP2-hippocalcin complex acts as a Ca(2+) sensor that couples NMDAR-dependent activation to regulated endocytosis of AMPARs during LTD... - Receptor-activity-modifying proteins are required for forward trafficking of the calcium-sensing receptor to the plasma membraneTristan Bouschet
Department of Anatomy, Medical Research Council Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, University Walk, Bristol, BS8 1TD, UK
J Cell Sci 118:4709-20. 2005.... - Protein SUMOylation modulates calcium influx and glutamate release from presynaptic terminalsMarco Feligioni
Department of Anatomy, MRC Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, Bristol, UK
Eur J Neurosci 29:1348-56. 2009..These results demonstrate that, in addition to postsynaptic effects, protein SUMOylation acts to modulate neurotransmitter release and thereby regulate synaptic function... - Picking out the details of cerebellar LTDJonathan G Hanley
MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, United Kingdom
Neuron 49:778-80. 2006..In this issue of Neuron, Steinberg et al. provide firm evidence that PICK 1 and the C terminus of GluR2 are central to this process by analyzing three different transgenic mice... - Investigating the mechanisms underlying neuronal death in ischemia using in vitro oxygen-glucose deprivation: potential involvement of protein SUMOylationHelena Cimarosti
MRC Centre for Synaptic Plasticity, Department of Anatomy, University Walk, University of Bristol, Bristol, UK
Neuroscientist 14:626-36. 2008.... - Dynamin-dependent membrane drift recruits AMPA receptors to dendritic spinesFrédéric Jaskolski
Department of Anatomy and Physiology, Medical Research Council Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
J Biol Chem 284:12491-503. 2009..These results provide a novel mechanistic explanation of how AMPARs and other membrane proteins are recruited to spines by synaptic activity... - Emerging extranuclear roles of protein SUMOylation in neuronal function and dysfunctionStephane Martin
MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, University Walk, Bristol, BS8 1TD, UK
Nat Rev Neurosci 8:948-59. 2007.... - The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifsHélène Hirbec
Department of Anatomy, Medical Research Council Centre of Synaptic Plasticity, Medical School, University of Bristol, Bristol BS8 1TD, United Kingdom
J Biol Chem 277:15221-4. 2002..These data also suggest that the structural determinants involved in PDZ interactions are more complex than originally envisaged... - GISP increases neurotransmitter receptor stability by down-regulating ESCRT-mediated lysosomal degradationSriharsha Kantamneni
MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
Neurosci Lett 452:106-10. 2009..These data suggest that GISP acts as a negative regulator of TSG101-dependent lysosomal degradation and plays an important role in determining the availability of neurotransmitter receptors... - It's green outside: tracking cell surface proteins with pH-sensitive GFPMichael C Ashby
MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
Trends Neurosci 27:257-61. 2004..g. pHluorins). These proteins hold considerable promise for the relatively non-invasive monitoring of events such as exocytosis, endocytosis and protein surface expression in living neurons with high spatial and temporal resolution... - The calcium-sensing receptor changes cell shape via a beta-arrestin-1 ARNO ARF6 ELMO protein networkTristan Bouschet
Department of Anatomy, MRC Centre for Synaptic Plasticity, University of Bristol, University Walk, Bristol, BS8 1TD, UK
J Cell Sci 120:2489-97. 2007.... - Targets and consequences of protein SUMOylation in neuronsKevin A Wilkinson
Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, University Walk, Bristol, UK
Brain Res Rev 64:195-212. 2010..Here we review the current understanding of the targets and consequences of protein SUMOylation in the brain and examine its established and potential involvement in a wide range of neurological and neurodegenerative diseases... - AMPA receptor potentiation by acetylcholinesterase is age-dependently upregulated at synaptogenesis sites of the rat brainSilvia Olivera
Molecular Neuroscience Unit, , Av. Italia 3318, 11600, Montevideo, Uruguay
Int J Dev Neurosci 21:49-61. 2003..It might also contribute to AChE-mediated neurotoxicity, as postulated in Alzheimer's disease and other CNS disorders... - PICK1 interacts with alpha7 neuronal nicotinic acetylcholine receptors and controls their clusteringKristin Baer
Department of Neurochemistry, Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Mol Cell Neurosci 35:339-55. 2007..These data show that PICK1 negatively regulates surface clustering of alpha7 nAChRs on hippocampal interneurons, which may be important in inhibitory functions of alpha7 in the hippocampus...