Brian Hendrich

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc Identification and characterization of a family of mammalian methyl-CpG binding proteins
    B Hendrich
    Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh EH9 3JR, Scotland
    Mol Cell Biol 18:6538-47. 1998
  2. ncbi Human diseases with underlying defects in chromatin structure and modification
    B Hendrich
    Centre for Genome Research, University of Edinburgh, Roger Land Building, Edinburgh EH9 3JQ, Scotland, UK
    Hum Mol Genet 10:2233-42. 2001
  3. pmc Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development
    B Hendrich
    Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, The University of Edinburgh, Michael Swann Building, The King s Buildings, Edinburgh EH9 3JR, Scotland
    Genes Dev 15:710-23. 2001
  4. ncbi The methyl-CpG binding domain and the evolving role of DNA methylation in animals
    Brian Hendrich
    Institute for Stem Cell Research, The University of Edinburgh, Roger Land Building, The King s Buildings, Edinburgh EH9 3JQ, UK
    Trends Genet 19:269-77. 2003
  5. ncbi Genomic structure and chromosomal mapping of the murine and human Mbd1, Mbd2, Mbd3, and Mbd4 genes
    B Hendrich
    Institute of Cell and Molecular Biology, University of Edinburgh, Darwin Building, King s Buildings, Edinburgh EH9 3JR Scotland, UK
    Mamm Genome 10:906-12. 1999
  6. ncbi Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells
    Keisuke Kaji
    Institute for Stem Cell Research, Centre Development in Stem Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JQ, UK
    Development 134:1123-32. 2007
  7. pmc Mbd2 contributes to DNA methylation-directed repression of the Xist gene
    Helen Barr
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, King s Buildings, Mayfield Road, Edinburgh, United Kingdom
    Mol Cell Biol 27:3750-7. 2007
  8. pmc Kaiso-deficient mice show resistance to intestinal cancer
    Anna Prokhortchouk
    Wellcome Trust Centre for Cell Biology, The King s Buildings, Edinburgh University, Edinburgh EH9 3JR, United Kingdom
    Mol Cell Biol 26:199-208. 2006
  9. ncbi The NuRD component Mbd3 is required for pluripotency of embryonic stem cells
    Keisuke Kaji
    Centre Development in Stem Cell Biology, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JQ, Scotland, UK
    Nat Cell Biol 8:285-92. 2006
  10. ncbi MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex
    H H Ng
    Institute of Cell and Molecular Biology, University of Edinburgh, The King s Buildings, Edinburgh EH9 3JR, UK
    Nat Genet 23:58-61. 1999

Collaborators

Detail Information

Publications19

  1. pmc Identification and characterization of a family of mammalian methyl-CpG binding proteins
    B Hendrich
    Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh EH9 3JR, Scotland
    Mol Cell Biol 18:6538-47. 1998
    ..The data demonstrate that MBD2 and MBD4 bind specifically to methyl-CpG in vitro and in vivo and are therefore likely to be mediators of the biological consequences of the methylation signal...
  2. ncbi Human diseases with underlying defects in chromatin structure and modification
    B Hendrich
    Centre for Genome Research, University of Edinburgh, Roger Land Building, Edinburgh EH9 3JQ, Scotland, UK
    Hum Mol Genet 10:2233-42. 2001
    ..Here we describe these 'chromatin diseases' and review what is known about the associated chromatin proteins in light of recent advances in the understanding of chromatin components, modification and function...
  3. pmc Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development
    B Hendrich
    Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, The University of Edinburgh, Michael Swann Building, The King s Buildings, Edinburgh EH9 3JR, Scotland
    Genes Dev 15:710-23. 2001
    ..Genetic and biochemical data together favor the view that MBD3 is a key component of the Mi-2/NuRD corepressor complex, whereas MBD2 may be one of several factors that can recruit this complex to DNA...
  4. ncbi The methyl-CpG binding domain and the evolving role of DNA methylation in animals
    Brian Hendrich
    Institute for Stem Cell Research, The University of Edinburgh, Roger Land Building, The King s Buildings, Edinburgh EH9 3JQ, UK
    Trends Genet 19:269-77. 2003
    ..We describe here the evolution of the MBD proteins and argue that the vertebrate MBD complement evolved to exploit the benefits and protect against the dangers of a globally methylated genome...
  5. ncbi Genomic structure and chromosomal mapping of the murine and human Mbd1, Mbd2, Mbd3, and Mbd4 genes
    B Hendrich
    Institute of Cell and Molecular Biology, University of Edinburgh, Darwin Building, King s Buildings, Edinburgh EH9 3JR Scotland, UK
    Mamm Genome 10:906-12. 1999
    ..The Mbd1 and Mbd2 genes, in contrast, map together to murine and human Chromosomes (Chrs)18. The Mbd3 and Mbd4 genes map to murine Chrs 10 and 6, respectively, while the human MBD3 and MBD4 genes map to Chrs 19 and 3, respectively...
  6. ncbi Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells
    Keisuke Kaji
    Institute for Stem Cell Research, Centre Development in Stem Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JQ, UK
    Development 134:1123-32. 2007
    ....
  7. pmc Mbd2 contributes to DNA methylation-directed repression of the Xist gene
    Helen Barr
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, King s Buildings, Mayfield Road, Edinburgh, United Kingdom
    Mol Cell Biol 27:3750-7. 2007
    ....
  8. pmc Kaiso-deficient mice show resistance to intestinal cancer
    Anna Prokhortchouk
    Wellcome Trust Centre for Cell Biology, The King s Buildings, Edinburgh University, Edinburgh EH9 3JR, United Kingdom
    Mol Cell Biol 26:199-208. 2006
    ..Our data suggest that Kaiso plays a role in intestinal cancer and may therefore represent a potential target for therapeutic intervention...
  9. ncbi The NuRD component Mbd3 is required for pluripotency of embryonic stem cells
    Keisuke Kaji
    Centre Development in Stem Cell Biology, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JQ, Scotland, UK
    Nat Cell Biol 8:285-92. 2006
    ..Our findings define a role for epigenetic silencing in the cell-fate commitment of pluripotent cells...
  10. ncbi MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex
    H H Ng
    Institute of Cell and Molecular Biology, University of Edinburgh, The King s Buildings, Edinburgh EH9 3JR, UK
    Nat Genet 23:58-61. 1999
    ..12). In our hands, MBD2 does not demethylate DNA. Our data suggest that HeLa cells, which lack the known methylation-dependent repressor MeCP2, use an alternative pathway involving MBD2 to silence methylated genes...
  11. pmc Keeping things quiet: roles of NuRD and Sin3 co-repressor complexes during mammalian development
    Patrick McDonel
    University of Edinburgh, Edinburgh EH9 3JQ, UK
    Int J Biochem Cell Biol 41:108-16. 2009
    ..In this review we will summarise the evidence that the two major class I histone deacetylase complexes in mammalian cells, the NuRD and Sin3 complexes, play important roles in distinct aspects of embryonic development...
  12. ncbi MeCP2 in neurons: closing in on the causes of Rett syndrome
    Isabel Martín Caballero
    Institute of Stem Cell Research, Centre Development in Stem Cell Biology, School of Biological Sciences, University of Edinburgh, UK
    Hum Mol Genet 14:R19-26. 2005
    ....
  13. ncbi A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome
    J Guy
    Wellcome Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, The King s Buildings, Edinburgh, UK
    Nat Genet 27:322-6. 2001
    ....
  14. ncbi Methylation moves into medicine
    B Hendrich
    Darwin Building, King s Buildings, Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh, EH9 3JR, UK Brian
    Curr Biol 10:R60-3. 2000
    ..The phenotypes of these two diseases are surprisingly distinct from each other and provide insights into the functions of DNA methylation in mammals...
  15. ncbi The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites
    B Hendrich
    Institute of Cell and Molecular Biology, University of Edinburgh, UK
    Nature 401:301-4. 1999
    ..The combined specificities of binding and catalysis indicate that this enzyme may function to minimize mutation at methyl-CpG...
  16. ncbi Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice
    Catherine B Millar
    Wellcome Trust Centre for Cell Biology, The King s Buildings, Edinburgh University, Edinburgh EH9 3JR, UK
    Science 297:403-5. 2002
    ..On a cancer-susceptible Apc(Min/+) background, Mbd4-/- mice showed accelerated tumor formation with CpG --> TpG mutations in the Apc gene. Thus MBD4 suppresses CpG mutability and tumorigenesis in vivo...
  17. ncbi Methyl-CpG binding proteins and cancer: are MeCpGs more important than MBDs?
    Egor Prokhortchouk
    Group of Transcriptional Control and Oncogenesis, Institute of Gene Biology, Vavilova 34 5, 117334 Moscow, Russian Federation
    Oncogene 21:5394-9. 2002
  18. ncbi Deficiency of Mbd2 suppresses intestinal tumorigenesis
    Owen J Sansom
    Cardiff School of Biosciences, Cardiff University, Cardiff, Wales, UK
    Nat Genet 34:145-7. 2003
    ..As Mbd2-deficient mice are viable and fertile, their resistance to intestinal cancer may be of therapeutic relevance...
  19. ncbi Dynamic reprogramming of DNA methylation in the early mouse embryo
    Fatima Santos
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, CB2 4AT, United Kingdom
    Dev Biol 241:172-82. 2002
    ..The three phases of methylation reprogramming may have roles in imprinting, the control of gene expression, and the establishment of nuclear totipotency...