Genomes and Genes
Affiliation: University of Edinburgh
- Identification and characterization of a family of mammalian methyl-CpG binding proteinsB Hendrich
Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh EH9 3JR, Scotland
Mol Cell Biol 18:6538-47. 1998..The data demonstrate that MBD2 and MBD4 bind specifically to methyl-CpG in vitro and in vivo and are therefore likely to be mediators of the biological consequences of the methylation signal...
- Human diseases with underlying defects in chromatin structure and modificationB Hendrich
Centre for Genome Research, University of Edinburgh, Roger Land Building, Edinburgh EH9 3JQ, Scotland, UK
Hum Mol Genet 10:2233-42. 2001..Here we describe these 'chromatin diseases' and review what is known about the associated chromatin proteins in light of recent advances in the understanding of chromatin components, modification and function...
- Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse developmentB Hendrich
Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, The University of Edinburgh, Michael Swann Building, The King s Buildings, Edinburgh EH9 3JR, Scotland
Genes Dev 15:710-23. 2001..Genetic and biochemical data together favor the view that MBD3 is a key component of the Mi-2/NuRD corepressor complex, whereas MBD2 may be one of several factors that can recruit this complex to DNA...
- The methyl-CpG binding domain and the evolving role of DNA methylation in animalsBrian Hendrich
Institute for Stem Cell Research, The University of Edinburgh, Roger Land Building, The King s Buildings, Edinburgh EH9 3JQ, UK
Trends Genet 19:269-77. 2003..We describe here the evolution of the MBD proteins and argue that the vertebrate MBD complement evolved to exploit the benefits and protect against the dangers of a globally methylated genome...
- Genomic structure and chromosomal mapping of the murine and human Mbd1, Mbd2, Mbd3, and Mbd4 genesB Hendrich
Institute of Cell and Molecular Biology, University of Edinburgh, Darwin Building, King s Buildings, Edinburgh EH9 3JR Scotland, UK
Mamm Genome 10:906-12. 1999..The Mbd1 and Mbd2 genes, in contrast, map together to murine and human Chromosomes (Chrs)18. The Mbd3 and Mbd4 genes map to murine Chrs 10 and 6, respectively, while the human MBD3 and MBD4 genes map to Chrs 19 and 3, respectively...
- Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cellsKeisuke Kaji
Institute for Stem Cell Research, Centre Development in Stem Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JQ, UK
Development 134:1123-32. 2007....
- Mbd2 contributes to DNA methylation-directed repression of the Xist geneHelen Barr
Wellcome Trust Centre for Cell Biology, University of Edinburgh, King s Buildings, Mayfield Road, Edinburgh, United Kingdom
Mol Cell Biol 27:3750-7. 2007..The presence of redundant mechanisms to enforce repression at Xist and other loci is compatible with the hypothesis that "stacking" of imperfect repressive tendencies may be an evolutionary strategy to ensure leakproof gene silencing...
- Kaiso-deficient mice show resistance to intestinal cancerAnna Prokhortchouk
Wellcome Trust Centre for Cell Biology, The King s Buildings, Edinburgh University, Edinburgh EH9 3JR, United Kingdom
Mol Cell Biol 26:199-208. 2006..Our data suggest that Kaiso plays a role in intestinal cancer and may therefore represent a potential target for therapeutic intervention...
- The NuRD component Mbd3 is required for pluripotency of embryonic stem cellsKeisuke Kaji
Centre Development in Stem Cell Biology, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JQ, Scotland, UK
Nat Cell Biol 8:285-92. 2006..Our findings define a role for epigenetic silencing in the cell-fate commitment of pluripotent cells...
- MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complexH H Ng
Institute of Cell and Molecular Biology, University of Edinburgh, The King s Buildings, Edinburgh EH9 3JR, UK
Nat Genet 23:58-61. 1999..12). In our hands, MBD2 does not demethylate DNA. Our data suggest that HeLa cells, which lack the known methylation-dependent repressor MeCP2, use an alternative pathway involving MBD2 to silence methylated genes...
- Keeping things quiet: roles of NuRD and Sin3 co-repressor complexes during mammalian developmentPatrick McDonel
University of Edinburgh, Edinburgh EH9 3JQ, UK
Int J Biochem Cell Biol 41:108-16. 2009..In this review we will summarise the evidence that the two major class I histone deacetylase complexes in mammalian cells, the NuRD and Sin3 complexes, play important roles in distinct aspects of embryonic development...
- MeCP2 in neurons: closing in on the causes of Rett syndromeIsabel Martín Caballero
Institute of Stem Cell Research, Centre Development in Stem Cell Biology, School of Biological Sciences, University of Edinburgh, UK
Hum Mol Genet 14:R19-26. 2005....
- A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndromeJ Guy
Wellcome Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, The King s Buildings, Edinburgh, UK
Nat Genet 27:322-6. 2001....
- Methylation moves into medicineB Hendrich
Darwin Building, King s Buildings, Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh, EH9 3JR, UK Brian
Curr Biol 10:R60-3. 2000..The phenotypes of these two diseases are surprisingly distinct from each other and provide insights into the functions of DNA methylation in mammals...
- The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sitesB Hendrich
Institute of Cell and Molecular Biology, University of Edinburgh, UK
Nature 401:301-4. 1999..The combined specificities of binding and catalysis indicate that this enzyme may function to minimize mutation at methyl-CpG...
- Enhanced CpG mutability and tumorigenesis in MBD4-deficient miceCatherine B Millar
Wellcome Trust Centre for Cell Biology, The King s Buildings, Edinburgh University, Edinburgh EH9 3JR, UK
Science 297:403-5. 2002..On a cancer-susceptible Apc(Min/+) background, Mbd4-/- mice showed accelerated tumor formation with CpG --> TpG mutations in the Apc gene. Thus MBD4 suppresses CpG mutability and tumorigenesis in vivo...
- Methyl-CpG binding proteins and cancer: are MeCpGs more important than MBDs?Egor Prokhortchouk
Group of Transcriptional Control and Oncogenesis, Institute of Gene Biology, Vavilova 34 5, 117334 Moscow, Russian Federation
Oncogene 21:5394-9. 2002
- Deficiency of Mbd2 suppresses intestinal tumorigenesisOwen J Sansom
Cardiff School of Biosciences, Cardiff University, Cardiff, Wales, UK
Nat Genet 34:145-7. 2003..As Mbd2-deficient mice are viable and fertile, their resistance to intestinal cancer may be of therapeutic relevance...
- Dynamic reprogramming of DNA methylation in the early mouse embryoFatima Santos
Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, CB2 4AT, United Kingdom
Dev Biol 241:172-82. 2002..The three phases of methylation reprogramming may have roles in imprinting, the control of gene expression, and the establishment of nuclear totipotency...