B Henderson

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc Bacterial modulins: a novel class of virulence factors which cause host tissue pathology by inducing cytokine synthesis
    B Henderson
    Maxillofacial Surgery Research Unit, University College London, United Kingdom
    Microbiol Rev 60:316-41. 1996
  2. pmc Caught with their PAMPs down? The extracellular signalling actions of molecular chaperones are not due to microbial contaminants
    Brian Henderson
    UCL Eastman Dental Institute, University College London, UK
    Cell Stress Chaperones 15:123-41. 2010
  3. pmc Unfolding the relationship between secreted molecular chaperones and macrophage activation states
    Brian Henderson
    Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, London, UK
    Cell Stress Chaperones 14:329-41. 2009
  4. pmc Oral bacterial disease and the science of cellular conversation
    Brian Henderson
    Cellular Microbiology Research Group, Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X 8LD, UK
    J R Soc Med 95:77-80. 2002
  5. ncbi request reprint The search for the chaperonin 60 receptors
    Brian Henderson
    Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X 8LD, UK
    Methods 43:223-8. 2007
  6. pmc Stress wars: the direct role of host and bacterial molecular chaperones in bacterial infection
    Brian Henderson
    Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X, United Kingdom
    Infect Immun 74:3693-706. 2006
  7. ncbi request reprint Hard labour: bacterial infection of the skeleton
    Brian Henderson
    Division of Infection and Immunity, Eastman Dental Institute, University College London, 256 Gray s Inn Road, WC1X 8LD, London, UK
    Trends Microbiol 11:570-7. 2003
  8. ncbi request reprint Molecular pathogenicity of the oral opportunistic pathogen Actinobacillus actinomycetemcomitans
    Brian Henderson
    Cellular Microbiology Research Group, Eastman Dental Institute, University College London, London WC1X 8LD, United Kingdom
    Annu Rev Microbiol 57:29-55. 2003
  9. ncbi request reprint Out of one eye: a life integrating cellular biochemistry and function
    Brian Henderson
    Division of Infection and Immunity, Eastman Dental Institute, University College London, UK
    Cell Biochem Funct 21:201-6. 2003
  10. pmc Bacterial virulence in the moonlight: multitasking bacterial moonlighting proteins are virulence determinants in infectious disease
    Brian Henderson
    Department of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X 8LD, United Kingdom
    Infect Immun 79:3476-91. 2011

Detail Information

Publications80

  1. pmc Bacterial modulins: a novel class of virulence factors which cause host tissue pathology by inducing cytokine synthesis
    B Henderson
    Maxillofacial Surgery Research Unit, University College London, United Kingdom
    Microbiol Rev 60:316-41. 1996
    ..We propose that modulins, by controlling the host immune and inflammatory responses, maintain the large commensal flora that all multicellular organisms support...
  2. pmc Caught with their PAMPs down? The extracellular signalling actions of molecular chaperones are not due to microbial contaminants
    Brian Henderson
    UCL Eastman Dental Institute, University College London, UK
    Cell Stress Chaperones 15:123-41. 2010
    ..They show that sufficient evidence exists to support fully the hypothesis that molecular chaperones have cell-cell signalling actions that are likely to be part of the homeostatic mechanism of the vertebrate...
  3. pmc Unfolding the relationship between secreted molecular chaperones and macrophage activation states
    Brian Henderson
    Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, London, UK
    Cell Stress Chaperones 14:329-41. 2009
    ....
  4. pmc Oral bacterial disease and the science of cellular conversation
    Brian Henderson
    Cellular Microbiology Research Group, Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X 8LD, UK
    J R Soc Med 95:77-80. 2002
  5. ncbi request reprint The search for the chaperonin 60 receptors
    Brian Henderson
    Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X 8LD, UK
    Methods 43:223-8. 2007
    ..BiP appears to be one of these receptor proteins but more work is needed to identify those responsible for signalling. Of interest, CD14 and TLR4 were not identified in this study as a receptor for Cpn60.1...
  6. pmc Stress wars: the direct role of host and bacterial molecular chaperones in bacterial infection
    Brian Henderson
    Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X, United Kingdom
    Infect Immun 74:3693-706. 2006
  7. ncbi request reprint Hard labour: bacterial infection of the skeleton
    Brian Henderson
    Division of Infection and Immunity, Eastman Dental Institute, University College London, 256 Gray s Inn Road, WC1X 8LD, London, UK
    Trends Microbiol 11:570-7. 2003
    ..The host cellular pathways that are activated and lead to destruction or loss of the bone matrix will be described...
  8. ncbi request reprint Molecular pathogenicity of the oral opportunistic pathogen Actinobacillus actinomycetemcomitans
    Brian Henderson
    Cellular Microbiology Research Group, Eastman Dental Institute, University College London, London WC1X 8LD, United Kingdom
    Annu Rev Microbiol 57:29-55. 2003
    ..This review focuses on recent advances in our understanding of the molecular and cellular pathogenicity of this fascinating oral bacterium...
  9. ncbi request reprint Out of one eye: a life integrating cellular biochemistry and function
    Brian Henderson
    Division of Infection and Immunity, Eastman Dental Institute, University College London, UK
    Cell Biochem Funct 21:201-6. 2003
  10. pmc Bacterial virulence in the moonlight: multitasking bacterial moonlighting proteins are virulence determinants in infectious disease
    Brian Henderson
    Department of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X 8LD, United Kingdom
    Infect Immun 79:3476-91. 2011
    ....
  11. ncbi request reprint Actinobacillus actinomycetemcomitans
    Brian Henderson
    Cellular Microbiology Research Group, Eastman Dental Institute, University College London, London
    J Med Microbiol 51:1013-20. 2002
  12. ncbi request reprint Microbial/host interactions in health and disease: who controls the cytokine network?
    B Henderson
    Maxillofacial Surgery Research Unit Eastman Dental Institute for Oral Health Care Sciences, University College London, UK
    Immunopharmacology 35:1-21. 1996
    ....
  13. doi request reprint Fibronectin: a multidomain host adhesin targeted by bacterial fibronectin-binding proteins
    Brian Henderson
    Department of Microbial Diseases, UCL Eastman Dental Institute, University College London, London, UK
    FEMS Microbiol Rev 35:147-200. 2011
    ..This article provides an update on our current understanding of FnBPs from both Gram-negative and Gram-positive bacteria and their proposed roles in bacterial colonization, bacterial virulence and bacteria-host interactions...
  14. doi request reprint Molecular chaperones and protein-folding catalysts as intercellular signaling regulators in immunity and inflammation
    Brian Henderson
    Department of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray s Inn Rd, London, WC1X 8LD, UK
    J Leukoc Biol 88:445-62. 2010
    ..The most fascinating aspect of molecular chaperones probably relates to evidence for their therapeutic potential in human disease, and ongoing studies are evaluating this potential in a range of clinical settings...
  15. ncbi request reprint Are bacterial exotoxins cytokine network regulators?
    B Henderson
    Cellular Microbiology Research Group, Eastman Dental Institute, University College London, UK
    Trends Microbiol 5:454-8. 1997
    ..Cytokine induction may play a significant role in exotoxin action, and therapeutic targeting of cytokines could be beneficial in infectious diseases involving bacterial exotoxins...
  16. ncbi request reprint Cellular microbiology: cycling into the millennium
    B Henderson
    Cellular Microbiology Research Group, Eastman Dental Institute, London, UK
    Trends Cell Biol 8:384-7. 1998
    ..This article discusses the cell-cycle effects of bacterially generated molecules, their role in virulence and their possible therapeutic potential...
  17. doi request reprint Multiple moonlighting functions of mycobacterial molecular chaperones
    Brian Henderson
    Department of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X 8LD, United Kingdom
    Tuberculosis (Edinb) 90:119-24. 2010
    ..This brief overview highlights the potential importance of the moonlighting functions of molecular chaperones in the biology and pathobiology of the mycobacteria...
  18. pmc Cloning and expression of the Actinobacillus actinomycetemcomitans thioredoxin (trx) gene and assessment of cytokine inhibitory activity
    B Henderson
    Cellular Microbiology Research Group, Eastman Dental Institute, University College London, London WC1X 8LD, United Kingdom
    Infect Immun 69:154-8. 2001
    ..We therefore conclude that the thioredoxin of A. actinomycetemcomitans does not act as an immunosuppressive factor, at least with human leukocytes in cultures, and that the identity of SF1 remains to be elucidated...
  19. doi request reprint Integrating the cell stress response: a new view of molecular chaperones as immunological and physiological homeostatic regulators
    Brian Henderson
    UCL Eastman Dental Institute, University College London, UK
    Cell Biochem Funct 28:1-14. 2010
    ..An important consideration is the role that these proteins may play in human disease and in the treatment of human disease...
  20. pmc Mycobacterium tuberculosis chaperonin 60.1 is a more potent cytokine stimulator than chaperonin 60.2 (Hsp 65) and contains a CD14-binding domain
    J C Lewthwaite
    Cellular Microbiology Research Group, Eastman Dental Institute, University College London, London, United Kingdom
    Infect Immun 69:7349-55. 2001
    ..The cytokine-inducing activity of both chaperonins is extremely resistant to heat. Cpn 60.1 may be an important virulence factor in tuberculosis, able to activate cells by diverse receptor-driven mechanisms...
  21. pmc Staphylococcus aureus fibronectin binding proteins are essential for internalization by osteoblasts but do not account for differences in intracellular levels of bacteria
    S Ahmed
    Cellular Microbiology Research Group, Eastman Dental Institute, University College London, United Kingdom
    Infect Immun 69:2872-7. 2001
    ..aureus are internalized by osteoblasts to different extents and suggest that in addition to the fibronectin binding proteins there are other, as yet undetermined virulence factors that play a role in the internalization process...
  22. pmc Recombinant Actinobacillus actinomycetemcomitans cytolethal distending toxin proteins are required to interact to inhibit human cell cycle progression and to stimulate human leukocyte cytokine synthesis
    S Akifusa
    Cellular Microbiology Research Group, Eastman Dental Institute, University College London, London WC1X 8LD, United Kingdom
    Infect Immun 69:5925-30. 2001
    ..There was evidence of synergism between these Cdt proteins in the stimulation of cytokine production, most markedly with gamma interferon, which required the minimum interaction of CdtB and -C to stimulate production...
  23. ncbi request reprint Human chaperonin 60 (Hsp60) stimulates bone resorption: structure/function relationships
    S Meghji
    Cellular Microbiology Research Group, Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X 8LD, UK
    Bone 33:419-25. 2003
    ..The possibility exists that this protein could play a role in bone remodelling...
  24. ncbi request reprint Expression of the S. aureus hysA gene in S. carnosus from a modified E. coli-staphylococcal shuttle vector
    R J Williams
    Cellular Microbiology Research Group, Division of Surgical Sciences, Eastman Dental Institute, UK
    Plasmid 47:241-5. 2002
    ..carnosus. Hyaluronate lyase was both produced and secreted by S. carnosus. In addition, the secreted HysA protein was enzymatically active, as determined using a zymographic assay...
  25. ncbi request reprint Analysis of the effect of changing environmental conditions on the expression patterns of exported surface-associated proteins of the oral pathogen Actinobacillus actinomycetemcomitans
    J M Fletcher
    Department of Microbiology, Eastman Dental Institute, University College London, 256 Grays Inn Road, London WC1X 8LD, UK
    Microb Pathog 30:359-68. 2001
    ..An ability to adapt to prevailing environmental conditions may facilitate the survival of the organism in the changing microIenvironment of the periodontal pocket...
  26. ncbi request reprint Bacterial resuscitation factors: revival of viable but non-culturable bacteria
    N H Keep
    School of Crystallography and Institute of Structural Molecular Biology, Birkbeck, University of London, Malet Street, London, WC1E 7HX, United Kingdom
    Cell Mol Life Sci 63:2555-9. 2006
  27. pmc Identification of a novel gene cluster encoding staphylococcal exotoxin-like proteins: characterization of the prototypic gene and its protein product, SET1
    R J Williams
    Cellular Microbiology Research Group, Division of Surgical Sciences, University College London, London, United Kingdom
    Infect Immun 68:4407-15. 2000
    ..The distribution of allelic variants of the set genes among strains of S. aureus may contribute to differences in the pathogenic potential of this bacterium...
  28. ncbi request reprint Identification of photolabile outer membrane proteins of Porphyromonas gingivalis
    M Bhatti
    Department of Microbiology, Eastman Dental Institute for Oral Health Care Sciences, University College London, 256 Grays Inn Road, London WC1X 8LD, UK
    Curr Microbiol 43:96-9. 2001
    ..Using a combination of Western blotting and protein sequencing the predominant photolabile proteins in P. gingivalis have been identified as the major secreted/cell surface proteases--Lys and Arg gingipain...
  29. doi request reprint Pathogen burden and cortisol profiles over the day
    A Steptoe
    Department of Epidemiology and Pubic Health, University College London, UK
    Epidemiol Infect 137:1816-24. 2009
    ..We conclude that pathogen burden is independently associated with flatter cortisol slopes over the day, and may contribute to disturbed neuroendocrine regulation...
  30. pmc Bacterial porins stimulate bone resorption
    S Meghji
    Division of Surgical Sciences, Eastman Dental Institute, University College London, United Kingdom
    Infect Immun 65:1313-6. 1997
    ....
  31. ncbi request reprint Pro-inflammatory--anti-inflammatory cytokine dynamics mediated by cytokine-receptor dynamics in monocytes
    R M Seymour
    Department of Mathematics, University College London, UK
    IMA J Math Appl Med Biol 18:159-92. 2001
    ..These behaviours depend crucially on the form of the cell's response functions. The possible biological implications of these phenomena are discussed...
  32. ncbi request reprint Effect of Mycobacterium tuberculosis chaperonins on bronchial eosinophilia and hyper-responsiveness in a murine model of allergic inflammation
    Y Riffo-Vasquez
    Sackler Institute of Pulmonary Pharmacology, GKT School of Biomedical Science and Medicine, King s College London, London, UK
    Clin Exp Allergy 34:712-9. 2004
    ....
  33. ncbi request reprint Staphylococcus aureus fibronectin binding proteins A and B possess a second fibronectin binding region that may have biological relevance to bone tissues
    R J Williams
    Cellular Microbiology Research Group, Division of Surgical Sciences, Eastman Dental Institute for Oral Health Care Sciences, University College London, London, UK
    Calcif Tissue Int 70:416-21. 2002
    ..Analysis of these binding regions for their ability to bind to other extracellular matrix proteins revealed a preference for fibronectin, with slight binding to fibrinogen and no binding to collagen or laminin...
  34. pmc Mycobacterium tuberculosis chaperonin 10 stimulates bone resorption: a potential contributory factor in Pott's disease
    S Meghji
    Maxillofacial Surgery Research Unit, Eastman Dental Institute, University College London, United Kingdom
    J Exp Med 186:1241-6. 1997
    ..Our findings suggest that Mt cpn10 may be a valuable pharmacological target for the clinical therapy of vertebral tuberculosis and possibly other bone diseases...
  35. pmc Socioeconomic status, pathogen burden and cardiovascular disease risk
    A Steptoe
    Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London WC1E 6BT, UK
    Heart 93:1567-70. 2007
    ..Cumulative pathogen burden may also predict future CHD. The hypothesis was tested that lower SES is associated with a greater pathogen burden, and that pathogen burden accounts in part for SES differences in cardiovascular risk factors...
  36. pmc Identification of the exported proteins of the oral opportunistic pathogen Actinobacillus actinomycetemcomitans by using alkaline phosphatase fusions
    J Ward
    Molecular Microbiology Group, Department of Biochemistry and Molecular Biology, University College London, London WC1E 6BT
    Infect Immun 69:2748-52. 2001
    ..The proteins encoded by these genes may, by virtue of their presence on the cell surface, be novel virulence determinants...
  37. ncbi request reprint Phage display in the study of infectious diseases
    Lisa M Mullen
    Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X 8LD, UK
    Trends Microbiol 14:141-7. 2006
    ..In particular, this technique has proved successful in identifying microbial adhesins that are vital for colonization...
  38. ncbi request reprint Stressing the obvious? Cell stress and cell stress proteins in cardiovascular disease
    Alireza Shamaei-Tousi
    Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X 8LD, UK
    Cardiovasc Res 74:19-28. 2007
    ..This review brings these various strands of research together to provide an overview of the role of molecular chaperones in cardiovascular disease...
  39. ncbi request reprint Comparative functional genomic analysis of Pasteurellaceae adhesins using phage display
    Lisa M Mullen
    Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, London WC1X 8LD, United Kingdom
    Vet Microbiol 122:123-34. 2007
    ..pleuropneumoniae. None of these genes have previously been proposed to code for adhesins. The applications of phage display with whole bacterial genomes to identify genes encoding novel adhesins in this family of bacteria are discussed...
  40. doi request reprint Periodontal infectogenomics
    Luigi Nibali
    Periodontology Unit and Division of Clinical Research, UCL Eastman Dental Institute, University College London, London, UK
    J Med Microbiol 58:1269-74. 2009
    ..Mechanisms of interaction between genetic and microbiological factors and prospects for future studies will be discussed...
  41. pmc Novel adhesin from Pasteurella multocida that binds to the integrin-binding fibronectin FnIII9-10 repeats
    Lisa M Mullen
    Division of Microbial Diseases, Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X 8LD, United Kingdom
    Infect Immun 76:1093-104. 2008
    ..These results support the hypothesis that the PM1665 protein is a member of a new family of fibronectin binding adhesins that are important in the adhesion of P. multocida to fibronectin...
  42. pmc Chaperonin 60 unfolds its secrets of cellular communication
    Maria Maguire
    Cellular Microbiology Research Group, Eastman Dental Institute, University College London, 256 Grays Inn Road, London WC1X 8LD, UK
    Cell Stress Chaperones 7:317-29. 2002
    ..This review discusses the work to date, which has revealed the cell-cell signaling actions of Cpn60 proteins...
  43. pmc Pasteurellaceae ComE1 proteins combine the properties of fibronectin adhesins and DNA binding competence proteins
    Lisa M Mullen
    Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, London, United Kingdom
    PLoS ONE 3:e3991. 2008
    ..Inactivation of the gene encoding the ComE1 homologue in Actinobacillus pleuropneumoniae indicates major roles for these proteins in at least two processes: natural transformation, and binding of bacteria to fibronectin...
  44. ncbi request reprint Cytolethal distending toxin: creating a gap in the cell cycle
    Wendy Heywood
    Division of Microbial Diseases, Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X 8LD, UK
    J Med Microbiol 54:207-16. 2005
    ..This review encompasses recent work on CDT and focuses on the molecular mechanisms used by this toxin to block cell-cycle progression, the benefit to the bacterium of possession of this toxin and the clinical relevance of intoxication...
  45. ncbi request reprint Resuscitation-promoting factors are expressed in Mycobacterium tuberculosis-infected human tissue
    A P Davies
    Centre for Medical Microbiology, Department of Infection, Royal Free and University College Medical School, London, UK
    Tuberculosis (Edinb) 88:462-8. 2008
    ..The work presented here demonstrates that Rpf expression can be detected in human tissues infected with M. tuberculosis and describes the pattern of this expression using immunocytochemistry with anti-Rpf antibodies...
  46. pmc Comparison of the moonlighting actions of the two highly homologous chaperonin 60 proteins of Mycobacterium tuberculosis
    Ana Cehovin
    Department of Microbial Diseases, UCL Eastman Dental Institute, University College London, London, United Kingdom
    Infect Immun 78:3196-206. 2010
    ..These results clearly show that, despite significant sequence homology, M. tuberculosis Cpn60 proteins interact in distinct ways with human or murine macrophages...
  47. ncbi request reprint Highly homologous Mycobacterium tuberculosis chaperonin 60 proteins with differential CD14 dependencies stimulate cytokine production by human monocytes through cooperative activation of p38 and ERK1/2 mitogen-activated protein kinases
    Jo C Lewthwaite
    Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, UK
    Int Immunopharmacol 7:230-40. 2007
    ....
  48. ncbi request reprint Mechanism of internalization of the cytolethal distending toxin of Actinobacillus actinomycetemcomitans
    Sumio Akifusa
    Division of Microbial Diseases, Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X 8LD, UK
    Microbiology 151:1395-402. 2005
    ....
  49. ncbi request reprint The structure of a resuscitation-promoting factor domain from Mycobacterium tuberculosis shows homology to lysozymes
    Martin Cohen-Gonsaud
    School of Crystallography and Institute for Structural Molecular Biology, Birkbeck College, University of London, Malet Street, London, WC1E 7HX, UK
    Nat Struct Mol Biol 12:270-3. 2005
    ..These data, as well as the presence of a clear binding pocket for a large molecule, indicate that oligosaccharide cleavage is probably the signal for revival from dormancy...
  50. pmc Chaperonins in disease: mechanisms, models, and treatments
    J C Ranford
    Cellular Microbiology Research Group, Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X 8LD, UK
    Mol Pathol 55:209-13. 2002
    ..This review focuses on the current knowledge of the roles of Cpn 60 in the pathology of infectious and immune diseases, and discusses models for the actions of this molecule. Some potential therapeutic strategies will also be reviewed...
  51. ncbi request reprint TNF-alpha neutralization in cytokine-driven diseases: a mathematical model to account for therapeutic success in rheumatoid arthritis but therapeutic failure in systemic inflammatory response syndrome
    M Jit
    Department of Mathematics, University College London, Gower Street, London WC1E 6BT, UK
    Rheumatology (Oxford) 44:323-31. 2005
    ..It is not clear why there is such a significant difference in the responses to TNF-alpha neutralization in these two conditions. Here we use mathematical modelling to investigate this discrepancy...
  52. pmc Identification of a fibronectin-binding protein from Staphylococcus epidermidis
    Rachel J Williams
    Cellular Microbiology Research Group, Eastman Dental Institute for Oral Health Care Sciences, University College London, United Kingdom
    Infect Immun 70:6805-10. 2002
    ..aureus fibronectin-binding protein FnBPB, blocked binding of S. aureus to fibronectin but had a negligible effect on the binding of S. epidermidis...
  53. pmc Plasma heat shock protein 60 and cardiovascular disease risk: the role of psychosocial, genetic, and biological factors
    Alireza Shamaei-Tousi
    Division of Microbial Diseases, Eastman Dental Institute, University College London, London WC1X 8LD, UK
    Cell Stress Chaperones 12:384-92. 2007
    ..The extended range of plasma Hsp60 concentrations in the general population is genuine and is likely to be related to genetic, biological, and psychosocial risk factors for coronary artery disease...
  54. ncbi request reprint Invasion of bone cells by Staphylococcus epidermidis
    Hesham Khalil
    Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X 8LD, UK
    Microbes Infect 9:460-5. 2007
    ..epidermidis. Therefore unlike S. aureus, S. epidermidis does not gain entrance into bone cells through a fibronectin bridge between the alpha5beta1 integrin and a bacterial adhesin...
  55. pmc Rhizobium leguminosarum chaperonin 60.3, but not chaperonin 60.1, induces cytokine production by human monocytes: activity is dependent on interaction with cell surface CD14
    Jo Lewthwaite
    Cellular Microbiology Research Group, Eastman Dental Institute, University College London, UK
    Cell Stress Chaperones 7:130-6. 2002
    ..3 was dependent on its interaction with CD14. This demonstrates that CD14 mediates not only lipopolysaccharide but also R. leguminosarum Cpn 60.3 cell signaling in human monocytes...
  56. pmc Comparative cell signalling activity of ultrapure recombinant chaperonin 60 proteins from prokaryotes and eukaryotes
    Maria Maguire
    Division of Microbial Diseases, Eastman Dental Institute, University College London, London, UK
    Immunology 115:231-8. 2005
    ....
  57. ncbi request reprint Cloning, expression and purification of three Chaperonin 60 homologues
    Maria Maguire
    Cellular Microbiology Research Group, Eastman Dental Institute, University College London, 256 Grays Inn Road, WC1X 8LD, London, UK
    J Chromatogr B Analyt Technol Biomed Life Sci 786:117-25. 2003
    ..Insoluble protein was solubilised using 8 M urea and then re-folded on the nickel column by stepwise removal of the urea. The immunostimulant LPS was removed by addition of the antibiotic polymyxin B as part of the purification process...
  58. pmc In vivo killing of Porphyromonas gingivalis by toluidine blue-mediated photosensitization in an animal model
    N Komerik
    Department of Microbiology, Eastman Dental Institute for Oral Health Care Sciences, University College London, United Kingdom
    Antimicrob Agents Chemother 47:932-40. 2003
    ..gingivalis is possible in vivo and that this results in decreased bone loss. These findings suggest that photodynamic therapy may be useful as an alternative approach for the antimicrobial treatment of periodontitis...
  59. pmc Protective effect of human heat shock protein 60 suggested by its association with decreased seropositivity to pathogens
    A Steptoe
    Department of Epidemiology and Public Health, UCL Eastman Dental Institute, University College London, London, United Kingdom
    Clin Vaccine Immunol 14:204-7. 2007
    ....
  60. ncbi request reprint Resuscitation-promoting factors possess a lysozyme-like domain
    Martin Cohen-Gonsaud
    School of Crystallography and BBRSC Centre for Structural Biology, Birkbeck College, University of London, Malet Street, London, WC1E 7HX, UK
    Trends Biochem Sci 29:7-10. 2004
    ..The model highlights the good conservation of residues involved in catalysis and substrate binding. A lysozyme-like function makes sense for this domain in the light of experimental characterization of the biological function of Rpfs...
  61. pmc Differential regulation of circulating levels of molecular chaperones in patients undergoing treatment for periodontal disease
    Alireza Shamaei-Tousi
    Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, London, United Kingdom
    PLoS ONE 2:e1198. 2007
    ..We have used periodontitis and its treatment as a model of inflammation in the human to determine its effects on levels of circulating HSP10, HSP60 and BiP...
  62. ncbi request reprint Cell stress proteins as modulators of bacteria--host interactions
    Brian Henderson
    Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X 8LD, UK
    Novartis Found Symp 291:141-54; discussion 154-9, 221-4. 2008
    ..In insects, endosymbiotic bacteria provide bacterial CSPs which are utilised by the host. Bacterial CSPs have also been shown to be antibacterial targets. These findings establish a range of roles for CSPs in bacteria-host interactions...
  63. ncbi request reprint Circulating human heat shock protein 60 in the plasma of British civil servants: relationship to physiological and psychosocial stress
    Jo Lewthwaite
    Cellular Microbiology Research Group, University College London, London, UK
    Circulation 106:196-201. 2002
    ..To identify mechanisms responsible for susceptibility to CHD, specific biological markers of stress are increasingly being measured. One marker linked to susceptibility to CHD is heat shock protein (Hsp) 60...
  64. ncbi request reprint Wake up! Peptidoglycan lysis and bacterial non-growth states
    Nicholas H Keep
    School of Crystallography and Institute of Structural Molecular Biology, Birkbeck, University of London, Malet Street, London, UK, WC1E 7HX
    Trends Microbiol 14:271-6. 2006
    ....
  65. ncbi request reprint Stress cytokines: pivotal proteins in immune regulatory networks; Opinion
    Gabriel S Panayi
    Academic Department of Rheumatology, Guy s, King s and St Thomas School of Medicine, Guy s Hospital, King s College, London, SE1 9RT, United Kingdom
    Curr Opin Immunol 16:531-4. 2004
    ..We predict that the exploitation of the downregulatory properties of stress cytokines will have therapeutic applications in the treatment of human chronic inflammatory diseases, such as rheumatoid arthritis...
  66. ncbi request reprint Streptococcus sanguis secretes CD14-binding proteins that stimulate cytokine synthesis: a clue to the pathogenesis of infective (bacterial) endocarditis?
    Julia Banks
    Cellular Microbiology Research Group, Eastman Dental Institute, University College London, 256 Gray s Inn Road, London, Hertfordshire, WC1X 8LD, U K
    Microb Pathog 32:105-16. 2002
    ..In addition, blocking of CD14 may have some therapeutic benefit...
  67. doi request reprint Ion-specific effects on the interaction between fibronectin and negatively charged mica surfaces
    Matthew D Heath
    Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, United Kingdom
    Langmuir 26:5304-8. 2010
    ..The origin of this ion-specific effect is discussed...
  68. pmc Structural relationships and cellular tropism of staphylococcal superantigen-like proteins
    Ali M Al-Shangiti
    Department of Immunology and Molecular Pathology, University College London, 46 Cleveland Street, London W1T 4JF, United Kingdom
    Infect Immun 72:4261-70. 2004
    ..Like classical superantigens, therefore, SSLs may distract the host's immune system, but they may do so via entirely different molecular mechanisms...
  69. doi request reprint The relationship between carotid stiffness and circulating levels of heat shock protein 60 in middle-aged men and women
    Elizabeth Ellins
    Vascular Physiology Unit, Institute of Child Health, University College London, UK
    J Hypertens 26:2389-92. 2008
    ..In this study, we measured the association between plasma HSP60 and carotid arterial stiffness in middle-aged men and women...
  70. ncbi request reprint Association between plasma levels of heat shock protein 60 and cardiovascular disease in patients with diabetes mellitus
    Alireza Shamaei-Tousi
    Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X 8LD, UK
    Eur Heart J 27:1565-70. 2006
    ..As diabetes is a risk factor for CHD, it was of interest to determine Hsp60 blood levels in a cross-sectional cohort of diabetic patients, some of whom had cardiovascular disease, and relate levels to relevant biochemical markers...
  71. doi request reprint The two homologous chaperonin 60 proteins of Mycobacterium tuberculosis have distinct effects on monocyte differentiation into osteoclasts
    Vivienne R Winrow
    School for Health and Royal National Hospital for Rheumatic Diseases, University of Bath, Bath BA2 7AY, UK
    Cell Microbiol 10:2091-104. 2008
    ..Taken together, these findings reveal that M. tuberculosis Cpn60.1 is a potent and novel inhibitor of osteoclastogenesis both in vitro and in vivo and a potential cure for bone-resorptive diseases like osteoporosis...
  72. ncbi request reprint Microbiology. We get by with a little help from our (little) friends
    Edward Ruby
    Pacific Biomedical Research Center, Kewalo Marine Laboratory, University of Hawaii, Honolulu, HI 96813, USA
    Science 303:1305-7. 2004
  73. ncbi request reprint Staphylococcus aureus capsular material promotes osteoclast formation
    Yu Sin Lau
    Department of Pathology, Nuffield Department of Orthopaedic Surgery, University of Oxford, Nuffield Orthopaedic Centre, Oxford, United Kingdom
    Injury 37:S41-8. 2006
    ..aureus SAM and that S. aureus SAM contains a soluble factor that promotes osteoclast formation by a RANKL-independent mechanism...
  74. ncbi request reprint The intercellular signaling activity of the Mycobacterium tuberculosis chaperonin 60.1 protein resides in the equatorial domain
    Peter Tormay
    Department of Cellular and Molecular Medicine, St George s Hospital Medical School, Cranmer Terrace, London
    J Biol Chem 280:14272-7. 2005
    ..It is therefore concluded that the monocyte-stimulating activity of M. tuberculosis Cpn60.1 resides in the monomeric subunit and within this subunit the biological activity is due to the equatorial domain...
  75. ncbi request reprint Circulating human heat shock protein 60 in the blood of healthy teenagers: a novel determinant of endothelial dysfunction and early vascular injury?
    Julian P J Halcox
    Arterioscler Thromb Vasc Biol 25:e141-2. 2005
  76. pmc Mycobacterium tuberculosis chaperonin 10 is secreted in the macrophage phagosome: is secretion due to dissociation and adoption of a partially helical structure at the membrane?
    Gianluca Fossati
    Italfarmaco Research Centre, Cinisello Balsamo 20092, Milan, Italy
    J Bacteriol 185:4256-67. 2003
    ..These results suggest that dissociation to partially helical monomers and interaction with acidic lipids may be two important steps in the mechanism of secretion of M. tuberculosis Cpn10 to the external environment...
  77. ncbi request reprint Improved yield of recombinant merozoite Surface protein 3 (MSP3) from Pichia pastoris using chemically defined media
    Jin Wang
    Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5640 Fishers Lane, Rockville, Maryland 20852, USA
    Biotechnol Bioeng 90:838-47. 2005
    ..pastoris biomass generated at a high specific growth rate (0.04/h) nor low induction temperatures during induction improved yield. Nitrogen source was the most important factor affecting expression of MSP3 in defined media...
  78. ncbi request reprint The unusual chaperonins of Mycobacterium tuberculosis
    Rohini Qamra
    Centre for DNA Fingerprinting and Diagnostics, ECIL Road, Nacharam, Hyderabad 500 076, India
    Tuberculosis (Edinb) 85:385-94. 2005
    ..Recent work has shown intriguing structural, biochemical and signaling properties of the M. tuberculosis chaperonins. This review details the recent developments in the study of the M. tuberculosis chaperonins...
  79. pmc A Mycobacterium tuberculosis mutant lacking the groEL homologue cpn60.1 is viable but fails to induce an inflammatory response in animal models of infection
    Yanmin Hu
    Medical Microbiology, Centre of Infection, Division of Cellular and Molecular Medicine, St George s University of London, London SW17 ORE, United Kingdom
    Infect Immun 76:1535-46. 2008
    ..Cell wall lipid acid composition was not altered in the mutant strain. Thus, it appears that Cpn60.1 is an important agent in the regulation of the cytokine-dependent granulomatous response in M. tuberculosis infection...
  80. ncbi request reprint The Mycobacterium tuberculosis chaperonin 10 monomer exhibits structural plasticity
    Gianluca Fossati
    Italfarmaco Research Centre, via Lavoratori 54, Cinisello Balsamo 20092 Milan, Italy
    Biopolymers 75:148-62. 2004
    ..Finally, the monomer self-associates in the pH range 5.8-2.9, where it forms small oligomers. A structure-activity relationship was investigated with the sequences known to be involved in the various biological activities of the monomer...