Research Topics
| B HendersonSummaryAffiliation: University College London Country: UK Publications
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Publications
Bacterial modulins: a novel class of virulence factors which cause host tissue pathology by inducing cytokine synthesisB Henderson
Maxillofacial Surgery Research Unit, University College London, United Kingdom
Microbiol Rev 60:316-41. 1996..We propose that modulins, by controlling the host immune and inflammatory responses, maintain the large commensal flora that all multicellular organisms support...- Caught with their PAMPs down? The extracellular signalling actions of molecular chaperones are not due to microbial contaminantsBrian Henderson
UCL Eastman Dental Institute, University College London, UK
Cell Stress Chaperones 15:123-41. 2010..They show that sufficient evidence exists to support fully the hypothesis that molecular chaperones have cell-cell signalling actions that are likely to be part of the homeostatic mechanism of the vertebrate... - Unfolding the relationship between secreted molecular chaperones and macrophage activation statesBrian Henderson
Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, London, UK
Cell Stress Chaperones 14:329-41. 2009.... - Oral bacterial disease and the science of cellular conversationBrian Henderson
Cellular Microbiology Research Group, Eastman Dental Institute, University College London, 256 Gray's Inn Road, London WC1X 8LD, UK
J R Soc Med 95:77-80. 2002 
The search for the chaperonin 60 receptorsBrian Henderson
Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X 8LD, UK
Methods 43:223-8. 2007..BiP appears to be one of these receptor proteins but more work is needed to identify those responsible for signalling. Of interest, CD14 and TLR4 were not identified in this study as a receptor for Cpn60.1...- Stress wars: the direct role of host and bacterial molecular chaperones in bacterial infectionBrian Henderson
Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray's Inn Road, London WC1X, United Kingdom
Infect Immun 74:3693-706. 2006 - Hard labour: bacterial infection of the skeletonBrian Henderson
Division of Infection and Immunity, Eastman Dental Institute, University College London, 256 Gray s Inn Road, WC1X 8LD, London, UK
Trends Microbiol 11:570-7. 2003..The host cellular pathways that are activated and lead to destruction or loss of the bone matrix will be described... - Molecular pathogenicity of the oral opportunistic pathogen Actinobacillus actinomycetemcomitansBrian Henderson
Cellular Microbiology Research Group, Eastman Dental Institute, University College London, London WC1X 8LD, United Kingdom
Annu Rev Microbiol 57:29-55. 2003..This review focuses on recent advances in our understanding of the molecular and cellular pathogenicity of this fascinating oral bacterium... - Out of one eye: a life integrating cellular biochemistry and functionBrian Henderson
Division of Infection and Immunity, Eastman Dental Institute, University College London, UK
Cell Biochem Funct 21:201-6. 2003 - Bacterial virulence in the moonlight: multitasking bacterial moonlighting proteins are virulence determinants in infectious diseaseBrian Henderson
Department of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X 8LD, United Kingdom
Infect Immun 79:3476-91. 2011.... - Actinobacillus actinomycetemcomitansBrian Henderson
Cellular Microbiology Research Group, Eastman Dental Institute, University College London, London
J Med Microbiol 51:1013-20. 2002 - Microbial/host interactions in health and disease: who controls the cytokine network?B Henderson
Maxillofacial Surgery Research Unit Eastman Dental Institute for Oral Health Care Sciences, University College London, UK
Immunopharmacology 35:1-21. 1996.... 
Fibronectin: a multidomain host adhesin targeted by bacterial fibronectin-binding proteinsBrian Henderson
Department of Microbial Diseases, UCL Eastman Dental Institute, University College London, London, UK
FEMS Microbiol Rev 35:147-200. 2011..This article provides an update on our current understanding of FnBPs from both Gram-negative and Gram-positive bacteria and their proposed roles in bacterial colonization, bacterial virulence and bacteria-host interactions...- Molecular chaperones and protein-folding catalysts as intercellular signaling regulators in immunity and inflammationBrian Henderson
Department of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray s Inn Rd, London, WC1X 8LD, UK
J Leukoc Biol 88:445-62. 2010..The most fascinating aspect of molecular chaperones probably relates to evidence for their therapeutic potential in human disease, and ongoing studies are evaluating this potential in a range of clinical settings... - Are bacterial exotoxins cytokine network regulators?B Henderson
Cellular Microbiology Research Group, Eastman Dental Institute, University College London, UK
Trends Microbiol 5:454-8. 1997..Cytokine induction may play a significant role in exotoxin action, and therapeutic targeting of cytokines could be beneficial in infectious diseases involving bacterial exotoxins... - Cellular microbiology: cycling into the millenniumB Henderson
Cellular Microbiology Research Group, Eastman Dental Institute, London, UK
Trends Cell Biol 8:384-7. 1998..This article discusses the cell-cycle effects of bacterially generated molecules, their role in virulence and their possible therapeutic potential... - Multiple moonlighting functions of mycobacterial molecular chaperonesBrian Henderson
Department of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X 8LD, United Kingdom
Tuberculosis (Edinb) 90:119-24. 2010..This brief overview highlights the potential importance of the moonlighting functions of molecular chaperones in the biology and pathobiology of the mycobacteria... - Cloning and expression of the Actinobacillus actinomycetemcomitans thioredoxin (trx) gene and assessment of cytokine inhibitory activityB Henderson
Cellular Microbiology Research Group, Eastman Dental Institute, University College London, London WC1X 8LD, United Kingdom
Infect Immun 69:154-8. 2001..We therefore conclude that the thioredoxin of A. actinomycetemcomitans does not act as an immunosuppressive factor, at least with human leukocytes in cultures, and that the identity of SF1 remains to be elucidated... - Integrating the cell stress response: a new view of molecular chaperones as immunological and physiological homeostatic regulatorsBrian Henderson
UCL Eastman Dental Institute, University College London, UK
Cell Biochem Funct 28:1-14. 2010..An important consideration is the role that these proteins may play in human disease and in the treatment of human disease... - Mycobacterium tuberculosis chaperonin 60.1 is a more potent cytokine stimulator than chaperonin 60.2 (Hsp 65) and contains a CD14-binding domainJ C Lewthwaite
Cellular Microbiology Research Group, Eastman Dental Institute, University College London, London, United Kingdom
Infect Immun 69:7349-55. 2001..The cytokine-inducing activity of both chaperonins is extremely resistant to heat. Cpn 60.1 may be an important virulence factor in tuberculosis, able to activate cells by diverse receptor-driven mechanisms... - Staphylococcus aureus fibronectin binding proteins are essential for internalization by osteoblasts but do not account for differences in intracellular levels of bacteriaS Ahmed
Cellular Microbiology Research Group, Eastman Dental Institute, University College London, United Kingdom
Infect Immun 69:2872-7. 2001..aureus are internalized by osteoblasts to different extents and suggest that in addition to the fibronectin binding proteins there are other, as yet undetermined virulence factors that play a role in the internalization process... - Recombinant Actinobacillus actinomycetemcomitans cytolethal distending toxin proteins are required to interact to inhibit human cell cycle progression and to stimulate human leukocyte cytokine synthesisS Akifusa
Cellular Microbiology Research Group, Eastman Dental Institute, University College London, London WC1X 8LD, United Kingdom
Infect Immun 69:5925-30. 2001..There was evidence of synergism between these Cdt proteins in the stimulation of cytokine production, most markedly with gamma interferon, which required the minimum interaction of CdtB and -C to stimulate production... - Human chaperonin 60 (Hsp60) stimulates bone resorption: structure/function relationshipsS Meghji
Cellular Microbiology Research Group, Eastman Dental Institute, University College London, 256 Gray's Inn Road, London WC1X 8LD, UK
Bone 33:419-25. 2003..The possibility exists that this protein could play a role in bone remodelling... - Expression of the S. aureus hysA gene in S. carnosus from a modified E. coli-staphylococcal shuttle vectorR J Williams
Cellular Microbiology Research Group, Division of Surgical Sciences, Eastman Dental Institute, UK
Plasmid 47:241-5. 2002..carnosus. Hyaluronate lyase was both produced and secreted by S. carnosus. In addition, the secreted HysA protein was enzymatically active, as determined using a zymographic assay... - Analysis of the effect of changing environmental conditions on the expression patterns of exported surface-associated proteins of the oral pathogen Actinobacillus actinomycetemcomitansJ M Fletcher
Department of Microbiology, Eastman Dental Institute, University College London, 256 Grays Inn Road, London WC1X 8LD, UK
Microb Pathog 30:359-68. 2001..An ability to adapt to prevailing environmental conditions may facilitate the survival of the organism in the changing microIenvironment of the periodontal pocket... - Bacterial resuscitation factors: revival of viable but non-culturable bacteriaN H Keep
School of Crystallography and Institute of Structural Molecular Biology, Birkbeck, University of London, Malet Street, London, WC1E 7HX, United Kingdom
Cell Mol Life Sci 63:2555-9. 2006 - Identification of a novel gene cluster encoding staphylococcal exotoxin-like proteins: characterization of the prototypic gene and its protein product, SET1R J Williams
Cellular Microbiology Research Group, Division of Surgical Sciences, University College London, London, United Kingdom
Infect Immun 68:4407-15. 2000..The distribution of allelic variants of the set genes among strains of S. aureus may contribute to differences in the pathogenic potential of this bacterium... - Identification of photolabile outer membrane proteins of Porphyromonas gingivalisM Bhatti
Department of Microbiology, Eastman Dental Institute for Oral Health Care Sciences, University College London, 256 Grays Inn Road, London WC1X 8LD, UK
Curr Microbiol 43:96-9. 2001..Using a combination of Western blotting and protein sequencing the predominant photolabile proteins in P. gingivalis have been identified as the major secreted/cell surface proteases--Lys and Arg gingipain... - Pathogen burden and cortisol profiles over the dayA Steptoe
Department of Epidemiology and Pubic Health, University College London, UK
Epidemiol Infect 137:1816-24. 2009..We conclude that pathogen burden is independently associated with flatter cortisol slopes over the day, and may contribute to disturbed neuroendocrine regulation... - Bacterial porins stimulate bone resorptionS Meghji
Division of Surgical Sciences, Eastman Dental Institute, University College London, United Kingdom
Infect Immun 65:1313-6. 1997.... - Pro-inflammatory--anti-inflammatory cytokine dynamics mediated by cytokine-receptor dynamics in monocytesR M Seymour
Department of Mathematics, University College London, UK
IMA J Math Appl Med Biol 18:159-92. 2001..These behaviours depend crucially on the form of the cell's response functions. The possible biological implications of these phenomena are discussed... - Effect of Mycobacterium tuberculosis chaperonins on bronchial eosinophilia and hyper-responsiveness in a murine model of allergic inflammationY Riffo-Vasquez
Sackler Institute of Pulmonary Pharmacology, GKT School of Biomedical Science and Medicine, King's College London, London, UK
Clin Exp Allergy 34:712-9. 2004..1. CONCLUSION: These data show that bacterial Cpns can suppress eosinophil recruitment and bronchial hyper-responsiveness in a murine model of allergic inflammation... - Staphylococcus aureus fibronectin binding proteins A and B possess a second fibronectin binding region that may have biological relevance to bone tissuesR J Williams
Cellular Microbiology Research Group, Division of Surgical Sciences, Eastman Dental Institute for Oral Health Care Sciences, University College London, London, UK
Calcif Tissue Int 70:416-21. 2002..Analysis of these binding regions for their ability to bind to other extracellular matrix proteins revealed a preference for fibronectin, with slight binding to fibrinogen and no binding to collagen or laminin... - Mycobacterium tuberculosis chaperonin 10 stimulates bone resorption: a potential contributory factor in Pott's diseaseS Meghji
Maxillofacial Surgery Research Unit, Eastman Dental Institute, University College London, United Kingdom
J Exp Med 186:1241-6. 1997..Our findings suggest that Mt cpn10 may be a valuable pharmacological target for the clinical therapy of vertebral tuberculosis and possibly other bone diseases... - Socioeconomic status, pathogen burden and cardiovascular disease riskA Steptoe
Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London WC1E 6BT, UK
Heart 93:1567-70. 2007..Cumulative pathogen burden may also predict future CHD. The hypothesis was tested that lower SES is associated with a greater pathogen burden, and that pathogen burden accounts in part for SES differences in cardiovascular risk factors... - Identification of the exported proteins of the oral opportunistic pathogen Actinobacillus actinomycetemcomitans by using alkaline phosphatase fusionsJ Ward
Molecular Microbiology Group, Department of Biochemistry and Molecular Biology, University College London, London WC1E 6BT
Infect Immun 69:2748-52. 2001..The proteins encoded by these genes may, by virtue of their presence on the cell surface, be novel virulence determinants... - Phage display in the study of infectious diseasesLisa M Mullen
Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X 8LD, UK
Trends Microbiol 14:141-7. 2006..In particular, this technique has proved successful in identifying microbial adhesins that are vital for colonization... - Stressing the obvious? Cell stress and cell stress proteins in cardiovascular diseaseAlireza Shamaei-Tousi
Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X 8LD, UK
Cardiovasc Res 74:19-28. 2007..This review brings these various strands of research together to provide an overview of the role of molecular chaperones in cardiovascular disease... - Comparative functional genomic analysis of Pasteurellaceae adhesins using phage displayLisa M Mullen
Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, London WC1X 8LD, United Kingdom
Vet Microbiol 122:123-34. 2007..pleuropneumoniae. None of these genes have previously been proposed to code for adhesins. The applications of phage display with whole bacterial genomes to identify genes encoding novel adhesins in this family of bacteria are discussed... - Periodontal infectogenomicsLuigi Nibali
Periodontology Unit and Division of Clinical Research, UCL Eastman Dental Institute, University College London, London, UK
J Med Microbiol 58:1269-74. 2009..Mechanisms of interaction between genetic and microbiological factors and prospects for future studies will be discussed... - Novel adhesin from Pasteurella multocida that binds to the integrin-binding fibronectin FnIII9-10 repeatsLisa M Mullen
Division of Microbial Diseases, Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X 8LD, United Kingdom
Infect Immun 76:1093-104. 2008..These results support the hypothesis that the PM1665 protein is a member of a new family of fibronectin binding adhesins that are important in the adhesion of P. multocida to fibronectin... - Chaperonin 60 unfolds its secrets of cellular communicationMaria Maguire
Cellular Microbiology Research Group, Eastman Dental Institute, University College London, 256 Grays Inn Road, London WC1X 8LD, UK
Cell Stress Chaperones 7:317-29. 2002..This review discusses the work to date, which has revealed the cell-cell signaling actions of Cpn60 proteins... - Pasteurellaceae ComE1 proteins combine the properties of fibronectin adhesins and DNA binding competence proteinsLisa M Mullen
Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, London, United Kingdom
PLoS ONE 3:e3991. 2008..Inactivation of the gene encoding the ComE1 homologue in Actinobacillus pleuropneumoniae indicates major roles for these proteins in at least two processes: natural transformation, and binding of bacteria to fibronectin... - Cytolethal distending toxin: creating a gap in the cell cycleWendy Heywood
Division of Microbial Diseases, Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X 8LD, UK
J Med Microbiol 54:207-16. 2005..This review encompasses recent work on CDT and focuses on the molecular mechanisms used by this toxin to block cell-cycle progression, the benefit to the bacterium of possession of this toxin and the clinical relevance of intoxication... - Resuscitation-promoting factors are expressed in Mycobacterium tuberculosis-infected human tissueA P Davies
Centre for Medical Microbiology, Department of Infection, Royal Free and University College Medical School, London, UK
Tuberculosis (Edinb) 88:462-8. 2008..The work presented here demonstrates that Rpf expression can be detected in human tissues infected with M. tuberculosis and describes the pattern of this expression using immunocytochemistry with anti-Rpf antibodies... - Comparison of the moonlighting actions of the two highly homologous chaperonin 60 proteins of Mycobacterium tuberculosisAna Cehovin
Department of Microbial Diseases, UCL Eastman Dental Institute, University College London, London, United Kingdom
Infect Immun 78:3196-206. 2010..These results clearly show that, despite significant sequence homology, M. tuberculosis Cpn60 proteins interact in distinct ways with human or murine macrophages... - Highly homologous Mycobacterium tuberculosis chaperonin 60 proteins with differential CD14 dependencies stimulate cytokine production by human monocytes through cooperative activation of p38 and ERK1/2 mitogen-activated protein kinasesJo C Lewthwaite
Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, UK
Int Immunopharmacol 7:230-40. 2007.... - Mechanism of internalization of the cytolethal distending toxin of Actinobacillus actinomycetemcomitansSumio Akifusa
Division of Microbial Diseases, Eastman Dental Institute, University College London, 256 Gray's Inn Road, London WC1X 8LD, UK
Microbiology 151:1395-402. 2005.... - The structure of a resuscitation-promoting factor domain from Mycobacterium tuberculosis shows homology to lysozymesMartin Cohen-Gonsaud
School of Crystallography and Institute for Structural Molecular Biology, Birkbeck College, University of London, Malet Street, London, WC1E 7HX, UK
Nat Struct Mol Biol 12:270-3. 2005..These data, as well as the presence of a clear binding pocket for a large molecule, indicate that oligosaccharide cleavage is probably the signal for revival from dormancy... - Chaperonins in disease: mechanisms, models, and treatmentsJ C Ranford
Cellular Microbiology Research Group, Eastman Dental Institute, University College London, 256 Gray's Inn Road, London WC1X 8LD, UK
Mol Pathol 55:209-13. 2002..This review focuses on the current knowledge of the roles of Cpn 60 in the pathology of infectious and immune diseases, and discusses models for the actions of this molecule. Some potential therapeutic strategies will also be reviewed... - TNF-alpha neutralization in cytokine-driven diseases: a mathematical model to account for therapeutic success in rheumatoid arthritis but therapeutic failure in systemic inflammatory response syndromeM Jit
Department of Mathematics, University College London, Gower Street, London WC1E 6BT, UK
Rheumatology (Oxford) 44:323-31. 2005..CONCLUSIONS: These results may explain the effectiveness of TNF-alpha blockade in the equilibrium condition RA and the ineffectiveness in the non-equilibrium condition SIRS... - Identification of a fibronectin-binding protein from Staphylococcus epidermidisRachel J Williams
Cellular Microbiology Research Group, Eastman Dental Institute for Oral Health Care Sciences, University College London, United Kingdom
Infect Immun 70:6805-10. 2002..aureus fibronectin-binding protein FnBPB, blocked binding of S. aureus to fibronectin but had a negligible effect on the binding of S. epidermidis... - Plasma heat shock protein 60 and cardiovascular disease risk: the role of psychosocial, genetic, and biological factorsAlireza Shamaei-Tousi
Division of Microbial Diseases, Eastman Dental Institute, University College London, London WC1X 8LD, UK
Cell Stress Chaperones 12:384-92. 2007..The extended range of plasma Hsp60 concentrations in the general population is genuine and is likely to be related to genetic, biological, and psychosocial risk factors for coronary artery disease... - Invasion of bone cells by Staphylococcus epidermidisHesham Khalil
Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X 8LD, UK
Microbes Infect 9:460-5. 2007..epidermidis. Therefore unlike S. aureus, S. epidermidis does not gain entrance into bone cells through a fibronectin bridge between the alpha5beta1 integrin and a bacterial adhesin... - Rhizobium leguminosarum chaperonin 60.3, but not chaperonin 60.1, induces cytokine production by human monocytes: activity is dependent on interaction with cell surface CD14Jo Lewthwaite
Cellular Microbiology Research Group, Eastman Dental Institute, University College London, UK
Cell Stress Chaperones 7:130-6. 2002..3 was dependent on its interaction with CD14. This demonstrates that CD14 mediates not only lipopolysaccharide but also R. leguminosarum Cpn 60.3 cell signaling in human monocytes... - Comparative cell signalling activity of ultrapure recombinant chaperonin 60 proteins from prokaryotes and eukaryotesMaria Maguire
Division of Microbial Diseases, Eastman Dental Institute, University College London, London, UK
Immunology 115:231-8. 2005.... - Cloning, expression and purification of three Chaperonin 60 homologuesMaria Maguire
Cellular Microbiology Research Group, Eastman Dental Institute, University College London, 256 Grays Inn Road, WC1X 8LD, London, UK
J Chromatogr B Analyt Technol Biomed Life Sci 786:117-25. 2003..Insoluble protein was solubilised using 8 M urea and then re-folded on the nickel column by stepwise removal of the urea. The immunostimulant LPS was removed by addition of the antibiotic polymyxin B as part of the purification process... - In vivo killing of Porphyromonas gingivalis by toluidine blue-mediated photosensitization in an animal modelN Komerik
Department of Microbiology, Eastman Dental Institute for Oral Health Care Sciences, University College London, United Kingdom
Antimicrob Agents Chemother 47:932-40. 2003..gingivalis is possible in vivo and that this results in decreased bone loss. These findings suggest that photodynamic therapy may be useful as an alternative approach for the antimicrobial treatment of periodontitis... - Protective effect of human heat shock protein 60 suggested by its association with decreased seropositivity to pathogensA Steptoe
Department of Epidemiology and Public Health, UCL Eastman Dental Institute, University College London, London, United Kingdom
Clin Vaccine Immunol 14:204-7. 2007.... - Resuscitation-promoting factors possess a lysozyme-like domainMartin Cohen-Gonsaud
School of Crystallography and BBRSC Centre for Structural Biology, Birkbeck College, University of London, Malet Street, London, WC1E 7HX, UK
Trends Biochem Sci 29:7-10. 2004..The model highlights the good conservation of residues involved in catalysis and substrate binding. A lysozyme-like function makes sense for this domain in the light of experimental characterization of the biological function of Rpfs... - Differential regulation of circulating levels of molecular chaperones in patients undergoing treatment for periodontal diseaseAlireza Shamaei-Tousi
Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, London, United Kingdom
PLoS ONE 2:e1198. 2007..We have used periodontitis and its treatment as a model of inflammation in the human to determine its effects on levels of circulating HSP10, HSP60 and BiP... - Cell stress proteins as modulators of bacteria--host interactionsBrian Henderson
Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X 8LD, UK
Novartis Found Symp 291:141-54; discussion 154-9, 221-4. 2008..In insects, endosymbiotic bacteria provide bacterial CSPs which are utilised by the host. Bacterial CSPs have also been shown to be antibacterial targets. These findings establish a range of roles for CSPs in bacteria-host interactions... - Circulating human heat shock protein 60 in the plasma of British civil servants: relationship to physiological and psychosocial stressJo Lewthwaite
Cellular Microbiology Research Group, University College London, London, UK
Circulation 106:196-201. 2002..To identify mechanisms responsible for susceptibility to CHD, specific biological markers of stress are increasingly being measured. One marker linked to susceptibility to CHD is heat shock protein (Hsp) 60... - Wake up! Peptidoglycan lysis and bacterial non-growth statesNicholas H Keep
School of Crystallography and Institute of Structural Molecular Biology, Birkbeck, University of London, Malet Street, London, UK, WC1E 7HX
Trends Microbiol 14:271-6. 2006.... - Stress cytokines: pivotal proteins in immune regulatory networks; OpinionGabriel S Panayi
Academic Department of Rheumatology, Guy s, King s and St Thomas School of Medicine, Guy s Hospital, King s College, London, SE1 9RT, United Kingdom
Curr Opin Immunol 16:531-4. 2004..We predict that the exploitation of the downregulatory properties of stress cytokines will have therapeutic applications in the treatment of human chronic inflammatory diseases, such as rheumatoid arthritis... - Streptococcus sanguis secretes CD14-binding proteins that stimulate cytokine synthesis: a clue to the pathogenesis of infective (bacterial) endocarditis?Julia Banks
Cellular Microbiology Research Group, Eastman Dental Institute, University College London, 256 Gray s Inn Road, London, Hertfordshire, WC1X 8LD, U K
Microb Pathog 32:105-16. 2002..In addition, blocking of CD14 may have some therapeutic benefit... - Ion-specific effects on the interaction between fibronectin and negatively charged mica surfacesMatthew D Heath
Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, United Kingdom
Langmuir 26:5304-8. 2010..The origin of this ion-specific effect is discussed... - Structural relationships and cellular tropism of staphylococcal superantigen-like proteinsAli M Al-Shangiti
Department of Immunology and Molecular Pathology, University College London, 46 Cleveland Street, London W1T 4JF, United Kingdom
Infect Immun 72:4261-70. 2004..Like classical superantigens, therefore, SSLs may distract the host's immune system, but they may do so via entirely different molecular mechanisms... - The relationship between carotid stiffness and circulating levels of heat shock protein 60 in middle-aged men and womenElizabeth Ellins
Vascular Physiology Unit, Institute of Child Health, University College London, UK
J Hypertens 26:2389-92. 2008..In this study, we measured the association between plasma HSP60 and carotid arterial stiffness in middle-aged men and women... - Association between plasma levels of heat shock protein 60 and cardiovascular disease in patients with diabetes mellitusAlireza Shamaei-Tousi
Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray's Inn Road, London WC1X 8LD, UK
Eur Heart J 27:1565-70. 2006.... - The two homologous chaperonin 60 proteins of Mycobacterium tuberculosis have distinct effects on monocyte differentiation into osteoclastsVivienne R Winrow
School for Health and Royal National Hospital for Rheumatic Diseases, University of Bath, Bath BA2 7AY, UK
Cell Microbiol 10:2091-104. 2008..Taken together, these findings reveal that M. tuberculosis Cpn60.1 is a potent and novel inhibitor of osteoclastogenesis both in vitro and in vivo and a potential cure for bone-resorptive diseases like osteoporosis... - Microbiology. We get by with a little help from our (little) friendsEdward Ruby
Pacific Biomedical Research Center, Kewalo Marine Laboratory, University of Hawaii, Honolulu, HI 96813, USA
Science 303:1305-7. 2004 - Staphylococcus aureus capsular material promotes osteoclast formationYu Sin Lau
Department of Pathology, Nuffield Department of Orthopaedic Surgery, University of Oxford, Nuffield Orthopaedic Centre, Oxford, United Kingdom
Injury 37:S41-8. 2006..aureus SAM and that S. aureus SAM contains a soluble factor that promotes osteoclast formation by a RANKL-independent mechanism... - The intercellular signaling activity of the Mycobacterium tuberculosis chaperonin 60.1 protein resides in the equatorial domainPeter Tormay
Department of Cellular and Molecular Medicine, St George s Hospital Medical School, Cranmer Terrace, London
J Biol Chem 280:14272-7. 2005..It is therefore concluded that the monocyte-stimulating activity of M. tuberculosis Cpn60.1 resides in the monomeric subunit and within this subunit the biological activity is due to the equatorial domain... - Circulating human heat shock protein 60 in the blood of healthy teenagers: a novel determinant of endothelial dysfunction and early vascular injury?Julian P J Halcox
Arterioscler Thromb Vasc Biol 25:e141-2. 2005 - Mycobacterium tuberculosis chaperonin 10 is secreted in the macrophage phagosome: is secretion due to dissociation and adoption of a partially helical structure at the membrane?Gianluca Fossati
Italfarmaco Research Centre, Cinisello Balsamo 20092, Milan, Italy
J Bacteriol 185:4256-67. 2003..These results suggest that dissociation to partially helical monomers and interaction with acidic lipids may be two important steps in the mechanism of secretion of M. tuberculosis Cpn10 to the external environment... - Improved yield of recombinant merozoite Surface protein 3 (MSP3) from Pichia pastoris using chemically defined mediaJin Wang
Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5640 Fishers Lane, Rockville, Maryland 20852, USA
Biotechnol Bioeng 90:838-47. 2005..pastoris biomass generated at a high specific growth rate (0.04/h) nor low induction temperatures during induction improved yield. Nitrogen source was the most important factor affecting expression of MSP3 in defined media... - The unusual chaperonins of Mycobacterium tuberculosisRohini Qamra
Centre for DNA Fingerprinting and Diagnostics, ECIL Road, Nacharam, Hyderabad 500 076, India
Tuberculosis (Edinb) 85:385-94. 2005..Recent work has shown intriguing structural, biochemical and signaling properties of the M. tuberculosis chaperonins. This review details the recent developments in the study of the M. tuberculosis chaperonins... - A Mycobacterium tuberculosis mutant lacking the groEL homologue cpn60.1 is viable but fails to induce an inflammatory response in animal models of infectionYanmin Hu
Medical Microbiology, Centre of Infection, Division of Cellular and Molecular Medicine, St George s University of London, London SW17 ORE, United Kingdom
Infect Immun 76:1535-46. 2008..Cell wall lipid acid composition was not altered in the mutant strain. Thus, it appears that Cpn60.1 is an important agent in the regulation of the cytokine-dependent granulomatous response in M. tuberculosis infection... - The Mycobacterium tuberculosis chaperonin 10 monomer exhibits structural plasticityGianluca Fossati
Italfarmaco Research Centre, via Lavoratori 54, Cinisello Balsamo 20092 Milan, Italy
Biopolymers 75:148-62. 2004..Finally, the monomer self-associates in the pH range 5.8-2.9, where it forms small oligomers. A structure-activity relationship was investigated with the sequences known to be involved in the various biological activities of the monomer...