Janet Hemingway

Summary

Affiliation: University of Liverpool
Country: UK

Publications

  1. pmc The emergence of insecticide resistance in central Mozambique and potential threat to the successful indoor residual spraying malaria control programme
    Ana P Abilio
    1National Institute of Health, Av Eduardo Mondlane Salvador Allende, PO Box 264, Maputo, Mozambique
    Malar J 10:110. 2011
  2. pmc Multiple insecticide resistance mechanisms involving metabolic changes and insensitive target sites selected in anopheline vectors of malaria in Sri Lanka
    M Devika B Perera
    Department of Zoology, Faculty of Science, University of Peradeniya, Peradeniya, Sri Lanka
    Malar J 7:168. 2008
  3. pmc Expression of the cytochrome P450s, CYP6P3 and CYP6M2 are significantly elevated in multiple pyrethroid resistant populations of Anopheles gambiae s.s. from Southern Benin and Nigeria
    Rousseau F Djouaka
    International Institute of Tropical Agriculture, Cotonou, 08BP0932, Benin
    BMC Genomics 9:538. 2008
  4. ncbi request reprint The Innovative Vector Control Consortium: improved control of mosquito-borne diseases
    Janet Hemingway
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK, L3 5QA
    Trends Parasitol 22:308-12. 2006
  5. ncbi request reprint The molecular basis of insecticide resistance in mosquitoes
    Janet Hemingway
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Insect Biochem Mol Biol 34:653-65. 2004
  6. pmc Two duplicated P450 genes are associated with pyrethroid resistance in Anopheles funestus, a major malaria vector
    Charles S Wondji
    Liverpool School of Tropical Medicine, Liverpool, L3 5QA, United Kingdom
    Genome Res 19:452-9. 2009
  7. doi request reprint Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed
    Bradley J Stevenson
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Insect Biochem Mol Biol 41:492-502. 2011
  8. pmc Impact of pyrethroid resistance on operational malaria control in Malawi
    Charles S Wondji
    Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom
    Proc Natl Acad Sci U S A 109:19063-70. 2012
  9. pmc Mapping a quantitative trait locus (QTL) conferring pyrethroid resistance in the African malaria vector Anopheles funestus
    Charles S Wondji
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK
    BMC Genomics 8:34. 2007
  10. ncbi request reprint Genomic analysis of detoxification genes in the mosquito Aedes aegypti
    Clare Strode
    Vector Group, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK
    Insect Biochem Mol Biol 38:113-23. 2008

Detail Information

Publications50

  1. pmc The emergence of insecticide resistance in central Mozambique and potential threat to the successful indoor residual spraying malaria control programme
    Ana P Abilio
    1National Institute of Health, Av Eduardo Mondlane Salvador Allende, PO Box 264, Maputo, Mozambique
    Malar J 10:110. 2011
    ..In 2007, these efforts were strengthened by the President's Malaria Initiative. This manuscript reports on the monitoring and evaluation of this programme as carried out by the Malaria Decision Support Project...
  2. pmc Multiple insecticide resistance mechanisms involving metabolic changes and insensitive target sites selected in anopheline vectors of malaria in Sri Lanka
    M Devika B Perera
    Department of Zoology, Faculty of Science, University of Peradeniya, Peradeniya, Sri Lanka
    Malar J 7:168. 2008
    ....
  3. pmc Expression of the cytochrome P450s, CYP6P3 and CYP6M2 are significantly elevated in multiple pyrethroid resistant populations of Anopheles gambiae s.s. from Southern Benin and Nigeria
    Rousseau F Djouaka
    International Institute of Tropical Agriculture, Cotonou, 08BP0932, Benin
    BMC Genomics 9:538. 2008
    ..The mosquitoes were sampled from a variety of breeding sites in a preliminary attempt to investigate the role of contamination of mosquito breeding sites in selecting for resistance in adult mosquitoes...
  4. ncbi request reprint The Innovative Vector Control Consortium: improved control of mosquito-borne diseases
    Janet Hemingway
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK, L3 5QA
    Trends Parasitol 22:308-12. 2006
    ....
  5. ncbi request reprint The molecular basis of insecticide resistance in mosquitoes
    Janet Hemingway
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Insect Biochem Mol Biol 34:653-65. 2004
    ..This paper reviews what is currently known about insecticide resistance conferred by metabolic or target site changes in mosquitoes...
  6. pmc Two duplicated P450 genes are associated with pyrethroid resistance in Anopheles funestus, a major malaria vector
    Charles S Wondji
    Liverpool School of Tropical Medicine, Liverpool, L3 5QA, United Kingdom
    Genome Res 19:452-9. 2009
    ..This will be a major advance for insecticide resistance management in malaria vectors, which requires the early detection of resistance alleles...
  7. doi request reprint Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed
    Bradley J Stevenson
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Insect Biochem Mol Biol 41:492-502. 2011
    ..gambiae, consistent with a role in detoxification. Our data indicates that CYP6M2 plays an important role in metabolic resistance to pyrethroids and thus an important target for the design of new tools to combat malaria...
  8. pmc Impact of pyrethroid resistance on operational malaria control in Malawi
    Charles S Wondji
    Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom
    Proc Natl Acad Sci U S A 109:19063-70. 2012
    ..This should be monitored carefully as part of the operational activities in country...
  9. pmc Mapping a quantitative trait locus (QTL) conferring pyrethroid resistance in the African malaria vector Anopheles funestus
    Charles S Wondji
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK
    BMC Genomics 8:34. 2007
    ..Microsatellite and SNP markers were used to construct a linkage map and to detect a quantitative trait locus (QTL) associated with pyrethroid resistance in the FUMOZ-R strain of An. funestus from Mozambique...
  10. ncbi request reprint Genomic analysis of detoxification genes in the mosquito Aedes aegypti
    Clare Strode
    Vector Group, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK
    Insect Biochem Mol Biol 38:113-23. 2008
    ..This 'Ae. aegypti Detox Chip' will facilitate the implementation of insecticide resistance management strategies for arboviral control programmes...
  11. ncbi request reprint An adult-specific CYP6 P450 gene is overexpressed in a pyrethroid-resistant strain of the malaria vector, Anopheles gambiae
    Dimitra Nikou
    Vector Biology Division, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK
    Gene 318:91-102. 2003
    ..The isolation of An. gambiae cDNAs encoding cytochrome b(5) and nicotinamide adenine dinucleotide phosphate (reduced form) (NADPH)-cytochrome P450 reductase cDNAs is also reported...
  12. pmc Country-level operational implementation of the Global Plan for Insecticide Resistance Management
    Janet Hemingway
    Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom
    Proc Natl Acad Sci U S A 110:9397-402. 2013
    ..The methods used provide a template for evidence-based insecticide resistance management by malaria control programs...
  13. pmc The Anopheles gambiae glutathione transferase supergene family: annotation, phylogeny and expression profiles
    Yunchuan Ding
    Vector Research Group, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK
    BMC Genomics 4:35. 2003
    ..We compared the expression level of all members of this GST class in two strains of A. gambiae to determine whether epsilon GST expression is correlated with insecticide resistance status...
  14. ncbi request reprint Elevated activity of an Epsilon class glutathione transferase confers DDT resistance in the dengue vector, Aedes aegypti
    Nongkran Lumjuan
    Vector Research Group, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK
    Insect Biochem Mol Biol 35:861-71. 2005
    ..Characterisation of recombinant AaGSTE2-2 confirmed the role of this enzyme in DDT metabolism. In addition, unlike its Anopheles ortholog, AaGSTE2-2 also exhibited glutathione peroxidase activity...
  15. ncbi request reprint Mosquito glutathione transferases
    Hilary Ranson
    Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    Methods Enzymol 401:226-41. 2005
    ..In this review, we first discuss the diversity of insect GST enzymes and their mode of action before focusing on the various functions that have been attributed to specific mosquito GSTs...
  16. pmc Monitoring the operational impact of insecticide usage for malaria control on Anopheles funestus from Mozambique
    Sonia L R Casimiro
    National Institute of Health, Av Eduardo Mondlane Salvador Allende, Maputo, Mozambique, P O Box 264, Liverpool, UK
    Malar J 6:142. 2007
    ..Low level resistance was detected by biochemical assay to bendiocarb in 1999 in both An. funestus and Anopheles arabiensis, although this was not evident in WHO bioassays of the same population...
  17. pmc The Anopheles gambiae detoxification chip: a highly specific microarray to study metabolic-based insecticide resistance in malaria vectors
    Jean Philippe David
    Vector Research Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L35QA, United Kingdom
    Proc Natl Acad Sci U S A 102:4080-4. 2005
    ..The applications of this detox chip and its potential contribution to malaria vector insecticide resistance management programs are discussed...
  18. pmc Field-caught permethrin-resistant Anopheles gambiae overexpress CYP6P3, a P450 that metabolises pyrethroids
    Pie Müller
    Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    PLoS Genet 4:e1000286. 2008
    ..This is the first study to demonstrate the capacity of a P450 identified in wild A. gambiae to metabolise insecticides. The findings add to the understanding of the genetic basis of insecticide resistance in wild mosquito populations...
  19. doi request reprint Characterization of knockdown resistance in DDT- and pyrethroid-resistant Culex quinquefasciatus populations from Sri Lanka
    Charles S Wondji
    Liverpool School of Tropical Medicine, Liverpool, UK
    Trop Med Int Health 13:548-55. 2008
    ..Furthermore, the high levels of these kdr mutations in C. quinquefasciatus populations throughout Sri Lanka are of concern for the future of pyrethroid-based control programmes on this island...
  20. pmc Pyrethroid activity-based probes for profiling cytochrome P450 activities associated with insecticide interactions
    Hanafy M Ismail
    Vector Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom
    Proc Natl Acad Sci U S A 110:19766-71. 2013
    ....
  21. ncbi request reprint Evolution of supergene families associated with insecticide resistance
    Hilary Ranson
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Science 298:179-81. 2002
    ..The analyses also provide the means for identifying previously unknown molecules involved in fundamental biological processes such as development...
  22. pmc Heterologous expression of four glutathione transferase genes genetically linked to a major insecticide-resistance locus from the malaria vector Anopheles gambiae
    Federica Ortelli
    Liverpool School of Tropical Medicine, Vector Biology Research Group, Pembroke Place, Liverpool L3 5QA, UK
    Biochem J 373:957-63. 2003
    ..Only GSTE2-2 was able to metabolize DDT. Western blots using antibodies raised against these GSTs indicated that the expression of GSTE2-2 is elevated in a DDT-resistant strain of A. gambiae...
  23. ncbi request reprint Developing an evidence-based decision support system for rational insecticide choice in the control of African malaria vectors
    Michael Coleman
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, United Kingdom
    J Med Entomol 43:663-8. 2006
    ....
  24. pmc Characterization of the promoters of Epsilon glutathione transferases in the mosquito Anopheles gambiae and their response to oxidative stress
    Yunchuan Ding
    Vector Research Group, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK
    Biochem J 387:879-88. 2005
    ..In the DDT-resistant strain, expression of GSTe1, GSTe2 and GSTe3 was significantly increased by a 1-h exposure to H2O2, whereas, in the susceptible strain, only GSTe3 expression responded to this treatment...
  25. doi request reprint Lessons from the past: managing insecticide resistance in malaria control and eradication programmes
    Louise Kelly-Hope
    Vector Group, Liverpool School of Tropical Medicine, Liverpool, UK
    Lancet Infect Dis 8:387-9. 2008
    ..Failure to act now will inevitably lead to a future breakdown in disease control and jeopardise hopes of eradicating this major public-health problem...
  26. pmc An integrated genetic and physical map for the malaria vector Anopheles funestus
    Charles S Wondji
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Genetics 171:1779-87. 2005
    ....
  27. pmc Environmental factors associated with the malaria vectors Anopheles gambiae and Anopheles funestus in Kenya
    Louise A Kelly-Hope
    Vector Group, Liverpool School of Tropical Medicine, Liverpool, UK
    Malar J 8:268. 2009
    ....
  28. ncbi request reprint Parasitology. New ways to control malaria
    Janet Hemingway
    Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK
    Science 303:1984-5. 2004
  29. ncbi request reprint Field evaluation of a recombinant glutathione S-transferase-based pyrethroid quantification assay
    Ahmad Ali Enayati
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Trans R Soc Trop Med Hyg 99:369-78. 2005
    ..When the same samples were analysed by HPLC, the dyes were separated from the insecticide by reverse phase column chromatography and hence did not affect the results...
  30. pmc Identification and analysis of single nucleotide polymorphisms (SNPs) in the mosquito Anopheles funestus, malaria vector
    Charles S Wondji
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK
    BMC Genomics 8:5. 2007
    ..Here we report a genome-wide set of SNP markers for use in genetic studies on this important human disease vector...
  31. ncbi request reprint Taking aim at mosquitoes
    Janet Hemingway
    Liverpool School of Tropical Medicine, Liverpool, UK
    Nature 430:936. 2004
  32. ncbi request reprint An overview of insecticide resistance
    Janet Hemingway
    Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK
    Science 298:96-7. 2002
    ..The Anopheles gambiae genome will enable identification of new resistance genes and will provide new molecular targets for the design of more effective insecticides...
  33. ncbi request reprint Short communication: Negative spatial association between lymphatic filariasis and malaria in West Africa
    Louise A Kelly-Hope
    Vector Research Group, Liverpool School of Tropical Medicine, Liverpool, UK
    Trop Med Int Health 11:129-35. 2006
    ..To determine the relationship between human lymphatic filariasis, caused by Wuchereria bancrofti, and falciparum malaria, which are co-endemic throughout West Africa...
  34. ncbi request reprint Susceptibility to three pyrethroids and detection of knockdown resistance mutation in Ghanaian Anopheles gambiae sensu stricto
    Kofi Adasi
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    J Vector Ecol 33:255-62. 2008
    ..However, it is even more important to complement these molecular tools with routine insecticide testing in the field, especially if the insecticides are earmarked for public health use...
  35. ncbi request reprint Malaria parasite and vector genomes: partners in crime
    Alister Craig
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Trends Parasitol 19:356-62. 2003
    ....
  36. pmc Malaria: past problems and future prospects. After more than a decade of neglect, malaria is finally black on the agenda for both biomedical research and public health politics
    Janet Hemingway
    Janet Hemingway and Imelda Bates are at the Liverpool School of Tropical Medicine, Liverpool, UK
    EMBO Rep 4:S29-31. 2003
  37. pmc Evaluating the feasibility of using insecticide quantification kits (IQK) for estimating cyanopyrethroid levels for indoor residual spraying in Vanuatu
    Tanya L Russell
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Malar J 13:178. 2014
    ..This study, therefore, evaluated a user-friendly, rapid colorimetric assay for detecting insecticide content after routine IRS operations were conducted...
  38. pmc The impact of pyrethroid resistance on the efficacy of insecticide-treated bed nets against African anopheline mosquitoes: systematic review and meta-analysis
    Clare Strode
    Liverpool School of Tropical Medicine, Liverpool, United Kingdom Edge Hill University, Ormskirk, United Kingdom
    PLoS Med 11:e1001619. 2014
    ..We therefore assessed the evidence that resistance is attenuating the effect of ITNs on entomological outcomes...
  39. doi request reprint A dehydrochlorinase-based pH change assay for determination of DDT in sprayed surfaces
    Evangelia Morou
    Vector Research, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK
    Anal Biochem 378:60-4. 2008
    ....
  40. pmc Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria
    Giancarlo A Biagini
    Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, University of Liverpool, Liverpool L3 5QA, United Kingdom
    Proc Natl Acad Sci U S A 109:8298-303. 2012
    ....
  41. ncbi request reprint Analysis of the promoters for the beta-esterase genes associated with insecticide resistance in the mosquito Culex quinquefasciatus
    Nicola J Hawkes
    The Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA, Liverpool, UK
    Biochim Biophys Acta 1574:51-62. 2002
    ..The arthropod initiator site TCAGT 135bp upstream of the ATG in both beta-esterase promoters is essential for transcription initiation, but a putative TATA box is not involved...
  42. ncbi request reprint Molecular characterization of the amplified aldehyde oxidase from insecticide resistant Culex quinquefasciatus
    Michael Coleman
    Liverpool School of Tropical Medicine, UK
    Eur J Biochem 269:768-79. 2002
    ..The role of AO in xenobiotic oxidation in mammals and the partial inhibition of elevated AO activity by a range of insecticides in Culex, suggest that this AO may play a role in insecticide resistance...
  43. pmc Purification, molecular cloning and heterologous expression of a glutathione S-transferase involved in insecticide resistance from the rice brown planthopper, Nilaparvata lugens
    John G Vontas
    School of Biosciences, Cardiff University, Main College, Museum Avenue, Cardiff CF10 3TL, Wales, UK
    Biochem J 362:329-37. 2002
    ..Southern analysis of genomic DNA from the resistant and susceptible strains indicated that GST-based insecticide resistance may be associated with gene amplification in N. lugens...
  44. ncbi request reprint Malaria control with genetically manipulated insect vectors
    Luke Alphey
    Oxford University, UK
    Science 298:119-21. 2002
    ..At a recent workshop, experts discussed the benefits, risks, and research priorities associated with using genetically manipulated insects in the control of vector-borne diseases...
  45. ncbi request reprint Structure of an insect delta-class glutathione S-transferase from a DDT-resistant strain of the malaria vector Anopheles gambiae
    Liqing Chen
    Laboratory for Structural Biology, Department of Chemistry, Graduate Programs of Biotechnology, Chemistry and Materials Science, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    Acta Crystallogr D Biol Crystallogr 59:2211-7. 2003
    ..A structure-based model for the binding of DDT to agGSTd1-6 reveals two subpockets in the hydrophobic binding site (H-site), each accommodating one planar p-chlorophenyl ring...
  46. ncbi request reprint Isolation and sequence analysis of P450 genes from a pyrethroid resistant colony of the major malaria vector Anopheles funestus
    Dolphine A Amenya
    Vector Control Reference Unit, National Institute for Communicable Diseases, Private bag X 4, Sandringham 2131, South Africa
    DNA Seq 16:437-45. 2005
    ..Intron positions, but not size, were highly conserved between the two species. The high level of orthology that exists in the P450 gene families of these two species may facilitate the prediction of individual P450 protein function...
  47. ncbi request reprint Knowledge and beliefs about malaria transmission and practices for vector control in southern Mexico
    Américo David Rodríguez
    Centro de Investigacion de Paludismo, Instituto Nacional de Salud Publica, Apartado Postal 537, 30700 Tapachula, Chiapas, Mexico
    Salud Publica Mex 45:110-6. 2003
    ..To investigate the knowledge and beliefs about malaria transmission and practices for vector control in eight villages on the coastal plain of Chiapas, Mexico...
  48. ncbi request reprint The role of agricultural use of insecticides in resistance to pyrethroids in Anopheles gambiae s.l. in Burkina Faso
    Abdoulaye Diabate
    Laboratoire d Entomologie et de Parasitologie, Centre Muraz, Bobo Dioulasso, Burkina Faso
    Am J Trop Med Hyg 67:617-22. 2002
    ..Pyrethroid resistance in west African An. gambiae was conferred by target site insensitivity through a knockdown resistance (kdr)-like mutation, which was present at high frequencies in mosquitoes in the cotton-growing and urban areas...
  49. ncbi request reprint Acceptability and perceived side effects of insecticide indoor residual spraying under different resistance management strategies
    Américo David Rodríguez
    Centro de Investigacion de Paludismo, Instituto Nacional de Salud Publica, Tapachula, Chiapas, Mexico
    Salud Publica Mex 48:317-24. 2006
    ....
  50. ncbi request reprint KDR mutation, a genetic marker to assess events of introgression between the molecular M and S forms of Anopheles gambiae (Diptera: Culicidae) in the tropical savannah area of West Africa
    Abdoulaye Diabate
    Laboratoire de Parasitologie et d Entomologie du Centre Muraz BP 390 Bobo Dioulasso, Burkina Faso
    J Med Entomol 40:195-8. 2003
    ..Pyrethroid resistant An. gambiae were caught in October and November, which is the time of year that the molecular S form migrates into this area as rain-fed breeding sites in the cotton fields dry out...