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Genomes and Genes | Janet HemingwaySummaryAffiliation: University of Liverpool Country: UK Publications
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Publications
The emergence of insecticide resistance in central Mozambique and potential threat to the successful indoor residual spraying malaria control programmeAna P Abilio
1National Institute of Health, Av Eduardo Mondlane Salvador Allende, PO Box 264, Maputo, Mozambique
Malar J 10:110. 2011..In 2007, these efforts were strengthened by the President's Malaria Initiative. This manuscript reports on the monitoring and evaluation of this programme as carried out by the Malaria Decision Support Project...- Multiple insecticide resistance mechanisms involving metabolic changes and insensitive target sites selected in anopheline vectors of malaria in Sri LankaM Devika B Perera
Department of Zoology, Faculty of Science, University of Peradeniya, Peradeniya, Sri Lanka
Malar J 7:168. 2008.... - Expression of the cytochrome P450s, CYP6P3 and CYP6M2 are significantly elevated in multiple pyrethroid resistant populations of Anopheles gambiae s.s. from Southern Benin and NigeriaRousseau F Djouaka
International Institute of Tropical Agriculture, Cotonou, 08BP0932, Benin
BMC Genomics 9:538. 2008..The mosquitoes were sampled from a variety of breeding sites in a preliminary attempt to investigate the role of contamination of mosquito breeding sites in selecting for resistance in adult mosquitoes... 
The molecular basis of insecticide resistance in mosquitoesJanet Hemingway
Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
Insect Biochem Mol Biol 34:653-65. 2004..This paper reviews what is currently known about insecticide resistance conferred by metabolic or target site changes in mosquitoes...- The Innovative Vector Control Consortium: improved control of mosquito-borne diseasesJanet Hemingway
Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK, L3 5QA
Trends Parasitol 22:308-12. 2006.... - Two duplicated P450 genes are associated with pyrethroid resistance in Anopheles funestus, a major malaria vectorCharles S Wondji
Liverpool School of Tropical Medicine, Liverpool, L3 5QA, United Kingdom
Genome Res 19:452-9. 2009..This will be a major advance for insecticide resistance management in malaria vectors, which requires the early detection of resistance alleles... 
Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: Sequential metabolism of deltamethrin revealedBradley J Stevenson
Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
Insect Biochem Mol Biol 41:492-502. 2011..gambiae, consistent with a role in detoxification. Our data indicates that CYP6M2 plays an important role in metabolic resistance to pyrethroids and thus an important target for the design of new tools to combat malaria...- Impact of pyrethroid resistance on operational malaria control in MalawiCharles S Wondji
Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom
Proc Natl Acad Sci U S A 109:19063-70. 2012..This should be monitored carefully as part of the operational activities in country... - Mapping a quantitative trait locus (QTL) conferring pyrethroid resistance in the African malaria vector Anopheles funestusCharles S Wondji
Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK
BMC Genomics 8:34. 2007..Microsatellite and SNP markers were used to construct a linkage map and to detect a quantitative trait locus (QTL) associated with pyrethroid resistance in the FUMOZ-R strain of An. funestus from Mozambique... - An adult-specific CYP6 P450 gene is overexpressed in a pyrethroid-resistant strain of the malaria vector, Anopheles gambiaeDimitra Nikou
Vector Biology Division, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK
Gene 318:91-102. 2003..The isolation of An. gambiae cDNAs encoding cytochrome b(5) and nicotinamide adenine dinucleotide phosphate (reduced form) (NADPH)-cytochrome P450 reductase cDNAs is also reported... - Genomic analysis of detoxification genes in the mosquito Aedes aegyptiClare Strode
Vector Group, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK
Insect Biochem Mol Biol 38:113-23. 2008..This 'Ae. aegypti Detox Chip' will facilitate the implementation of insecticide resistance management strategies for arboviral control programmes... - The Anopheles gambiae glutathione transferase supergene family: annotation, phylogeny and expression profilesYunchuan Ding
Vector Research Group, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK
BMC Genomics 4:35. 2003..We compared the expression level of all members of this GST class in two strains of A. gambiae to determine whether epsilon GST expression is correlated with insecticide resistance status... - Elevated activity of an Epsilon class glutathione transferase confers DDT resistance in the dengue vector, Aedes aegyptiNongkran Lumjuan
Vector Research Group, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK
Insect Biochem Mol Biol 35:861-71. 2005..Characterisation of recombinant AaGSTE2-2 confirmed the role of this enzyme in DDT metabolism. In addition, unlike its Anopheles ortholog, AaGSTE2-2 also exhibited glutathione peroxidase activity... - Mosquito glutathione transferasesHilary Ranson
Liverpool School of Tropical Medicine, Liverpool, United Kingdom
Methods Enzymol 401:226-41. 2005..In this review, we first discuss the diversity of insect GST enzymes and their mode of action before focusing on the various functions that have been attributed to specific mosquito GSTs... - Monitoring the operational impact of insecticide usage for malaria control on Anopheles funestus from MozambiqueSonia L R Casimiro
National Institute of Health, Av Eduardo Mondlane Salvador Allende, Maputo, Mozambique, P O Box 264, Liverpool, UK
Malar J 6:142. 2007..Low level resistance was detected by biochemical assay to bendiocarb in 1999 in both An. funestus and Anopheles arabiensis, although this was not evident in WHO bioassays of the same population... - The Anopheles gambiae detoxification chip: a highly specific microarray to study metabolic-based insecticide resistance in malaria vectorsJean-Philippe David
Vector Research Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L35QA, United Kingdom
Proc Natl Acad Sci U S A 102:4080-4. 2005..The applications of this detox chip and its potential contribution to malaria vector insecticide resistance management programs are discussed... - Characterization of knockdown resistance in DDT- and pyrethroid-resistant Culex quinquefasciatus populations from Sri LankaCharles S Wondji
Liverpool School of Tropical Medicine, Liverpool, UK
Trop Med Int Health 13:548-55. 2008..Furthermore, the high levels of these kdr mutations in C. quinquefasciatus populations throughout Sri Lanka are of concern for the future of pyrethroid-based control programmes on this island... - Field-caught permethrin-resistant Anopheles gambiae overexpress CYP6P3, a P450 that metabolises pyrethroidsPie Müller
Liverpool School of Tropical Medicine, Liverpool, United Kingdom
PLoS Genet 4:e1000286. 2008..This is the first study to demonstrate the capacity of a P450 identified in wild A. gambiae to metabolise insecticides. The findings add to the understanding of the genetic basis of insecticide resistance in wild mosquito populations... - Developing an evidence-based decision support system for rational insecticide choice in the control of African malaria vectorsMichael Coleman
Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, United Kingdom
J Med Entomol 43:663-8. 2006.... - Heterologous expression of four glutathione transferase genes genetically linked to a major insecticide-resistance locus from the malaria vector Anopheles gambiaeFederica Ortelli
Liverpool School of Tropical Medicine, Vector Biology Research Group, Pembroke Place, Liverpool L3 5QA, UK
Biochem J 373:957-63. 2003..Only GSTE2-2 was able to metabolize DDT. Western blots using antibodies raised against these GSTs indicated that the expression of GSTE2-2 is elevated in a DDT-resistant strain of A. gambiae... - Evolution of supergene families associated with insecticide resistanceHilary Ranson
Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
Science 298:179-81. 2002..The analyses also provide the means for identifying previously unknown molecules involved in fundamental biological processes such as development... - Lessons from the past: managing insecticide resistance in malaria control and eradication programmesLouise Kelly-Hope
Vector Group, Liverpool School of Tropical Medicine, Liverpool, UK
Lancet Infect Dis 8:387-9. 2008..Failure to act now will inevitably lead to a future breakdown in disease control and jeopardise hopes of eradicating this major public-health problem... - An integrated genetic and physical map for the malaria vector Anopheles funestusCharles S Wondji
Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
Genetics 171:1779-87. 2005.... - Characterization of the promoters of Epsilon glutathione transferases in the mosquito Anopheles gambiae and their response to oxidative stressYunchuan Ding
Vector Research Group, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK
Biochem J 387:879-88. 2005..In the DDT-resistant strain, expression of GSTe1, GSTe2 and GSTe3 was significantly increased by a 1-h exposure to H2O2, whereas, in the susceptible strain, only GSTe3 expression responded to this treatment... - Field evaluation of a recombinant glutathione S-transferase-based pyrethroid quantification assayAhmad Ali Enayati
Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
Trans R Soc Trop Med Hyg 99:369-78. 2005..When the same samples were analysed by HPLC, the dyes were separated from the insecticide by reverse phase column chromatography and hence did not affect the results... - Parasitology. New ways to control malariaJanet Hemingway
Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK
Science 303:1984-5. 2004 - Environmental factors associated with the malaria vectors Anopheles gambiae and Anopheles funestus in KenyaLouise A Kelly-Hope
Vector Group, Liverpool School of Tropical Medicine, Liverpool, UK
Malar J 8:268. 2009.... - Taking aim at mosquitoesJanet Hemingway
Liverpool School of Tropical Medicine, Liverpool, UK
Nature 430:936. 2004 - Identification and analysis of single nucleotide polymorphisms (SNPs) in the mosquito Anopheles funestus, malaria vectorCharles S Wondji
Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK
BMC Genomics 8:5. 2007..Here we report a genome-wide set of SNP markers for use in genetic studies on this important human disease vector... - An overview of insecticide resistanceJanet Hemingway
Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK
Science 298:96-7. 2002..The Anopheles gambiae genome will enable identification of new resistance genes and will provide new molecular targets for the design of more effective insecticides... - Susceptibility to three pyrethroids and detection of knockdown resistance mutation in Ghanaian Anopheles gambiae sensu strictoKofi Adasi
Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
J Vector Ecol 33:255-62. 2008..However, it is even more important to complement these molecular tools with routine insecticide testing in the field, especially if the insecticides are earmarked for public health use... - Short communication: Negative spatial association between lymphatic filariasis and malaria in West AfricaLouise A Kelly-Hope
Vector Research Group, Liverpool School of Tropical Medicine, Liverpool, UK
Trop Med Int Health 11:129-35. 2006..To determine the relationship between human lymphatic filariasis, caused by Wuchereria bancrofti, and falciparum malaria, which are co-endemic throughout West Africa... - Malaria parasite and vector genomes: partners in crimeAlister Craig
Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
Trends Parasitol 19:356-62. 2003.... - Malaria: past problems and future prospects. After more than a decade of neglect, malaria is finally black on the agenda for both biomedical research and public health politicsJanet Hemingway
Janet Hemingway and Imelda Bates are at the Liverpool School of Tropical Medicine, Liverpool, UK
EMBO Rep 4:S29-31. 2003 - A dehydrochlorinase-based pH change assay for determination of DDT in sprayed surfacesEvangelia Morou
Vector Research, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK
Anal Biochem 378:60-4. 2008.... - Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malariaGiancarlo A Biagini
Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, University of Liverpool, Liverpool L3 5QA, United Kingdom
Proc Natl Acad Sci U S A 109:8298-303. 2012.... - Analysis of the promoters for the beta-esterase genes associated with insecticide resistance in the mosquito Culex quinquefasciatusNicola J Hawkes
The Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA, Liverpool, UK
Biochim Biophys Acta 1574:51-62. 2002..The arthropod initiator site TCAGT 135bp upstream of the ATG in both beta-esterase promoters is essential for transcription initiation, but a putative TATA box is not involved... - Molecular characterization of the amplified aldehyde oxidase from insecticide resistant Culex quinquefasciatusMichael Coleman
Liverpool School of Tropical Medicine, UK
Eur J Biochem 269:768-79. 2002..The role of AO in xenobiotic oxidation in mammals and the partial inhibition of elevated AO activity by a range of insecticides in Culex, suggest that this AO may play a role in insecticide resistance... - Purification, molecular cloning and heterologous expression of a glutathione S-transferase involved in insecticide resistance from the rice brown planthopper, Nilaparvata lugensJohn G Vontas
School of Biosciences, Cardiff University, Main College, Museum Avenue, Cardiff CF10 3TL, Wales, UK
Biochem J 362:329-37. 2002..Southern analysis of genomic DNA from the resistant and susceptible strains indicated that GST-based insecticide resistance may be associated with gene amplification in N. lugens... - Malaria control with genetically manipulated insect vectorsLuke Alphey
Oxford University, UK
Science 298:119-21. 2002..At a recent workshop, experts discussed the benefits, risks, and research priorities associated with using genetically manipulated insects in the control of vector-borne diseases... - Isolation and sequence analysis of P450 genes from a pyrethroid resistant colony of the major malaria vector Anopheles funestusDolphine A Amenya
Vector Control Reference Unit, National Institute for Communicable Diseases, Private bag X 4, Sandringham 2131, South Africa
DNA Seq 16:437-45. 2005..Intron positions, but not size, were highly conserved between the two species. The high level of orthology that exists in the P450 gene families of these two species may facilitate the prediction of individual P450 protein function... - The role of agricultural use of insecticides in resistance to pyrethroids in Anopheles gambiae s.l. in Burkina FasoAbdoulaye Diabate
Laboratoire d Entomologie et de Parasitologie, Centre Muraz, Bobo Dioulasso, Burkina Faso
Am J Trop Med Hyg 67:617-22. 2002..Pyrethroid resistance in west African An. gambiae was conferred by target site insensitivity through a knockdown resistance (kdr)-like mutation, which was present at high frequencies in mosquitoes in the cotton-growing and urban areas... - Knowledge and beliefs about malaria transmission and practices for vector control in southern MexicoAmérico David Rodríguez
Centro de Investigacion de Paludismo, Instituto Nacional de Salud Publica, Apartado Postal 537, 30700 Tapachula, Chiapas, Mexico
Salud Publica Mex 45:110-6. 2003..To investigate the knowledge and beliefs about malaria transmission and practices for vector control in eight villages on the coastal plain of Chiapas, Mexico... - Structure of an insect delta-class glutathione S-transferase from a DDT-resistant strain of the malaria vector Anopheles gambiaeLiqing Chen
Laboratory for Structural Biology, Department of Chemistry, Graduate Programs of Biotechnology, Chemistry and Materials Science, University of Alabama in Huntsville, Huntsville, AL 35899, USA
Acta Crystallogr D Biol Crystallogr 59:2211-7. 2003..A structure-based model for the binding of DDT to agGSTd1-6 reveals two subpockets in the hydrophobic binding site (H-site), each accommodating one planar p-chlorophenyl ring... - KDR mutation, a genetic marker to assess events of introgression between the molecular M and S forms of Anopheles gambiae (Diptera: Culicidae) in the tropical savannah area of West AfricaAbdoulaye Diabate
Laboratoire de Parasitologie et d Entomologie du Centre Muraz BP 390 Bobo Dioulasso, Burkina Faso
J Med Entomol 40:195-8. 2003..Pyrethroid resistant An. gambiae were caught in October and November, which is the time of year that the molecular S form migrates into this area as rain-fed breeding sites in the cotton fields dry out... - Acceptability and perceived side effects of insecticide indoor residual spraying under different resistance management strategiesAmérico David Rodríguez
Centro de Investigacion de Paludismo, Instituto Nacional de Salud Publica, Tapachula, Chiapas, Mexico
Salud Publica Mex 48:317-24. 2006....