Research Topics
| Simon R HellerSummaryAffiliation: University of Sheffield Country: UK Publications
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Detail Information
Publications
Does self monitoring of blood glucose as opposed to urinalysis provide additional benefit in patients newly diagnosed with type 2 diabetes receiving structured education? The DESMOND SMBG randomised controlled trial protocolHelen M Dallosso
Diabetes Research Department, University Hospitals of Leicester NHS Trust, Leicester, UK
BMC Fam Pract 13:18. 2012..However, what was unclear was whether a cheaper method of self-monitoring (such as urine glucose monitoring) could produce comparable benefit and patient acceptability for less cost...- Using dynamic pupillometry as a simple screening tool to detect autonomic neuropathy in patients with diabetes: a pilot studyGiselle L Ferrari
School of Electrical Engineering and Applied Computer Sciences CPGEI, Federal University of Technology Parana, Curitiba, PR Brazil
Biomed Eng Online 9:26. 2010..The aim of this study was to investigate pupil responsiveness in diabetic subjects with and without cardiovascular autonomic neuropathy (CAN) using dynamic pupillometry in two sets of experiments... 
Weight gain during insulin therapy in patients with type 2 diabetes mellitusSimon Heller
University of Sheffield, Section of Medicine, Clinical Sciences Centre, Sheffield S102TN, UK
Diabetes Res Clin Pract 65:S23-7. 2004..Bariatric surgery is the only treatment recognized to have lasting effects on weight control, but its use is limited at present to those who are morbidly obese...- Effect of the fast-acting insulin analog lispro on the risk of nocturnal hypoglycemia during intensified insulin therapy. U.K. Lispro Study GroupS R Heller
Northern General Hospital, Sheffield, U K
Diabetes Care 22:1607-11. 1999..To measure the effectiveness of insulin lispro, a fast-acting insulin analog, in reducing hypoglycemic episodes when used in a basal bolus regimen by patients with type 1 diabetes using intensive insulin therapy... - Insulin's 85th anniversary--An enduring medical miracleSimon Heller
Academic Unit of Diabetes, Endocrinology and Metabolism, University of Sheffield, Royal Hallamshire Hospital, Glossop Road, Sheffield, South Yorkshire S10 2JF, UK
Diabetes Res Clin Pract 78:149-58. 2007.... 
Hypoglycaemia in Type 2 diabetesSimon R Heller
Academic Unit of Diabetes, Endocrinology and Metabolism, University of Sheffield, Room OU141, School of Medicine and Biomedical Sciences, Beech Hill Road, Sheffield S10 2RX, UK
Diabetes Res Clin Pract 82:S108-11. 2008..Thus the inevitable decline in endogenous insulin, eventually produces a similar failure of physiological protection to hypoglycaemia as in Type 1 diabetes...- Comparison of insulin detemir and insulin glargine in a basal-bolus regimen, with insulin aspart as the mealtime insulin, in patients with type 1 diabetes: a 52-week, multinational, randomized, open-label, parallel-group, treat-to-target noninferiority trSimon Heller
Diabetes Centre, Clinical Sciences Centre, Northern General Hospital, Sheffield, United Kingdom
Clin Ther 31:2086-97. 2009.... - Hypoglycemia in type 1 diabetic pregnancy: role of preconception insulin aspart treatment in a randomized studySimon Heller
Northern General Hospital, Sheffield, UK
Diabetes Care 33:473-7. 2010..CONCLUSIONS These data suggest that initiation of insulin analog treatment preconception rather than during early pregnancy may result in a lower risk of severe hypoglycemia in women with type 1 diabetes... - Diversity in diabetes: the role of insulin aspartSimon Heller
Department of Human Metabolism, School of Medicine and Biosciences, University of Sheffield, Sheffield, UK
Diabetes Metab Res Rev 28:50-61. 2012..In summary, the evidence would suggest that insulin aspart is suitable for use in a variety of patients with diabetes... - Hypoglycaemia with insulin aspart: a double-blind, randomised, crossover trial in subjects with Type 1 diabetesS R Heller
Northern General Hospital, Sheffield S5 7AU, UK
Diabet Med 21:769-75. 2004.... - Insulin lispro: a useful advance in insulin therapySimon Heller
University of Sheffield, Clinical Sciences Centre, Northern General Hospital, Herries Road, Sheffield, S5 7AU, UK
Expert Opin Pharmacother 4:1407-16. 2003..Other indications include its use in continuous subcutaneous insulin infusion and postprandially in young children... - Insulin analoguesSimon R Heller
University of Sheffield, Clinical Sciences Centre, Northern General Hospital, UK
Curr Med Res Opin 18:s40-7. 2002.... - Reducing hypoglycaemia with insulin analoguesS Heller
Diabetes Centre, Northern General Hospital, Sheffield, UK
Int J Obes Relat Metab Disord 26:S31-6. 2002..On-going clinical trials will establish whether they can be used to achieve better glycaemic control with less hypoglycaemia... - Cardiac arrhythmias in hypoglycaemiaS R Heller
University of Sheffield, Sheffield, UK
Diabetes Nutr Metab 15:461-5; discussion 465-7. 2002 - Does insulin lispro preserve the physiological defences to hypoglycaemia during intensive insulin therapy with a conventional basal bolus regimen?S R Heller
University of Sheffield, Sheffield, UK
Diabetes Obes Metab 4:106-12. 2002..We tested the hypothesis that the use of rapid-acting analogues might prevent the development of defective hypoglycaemic counterregulation during intensive insulin therapy... - Insulin aspart: promising early results borne out in clinical practiceSimon Heller
Northern General Hospital, Diabetes Centre, Herries Road, Sheffield S5 7AU, UK
Expert Opin Pharmacother 3:183-95. 2002..The safety profile, including cardiovascular risk, is equivalent to HI... - What we know about counterregulation in Type 2 diabetesS R Heller
University of Sheffield, Sheffield, UK
Diabetes Nutr Metab 15:372-5; discussion 375-6. 2002 - Influence of autonomic neuropathy on QTc interval lengthening during hypoglycemia in type 1 diabetesStuart P Lee
Clinical Sciences Centre, Northern General Hospital, Herries Road, Sheffield S5 7AU, UK
Diabetes 53:1535-42. 2004..Indeed, they suggest that such patients may be relatively protected, perhaps as a result of attenuated sympatho-adrenal responses... - Mechanisms of abnormal cardiac repolarization during insulin-induced hypoglycemiaRobert T C E Robinson
Clinical Sciences Center, Northern General Hospital, University of Sheffield, Sheffield S57 AU, U.K
Diabetes 52:1469-74. 2003..Sympathoadrenal stimulation is the main cause, through mechanisms that involve but are not limited to catecholamine-mediated hypokalemia. These abnormalities are prevented by selective beta-blockade... - Comparative effect of human soluble insulin and insulin aspart upon hypoglycaemia-induced alterations in cardiac repolarizationRobert T C E Robinson
University of Sheffield, Clinical Sciences Centre, Northern General Hospital, Sheffield S5 7AU, UK
Br J Clin Pharmacol 55:246-51. 2003.... - Relationship between interstitial and blood glucose during hypoglycemia in subjects with type 2 diabetesPratik Choudhary
Academic Unit of Diabetes, Endocrinology and Metabolism, University of Sheffield, Sheffield, United Kingdom
Diabetes Technol Ther 13:1121-7. 2011..We studied the relationship between blood and interstitial glucose during experimental hypoglycemia in subjects with type 2 diabetes treated with insulin or sulfonylureas and matched controls without diabetes... - Aircrew and type 1 diabetes mellitusSimon R Heller
Department of Diabetes and Endocrine Medicine, University of Sheffield, Western Bank, Sheffield, UK
Aviat Space Environ Med 77:456-8. 2006..Further, cognition may be impaired for a considerable period of time beyond the correction of any episode. These observations and their implications to operational aircrew with Type 1 DM are discussed... - Delivering the diabetes education and self management for ongoing and newly diagnosed (DESMOND) programme for people with newly diagnosed type 2 diabetes: cost effectiveness analysisM Gillett
School of Health and Related Research ScHARR, University of Sheffield, Sheffield
BMJ 341:c4093. 2010..To assess the long term clinical and cost effectiveness of the diabetes education and self management for ongoing and newly diagnosed (DESMOND) intervention compared with usual care in people with newly diagnosed type 2 diabetes... - Three-year efficacy of complex insulin regimens in type 2 diabetesRury R Holman
Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom
N Engl J Med 361:1736-47. 2009..Evidence supporting the addition of specific insulin regimens to oral therapy in patients with type 2 diabetes mellitus is limited... - Pilot study of a novel educational programme for 11-16 year olds with type 1 diabetes mellitus: the KICk-OFF courseH Waller
Department of Psychology, University of Sheffield, Sheffield, UK
Arch Dis Child 93:927-31. 2008.... - Acute changes of bone turnover and PTH induced by insulin and glucose: euglycemic and hypoglycemic hyperinsulinemic clamp studiesJackie A Clowes
Bone Metabolism Group, Division of Clinical Sciences (North, Northern General Hospital, University of Sheffield, Herries Road, Sheffield S5 7 AU, United Kingdom
J Clin Endocrinol Metab 87:3324-9. 2002..The reduction in bone turnover during hypoglycemia may be related to hypoglycemia itself, acute changes in PTH, or other hormones released in response to hypoglycemia... - Adolescents' and their parents' views on the acceptability and design of a new diabetes education programme: a focus group analysisH Waller
Department of Psychology, University of Sheffield, Sheffield, UK
Child Care Health Dev 31:283-9. 2005..We aimed to seek the views of children and adolescents with type 1 diabetes and their parents regarding (i) the acceptability of the new programme and (ii) practical aspects regarding course design and delivery... - Home blood glucose monitoring in type 2 diabetesS Heller
Department of Diabetes and Endocrinology, Northern General Hospital, Sheffield University Hospitals NHS Trust, Sheffield, UK
Diabet Med 22:11-3. 2005 - Rate-dependent measures of repolarization predict inducibility of ventricular arrhythmiasPaul J Sheridan
South Yorkshire Cardiac Centre, Northern General Hospital, Herries Road, Sheffield S57AU, UK
Europace 12:553-60. 2010.... - Using continuous glucose monitoring to measure the frequency of low glucose values when using biphasic insulin aspart 30 compared with biphasic human insulin 30: a double-blind crossover study in individuals with type 2 diabetesPaul G McNally
Leicester Royal Infirmary NHS Trust, Leicester, UK
Diabetes Care 30:1044-8. 2007.... - Severe hypoglycaemia in 1076 adult patients with type 1 diabetes: influence of risk markers and selectionUlrik Pedersen-Bjergaard
Department of Internal Medicine F, Hillerød Hospital, Helsevej, Hillerød, Denmark
Diabetes Metab Res Rev 20:479-86. 2004..The purpose of this study was to assess the frequency of severe hypoglycaemia in unselected patients treated in different secondary care centres and to evaluate the influence of risk markers, clinical setting and selection... - Self monitoring of blood glucose in type 2 diabetesSimon R Heller
BMJ 335:105-6. 2007