LORA HEISLER

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi Serotonin and energy balance: molecular mechanisms and implications for type 2 diabetes
    Daniel D Lam
    Department of Clinical Biochemistry, Addenbrooke s Hospital, University of Cambridge, Cambridge, CB2 2QQ, UK
    Expert Rev Mol Med 9:1-24. 2007
  2. ncbi Neurochemical characterization of body weight-regulating leptin receptor neurons in the nucleus of the solitary tract
    Alastair S Garfield
    University of Cambridge, Department of Pharmacology, Tennis Court Road, Cambridge CB2 1PD, United Kingdom
    Endocrinology 153:4600-7. 2012
  3. ncbi Glucokinase inhibitor glucosamine stimulates feeding and activates hypothalamic neuropeptide Y and orexin neurons
    Ligang Zhou
    Department of Pharmacology, University of Cambridge, Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Behav Brain Res 222:274-8. 2011
  4. ncbi Distribution and neurochemical characterization of neurons within the nucleus of the solitary tract responsive to serotonin agonist-induced hypophagia
    Daniel D Lam
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Behav Brain Res 196:139-43. 2009
  5. ncbi Serotonin reciprocally regulates melanocortin neurons to modulate food intake
    Lora K Heisler
    Department of Clinical Biochemistry, Addenbrooke s Hospital, University of Cambridge, Cambridge, CB2 2QQ, United Kingdom
    Neuron 51:239-49. 2006
  6. ncbi Serotonin 5-HT(2C) receptors regulate anxiety-like behavior
    L K Heisler
    Department of Clinical Biochemistry, University of Cambridge, Cambridge, United Kingdom
    Genes Brain Behav 6:491-6. 2007
  7. ncbi Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation
    Lora K Heisler
    Department of Clinical Biochemistry, Addenbrooke s Hospital and the University of Cambridge, Cambridge CB2 2QR, United Kingdom
    J Neurosci 27:6956-64. 2007
  8. ncbi Serotonin 5-HT2C receptor agonist promotes hypophagia via downstream activation of melanocortin 4 receptors
    Daniel D Lam
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, United Kingdom
    Endocrinology 149:1323-8. 2008
  9. ncbi Serotonin 2C receptor agonists improve type 2 diabetes via melanocortin-4 receptor signaling pathways
    Ligang Zhou
    Department of Clinical Biochemistry, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, UK
    Cell Metab 6:398-405. 2007
  10. ncbi Melanocortin receptors as targets in the treatment of obesity
    Daniel D Lam
    Department of Clinical Biochemistry, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Curr Top Med Chem 7:1085-1097. 2007

Research Grants

  1. Central Serotonergic Pathways Regulating Energy Balance
    LORA HEISLER; Fiscal Year: 2007

Collaborators

Detail Information

Publications13

  1. ncbi Serotonin and energy balance: molecular mechanisms and implications for type 2 diabetes
    Daniel D Lam
    Department of Clinical Biochemistry, Addenbrooke s Hospital, University of Cambridge, Cambridge, CB2 2QQ, UK
    Expert Rev Mol Med 9:1-24. 2007
    ..Finally, future directions in the elucidation of serotonergic metabolic regulation are discussed...
  2. ncbi Neurochemical characterization of body weight-regulating leptin receptor neurons in the nucleus of the solitary tract
    Alastair S Garfield
    University of Cambridge, Department of Pharmacology, Tennis Court Road, Cambridge CB2 1PD, United Kingdom
    Endocrinology 153:4600-7. 2012
    ..These data provide new insight into the appetitive brainstem circuits engaged by leptin...
  3. ncbi Glucokinase inhibitor glucosamine stimulates feeding and activates hypothalamic neuropeptide Y and orexin neurons
    Ligang Zhou
    Department of Pharmacology, University of Cambridge, Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Behav Brain Res 222:274-8. 2011
    ..Our data suggest that GK within these specific feeding and arousal related populations of AgRP/NPY and ORX neurons may play a modulatory role in the sensing of and appetitive response to hypoglycaemia...
  4. ncbi Distribution and neurochemical characterization of neurons within the nucleus of the solitary tract responsive to serotonin agonist-induced hypophagia
    Daniel D Lam
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Behav Brain Res 196:139-43. 2009
    ..The data presented here identify a novel mechanism through which a serotonin receptor agonist acting in the caudal brainstem may regulate ingestive behavior...
  5. ncbi Serotonin reciprocally regulates melanocortin neurons to modulate food intake
    Lora K Heisler
    Department of Clinical Biochemistry, Addenbrooke s Hospital, University of Cambridge, Cambridge, CB2 2QQ, United Kingdom
    Neuron 51:239-49. 2006
    ....
  6. ncbi Serotonin 5-HT(2C) receptors regulate anxiety-like behavior
    L K Heisler
    Department of Clinical Biochemistry, University of Cambridge, Cambridge, United Kingdom
    Genes Brain Behav 6:491-6. 2007
    ..These findings illustrate a mechanism through which 5-HT(2C)Rs affect anxiety-related behavior and provide insight into the neural circuitry mediating the complex psychological process of anxiety...
  7. ncbi Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation
    Lora K Heisler
    Department of Clinical Biochemistry, Addenbrooke s Hospital and the University of Cambridge, Cambridge CB2 2QR, United Kingdom
    J Neurosci 27:6956-64. 2007
    ....
  8. ncbi Serotonin 5-HT2C receptor agonist promotes hypophagia via downstream activation of melanocortin 4 receptors
    Daniel D Lam
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, United Kingdom
    Endocrinology 149:1323-8. 2008
    ..X warrants further investigation as a treatment for obesity but also elucidate specific neuronal pathways potently affecting energy balance through which 5-HT(2C)R agonists regulate ingestive behavior...
  9. ncbi Serotonin 2C receptor agonists improve type 2 diabetes via melanocortin-4 receptor signaling pathways
    Ligang Zhou
    Department of Clinical Biochemistry, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, UK
    Cell Metab 6:398-405. 2007
    ....
  10. ncbi Melanocortin receptors as targets in the treatment of obesity
    Daniel D Lam
    Department of Clinical Biochemistry, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Curr Top Med Chem 7:1085-1097. 2007
    ..However, various promising strategies are being pursued to overcome these limitations, including the synthesis of more selective and potent melanocortin analogs...
  11. ncbi Serotonergic pathways converge upon central melanocortin systems to regulate energy balance
    Ligang Zhou
    Department of Clinical Biochemistry, Addenbrooke's Hospital, Level 4, University of Cambridge, Hills Road, Cambridge CB2 2QQ, UK
    Peptides 26:1728-32. 2005
    ..We propose that downstream activation of MC4R-expressing neurons substantially contributes to serotonin's effects on energy homeostasis...
  12. ncbi Activation of central melanocortin pathways by fenfluramine
    Lora K Heisler
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Science 297:609-11. 2002
    ..These results provide a mechanistic explanation of d-FEN's anorexic actions and indicate that drugs targeting these downstream melanocortin pathways may prove to be effective and more selective anti-obesity treatments...
  13. ncbi Central serotonin and melanocortin pathways regulating energy homeostasis
    Lora K Heisler
    Departments of Medicine and Neurology, Beth Israel Deaconess Medical Center and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02215, USA
    Ann N Y Acad Sci 994:169-74. 2003
    ..The data reviewed in this paper incorporate the central 5-HT system to the growing list of metabolic signals that converge on melanocortin neurons in the hypothalamus...

Research Grants5

  1. Central Serotonergic Pathways Regulating Energy Balance
    LORA HEISLER; Fiscal Year: 2007
    ....