R Heer

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. pmc A review of tasquinimod in the treatment of advanced prostate cancer
    Stuart Charles Williamson
    Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, Tyne and Wear, UK
    Drug Des Devel Ther 7:167-74. 2013
  2. pmc Side population in human non-muscle invasive bladder cancer enriches for cancer stem cells that are maintained by MAPK signalling
    Anastasia C Hepburn
    Northern Institute for Cancer Research, Newcastle University, Framlington Place, Newcastle upon Tyne, United Kingdom
    PLoS ONE 7:e50690. 2012
  3. pmc Human α(2)β(1)(HI) CD133(+VE) epithelial prostate stem cells express low levels of active androgen receptor
    Stuart C Williamson
    Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom
    PLoS ONE 7:e48944. 2012
  4. ncbi request reprint A critical systematic review of recent clinical trials comparing open retropubic, laparoscopic and robot-assisted laparoscopic radical prostatectomy
    R Heer
    Northern Institute for Cancer Research, Newcastle upon Tyne, UK
    Rev Recent Clin Trials 6:241-9. 2011
  5. ncbi request reprint KGF suppresses alpha2beta1 integrin function and promotes differentiation of the transient amplifying population in human prostatic epithelium
    Rakesh Heer
    Urology Research Group, Northern Institute for Cancer Research, University of Newcastle, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    J Cell Sci 119:1416-24. 2006
  6. ncbi request reprint The role of androgen in determining differentiation and regulation of androgen receptor expression in the human prostatic epithelium transient amplifying population
    R Heer
    Urology Research Group, Northern Institute for Cancer Research, Newcastle University, Framlington Place, Newcastle upon Tyne, UK
    J Cell Physiol 212:572-8. 2007
  7. pmc Hunterian Lecture. Characterisation of human prostate epithelial progenitor differentiation in response to androgens
    R Heer
    Department of Urology, Freeman Hospital, High Heaton, Newcastle upon Tyne, NE7 7DN, UK
    Ann R Coll Surg Engl 93:424-8. 2011
  8. pmc Characterisations of human prostate stem cells reveal deficiency in class I UGT enzymes as a novel mechanism for castration-resistant prostate cancer
    S C Williamson
    Northern Institute for Cancer Research, Newcastle University, NE2 4HH, Newcastle upon Tyne United Kingdom
    Br J Cancer 109:950-6. 2013
  9. ncbi request reprint Aberrant expression of extracellular signal-regulated kinase 5 in human prostate cancer
    S R C McCracken
    Urology Research Group, Northern Institute for Cancer Research, University of Newcastle, Tyne and Wear, UK
    Oncogene 27:2978-88. 2008
  10. ncbi request reprint Fibroblast growth factor 17 is over-expressed in human prostate cancer
    R Heer
    Urology Research Group, Northern Institute for Cancer Research, University of Newcastle, Newcastle upon Tyne, UK
    J Pathol 204:578-86. 2004

Collaborators

Detail Information

Publications14

  1. pmc A review of tasquinimod in the treatment of advanced prostate cancer
    Stuart Charles Williamson
    Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, Tyne and Wear, UK
    Drug Des Devel Ther 7:167-74. 2013
    ..Although Phase III clinical trials are on-going, the findings to date highlight the promise of this drug in the treatment of advanced prostate cancer...
  2. pmc Side population in human non-muscle invasive bladder cancer enriches for cancer stem cells that are maintained by MAPK signalling
    Anastasia C Hepburn
    Northern Institute for Cancer Research, Newcastle University, Framlington Place, Newcastle upon Tyne, United Kingdom
    PLoS ONE 7:e50690. 2012
    ..In conclusion, we confirm ABCG2(hi) SP enriches for CSCs in human NMIBC and MAPK/ERK pathway is a suitable therapeutic target...
  3. pmc Human α(2)β(1)(HI) CD133(+VE) epithelial prostate stem cells express low levels of active androgen receptor
    Stuart C Williamson
    Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom
    PLoS ONE 7:e48944. 2012
    ..Further study of specific AR functions in prostate stem and differentiated cells may highlight novel mechanisms of prostate homeostasis and insights into tumourigenesis...
  4. ncbi request reprint A critical systematic review of recent clinical trials comparing open retropubic, laparoscopic and robot-assisted laparoscopic radical prostatectomy
    R Heer
    Northern Institute for Cancer Research, Newcastle upon Tyne, UK
    Rev Recent Clin Trials 6:241-9. 2011
    ..This systematic review examines the current status of minimally- invasive prostatectomy focussing on peri-operative, oncological and urogenital functional outcomes...
  5. ncbi request reprint KGF suppresses alpha2beta1 integrin function and promotes differentiation of the transient amplifying population in human prostatic epithelium
    Rakesh Heer
    Urology Research Group, Northern Institute for Cancer Research, University of Newcastle, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    J Cell Sci 119:1416-24. 2006
    ..Taken together, using a human primary culture model, we have demonstrated key roles for interactions between KGF and integrin-mediated function in the regulation of prostate epithelial differentiation...
  6. ncbi request reprint The role of androgen in determining differentiation and regulation of androgen receptor expression in the human prostatic epithelium transient amplifying population
    R Heer
    Urology Research Group, Northern Institute for Cancer Research, Newcastle University, Framlington Place, Newcastle upon Tyne, UK
    J Cell Physiol 212:572-8. 2007
    ....
  7. pmc Hunterian Lecture. Characterisation of human prostate epithelial progenitor differentiation in response to androgens
    R Heer
    Department of Urology, Freeman Hospital, High Heaton, Newcastle upon Tyne, NE7 7DN, UK
    Ann R Coll Surg Engl 93:424-8. 2011
    ..However, AR was thought to be lacking in prostate stem cell enriched fractions. Potential low levels of AR expression in stem cell enriched cells were investigated and potential direct effects of androgen were examined...
  8. pmc Characterisations of human prostate stem cells reveal deficiency in class I UGT enzymes as a novel mechanism for castration-resistant prostate cancer
    S C Williamson
    Northern Institute for Cancer Research, Newcastle University, NE2 4HH, Newcastle upon Tyne United Kingdom
    Br J Cancer 109:950-6. 2013
    ..Furthermore, many SC-signalling pathways are shown to be shared in prostate cancer. Therefore, we planned transcriptome characterisation of adult prostate SCs as a strategy to consider new targets for cancer treatment...
  9. ncbi request reprint Aberrant expression of extracellular signal-regulated kinase 5 in human prostate cancer
    S R C McCracken
    Urology Research Group, Northern Institute for Cancer Research, University of Newcastle, Tyne and Wear, UK
    Oncogene 27:2978-88. 2008
    ..Taken together, our results establish the potential importance of ERK5 in aggressive prostate cancer...
  10. ncbi request reprint Fibroblast growth factor 17 is over-expressed in human prostate cancer
    R Heer
    Urology Research Group, Northern Institute for Cancer Research, University of Newcastle, Newcastle upon Tyne, UK
    J Pathol 204:578-86. 2004
    ..These data support a role for FGF17, and a model of co-expression of multiple FGFs, with FGF17 as a potential mediator of FGF8 function, in human prostate carcinogenesis...
  11. doi request reprint Accuracy of the revised 2010 TNM classification in predicting the prognosis of patients treated for renal cell cancer in the north east of England
    R Veeratterapillay
    Department of Urology, Freeman Hospital, Newcastle upon Tyne, UK
    J Clin Pathol 65:367-71. 2012
    ..In this study the recent 2010 revision to the TNM classification was compared with the previous 2002 classification with regard to survival outcomes...
  12. ncbi request reprint A prospective audit of hypospadias correction in a regional paediatric surgery centre
    R Heer
    Department of Paediatric Surgery, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Eur J Pediatr Surg 14:328-32. 2004
    ..To prospectively review the management and treatment of hypospadias in a single regional centre, and in particular, to assess the spectrum of cases treated, techniques used and to determine the nature of the complications...
  13. ncbi request reprint Phenotypic modulation of human urinary tract stroma-derived fibroblasts by transforming growth factor beta3
    Rakesh Heer
    Northern Institute of Cancer Research, Newcastle University, Newcastle upon Tyne, UK
    Urology 76:509.e13-20. 2010
    ..In this study, we aim to determine whether TGFbeta3 treatment induced differentiation of human urinary tract stroma-derived fibroblasts to a smooth muscle-like phenotype...
  14. ncbi request reprint Epigenetic inactivation of the human sprouty2 (hSPRY2) homologue in prostate cancer
    Arthur B McKie
    Urology Research Group, Northern Institute for Cancer Research, The Medical School, University of Newcastle, Newcastle upon Tyne NE2 4AD, UK
    Oncogene 24:2166-74. 2005
    ..We therefore propose hSPRY2 as a potential tumour suppressor locus in CaP...