J E Heckels

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. pmc The influence of genomics and proteomics on the development of potential vaccines against meningococcal infection
    John E Heckels
    Molecular Microbiology Group, Sir Henry Wellcome Laboratories, Division of Infection, Inflammation and Immunity, University of Southampton Faculty of Medicine, Mailpoint 814, Southampton General Hospital, Southampton SO16 6YD, UK
    Genome Med 2:43. 2010
  2. ncbi request reprint Dynamics of carriage of Neisseria meningitidis in a group of military recruits: subtype stability and specificity of the immune response following colonization
    G R Jones
    Molecular Microbiology Group, University of Southampton Medical School, Southampton General Hospital, United Kingdom
    J Infect Dis 178:451-9. 1998
  3. ncbi request reprint Immunization with recombinant class 1 outer-membrane protein from Neisseria meningitidis: influence of liposomes and adjuvants on antibody avidity, recognition of native protein and the induction of a bactericidal immune response against meningococci
    M Christodoulides
    Molecular Microbiology Group, University of Southampton Medical School, Southampton General Hospital, UK
    Microbiology 144:3027-37. 1998
  4. ncbi request reprint Effect of adjuvant composition on immune response to a multiple antigen peptide (MAP) containing a protective epitope from Neisseria meningitidis class 1 porin
    M Christodoulides
    Molecular Microbiology Group, University of Southampton Medical School, Southampton General Hospital, UK
    Vaccine 18:131-9. 1999
  5. ncbi request reprint Naturally occurring isolates of Neisseria gonorrhoeae, which display anomalous serovar properties, express PIA/PIB hybrid porins, deletions in PIB or novel PIA molecules
    S J Cooke
    Molecular Microbiology Group, Southampton General Hospital, Southampton, UK
    FEMS Microbiol Lett 162:75-82. 1998
  6. pmc Immunization with recombinant Opc outer membrane protein from Neisseria meningitidis: influence of sequence variation and levels of expression on the bactericidal immune response against meningococci
    K A Jolley
    Molecular Microbiology Group, Division of Cell and Molecular Medicine, University of Southampton Medical School, Southampton General Hospital, United Kingdom
    Infect Immun 69:3809-16. 2001
  7. ncbi request reprint Lack of immunity in university students before an outbreak of serogroup C meningococcal infection
    G R Jones
    Public Health Laboratory, Southampton General Hospital, Southampton SO16 6YD, United Kingdom
    J Infect Dis 181:1172-5. 2000
  8. ncbi request reprint Interaction of primary human endometrial cells with Neisseria gonorrhoeae expressing green fluorescent protein
    M Christodoulides
    Molecular Microbiology Group, University of Southampton Medical School, UK
    Mol Microbiol 35:32-43. 2000
  9. pmc Deduced amino acid sequences of class 1 protein (PorA) from three strains of Neisseria meningitidis. Synthetic peptides define the epitopes responsible for serosubtype specificity
    B McGuinness
    Department of Microbiology, University of Southampton Medical School, United Kingdom
    J Exp Med 171:1871-82. 1990
  10. ncbi request reprint Gonococcal outer-membrane protein PIB: comparative sequence analysis and localization of epitopes which are recognized by type-specific and cross-reacting monoclonal antibodies
    N J Butt
    Department of Microbiology, Southampton University Medical School, Southampton General Hospital, UK
    J Gen Microbiol 136:2165-72. 1990

Collaborators

Detail Information

Publications16

  1. pmc The influence of genomics and proteomics on the development of potential vaccines against meningococcal infection
    John E Heckels
    Molecular Microbiology Group, Sir Henry Wellcome Laboratories, Division of Infection, Inflammation and Immunity, University of Southampton Faculty of Medicine, Mailpoint 814, Southampton General Hospital, Southampton SO16 6YD, UK
    Genome Med 2:43. 2010
    ..This has resulted in the identification of potential candidate antigens for incorporation into multicomponent meningococcal vaccines...
  2. ncbi request reprint Dynamics of carriage of Neisseria meningitidis in a group of military recruits: subtype stability and specificity of the immune response following colonization
    G R Jones
    Molecular Microbiology Group, University of Southampton Medical School, Southampton General Hospital, United Kingdom
    J Infect Dis 178:451-9. 1998
    ..The subtype specificity of the bactericidal response to meningococci and the stability of expression of the class 1 protein have important implications for the design of vaccines for prevention of serogroup B meningococcal disease...
  3. ncbi request reprint Immunization with recombinant class 1 outer-membrane protein from Neisseria meningitidis: influence of liposomes and adjuvants on antibody avidity, recognition of native protein and the induction of a bactericidal immune response against meningococci
    M Christodoulides
    Molecular Microbiology Group, University of Southampton Medical School, Southampton General Hospital, UK
    Microbiology 144:3027-37. 1998
    ..These data show that liposomes containing recombinant class 1 protein represent a potential basis of future vaccines, of defined composition, designed for the prevention of group B meningococcal infections...
  4. ncbi request reprint Effect of adjuvant composition on immune response to a multiple antigen peptide (MAP) containing a protective epitope from Neisseria meningitidis class 1 porin
    M Christodoulides
    Molecular Microbiology Group, University of Southampton Medical School, Southampton General Hospital, UK
    Vaccine 18:131-9. 1999
    ....
  5. ncbi request reprint Naturally occurring isolates of Neisseria gonorrhoeae, which display anomalous serovar properties, express PIA/PIB hybrid porins, deletions in PIB or novel PIA molecules
    S J Cooke
    Molecular Microbiology Group, Southampton General Hospital, Southampton, UK
    FEMS Microbiol Lett 162:75-82. 1998
    ..This is the first demonstration of naturally occurring gonococci expressing a hybrid Protein IA/IB...
  6. pmc Immunization with recombinant Opc outer membrane protein from Neisseria meningitidis: influence of sequence variation and levels of expression on the bactericidal immune response against meningococci
    K A Jolley
    Molecular Microbiology Group, Division of Cell and Molecular Medicine, University of Southampton Medical School, Southampton General Hospital, United Kingdom
    Infect Immun 69:3809-16. 2001
    ..The magnitude of the bactericidal effect was strongly influenced by the level of expression of the Opc protein and was abolished by limited variation in the sequence of the protein expressed by heterologous strains...
  7. ncbi request reprint Lack of immunity in university students before an outbreak of serogroup C meningococcal infection
    G R Jones
    Public Health Laboratory, Southampton General Hospital, Southampton SO16 6YD, United Kingdom
    J Infect Dis 181:1172-5. 2000
    ..A low prevalence of carriage of the outbreak strain, together with a low prevalence of protective immunity within the student population, was associated with a high incidence of invasive disease in those who acquired the outbreak strain...
  8. ncbi request reprint Interaction of primary human endometrial cells with Neisseria gonorrhoeae expressing green fluorescent protein
    M Christodoulides
    Molecular Microbiology Group, University of Southampton Medical School, UK
    Mol Microbiol 35:32-43. 2000
    ....
  9. pmc Deduced amino acid sequences of class 1 protein (PorA) from three strains of Neisseria meningitidis. Synthetic peptides define the epitopes responsible for serosubtype specificity
    B McGuinness
    Department of Microbiology, University of Southampton Medical School, United Kingdom
    J Exp Med 171:1871-82. 1990
    ..Thus we have been able to define linear peptides on each class 1 protein molecule that are responsible for subtype specificity and that represent targets for a protective immune response...
  10. ncbi request reprint Gonococcal outer-membrane protein PIB: comparative sequence analysis and localization of epitopes which are recognized by type-specific and cross-reacting monoclonal antibodies
    N J Butt
    Department of Microbiology, Southampton University Medical School, Southampton General Hospital, UK
    J Gen Microbiol 136:2165-72. 1990
    ..However, the conserved epitope recognized by mAb SM24 is centred on residues 198-199, close to Var1 , and is exposed for bactericidal killing...
  11. ncbi request reprint Sequence variation in class 1 outer membrane protein in Neisseria meningitidis isolated from patients with meningococcal infection and close household contacts
    J L Brooks
    Molecular Microbiology Group, University of Southampton Medical School, Southampton General Hospital, UK
    FEMS Microbiol Lett 128:145-50. 1995
    ..These data demonstrate that it is possible to use sequence information to differentiate between potential sources of infection which appear identical using conventional serological methods...
  12. pmc Interactions of Neisseria gonorrhoeae with mature human macrophage opacity proteins influence production of proinflammatory cytokines
    B L Makepeace
    Molecular Microbiology Group, Division of Cell and Molecular Medicine, University of Southampton Medical School, Southampton General Hospital, Southampton SO16 6YD, United Kingdom
    Infect Immun 69:1909-13. 2001
    ..Thus, variation in Opa protein expression by the gonococcus may be a determining factor in the severity of pelvic inflammatory disease...
  13. pmc The nucleotide sequence of the por gene from Neisseria gonorrhoeae strain P9 encoding outer membrane protein PIB
    N J Butt
    Department of Microbiology, Southampton University Medical School, Southampton General Hospital, UK
    Nucleic Acids Res 18:4258. 1990
  14. ncbi request reprint The class 1 outer membrane protein of Neisseria meningitidis: gene sequence and structural and immunological similarities to gonococcal porins
    A K Barlow
    Department of Microbiology, University of Southampton Medical School, UK
    Mol Microbiol 3:131-9. 1989
    ..A restriction fragment from the class 1 gene hybridizes to gonococcal genomic fragments in Southern blots. In addition to the class 1 gene coding region there is a large open reading frame on the opposite strand...
  15. ncbi request reprint Variation within serovars of Neisseria gonorrhoeae detected by structural analysis of outer-membrane protein PIB and by pulsed-field gel electrophoresis
    S J Cooke
    Molecular Microbiology Group, University of Southampton Medical School, Southampton General Hospital, UK
    Microbiology 143:1415-22. 1997
    ....
  16. ncbi request reprint Sequence analysis and relationships between meningococcal class 3 serotype proteins and other porins from pathogenic and non-pathogenic Neisseria species
    M J Ward
    Department of Microbiology, Southampton University Medical School, Southampton General Hospital, UK
    FEMS Microbiol Lett 73:283-9. 1992
    ....