C S Healey

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint A common variant in BRCA2 is associated with both breast cancer risk and prenatal viability
    C S Healey
    CRC Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK
    Nat Genet 26:362-4. 2000
  2. ncbi request reprint Polymorphisms in the human aromatase cytochrome P450 gene (CYP19) and breast cancer risk
    C S Healey
    CRC Department of Oncology, CRC Genetic Epidemiology Group and EPIC, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN, UK
    Carcinogenesis 21:189-93. 2000
  3. ncbi request reprint Point mutation within the tyrosine kinase domain of the RET proto-oncogene in multiple endocrine neoplasia type 2B and related sporadic tumours
    C Eng
    Department of Pathology, University of Cambridge, UK
    Hum Mol Genet 3:237-41. 1994
  4. ncbi request reprint Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A
    L M Mulligan
    Department of Pathology, University of Cambridge, UK
    Nature 363:458-60. 1993
  5. ncbi request reprint Specific mutations of the RET proto-oncogene are related to disease phenotype in MEN 2A and FMTC
    L M Mulligan
    Department of Pathology, University of Cambridge, UK
    Nat Genet 6:70-4. 1994
  6. pmc Mutation analysis of the c-mos proto-oncogene and the endothelin-B receptor gene in medullary thyroid carcinoma and phaeochromocytoma
    C Eng
    CRC Human Cancer Genetics Research Group, University of Cambridge, Addenbrooke s Hospital, UK
    Br J Cancer 74:339-41. 1996
  7. ncbi request reprint Haplotype analysis of MEN 2 mutations
    E Gardner
    Department of Pathology, University of Cambridge, UK
    Hum Mol Genet 3:1771-4. 1994
  8. ncbi request reprint Polymorphisms in CYP1A1 and smoking: no association with breast cancer risk
    V M Basham
    CRC Human Cancer Genetics Group, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK
    Carcinogenesis 22:1797-800. 2001
  9. pmc The extent of linkage disequilibrium in four populations with distinct demographic histories
    A M Dunning
    CRC Department of Oncology, University of Cambridge, Cambridge CB1 8RN, United Kingdom
    Am J Hum Genet 67:1544-54. 2000
  10. ncbi request reprint No association between androgen or vitamin D receptor gene polymorphisms and risk of breast cancer
    A M Dunning
    CRC Human Cancer Genetics Research Group, University of Cambridge, Strangeways Research Laboratory, Wort s Causeway, Cambridge CB1 8RN, UK
    Carcinogenesis 20:2131-5. 1999

Collaborators

Detail Information

Publications13

  1. ncbi request reprint A common variant in BRCA2 is associated with both breast cancer risk and prenatal viability
    C S Healey
    CRC Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK
    Nat Genet 26:362-4. 2000
    ..82 in females and 1.38 in males. Therefore, this variant of BRCA2 appears also to affect fetal survival in a sex-dependent manner...
  2. ncbi request reprint Polymorphisms in the human aromatase cytochrome P450 gene (CYP19) and breast cancer risk
    C S Healey
    CRC Department of Oncology, CRC Genetic Epidemiology Group and EPIC, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN, UK
    Carcinogenesis 21:189-93. 2000
    ..63-3.83) for the intron 4 [TTTA](10) allele; 1.29 (95% CI 0. 75-2.21) for the intron 6 G-->T polymorphism [TT versus GG]. We conclude that the CYP19 gene has no major role in common breast cancer incidence in the British population...
  3. ncbi request reprint Point mutation within the tyrosine kinase domain of the RET proto-oncogene in multiple endocrine neoplasia type 2B and related sporadic tumours
    C Eng
    Department of Pathology, University of Cambridge, UK
    Hum Mol Genet 3:237-41. 1994
    ..DNA from five of 13 apparently sporadic MTC and one of 12 apparently sporadic phaeochromocytomas harboured a similar mutation, but the corresponding germline DNA was wildtype in each case...
  4. ncbi request reprint Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A
    L M Mulligan
    Department of Pathology, University of Cambridge, UK
    Nature 363:458-60. 1993
    ..Further, 19 of these 20 mutations affect the same conserved cysteine residue at the boundary of the RET extracellular and transmembrane domains...
  5. ncbi request reprint Specific mutations of the RET proto-oncogene are related to disease phenotype in MEN 2A and FMTC
    L M Mulligan
    Department of Pathology, University of Cambridge, UK
    Nat Genet 6:70-4. 1994
    ....
  6. pmc Mutation analysis of the c-mos proto-oncogene and the endothelin-B receptor gene in medullary thyroid carcinoma and phaeochromocytoma
    C Eng
    CRC Human Cancer Genetics Research Group, University of Cambridge, Addenbrooke s Hospital, UK
    Br J Cancer 74:339-41. 1996
    ..No somatic mutations were found...
  7. ncbi request reprint Haplotype analysis of MEN 2 mutations
    E Gardner
    Department of Pathology, University of Cambridge, UK
    Hum Mol Genet 3:1771-4. 1994
    ..The results also indicate that new mutations to MEN 2 are not infrequent...
  8. ncbi request reprint Polymorphisms in CYP1A1 and smoking: no association with breast cancer risk
    V M Basham
    CRC Human Cancer Genetics Group, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK
    Carcinogenesis 22:1797-800. 2001
    ..9 (0.7-1.1), Val/Val OR = 2.3 (0.4-12), and Val carrier OR = 1.0 (0.9-1.1)]...
  9. pmc The extent of linkage disequilibrium in four populations with distinct demographic histories
    A M Dunning
    CRC Department of Oncology, University of Cambridge, Cambridge CB1 8RN, United Kingdom
    Am J Hum Genet 67:1544-54. 2000
    ..Results of the present study, if representative of the whole genome, suggest that a whole-genome scan searching for common disease-susceptibility alleles would require markers spaced < or = 5 kb apart...
  10. ncbi request reprint No association between androgen or vitamin D receptor gene polymorphisms and risk of breast cancer
    A M Dunning
    CRC Human Cancer Genetics Research Group, University of Cambridge, Strangeways Research Laboratory, Wort s Causeway, Cambridge CB1 8RN, UK
    Carcinogenesis 20:2131-5. 1999
    ..01 (95% CI 0.81-1.27) and 0.97 (95% CI 0.71-1.32), respectively. None of the AR or VDR polymorphisms investigated has a major effect on risk of breast cancer in the British population...
  11. pmc No association between a polymorphism in the steroid metabolism gene CYP17 and risk of breast cancer
    A M Dunning
    CRC Human Cancer Genetics Research Group, Addenbrooke s Hospital, Cambridge, UK
    Br J Cancer 77:2045-7. 1998
    ..37] or advanced breast cancer (OR 0.88, CI 0.38-2.01) in C allele carriers, nor any association between age at menarche and genotype. We conclude that these alleles do not significantly alter breast cancer risk in the English population...
  12. pmc Mutations in the RET proto-oncogene and the von Hippel-Lindau disease tumour suppressor gene in sporadic and syndromic phaeochromocytomas
    C Eng
    CRC Human Cancer Genetics Research Group, University of Cambridge, UK
    J Med Genet 32:934-7. 1995
    ..Four of 48 had VHL mutations; these included both the bilateral cases in the series (one was proven to be a germline mutation) and two others, of which one was proven somatic...
  13. ncbi request reprint A novel point mutation in the tyrosine kinase domain of the RET proto-oncogene in sporadic medullary thyroid carcinoma and in a family with FMTC
    C Eng
    Department of Pathology, University of Cambridge, UK
    Oncogene 10:509-13. 1995
    ..The same mutation was also detected in sporadic MTC but not in corresponding constitutional DNA, confirming that it is likely to be of pathological significance rather than a rare polymorphism...