Mark W Head

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi request reprint Sporadic Creutzfeldt-Jakob disease in a young Dutch valine homozygote: atypical molecular phenotype
    M W Head
    Department of Pathology, University of Edinburgh, Western General Hospital, UK
    Ann Neurol 50:258-61. 2001
  2. doi request reprint Human prion diseases: molecular, cellular and population biology
    Mark W Head
    National CJD Research and Surveillance unit, Centre for Clinical Brain Sciences, School of Clinical Sciences, The University of Edinburgh, Edinburgh, UK
    Neuropathology 33:221-36. 2013
  3. doi request reprint Variably protease-sensitive prionopathy in the UK: a retrospective review 1991-2008
    Mark W Head
    National Creutzfeldt Jakob Disease Research and Surveillance Unit, Bryan Matthews Building, Western General Hospital, Edinburgh EH4 2XU, UK
    Brain 136:1102-15. 2013
  4. doi request reprint The contribution of different prion protein types and host polymorphisms to clinicopathological variations in Creutzfeldt-Jakob disease
    Mark W Head
    The National CJD Research and Surveillance Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, UK
    Rev Med Virol 22:214-29. 2012
  5. doi request reprint Review: Creutzfeldt-Jakob disease: prion protein type, disease phenotype and agent strain
    M W Head
    National CJD Research and Surveillance unit, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, UK
    Neuropathol Appl Neurobiol 38:296-310. 2012
  6. ncbi request reprint Prion protein heterogeneity in sporadic but not variant Creutzfeldt-Jakob disease: UK cases 1991-2002
    Mark W Head
    National Creutzfeldt Jakob Disease Surveillance Unit and Division of Pathology, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, United Kingdom
    Ann Neurol 55:851-9. 2004
  7. ncbi request reprint Evaluation of urinary PrPSc as a diagnostic test for sporadic, variant, and familial CJD
    M W Head
    National CJD Surveillance Unit, School of Molecular and Clinical Medicine, University of Edinburgh, UK
    Neurology 64:1794-6. 2005
  8. pmc Abnormal prion protein in the retina of the most commonly occurring subtype of sporadic Creutzfeldt-Jakob disease
    M W Head
    National CJD Surveillance Unit, Bryan Matthews Building, Western General Hospital, University of Edinburgh EH4 2XU, UK
    Br J Ophthalmol 89:1131-3. 2005
  9. pmc Peripheral tissue involvement in sporadic, iatrogenic, and variant Creutzfeldt-Jakob disease: an immunohistochemical, quantitative, and biochemical study
    Mark W Head
    National Creutzfeldt Jakob Disease Surveillance Unit and Division of Pathology, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom
    Am J Pathol 164:143-53. 2004
  10. doi request reprint An antibody to the aggregated synthetic prion protein peptide (PrP106-126) selectively recognizes disease-associated prion protein (PrP) from human brain specimens
    Michael Jones
    National CJD Surveillance Unit, School of Molecular and Clinical Medicine Pathology, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Brain Pathol 19:293-302. 2009

Collaborators

Detail Information

Publications60

  1. ncbi request reprint Sporadic Creutzfeldt-Jakob disease in a young Dutch valine homozygote: atypical molecular phenotype
    M W Head
    Department of Pathology, University of Edinburgh, Western General Hospital, UK
    Ann Neurol 50:258-61. 2001
    ..Certain clinical and molecular features of this case overlap those of variant CJD. The case highlights possible difficulties in the differential diagnosis of vCJD and the more rare sCJD subtypes based on molecular features alone...
  2. doi request reprint Human prion diseases: molecular, cellular and population biology
    Mark W Head
    National CJD Research and Surveillance unit, Centre for Clinical Brain Sciences, School of Clinical Sciences, The University of Edinburgh, Edinburgh, UK
    Neuropathology 33:221-36. 2013
    ..Studies at the molecular and cellular level have helped to provide a better understanding of human prion diseases, aided pathological diagnosis and helped inform public health decision-making...
  3. doi request reprint Variably protease-sensitive prionopathy in the UK: a retrospective review 1991-2008
    Mark W Head
    National Creutzfeldt Jakob Disease Research and Surveillance Unit, Bryan Matthews Building, Western General Hospital, Edinburgh EH4 2XU, UK
    Brain 136:1102-15. 2013
    ....
  4. doi request reprint The contribution of different prion protein types and host polymorphisms to clinicopathological variations in Creutzfeldt-Jakob disease
    Mark W Head
    The National CJD Research and Surveillance Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, UK
    Rev Med Virol 22:214-29. 2012
    ....
  5. doi request reprint Review: Creutzfeldt-Jakob disease: prion protein type, disease phenotype and agent strain
    M W Head
    National CJD Research and Surveillance unit, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, UK
    Neuropathol Appl Neurobiol 38:296-310. 2012
    ....
  6. ncbi request reprint Prion protein heterogeneity in sporadic but not variant Creutzfeldt-Jakob disease: UK cases 1991-2002
    Mark W Head
    National Creutzfeldt Jakob Disease Surveillance Unit and Division of Pathology, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, United Kingdom
    Ann Neurol 55:851-9. 2004
    ..The results show PrP(Sc) in variant Creutzfeldt-Jakob disease to be remarkably stereotyped. In contrast, considerable heterogeneity in PrP(Sc) exists both between and within cases of sporadic Creutzfeldt-Jakob disease...
  7. ncbi request reprint Evaluation of urinary PrPSc as a diagnostic test for sporadic, variant, and familial CJD
    M W Head
    National CJD Surveillance Unit, School of Molecular and Clinical Medicine, University of Edinburgh, UK
    Neurology 64:1794-6. 2005
    ..In this context, the test had a low sensitivity and was not completely specific for CJD. Additionally, the proteins detected by this assay were not PrP(Sc) but appeared to be immunoglobulins...
  8. pmc Abnormal prion protein in the retina of the most commonly occurring subtype of sporadic Creutzfeldt-Jakob disease
    M W Head
    National CJD Surveillance Unit, Bryan Matthews Building, Western General Hospital, University of Edinburgh EH4 2XU, UK
    Br J Ophthalmol 89:1131-3. 2005
    ..Involvement of the eye has been reported in patients with variant Creutzfeldt-Jakob disease (vCJD), but there is disagreement on whether retinal involvement occurs in sporadic Creutzfeldt-Jakob disease (sCJD)...
  9. pmc Peripheral tissue involvement in sporadic, iatrogenic, and variant Creutzfeldt-Jakob disease: an immunohistochemical, quantitative, and biochemical study
    Mark W Head
    National Creutzfeldt Jakob Disease Surveillance Unit and Division of Pathology, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom
    Am J Pathol 164:143-53. 2004
    ..The results show that involvement of the lymphoreticular system is a defining feature of variant Creutzfeldt-Jakob disease, but that the biochemical isoform of PrP(Sc) found is influenced by the cell type in which it accumulates...
  10. doi request reprint An antibody to the aggregated synthetic prion protein peptide (PrP106-126) selectively recognizes disease-associated prion protein (PrP) from human brain specimens
    Michael Jones
    National CJD Surveillance Unit, School of Molecular and Clinical Medicine Pathology, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Brain Pathol 19:293-302. 2009
    ..These results suggest that P1:1 recognizes an epitope formed during the structural rearrangement or aggregation of the PrP that is common to the major PrP(Sc) types found in the most common forms of human prion disease...
  11. doi request reprint Effects of human PrPSc type and PRNP genotype in an in-vitro conversion assay
    Michael Jones
    National CJD Surveillance Unit, School of Molecular and Clinical Medicine Pathology, The Roslin Institute, Edinburgh, UK
    Neuroreport 19:1783-6. 2008
    ....
  12. doi request reprint Human platelets as a substrate source for the in vitro amplification of the abnormal prion protein (PrP) associated with variant Creutzfeldt-Jakob disease
    Michael Jones
    University of Edinburgh, Western General Hospital, UK
    Transfusion 49:376-84. 2009
    ....
  13. pmc Molecular model of prion transmission to humans
    Michael Jones
    National CJD Surveillance Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland EH4 2XU, UK
    Emerg Infect Dis 15:2013-6. 2009
    ..Protein misfolding cyclic amplification showed that conformation of PrPd partly determines host susceptibility...
  14. doi request reprint Transmissions of variant Creutzfeldt-Jakob disease from brain and lymphoreticular tissue show uniform and conserved bovine spongiform encephalopathy-related phenotypic properties on primary and secondary passage in wild-type mice
    Diane L Ritchie
    National CJD Surveillance Unit, School of Molecular and Clinical Medicine Pathology, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    J Gen Virol 90:3075-82. 2009
    ..Overall, the results closely resembled those of previously reported transmissions of BSE in the same mouse strains, consistent with BSE being the origin of all of these vCJD cases...
  15. pmc Detection of type 1 prion protein in variant Creutzfeldt-Jakob disease
    Helen M Yull
    National CJD Surveillance Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK
    Am J Pathol 168:151-7. 2006
    ..These results indicate that PrP(Sc) molecular typing is based on quantitative rather than qualitative phenomena and point to a complex relationship between prion protein biochemistry, disease phenotype and agent strain...
  16. doi request reprint Correlation of polydispersed prion protein and characteristic pathology in the thalamus in variant Creutzfeldt-Jakob disease: implication of small oligomeric species
    Young Pyo Choi
    National Creutzfeldt Jakob Disease Surveillance Unit, School of Molecular and Clinical Medicine Pathology, University of Edinburgh, Edinburgh, UK
    Brain Pathol 21:298-307. 2011
    ....
  17. pmc Real time quaking-induced conversion analysis of cerebrospinal fluid in sporadic Creutzfeldt-Jakob disease
    Lynne I McGuire
    National Creutzfeldt Jakob Disease Research and Surveillance Unit, University of Edinburgh, Edinburgh, United Kingdom
    Ann Neurol 72:278-85. 2012
    ..The objective of this study is to investigate whether CSF RT-QuIC analysis could be used as a diagnostic test in sCJD...
  18. pmc No major change in vCJD agent strain after secondary transmission via blood transfusion
    Matthew T Bishop
    National CJD Surveillance Unit, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom
    PLoS ONE 3:e2878. 2008
    ..Since there are likely to be carriers of the vCJD agent in the general population, there is a potential for further infection by routes such as blood transfusion or contaminated surgical instruments...
  19. doi request reprint Production and characterization of a panel of monoclonal antibodies against native human cellular prion protein
    Michael Jones
    National CJD Surveillance Unit, School of Molecular and Clinical Medicine Pathology, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
    Hybridoma (Larchmt) 28:13-20. 2009
    ..Furthermore, several of these MAbs showed a selectivity in their ability to immunoprecipitate disease associated PrP(Sc) and its corresponding protease resistant core (PrP(res))...
  20. ncbi request reprint Prion protein accumulation in eyes of patients with sporadic and variant Creutzfeldt-Jakob disease
    Mark W Head
    National Creutzfeldt Jakob Disease Surveillance Unit and Department of Pathology, University of Edinburgh, Scotland, United Kingdom
    Invest Ophthalmol Vis Sci 44:342-6. 2003
    ..This study was conducted to assess the possible involvement of the eye in sporadic and variant CJD by testing for the presence of the disease-associated, protease-resistant isoform of the prion protein (PrP(Sc)) in ocular tissue...
  21. pmc Distinct stability states of disease-associated human prion protein identified by conformation-dependent immunoassay
    Young Pyo Choi
    National CJD Surveillance Unit, Western General Hospital, Edinburgh, EH4 2XU, UK
    J Virol 84:12030-8. 2010
    ..These results suggest that conformational stability represents a further dimension to a complete description of potentially phenotype-related properties of PrP(Sc) in human prion diseases...
  22. ncbi request reprint Neuropathology of variant Creutzfeldt-Jakob disease
    James W Ironside
    National Creutzfeldt Jakob Disease Surveillance Unit, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
    Acta Neurobiol Exp (Wars) 62:175-82. 2002
    ....
  23. ncbi request reprint Sporadic Creutzfeldt-Jakob disease: further twists and turns in a convoluted protein
    Mark W Head
    National Creutzfeldt Jakob Disease Surveillance Unit, University of Edinburgh, Western General Hospital, Edinburgh EH4 2 XU, UK
    Brain 129:2238-40. 2006
  24. doi request reprint The application of in vitro cell-free conversion systems to human prion diseases
    Michael Jones
    Components and vCJD Research, National Science Laboratories, Scottish National Blood Transfusion Service, Edinburgh, EH 17 7QT, UK
    Acta Neuropathol 121:135-43. 2011
    ....
  25. ncbi request reprint Abnormal prion protein in the pituitary in sporadic and variant Creutzfeldt-Jakob disease
    Alexander H Peden
    National Creutzfeldt Jakob Disease Surveillance Unit NCJDSU and Division of Pathology, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK
    J Gen Virol 88:1068-72. 2007
    ....
  26. pmc Sensitive and specific detection of sporadic Creutzfeldt-Jakob disease brain prion protein using real-time quaking-induced conversion
    Alexander H Peden
    National CJD Research and Surveillance unit, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, UK
    J Gen Virol 93:438-49. 2012
    ..Comparison of these QuIC results with those previously obtained using PMCA suggested that these two seemingly similar assays differ in important respects...
  27. doi request reprint Human embryonic stem cells rapidly take up and then clear exogenous human and animal prions in vitro
    Zuzana Krejciova
    National CJD Surveillance Unit, School of Molecular and Clinical Medicine Pathology, University of Edinburgh, Western General Hospital, Edinburgh, UK
    J Pathol 223:635-45. 2011
    ....
  28. ncbi request reprint Predicting susceptibility and incubation time of human-to-human transmission of vCJD
    M T Bishop
    National CJD Surveillance Unit, Bryan Matthews Building, Western General Hospital, Edinburgh, UK
    Lancet Neurol 5:393-8. 2006
    ..We aimed to model iatrogenic spread to enable a comparison of transmission efficiencies of vCJD and bovine spongiform encephalopathy (BSE) and an assessment of the effect of the codon-129 polymorphism on human susceptibility...
  29. doi request reprint Variant CJD infection in the spleen of a neurologically asymptomatic UK adult patient with haemophilia
    A Peden
    National Creutzfeldt Jakob Disease Surveillance Unit, University of Edinburgh, Edinburgh, UK
    Haemophilia 16:296-304. 2010
    ....
  30. pmc Prion protein accumulation and neuroprotection in hypoxic brain damage
    Neil F McLennan
    National Creutzfeldt Jakob Disease Surveillance Unit and Pathology Neuropathology, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, Scotland, UK
    Am J Pathol 165:227-35. 2004
    ..Furthermore, the infarct size in PrP-null mice was significantly greater than in the wild type, supporting the proposed role for PrP(C) in the neuroprotective adaptive cellular response to hypoxic injury...
  31. ncbi request reprint Preclinical vCJD after blood transfusion in a PRNP codon 129 heterozygous patient
    Alexander H Peden
    National Creutzfeldt Jakob Disease Surveillance Unit, Division of Pathology, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
    Lancet 364:527-9. 2004
    ..These findings have major implications for future estimates and surveillance of vCJD in the UK...
  32. pmc Detection and localization of PrPSc in the skeletal muscle of patients with variant, iatrogenic, and sporadic forms of Creutzfeldt-Jakob disease
    Alexander H Peden
    National Creutzfeldt Jakob Disease Surveillance Unit and Division of Pathology, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom
    Am J Pathol 168:927-35. 2006
    ....
  33. doi request reprint Comparison of the level, distribution and form of disease-associated prion protein in variant and sporadic Creutzfeldt-Jakob diseased brain using conformation-dependent immunoassay and Western blot
    Young Pyo Choi
    National CJD Surveillance Unit, School of Molecular and Clinical Medicine Pathology, University of Edinburgh, Edinburgh, UK
    J Gen Virol 92:727-32. 2011
    ..Additionally, the combination of protease digestion and CDI detection demonstrated, for the first time, the presence of PrP(Sc) in variant CJD brains that is susceptible to proteolysis under standard conditions...
  34. doi request reprint Advances in the development of a screening test for variant Creutzfeldt-Jakob disease
    Alexander H Peden
    Postdoctoral Research Fellow University of Edinburgh, National CJD Surveillance Unit NCJDSU, School of Molecular and Clinical Medicine Pathology, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK 44 0131 537 1980 44 0131 343 1404
    Expert Opin Med Diagn 2:207-19. 2008
    ..This paper reviews progress that has been made in the development of potential tests and the protocols that have been devised for their evaluation...
  35. doi request reprint Further characterisation of the prion protein molecular types detectable in the NIBSC Creutzfeldt-Jakob disease brain reference materials
    Helen M Yull
    National CJD Surveillance Unit, School of Molecular and Clinical Medicine Pathology, University of Edinburgh, Edinburgh, United Kingdom
    Biologicals 37:210-5. 2009
    ..We conclude that these reagents provide a valuable resource for future research and development...
  36. ncbi request reprint In vitro amplification and detection of variant Creutzfeldt-Jakob disease PrPSc
    M Jones
    National CJD Surveillance Unit, School of Molecular and Clinical Medicine Pathology, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
    J Pathol 213:21-6. 2007
    ....
  37. ncbi request reprint Pathological diagnosis of variant Creutzfeldt-Jakob disease
    J W Ironside
    Department of Pathology, University of Edinburgh, Western General Hospital, United Kingdom
    APMIS 110:79-87. 2002
    ....
  38. ncbi request reprint Variant Creutzfeldt-Jakob disease and its transmission by blood
    J W Ironside
    National Creutzfeldt Jakob Disease Surveillance Unit, Division of Pathology, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, UK
    J Thromb Haemost 1:1479-86. 2003
    ....
  39. ncbi request reprint Small heat shock proteins, the cytoskeleton, and inclusion body formation
    M W Head
    The National CJD Surveillance Unit, Western General Hospital, Edinburgh
    Neuropathol Appl Neurobiol 26:304-12. 2000
    ....
  40. ncbi request reprint Laboratory diagnosis of variant Creutzfeldt-Jakob disease
    J W Ironside
    Departments of Pathology, Clinical Neurosciences, CJD Surveillance Unit, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Histopathology 37:1-9. 2000
    ..Continued surveillance is required to further investigate this possibility, with the need to investigate autopsy tissues from suspected cases by histological and biochemical techniques...
  41. ncbi request reprint Advances in the detection of prion protein in peripheral tissues of variant Creutzfeldt-Jakob disease patients using paraffin-embedded tissue blotting
    D L Ritchie
    National Creutzfeldt Jakob Disease Surveillance Unit, School of Clinical and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Neuropathol Appl Neurobiol 30:360-8. 2004
    ..Autopsy and biopsy brain material from sporadic CJD cases also showed an increased sensitivity of PrP(res) detection with the PET blot, confirming its value as an important diagnostic and research tool in human prion diseases...
  42. ncbi request reprint Variant Creutzfeldt-Jakob disease: risk of transmission by blood and blood products
    J W Ironside
    National Creutzfeldt Jakob Disease Surveillance Unit, Edinburgh, UK
    Haemophilia 10:64-9. 2004
    ....
  43. ncbi request reprint Phenotypic variability in human prion diseases
    J W Ironside
    National Creutzfeldt Jakob Disease Surveillance Unit, Division of Pathology, University of Edinburgh, UK
    Neuropathol Appl Neurobiol 31:565-79. 2005
    ..Further work is required to clarify these relationships and to explain the mechanism of neuropathological targeting of specific brain regions, which accounts for the diversity of clinical features within human prion diseases...
  44. ncbi request reprint Neuropathology and molecular biology of variant Creutzfeldt-Jakob disease
    J W Ironside
    National Creutzfeldt Jakob Disease Surveillance Unit, Department of Pathology, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK
    Curr Top Microbiol Immunol 284:133-59. 2004
    ..Histological, genetic and biochemical techniques are essential tools for the adequate diagnosis and investigation of human prion diseases...
  45. pmc Human Tonsil-Derived Follicular Dendritic-Like Cells are Refractory to Human Prion Infection in Vitro and Traffic Disease-Associated Prion Protein to Lysosomes
    Zuzana Krejciova
    National Creutzfeldt Jakob Disease Research and Surveillance Unit, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom
    Am J Pathol 184:64-70. 2014
    ..Our data suggest that human follicular dendritic-like cells and perhaps other human cell types are able to avoid prion infection by efficient lysosomal degradation of PrP(TSE). ..
  46. ncbi request reprint Purification of normal cellular prion protein from human platelets and the formation of a high molecular weight prion protein complex following platelet activation
    Michael Jones
    National CJD Surveillance Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
    Biochem Biophys Res Commun 335:48-56. 2005
    ..Subsequently, PrP(C) was purified from the Triton X-100 lysate by sequential cation ion exchange and Cu2+ affinity chromatography. From 10 L of outdated platelet concentrate, we were able to recover 1.29 mg PrP(C) at a purity of 92%...
  47. pmc Differential protein profiling as a potential multi-marker approach for TSE diagnosis
    Janice B Barr
    The Roslin Institute and R D SVS, University of Edinburgh, Roslin, Midlothian, EH25 9PS, UK
    BMC Infect Dis 9:188. 2009
    ..Recently, concern that this marker may not be as reliable as previously thought, coupled with an urgentneed for a pre-clinical live animal test, has led to the search for alternative assays for the detection of TSE disease...
  48. pmc Application of Atomic Dielectric Resonance Spectroscopy for the screening of blood samples from patients with clinical variant and sporadic CJD
    Timothy J Fagge
    National CJD Surveillance Unit and Division of Pathology, University of Edinburgh School of Molecular and Clinical Medicine, Western General Hospital, Edinburgh EH4 2XU, UK
    J Transl Med 5:41. 2007
    ..Most assays aim to detect abnormal prion protein (PrPSc), although achieving required sensitivity is a challenge...
  49. ncbi request reprint Application of an immunocapillary electrophoresis assay to the detection of abnormal prion protein in brain, spleen and blood specimens from patients with variant Creutzfeldt-Jakob disease
    Paula C Lourenco
    National CJD Surveillance Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
    J Gen Virol 87:3119-24. 2006
    ..In this context, the ICE assay was specific, but incompletely sensitive (55%). The method was unable to detect abnormal prion protein in variant CJD brain or spleen reference materials due to its loss during the extraction process...
  50. ncbi request reprint Mad cows and monkey business: the end of vCJD?
    Mark W Head
    National Creutzfeldt Jakob Disease Surveillance Unit, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
    Lancet 365:730-1. 2005
  51. pmc vCJD and the gut: implications for endoscopy
    M W Head
    National Creutzfeldt Jakob Disease Surveillance Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
    Gut 56:9-11. 2007
  52. ncbi request reprint Investigation of PrPres in dental tissues in variant CJD
    M W Head
    National Creutzfeldt Jakob Disease Surveillance Unit, Division of Pathology, School of Clinical and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU
    Br Dent J 195:339-43; discussion 331. 2003
    ..To study the distribution of disease-associated prion protein (PrP) in oral and dental tissues in variant CJD...
  53. pmc Dura mater-associated Creutzfeldt-Jakob disease: experience from surveillance in the UK
    C A Heath
    National CJD Surveillance Unit, Bryan Matthews Building, Western General Hospital, Edinburgh EH4 2XU, UK
    J Neurol Neurosurg Psychiatry 77:880-2. 2006
    ..The mean incubation period of the human dura mater cases was 93 (range 45-177) months. The clinico-pathological features of the cases are described and compared with cases previously reported in the world literature...
  54. pmc Raised CSF phospho-tau concentrations in variant Creutzfeldt-Jakob disease: diagnostic and pathological implications
    C A Goodall
    The National Creutzfeldt Jakob Disease Surveillance Unit, Western General Hospital, Crewe Road, Edinburgh, UK
    J Neurol Neurosurg Psychiatry 77:89-91. 2006
    ..To investigate whether phosphorylated tau protein (tau-pT181) is increased in variant Creutzfeldt-Jakob disease (vCJD) and if the tau-pT181/tau protein ratio is useful for distinguishing between patients with and without CJD...
  55. ncbi request reprint Variant Creutzfeldt-Jakob disease
    H J T Ward
    National Creutzfeldt Jakob Disease Surveillance Unit, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
    Clin Lab Med 23:87-108. 2003
    ..Indeed a recent publication has suggested that the drugs quinacrine or chloropromazine may be candidates for the treatment of human prion diseases [42]...
  56. ncbi request reprint Immunohistochemistry for the prion protein: comparison of different monoclonal antibodies in human prion disease subtypes
    Gabor G Kovacs
    Institute of Neurology, University of Vienna, and Austrian Reference Centre for Human Prion Diseases
    Brain Pathol 12:1-11. 2002
    ..Antibodies such as 6H4 and 12F10 failed to give this type of labeling and are therefore less likely to recognise non-pathological PrP material in immunohistochemistry...
  57. ncbi request reprint Beyond PrP res type 1/type 2 dichotomy in Creutzfeldt-Jakob disease
    Emmanuelle Uro-Coste
    INSERM U858, Institut de Médecine Moléculaire de Rangueil and Service d Anatomie Pathologique et Histologie Cytologie, C H U Rangueil, Toulouse, France
    PLoS Pathog 4:e1000029. 2008
    ....
  58. pmc Beyond PrP9res) type 1/type 2 dichotomy in Creutzfeldt-Jakob disease
    Emmanuelle Uro-Coste
    INSERM U858, Institut de Médecine Moléculaire de Rangueil and Service d Anatomie Pathologique et Histologie Cytologie, C H U Rangueil, Toulouse, France
    PLoS Pathog 4:e1000029. 2008
    ....
  59. ncbi request reprint Properties of the cellular prion protein expressed in Xenopus oocytes
    John G Connolly
    Department of Physiology and Pharmacology, University of Strathclyde, SIBS, 27, Taylor Street, Glasgow G4 0NR, UK
    Neuroreport 13:1229-33. 2002
    ..The protein is glycosylated, fully protease sensitive and expressed on the cell surface. Xenopus oocytes therefore provide a useful model system for the study of prion proteins and their associated disease processes...
  60. ncbi request reprint Transplantation of ocular tissue from a donor with sporadic Creutzfeldt-Jakob disease
    Andrew B Tullo
    Manchester Royal Eye Hospital, Manchester, UK
    Clin Experiment Ophthalmol 34:645-9. 2006
    ..We report an incident in the UK in 1997 in which both corneas and scleras from a donor, subsequently confirmed to have had sCJD, were transplanted. The final clinical outcome for two surviving recipients is still not yet known...