Finbarr Hayes

Summary

Affiliation: University of Manchester Institute of Science and Technology
Country: UK

Publications

  1. ncbi request reprint Toxins-antitoxins: plasmid maintenance, programmed cell death, and cell cycle arrest
    Finbarr Hayes
    Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology, Manchester M60 1QD, UK
    Science 301:1496-9. 2003
  2. ncbi request reprint Transposon-based strategies for microbial functional genomics and proteomics
    Finbarr Hayes
    Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology, PO Box 88, Manchester M60 1QD, England
    Annu Rev Genet 37:3-29. 2003
  3. ncbi request reprint ParG, a protein required for active partition of bacterial plasmids, has a dimeric ribbon-helix-helix structure
    Alexander P Golovanov
    Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology UMIST, PO Box 88, Manchester M60 1QD, UK
    Mol Microbiol 50:1141-53. 2003
  4. pmc Protein diversity confers specificity in plasmid segregation
    Timothy J G Fothergill
    Faculty of Life Sciences, University of Manchester, Jackson s Mill, Sackville St, Manchester M60 1QD, England
    J Bacteriol 187:2651-61. 2005
  5. ncbi request reprint The function and organization of plasmids
    Finbarr Hayes
    Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology, UK
    Methods Mol Biol 235:1-17. 2003
  6. ncbi request reprint The bacterial segrosome: a dynamic nucleoprotein machine for DNA trafficking and segregation
    Finbarr Hayes
    Faculty of Life Sciences, University of Manchester, Jackson s Mill, PO Box 88, Sackville Street, Manchester M60 1QD, UK
    Nat Rev Microbiol 4:133-43. 2006
  7. ncbi request reprint Architecture of the ParF*ParG protein complex involved in prokaryotic DNA segregation
    Daniela Barillà
    Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology, PO Box 88, Manchester M60 1QD, UK
    Mol Microbiol 49:487-99. 2003
  8. ncbi request reprint Axe-Txe, a broad-spectrum proteic toxin-antitoxin system specified by a multidrug-resistant, clinical isolate of Enterococcus faecium
    Ruth Grady
    Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology UMIST, PO Box 88, Manchester M60 1QD, UK
    Mol Microbiol 47:1419-32. 2003
  9. ncbi request reprint Assembling the bacterial segrosome
    Finbarr Hayes
    Faculty of Life Sciences and Manchester Interdisciplinary Biocentre, University of Manchester, 131 Princess Street, Manchester M1 7ND, UK
    Trends Biochem Sci 31:247-50. 2006
  10. pmc Genomic and functional characterization of the modular broad-host-range RA3 plasmid, the archetype of the IncU group
    Anna Kulinska
    Department of Microbial Biochemistry, Institute of Biochemistry and Biophysics, PAS, Pawinskiego 5A, 02 106 Warsaw, Poland
    Appl Environ Microbiol 74:4119-32. 2008

Collaborators

  • Daniela Barillà
  • Alexander P Golovanov
  • Timothy J G Fothergill
  • Anna Kulinska
  • Cristina Machón
  • Barbara Kedzierska
  • Lu Yun Lian
  • Emma Carmelo
  • Ruth Grady
  • Viviane Robert
  • Magdalena Czeredys
  • Grazyna Jagura-Burdzy
  • Andrew Derome
  • Andrée Lazdunski
  • Gérard P F Michel

Detail Information

Publications16

  1. ncbi request reprint Toxins-antitoxins: plasmid maintenance, programmed cell death, and cell cycle arrest
    Finbarr Hayes
    Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology, Manchester M60 1QD, UK
    Science 301:1496-9. 2003
    ..The dissection of the interaction of the toxins with intracellular targets and the elucidation of the tertiary structures of toxin-antitoxin complexes have provided exciting insights into toxin-antitoxin behavior...
  2. ncbi request reprint Transposon-based strategies for microbial functional genomics and proteomics
    Finbarr Hayes
    Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology, PO Box 88, Manchester M60 1QD, England
    Annu Rev Genet 37:3-29. 2003
    ..These and other transposon-based approaches have reaffirmed the usefulness of these elements as simple yet highly effective mutagens for both functional genomic and proteomic studies of microorganisms...
  3. ncbi request reprint ParG, a protein required for active partition of bacterial plasmids, has a dimeric ribbon-helix-helix structure
    Alexander P Golovanov
    Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology UMIST, PO Box 88, Manchester M60 1QD, UK
    Mol Microbiol 50:1141-53. 2003
    ....
  4. pmc Protein diversity confers specificity in plasmid segregation
    Timothy J G Fothergill
    Faculty of Life Sciences, University of Manchester, Jackson s Mill, Sackville St, Manchester M60 1QD, England
    J Bacteriol 187:2651-61. 2005
    ..The results reveal that the partition complexes of these and related plasmids have recruited disparate DNA-binding factors that provide a layer of specificity to the macromolecular interactions that mediate plasmid segregation...
  5. ncbi request reprint The function and organization of plasmids
    Finbarr Hayes
    Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology, UK
    Methods Mol Biol 235:1-17. 2003
  6. ncbi request reprint The bacterial segrosome: a dynamic nucleoprotein machine for DNA trafficking and segregation
    Finbarr Hayes
    Faculty of Life Sciences, University of Manchester, Jackson s Mill, PO Box 88, Sackville Street, Manchester M60 1QD, UK
    Nat Rev Microbiol 4:133-43. 2006
    ..Shedding light on the basis of genome segregation in bacteria could indicate new strategies aimed at combating pathogenic and antibiotic-resistant bacteria...
  7. ncbi request reprint Architecture of the ParF*ParG protein complex involved in prokaryotic DNA segregation
    Daniela Barillà
    Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology, PO Box 88, Manchester M60 1QD, UK
    Mol Microbiol 49:487-99. 2003
    ..Intriguingly, the ParF and ParG proteins form at least two types of discrete complex in the absence of this region suggesting that the assembly dynamics of these proteins onto DNA is intricate...
  8. ncbi request reprint Axe-Txe, a broad-spectrum proteic toxin-antitoxin system specified by a multidrug-resistant, clinical isolate of Enterococcus faecium
    Ruth Grady
    Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology UMIST, PO Box 88, Manchester M60 1QD, UK
    Mol Microbiol 47:1419-32. 2003
    ..Axe-Txe is one of the first functional proteic toxin-antitoxin systems to be accurately described for Gram-positive bacteria...
  9. ncbi request reprint Assembling the bacterial segrosome
    Finbarr Hayes
    Faculty of Life Sciences and Manchester Interdisciplinary Biocentre, University of Manchester, 131 Princess Street, Manchester M1 7ND, UK
    Trends Biochem Sci 31:247-50. 2006
    ....
  10. pmc Genomic and functional characterization of the modular broad-host-range RA3 plasmid, the archetype of the IncU group
    Anna Kulinska
    Department of Microbial Biochemistry, Institute of Biochemistry and Biophysics, PAS, Pawinskiego 5A, 02 106 Warsaw, Poland
    Appl Environ Microbiol 74:4119-32. 2008
    ..The putative conjugative-transfer module is highly similar in organization and in its products to transfer regions of certain broad-host-range environmental plasmids...
  11. ncbi request reprint The unstructured N-terminal tail of ParG modulates assembly of a quaternary nucleoprotein complex in transcription repression
    Emma Carmelo
    Faculty of Life Sciences, The University of Manchester, Manchester M60 1QD, United Kingdom
    J Biol Chem 280:28683-91. 2005
    ..The results provide new insights into the role of natively unfolded domains in protein function, the molecular mechanisms of transcription regulation, and the control of plasmid segregation...
  12. pmc Bacterial DNA segregation dynamics mediated by the polymerizing protein ParF
    Daniela Barillà
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    EMBO J 24:1453-64. 2005
    ..This points to an evolutionary parallel between DNA segregation and cytokinesis in prokaryotic cells, and reveals a potential molecular mechanism for plasmid and chromosome segregation mediated by the ubiquitous ParA-type proteins...
  13. pmc Toxin-antitoxin regulation: bimodal interaction of YefM-YoeB with paired DNA palindromes exerts transcriptional autorepression
    Barbara Kedzierska
    Faculty of Life Sciences and Manchester Interdisciplinary Biocentre, The University of Manchester, 131 Princess Street, Manchester M1 7DN, UK
    Nucleic Acids Res 35:325-39. 2007
    ..Artificial perturbation of transcriptional autorepression could elicit inappropriate YoeB toxin production and induction of bacterial cell suicide, a potentially novel antibacterial strategy...
  14. pmc The tail of the ParG DNA segregation protein remodels ParF polymers and enhances ATP hydrolysis via an arginine finger-like motif
    Daniela Barillà
    Department of Biology Area 10, University of York, York, United Kingdom
    Proc Natl Acad Sci U S A 104:1811-6. 2007
    ....
  15. ncbi request reprint Promiscuous stimulation of ParF protein polymerization by heterogeneous centromere binding factors
    Cristina Machón
    Faculty of Life Sciences, The University of Manchester, 131 Princess Street, Manchester M1 7DN, UK
    J Mol Biol 374:1-8. 2007
    ..The CBFs appear to function as bacterial analogues of formins, microtubule-associated proteins or related ancillary factors that regulate eucaryotic cytoskeletal dynamics...
  16. pmc Identification of XcpZ domains required for assembly of the secreton of Pseudomonas aeruginosa
    Viviane Robert
    Laboratoire d Ingenierie des Systemes Macromoleculaires, Institut de Biologie Structurale et Microbiologie, CNRS, 13402 Marseille Cedex 20, France
    J Bacteriol 184:1779-82. 2002
    ..Interestingly, we also demonstrated that another component of the machinery, XcpP, can modulate the stabilizing activity of XcpZ on XcpY...