P M Hawkey

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. ncbi request reprint Prevalence and clonality of extended-spectrum beta-lactamases in Asia
    P M Hawkey
    Division of Immunity and Infection, University of Birmingham, Birmingham and Health Protection Agency, West Midlands Public Health Laboratory, Birmingham Heart of England NHS Trust, Bordesley Green East, Birmingham, UK
    Clin Microbiol Infect 14:159-65. 2008
  2. ncbi request reprint Occurrence, prevalence and genetic environment of CTX-M beta-lactamases in Enterobacteriaceae from Indian hospitals
    V M Ensor
    Antimicrobial Agents Research Group, Institute of Biomedical Research, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, UK
    J Antimicrob Chemother 58:1260-3. 2006
  3. ncbi request reprint Predominance and genetic diversity of community- and hospital-acquired CTX-M extended-spectrum beta-lactamases in York, UK
    C J Munday
    Antimicrobial Agents Research Group, Division of Immunobiology and Infection, The Medical School, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, UK
    J Antimicrob Chemother 54:628-33. 2004
  4. doi request reprint Reducing Clostridium difficile through early identification of clusters and the use of a standardised set of interventions
    K J Hardy
    West Midlands Public Health Laboratory, Heart of England NHS Foundation Trust, Birmingham B9 5SS, UK
    J Hosp Infect 75:277-81. 2010
  5. ncbi request reprint Rapid recontamination with MRSA of the environment of an intensive care unit after decontamination with hydrogen peroxide vapour
    K J Hardy
    West Midlands Public Health Laboratory, Health Protection Agency, Heartlands Hospital, Bordesley Green East, Birmingham, UK
    J Hosp Infect 66:360-8. 2007
  6. ncbi request reprint Dissemination of CTX-M type beta-lactamases in Enterobacteriaceae isolates in the People's Republic of China
    C J Munday
    Division of Immunobiology and Infection, The Medical School, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK
    Int J Antimicrob Agents 23:175-80. 2004
  7. ncbi request reprint Prevalence and mechanism of resistance to 'third-generation' cephalosporins in clinically relevant isolates of Enterobacteriaceae from 43 hospitals in the UK, 1990-1991
    L J Piddock
    Department of Infection, The Medical School, University of Birmingham, UK
    J Antimicrob Chemother 39:177-87. 1997
  8. doi request reprint Pre-clinical experience with daptomycin
    P M Hawkey
    Division of Immunity and Infection, The Medical School, University of Birmingham, Birmingham, UK
    J Antimicrob Chemother 62:iii7-14. 2008
  9. doi request reprint Low-level glycopeptide resistance in methicillin-resistant Staphylococcus aureus and how to test it
    P M Hawkey
    Division of Immunity and Infection, The Medical School, University of Birmingham, and Health Protection Agency West Midlands Public Health Laboratory, Heart of England NHS Foundation Trust, Birmingham, UK
    Clin Microbiol Infect 15:2-9. 2009
  10. doi request reprint The growing burden of antimicrobial resistance
    P M Hawkey
    Division of Immunity and Infection, The Medical School, University of Birmingham, Birmingham B15 2TT, UK
    J Antimicrob Chemother 62:i1-9. 2008

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Prevalence and clonality of extended-spectrum beta-lactamases in Asia
    P M Hawkey
    Division of Immunity and Infection, University of Birmingham, Birmingham and Health Protection Agency, West Midlands Public Health Laboratory, Birmingham Heart of England NHS Trust, Bordesley Green East, Birmingham, UK
    Clin Microbiol Infect 14:159-65. 2008
    ..The high prevalence of ESBL genes in Asia means that the empirical treatment of serious infections with beta-lactam antibiotics, except carbapenems, is seriously compromised...
  2. ncbi request reprint Occurrence, prevalence and genetic environment of CTX-M beta-lactamases in Enterobacteriaceae from Indian hospitals
    V M Ensor
    Antimicrobial Agents Research Group, Institute of Biomedical Research, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, UK
    J Antimicrob Chemother 58:1260-3. 2006
    ....
  3. ncbi request reprint Predominance and genetic diversity of community- and hospital-acquired CTX-M extended-spectrum beta-lactamases in York, UK
    C J Munday
    Antimicrobial Agents Research Group, Division of Immunobiology and Infection, The Medical School, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, UK
    J Antimicrob Chemother 54:628-33. 2004
    ....
  4. doi request reprint Reducing Clostridium difficile through early identification of clusters and the use of a standardised set of interventions
    K J Hardy
    West Midlands Public Health Laboratory, Heart of England NHS Foundation Trust, Birmingham B9 5SS, UK
    J Hosp Infect 75:277-81. 2010
    ..By taking early action with a set of standardised measures the incidence of hospital-acquired CDI can be reduced...
  5. ncbi request reprint Rapid recontamination with MRSA of the environment of an intensive care unit after decontamination with hydrogen peroxide vapour
    K J Hardy
    West Midlands Public Health Laboratory, Health Protection Agency, Heartlands Hospital, Bordesley Green East, Birmingham, UK
    J Hosp Infect 66:360-8. 2007
    ....
  6. ncbi request reprint Dissemination of CTX-M type beta-lactamases in Enterobacteriaceae isolates in the People's Republic of China
    C J Munday
    Division of Immunobiology and Infection, The Medical School, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK
    Int J Antimicrob Agents 23:175-80. 2004
    ..After comparison with other previously published studies in the English language, we conclude that the most prevalent bla(CTX-M) so far reported in Asia are bla(CTX-M-14) and bla(CTX-M-3)...
  7. ncbi request reprint Prevalence and mechanism of resistance to 'third-generation' cephalosporins in clinically relevant isolates of Enterobacteriaceae from 43 hospitals in the UK, 1990-1991
    L J Piddock
    Department of Infection, The Medical School, University of Birmingham, UK
    J Antimicrob Chemother 39:177-87. 1997
    ..It is important that surveillance of resistance to these clinically important antibiotics is maintained as the occurrence of localized or more widespread outbreaks caused by bacteria producing ESBLs is to be expected...
  8. doi request reprint Pre-clinical experience with daptomycin
    P M Hawkey
    Division of Immunity and Infection, The Medical School, University of Birmingham, Birmingham, UK
    J Antimicrob Chemother 62:iii7-14. 2008
    ....
  9. doi request reprint Low-level glycopeptide resistance in methicillin-resistant Staphylococcus aureus and how to test it
    P M Hawkey
    Division of Immunity and Infection, The Medical School, University of Birmingham, and Health Protection Agency West Midlands Public Health Laboratory, Heart of England NHS Foundation Trust, Birmingham, UK
    Clin Microbiol Infect 15:2-9. 2009
    ..Further confirmation would be required using either macrodilution Etest methodology using an MIC >or= 8mg/L of vancomycin and/or teicoplanin as the cut off for hGISA or the newer GRD (glycopeptide resistance detection) strip...
  10. doi request reprint The growing burden of antimicrobial resistance
    P M Hawkey
    Division of Immunity and Infection, The Medical School, University of Birmingham, Birmingham B15 2TT, UK
    J Antimicrob Chemother 62:i1-9. 2008
    ..Although efforts are being made in all these areas, there is an urgent need to increase the effectiveness of these interventions or some bacterial infections will become difficult if not impossible to treat reliably...
  11. ncbi request reprint Distribution and characterization of staphylococcal interspersed repeat units (SIRUs) and potential use for strain differentiation
    K J Hardy
    West Midlands Public Health Laboratory, Health Protection Agency, Heartlands Hospital, Bordesley Green East, Birmingham B9 5SS, UK
    Microbiology 150:4045-52. 2004
    ..aureus clades...
  12. pmc Molecular epidemiology of clinically significant antibiotic resistance genes
    P M Hawkey
    Division of Immunity and Infection, The Medical School, University of Birmingham, Birmingham B15 2TT, UK
    Br J Pharmacol 153:S406-13. 2008
    ..The role of selective pressures in the environment as well as the medical use of antimicrobials together with the interplay of various genetic mechanisms for horizontal gene transfer are considered in the concluding part of this review...
  13. doi request reprint Imported chicken meat as a potential source of quinolone-resistant Escherichia coli producing extended-spectrum beta-lactamases in the UK
    R E Warren
    Microbiology Laboratory, Shrewsbury and Telford Hospital NHS Trust, Shrewsbury SY3 8XQ, UK
    J Antimicrob Chemother 61:504-8. 2008
    ..coli with bla(CTX-M) genes. A further 40 samples for which the country of rearing could not be identified were examined...
  14. ncbi request reprint A novel reverse-line hybridization assay for identifying genotypes of CTX-M-type extended-spectrum beta-lactamases
    V M Ensor
    West Midlands Health Protection Agency, Heart of England NHS Foundation Trust, Bordesley Green, Birmingham B9 5SS, UK
    J Antimicrob Chemother 59:387-95. 2007
    ..To develop a reverse-line hybridization assay to identify CTX-M genotypes, potentially useful for large-scale investigation of surveillance collections...
  15. ncbi request reprint CTX-M: changing the face of ESBLs in the UK
    D M Livermore
    Antibiotic Resistance Monitoring and Reference Laboratory, Centre for Infections, Health Protection Agency, London NW9 5HT, UK
    J Antimicrob Chemother 56:451-4. 2005
    ..coli but other Enterobacteriaceae in the UK and this will represent a substantial threat to both the treatment of infections caused by these bacteria in the community and within hospitals...
  16. pmc Incidence of class 1 integrons in a quaternary ammonium compound-polluted environment
    W H Gaze
    Environmental Microbiology, University of Warwick, Coventry CV4 7AL, UK
    Antimicrob Agents Chemother 49:1802-7. 2005
    ....
  17. ncbi request reprint Description and clinical treatment of an early outbreak of severe acute respiratory syndrome (SARS) in Guangzhou, PR China
    Z Zhao
    Department of Respiratory Disease, First Municipal People s Hospital of Guangzhou, 1 Panfu Road, Guangzhou, People s Republic of China
    J Med Microbiol 52:715-20. 2003
    ..Early administration of high-dose steroids and CPAP ventilation appears to offer the best supportive treatment with a reduced mortality compared with other treatment regimens...
  18. ncbi request reprint CTX-M extended-spectrum beta-lactamase arrives in the UK
    I Alobwede
    J Antimicrob Chemother 51:470-1. 2003
  19. ncbi request reprint SHV-12, SHV-5, SHV-2a and VEB-1 extended-spectrum beta-lactamases in Gram-negative bacteria isolated in a university hospital in Thailand
    A Chanawong
    Department of Microbiology, University of Leeds, Leeds LS2 9JT, UK
    J Antimicrob Chemother 48:839-52. 2001
    ..putida. These findings indicate that ESBL genes in the Far East are part of a gene pool capable of broad horizontal gene transfer, in that these genes can transfer between different families of Gram-negative bacilli...
  20. pmc Discrimination of SHV beta-lactamase genes by restriction site insertion-PCR
    A Chanawong
    Division of Microbiology, School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
    Antimicrob Agents Chemother 45:2110-4. 2001
    ..These simple techniques are readily applied to epidemiological studies of the SHV beta-lactamases and may be extended to the characterisation of other resistance determinants...
  21. ncbi request reprint Molecular epidemiology of ceftazidime resistant Enterobacteriaceae from patients on a paediatric oncology ward
    L C Hibbert-Rogers
    Department of Microbiology, University of Leeds, UK
    J Antimicrob Chemother 36:65-82. 1995
    ..Four years after discontinuing ceftazidime and other extended-spectrum cephalosporins on this ward, patients were still colonised with bacteria that produced extended-spectrum beta-lactamases...
  22. ncbi request reprint Convergent evolution of TEM-26, a beta-lactamase with extended-spectrum activity
    L C Hibbert-Rogers
    Department of Microbiology, University of Leeds, UK
    J Antimicrob Chemother 33:707-20. 1994
    ..This indicates that the genes encoding TEM-26 have evolved from different progenitors...
  23. pmc Transposition of the gene encoding a TEM-12 extended-spectrum beta-lactamase
    J Heritage
    Department of Microbiology, University of Leeds, United Kingdom
    Antimicrob Agents Chemother 36:1981-6. 1992
    ....