C Haslett

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc Activation of conventional protein kinase C (PKC) is critical in the generation of human neutrophil extracellular traps
    Robert D Gray
    MRC Centre for Inflammation Research, The Queen s Medical Research Institute, University of Edinburgh Medical School, 47 Little France Crescent, Edinburgh, Scotland, UK
    J Inflamm (Lond) 10:12. 2013
  2. ncbi request reprint Granulocyte apoptosis and its role in the resolution and control of lung inflammation
    C Haslett
    Rayne Laboratories, University of Edinburgh, Edinburgh, United Kingdom
    Am J Respir Crit Care Med 160:S5-11. 1999
  3. pmc Regulation of pulmonary and systemic bacterial lipopolysaccharide responses in transgenic mice expressing human elafin
    J M Sallenave
    Rayne Laboratory, Respiratory Medicine Unit, MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh EH8 9AG, Scotland, United Kingdom
    Infect Immun 71:3766-74. 2003
  4. doi request reprint Relevance of granulocyte apoptosis to resolution of inflammation at the respiratory mucosa
    A E Leitch
    MRC Centre for Inflammation Research, The Queen s Medical Research Institute, University of Edinburgh Medical School, Edinburgh, Scotland, UK
    Mucosal Immunol 1:350-63. 2008
  5. ncbi request reprint Modulation of granulocyte apoptosis can influence the resolution of inflammation
    A G Rossi
    MRC Centre for Inflammation Research, Queen s Medical Research Institute, University of Edinburgh Medical School, 47 Little France Crescent, Edinburgh, UK
    Biochem Soc Trans 35:288-91. 2007
  6. ncbi request reprint Regulation of granulocyte apoptosis by NF-kappaB
    C Ward
    Respiratory Medicine Unit, MRC Centre for Inflammation Research, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    Biochem Soc Trans 32:465-7. 2004
  7. ncbi request reprint Nitric oxide: a key regulator of myeloid inflammatory cell apoptosis
    E L Taylor
    Centre for Inflammation Research, Rayne Laboratory, University of Edinburgh, Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    Cell Death Differ 10:418-30. 2003
  8. ncbi request reprint Constitutive neutrophil apoptosis in culture is modulated by cell density independently of beta2 integrin-mediated adhesion
    S Hannah
    Department of Medicine R I E, University of Edinburgh Medical School, Scotland, UK
    FEBS Lett 421:141-6. 1998
  9. ncbi request reprint Pharmacological manipulation of granulocyte apoptosis: potential therapeutic targets
    C Ward
    The Rayne Laboratory, Respiratory Medicine Unit, University of Edinburgh Medical School, Teviot Place, Edinburgh, UK EH8 9AG
    Trends Pharmacol Sci 20:503-9. 1999
  10. ncbi request reprint Soluble E-selectin acts in synergy with platelet-activating factor to activate neutrophil beta 2-integrins. Role of tyrosine kinases and Ca2+ mobilization
    M H Ruchaud-Sparagano
    Rayne Laboratory, Respiratory Medicine Unit, University of Edinburgh Medical School, Edinburgh EH8 9AG, United Kingdom
    J Biol Chem 275:15758-64. 2000

Collaborators

Detail Information

Publications25

  1. pmc Activation of conventional protein kinase C (PKC) is critical in the generation of human neutrophil extracellular traps
    Robert D Gray
    MRC Centre for Inflammation Research, The Queen s Medical Research Institute, University of Edinburgh Medical School, 47 Little France Crescent, Edinburgh, Scotland, UK
    J Inflamm (Lond) 10:12. 2013
    ..Activation of NADPH oxidase is required for neutrophil extracellular trap (NET) formation. Protein kinase C (PKC) is an upstream mediator of NADPH oxidase activation and thus likely to have a role in NET formation...
  2. ncbi request reprint Granulocyte apoptosis and its role in the resolution and control of lung inflammation
    C Haslett
    Rayne Laboratories, University of Edinburgh, Edinburgh, United Kingdom
    Am J Respir Crit Care Med 160:S5-11. 1999
    ..Furthermore, such differences may lead to novel therapies based on the specific induction of eosinophil apoptosis. Haslett C. Granulocyte apoptosis and its role in the resolution and control of lung inflammation...
  3. pmc Regulation of pulmonary and systemic bacterial lipopolysaccharide responses in transgenic mice expressing human elafin
    J M Sallenave
    Rayne Laboratory, Respiratory Medicine Unit, MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh EH8 9AG, Scotland, United Kingdom
    Infect Immun 71:3766-74. 2003
    ..These results indicate that elafin may have a dual function, promoting up-regulation of local lung innate immunity while simultaneously down-regulating potentially unwanted systemic inflammatory responses in the circulation...
  4. doi request reprint Relevance of granulocyte apoptosis to resolution of inflammation at the respiratory mucosa
    A E Leitch
    MRC Centre for Inflammation Research, The Queen s Medical Research Institute, University of Edinburgh Medical School, Edinburgh, Scotland, UK
    Mucosal Immunol 1:350-63. 2008
    ..Therapeutic strategies to drive resolution of inflammation may be directed at the induction of granulocyte apoptosis and the enhancement of granulocyte clearance...
  5. ncbi request reprint Modulation of granulocyte apoptosis can influence the resolution of inflammation
    A G Rossi
    MRC Centre for Inflammation Research, Queen s Medical Research Institute, University of Edinburgh Medical School, 47 Little France Crescent, Edinburgh, UK
    Biochem Soc Trans 35:288-91. 2007
    ..Thus manipulation of apoptotic pathways, together with ensuring macrophage clearance of apoptotic cells, appears to be a viable pharmacological target for reducing established inflammation...
  6. ncbi request reprint Regulation of granulocyte apoptosis by NF-kappaB
    C Ward
    Respiratory Medicine Unit, MRC Centre for Inflammation Research, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    Biochem Soc Trans 32:465-7. 2004
    ..Although NF-kappaB is an important target for anti-inflammatory therapy, the timing of inhibition in vivo may be crucial, to ensure that production of PGD2 and its sequential metabolites can occur...
  7. ncbi request reprint Nitric oxide: a key regulator of myeloid inflammatory cell apoptosis
    E L Taylor
    Centre for Inflammation Research, Rayne Laboratory, University of Edinburgh, Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    Cell Death Differ 10:418-30. 2003
    ..This review summarises the differential effects of NO on inflammatory cell apoptosis and outlines potential mechanisms that have been proposed to explain such actions...
  8. ncbi request reprint Constitutive neutrophil apoptosis in culture is modulated by cell density independently of beta2 integrin-mediated adhesion
    S Hannah
    Department of Medicine R I E, University of Edinburgh Medical School, Scotland, UK
    FEBS Lett 421:141-6. 1998
    ....
  9. ncbi request reprint Pharmacological manipulation of granulocyte apoptosis: potential therapeutic targets
    C Ward
    The Rayne Laboratory, Respiratory Medicine Unit, University of Edinburgh Medical School, Teviot Place, Edinburgh, UK EH8 9AG
    Trends Pharmacol Sci 20:503-9. 1999
    ..It is suggested that apoptosis can be specifically regulated pharmacologically and could be exploited to develop new drug therapies...
  10. ncbi request reprint Soluble E-selectin acts in synergy with platelet-activating factor to activate neutrophil beta 2-integrins. Role of tyrosine kinases and Ca2+ mobilization
    M H Ruchaud-Sparagano
    Rayne Laboratory, Respiratory Medicine Unit, University of Edinburgh Medical School, Edinburgh EH8 9AG, United Kingdom
    J Biol Chem 275:15758-64. 2000
    ....
  11. ncbi request reprint Regulation of macrophage phagocytosis of apoptotic cells by cAMP
    A G Rossi
    Department of Medicine RIE, Rayne Laboratory, The University of Edinburgh Medical School, Scotland, UK
    J Immunol 160:3562-8. 1998
    ....
  12. ncbi request reprint Temperature-dependent arrest of neutrophil apoptosis. Failure of Bax insertion into mitochondria at 15 degrees C prevents the release of cytochrome c
    J G Pryde
    Rayne Laboratory, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, United Kingdom
    J Biol Chem 275:33574-84. 2000
    ..Bax insertion was only sensitive to zVAD-fmk when added at the start of the 15 degrees C culture period, suggesting that a cytoplasmic substrate of the effector caspases may mediate in the mechanism of Bax insertion into mitochondria...
  13. ncbi request reprint Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivo
    T Sethi
    Respiratory Medicine Unit, Rayne Laboratory, University of Edinburgh Medical School, Scotland, UK
    Nat Med 5:662-8. 1999
    ..Strategies based on blocking beta1 integrin-mediated survival signals may represent a new therapeutic approach to improve the response to chemotherapy in SCLC...
  14. ncbi request reprint Adenoviral augmentation of elafin protects the lung against acute injury mediated by activated neutrophils and bacterial infection
    A J Simpson
    Rayne Laboratory, Respiratory Medicine Unit, Medical Research Council Centre for Inflammation Research, University of Edinburgh, Edinburgh EH8 9AG, Scotland, United Kingdom
    J Immunol 167:1778-86. 2001
    ..Genetic augmentation of elafin therefore has the capacity to protect the lung against the injurious effects of both bacterial pathogens resistant to conventional antibiotics and activated neutrophils...
  15. ncbi request reprint Dissociation of DNA fragmentation from other hallmarks of apoptosis in nitric oxide-treated neutrophils: differences between individual nitric oxide donor drugs
    E L Taylor
    Centre for Inflammation Research, University of Edinburgh, Edinburgh, EH8 9AG, United Kingdom
    Biochem Biophys Res Commun 289:1229-36. 2001
    ....
  16. doi request reprint Imaging inflammation: molecular strategies to visualize key components of the inflammatory cascade, from initiation to resolution
    D A Dorward
    MRC Centre for Inflammation Research, The Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Pharmacol Ther 135:182-99. 2012
    ....
  17. ncbi request reprint Bombesin and substance P analogues differentially regulate G-protein coupling to the bombesin receptor. Direct evidence for biased agonism
    A C MacKinnon
    Rayne Laboratory, Centre for Inflammation Research, Respiratory Medicine Unit, University of Edinburgh Medical School, Teviot Place, Edinburgh, EH8 9AG, United Kingdom
    J Biol Chem 276:28083-91. 2001
    ..This validation of the concept of biased agonism has important implications in the development of novel pharmacological agents to dissect receptor-mediated signal transduction and of highly selective drugs to treat human disease...
  18. pmc Human circulating eosinophils secrete macrophage migration inhibitory factor (MIF). Potential role in asthma
    A G Rossi
    Respiratory Medicine Unit, Department of Medicine RIE, Rayne Laboratory, University of Edinburgh Medical School, Edinburgh, United Kingdom
    J Clin Invest 101:2869-74. 1998
    ..5+/-92 pg/ml; controls, 274+/-91 pg/ml). These results highlight the potential importance of MIF in asthma and other eosinophil-dependent inflammatory disorders...
  19. ncbi request reprint Regulation of adenovirus-mediated elafin transgene expression by bacterial lipopolysaccharide
    A J Simpson
    Rayne Laboratory, Respiratory Medicine Unit, MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh EH8 9AG, Scotland, UK
    Hum Gene Ther 12:1395-406. 2001
    ....
  20. pmc The regulation of interleukin-8 by hypoxia in human macrophages--a potential role in the pathogenesis of the acute respiratory distress syndrome (ARDS)
    N Hirani
    The Respiratory Medicine Unit, Centre for Inflammation Research, University of Edinburgh, UK
    Mol Med 7:685-97. 2001
    ..Acute hypoxia may represent one of potentially several proinflammatory stimuli responsible for rapid intrapulmonary IL-8 generation in patients at-risk of ARDS...
  21. ncbi request reprint Regulation of granulocyte apoptosis by hemopoietic growth factors, cytokines and drugs: potential relevance to allergic inflammation
    A Walker
    Respiratory Medicine Unit, Centre for Inflammation Research, University of Edinburgh Medical School, Teviot Place, Edinburgh, EH8 9AG, Scotland, UK
    Curr Drug Targets Inflamm Allergy 2:339-47. 2003
    ..Here we review the progress that has been made in the understanding of granulocyte apoptosis and the implications for immunotherapy and pharmacological strategies in the treatment of allergic inflammatory diseases for therapeutic gain...
  22. ncbi request reprint Glucocorticoid-mediated regulation of granulocyte apoptosis and macrophage phagocytosis of apoptotic cells: implications for the resolution of inflammation
    S J Heasman
    MRC Centre for Inflammation Research, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    J Endocrinol 178:29-36. 2003
    ....
  23. ncbi request reprint Kinetics of pulmonary neutrophil recruitment and clearance in a natural and spontaneously resolving model of airway inflammation
    T J Brazil
    Wellcome Trust Centre for Research in Comparative Respiratory Medicine, Easter Bush Veterinary Centre, University of Edinburgh, Roslin, Midlothian, Scotland, UK
    Clin Exp Allergy 35:854-65. 2005
    ..Objective To determine the kinetics of neutrophil priming, recruitment, activation and subsequent clearance in a naturally occurring equine disease model of neutrophilic pulmonary inflammation...
  24. ncbi request reprint Glucocorticoid augmentation of macrophage capacity for phagocytosis of apoptotic cells is associated with reduced p130Cas expression, loss of paxillin/pyk2 phosphorylation, and high levels of active Rac
    K M Giles
    Medical Research Council Centre for Inflammation Research, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, United Kingdom
    J Immunol 167:976-86. 2001
    ..We propose that changes in the capacity for reorganization of cytoskeletal elements induced by glucocorticoids are essential for efficient phagocytic uptake of apoptotic cells...
  25. ncbi request reprint Elevated levels of interleukin-8 in donor lungs is associated with early graft failure after lung transplantation
    A J Fisher
    Department of Respiratory Medicine, Freeman Hospital, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    Am J Respir Crit Care Med 163:259-65. 2001
    ..Attenuating the donor's inflammatory response before organ retrieval may improve early outcome after lung transplantation, and help maximize lung use from the existing donor pool...