Affiliation: University College London
- A prehistory of cell adhesionAdrian Harwood
MRC Laboratory of Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT
Curr Opin Cell Biol 16:470-6. 2004..Furthermore, proteins containing features of animal adhesion systems, such as Fas-1 and thrombospondin domains, are distributed throughout the eukaryotes and function in cell adhesion...
- Lithium and bipolar mood disorder: the inositol-depletion hypothesis revisitedA J Harwood
MRC Laboratory for Molecular Biology, Department of Biology, University College London, London, UK
Mol Psychiatry 10:117-26. 2005..In this review of our current knowledge, I will consider where the inositol-depletion hypothesis stands today and how it may be further investigated in the future...
- Neurodevelopment and mood stabilizersA J Harwood
MRC Laboratory for Molecular Cell Biology and Dept of Biology, University College London, London, UK
Curr Mol Med 3:472-82. 2003..Despite these intriguing observations, it remains unclear whether GSK-3, inositol signaling or both underlie the origins of bipolar disorder...
- Search for a common mechanism of mood stabilizersAdrian J Harwood
MRC Laboratory for Molecular Cell Biology, University College London, Gower St, London, WC1E 6BT, UK
Biochem Pharmacol 66:179-89. 2003..Despite these intriguing observations, it remains unclear how changes in inositol signaling underlie the origins of bipolar disorder...
- Lithium therapy and signal transductionR S Williams
MRC Laboratory for Molecular Cell Biology and Department of Biology, University College London, Gower St, London, UK WC1E 6BT
Trends Pharmacol Sci 21:61-4. 2000..This article describes recent experiments in cell and developmental biology that advance our understanding of how lithium works and it presents new directions for the study of both depression and Alzheimer's disease (AD)...
- A molecular cell biology of lithiumR Williams
MRC Laboratory for Molecular Cell Biology and Department of Biology, University College London, Gower St, London WC1E 6BT, UK
Biochem Soc Trans 32:799-802. 2004..Given the presence of neurogenesis in the adult brain, we speculate that changes in growth cone behaviour could also occur during treatment of mental disorders...
- Loss of a prolyl oligopeptidase confers resistance to lithium by elevation of inositol (1,4,5) trisphosphateR S Williams
MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK
EMBO J 18:2734-45. 1999..Our results offer a novel mechanism that links POase activity to IP3 signalling and provides further clues for the action of Li+ in the treatment of depression...
- A common mechanism of action for three mood-stabilizing drugsRobin S B Williams
Intracellular Signalling Group, MRC Laboratory for Molecular Cell Biology, University College London, Gower St, London WC1E 6BT, UK
Nature 417:292-5. 2002..Inhibitors of prolyl oligopeptidase reverse the effects of all three drugs on sensory neuron growth cone area and collapse. These results suggest a molecular basis for both bipolar affective disorder and its treatment...
- GSK-3 activity in neocortical cells is inhibited by lithium but not carbamazepine or valproic acidW Jonathan Ryves
MRC LMCB, University College London, London, UK
Bipolar Disord 7:260-5. 2005..It is currently unknown if carbamazepine (CBZ) inhibits GSK-3 activity. We have sought to compare the inhibitory effect of Li(+), VPA and CBZ on GSK-3 activity...
- Specificity of mood stabilizer action on neuronal growth conesGalit Shaltiel
Stanley Research Center and Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, and Mental Health Center, Beersheva, Israel
Bipolar Disord 9:281-9. 2007..However, due to limitations in earlier analysis, the effects of combining drugs, drug specificity and inositol stereoisomer specificity are unknown. We devised an improved analytical method to address these issues...
- Valproate decreases inositol biosynthesisGalit Shaltiel
Stanley Research Center and Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Mental Health Center, Beersheva, Israel
Biol Psychiatry 56:868-74. 2004..Valproate also depletes inositol in yeast, Dictyostelium, and rat neurons. This raised the possibility that the effect is the result of myo-inositol-1-phosphate (MIP) synthase inhibition...
- cAMP-induced degradation of cyclin D3 through association with GSK-3betaSoheil Naderi
Department of Medical Biochemistry, University of Oslo, P O Box 1112 Blindern, Oslo, N 0317, Norway
J Cell Sci 117:3769-83. 2004..These results demonstrate how cAMP enhances degradation of cyclin D3. Furthermore, we provide evidence for a novel mechanism by which GSK-3beta might phosphorylate unprimed substrates in vivo...
- Two peptidase activities decrease in treated bipolar disorder not schizophrenic patientsGerome Breen
Section of Molecular Genetics, Division of Psychological Medicine, Institute of Psychiatry, Kings College London, London, UK
Bipolar Disord 6:156-61. 2004..However, this association is complicated by the discovery in bovine plasma of a Z-Pro-prolinal-insensitive peptidase (ZIP), a novel enzyme that cleaves the same substrate as PO...
- The interaction of glycogen synthase kinase-3 (GSK-3) with the cell cycleW Jonathan Ryves
MRC Laboratory for Molecular Cell Biology, Department of Biology, University College London, Gower St, WC1E 6BT, London, U K
Prog Cell Cycle Res 5:489-95. 2003..In this chapter we examine how GSK-3 mediates these effects and consider how therapeutic strategies may be developed to specifically target these pathways...
- Loss of the beta-catenin homologue aardvark causes ectopic stalk formation in DictyosteliumJuliet C Coates
MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, UK
Mech Dev 116:117-27. 2002..We postulate that poor synthesis of the stalk tube matrix allows diffusion of a stalk cell-inducing factor into the surrounding tissue...
- Signal transduction in development: holding the keyAdrian J Harwood
MRC Laboratory for Molecular Cell Biology and Department of Biology, University College London, Gower Street, WC1E 6BT, London, United Kingdom
Dev Cell 2:384-5. 2002..Two papers in the March 22nd issue of Cell highlight the importance of this priming phosphorylation for signal transduction during development...
- Glycogen synthase kinase-3 inhibition by lithium and beryllium suggests the presence of two magnesium binding sitesW Jonathan Ryves
MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, WC1E 6BT, United Kingdom
Biochem Biophys Res Commun 290:967-72. 2002..These results suggest that Be(2+) competes for two distinct Mg(2+) binding sites: one is Li(+)-sensitive and the other, which is Li(+)-insensitive, binds the Mg:ATP complex...
- Dephosphorylation of 2,3-bisphosphoglycerate by MIPP expands the regulatory capacity of the Rapoport-Luebering glycolytic shuntJaiesoon Cho
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Social Services, P O Box 12233, Research Triangle Park, NC 27709, USA
Proc Natl Acad Sci U S A 105:5998-6003. 2008..4. This phenomenon provides a homeostatic mechanism for elevating 2,3-BPG levels, thereby enhancing oxygen release to tissues. Our data indicate greater biological significance of the Rapoport-Luebering shunt than previously considered...