Jenni Harvey

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. pmc Leptin promotes rapid dynamic changes in hippocampal dendritic morphology
    Neil MacDonald
    Neurosciences Institute, Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK
    Mol Cell Neurosci 35:559-72. 2007
  2. pmc Leptin: a novel therapeutic target in Alzheimer's disease?
    Dayne Beccano-Kelly
    Division of Neuroscience, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    Int J Alzheimers Dis 2012:594137. 2012
  3. pmc Leptin: a diverse regulator of neuronal function
    Jenni Harvey
    Neurosciences Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    J Neurochem 100:307-13. 2007
  4. pmc Leptin and its role in hippocampal synaptic plasticity
    Jenni Harvey
    Neurosciences Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
    Prog Lipid Res 45:369-78. 2006
  5. ncbi request reprint Leptin: a potential cognitive enhancer?
    J Harvey
    Neurosciences Institute, Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    Biochem Soc Trans 33:1029-32. 2005
  6. pmc Leptin regulation of neuronal excitability and cognitive function
    Jenni Harvey
    Neurosciences Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom
    Curr Opin Pharmacol 7:643-7. 2007
  7. ncbi request reprint Leptin: a multifaceted hormone in the central nervous system
    Jenni Harvey
    Department of Pharmacology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Mol Neurobiol 28:245-58. 2003
  8. ncbi request reprint Novel actions of leptin in the hippocampus
    Jenni Harvey
    Department of Pharmacology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    Ann Med 35:197-206. 2003
  9. ncbi request reprint Leptin in the CNS: much more than a satiety signal
    J Harvey
    Department of Pharmacology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    Neuropharmacology 44:845-54. 2003
  10. ncbi request reprint Leptin-induced dynamic alterations in the actin cytoskeleton mediate the activation and synaptic clustering of BK channels
    Dervla O'Malley
    Neuroscience Institute, Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    FASEB J 19:1917-9. 2005

Collaborators

Detail Information

Publications30

  1. pmc Leptin promotes rapid dynamic changes in hippocampal dendritic morphology
    Neil MacDonald
    Neurosciences Institute, Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK
    Mol Cell Neurosci 35:559-72. 2007
    ....
  2. pmc Leptin: a novel therapeutic target in Alzheimer's disease?
    Dayne Beccano-Kelly
    Division of Neuroscience, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    Int J Alzheimers Dis 2012:594137. 2012
    ..Characterisation of the novel actions of leptin in limbic brain regions is providing valuable insights into leptin's role in higher cognitive functions in health and disease...
  3. pmc Leptin: a diverse regulator of neuronal function
    Jenni Harvey
    Neurosciences Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    J Neurochem 100:307-13. 2007
    ..Here, we review the evidence supporting a role for this hormone in regulating hippocampal excitability...
  4. pmc Leptin and its role in hippocampal synaptic plasticity
    Jenni Harvey
    Neurosciences Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
    Prog Lipid Res 45:369-78. 2006
    ..Here, we review the evidence implicating a key role for the hormone leptin in modulating hippocampal synaptic plasticity and discuss the role of lipid signaling cascades in this process...
  5. ncbi request reprint Leptin: a potential cognitive enhancer?
    J Harvey
    Neurosciences Institute, Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    Biochem Soc Trans 33:1029-32. 2005
    ..We also provide evidence that rapid trafficking of NMDA receptors to the plasma membrane may underlie the effects of leptin on excitatory synaptic strength...
  6. pmc Leptin regulation of neuronal excitability and cognitive function
    Jenni Harvey
    Neurosciences Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom
    Curr Opin Pharmacol 7:643-7. 2007
    ..Characterisation of these novel actions of leptin is providing valuable insights into the role of this hormone in the regulation of diverse neuronal functions in health and disease...
  7. ncbi request reprint Leptin: a multifaceted hormone in the central nervous system
    Jenni Harvey
    Department of Pharmacology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Mol Neurobiol 28:245-58. 2003
    ..In this review the author discusses recent advances made in leptin neurobiology, with particular emphasis on the role of this endocrine peptide in normal and pathophysiological hippocampal function...
  8. ncbi request reprint Novel actions of leptin in the hippocampus
    Jenni Harvey
    Department of Pharmacology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    Ann Med 35:197-206. 2003
    ..In this review we summarize the recent advances made in leptin biology, with particular focus on its potential role as a cognitive enhancer and antiepileptic agent in the hippocampus...
  9. ncbi request reprint Leptin in the CNS: much more than a satiety signal
    J Harvey
    Department of Pharmacology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    Neuropharmacology 44:845-54. 2003
    ..In this review, we summarise recent progress in leptin biology, with particular focus on its diversity of actions within the CNS, ranging from satiety signal, to regulator of bone formation and inhibitor of neuronal excitability...
  10. ncbi request reprint Leptin-induced dynamic alterations in the actin cytoskeleton mediate the activation and synaptic clustering of BK channels
    Dervla O'Malley
    Neuroscience Institute, Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    FASEB J 19:1917-9. 2005
    ..These data are consistent with the notion that leptin activates BK channels via PI 3-kinase-dependent reorganization of actin filaments and subsequent clustering of BK channels at synapses...
  11. pmc Leptin reverses long-term potentiation at hippocampal CA1 synapses
    Peter R Moult
    Neurosciences Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    J Neurochem 108:685-96. 2009
    ....
  12. pmc NMDA receptor subunit composition determines the polarity of leptin-induced synaptic plasticity
    Peter R Moult
    Centre for Neuroscience, Division of Medical Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    Neuropharmacology 61:924-36. 2011
    ..These findings have important implications for the role of leptin in hippocampal synaptic function during early neuronal development and in aging...
  13. pmc Leptin induces a novel form of NMDA receptor-dependent long-term depression
    Murat Durakoglugil
    Neurosciences Institute, Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee UK
    J Neurochem 95:396-405. 2005
    ....
  14. ncbi request reprint Insulin activates native and recombinant large conductance Ca(2+)-activated potassium channels via a mitogen-activated protein kinase-dependent process
    Dervla O'Malley
    Department of Pharmacology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    Mol Pharmacol 65:1352-63. 2004
    ....
  15. ncbi request reprint MAPK-dependent actin cytoskeletal reorganization underlies BK channel activation by insulin
    Jenni Harvey
    Neurosciences Institute, Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    Eur J Neurosci 25:673-82. 2007
    ..These data are consistent with BK channel activation by insulin involving MAPK-dependent alterations in actin dynamics. This process may have important implications for the role of insulin in regulating hippocampal excitability...
  16. doi request reprint Leptin prevents hippocampal synaptic disruption and neuronal cell death induced by amyloid β
    Gayle H Doherty
    School of Biology, University of St Andrews, St Andrews, Fife, Scotland, UK
    Neurobiol Aging 34:226-37. 2013
    ..Thus leptin benefits the functional characteristics and viability of neurons that degenerate in AD. These novel findings establish that the leptin system is an important therapeutic target in neurodegenerative conditions...
  17. pmc Bi-directional modulation of fast inhibitory synaptic transmission by leptin
    Natasha Solovyova
    Neurosciences Institute, Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    J Neurochem 108:190-201. 2009
    ..These findings have important implications for the role of this hormone in regulating hippocampal pyramidal neuron excitability...
  18. ncbi request reprint Insulin inhibits rat hippocampal neurones via activation of ATP-sensitive K+ and large conductance Ca2+-activated K+ channels
    Dervla O'Malley
    Department of Pharmacology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    Neuropharmacology 44:855-63. 2003
    ..This process may be a useful therapeutic target for the treatment of epilepsy and certain neurodegenerative diseases...
  19. ncbi request reprint Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels
    Lynne J Shanley
    Department of Pharmacology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    Nat Neurosci 5:299-300. 2002
  20. pmc Hormonal regulation of hippocampal dendritic morphology and synaptic plasticity
    Peter R Moult
    Neurosciences Institute, Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    Cell Adh Migr 2:269-75. 2008
    ..Here we review recent findings demonstrating that a number of hormones are capable of modulating both these phenomena...
  21. pmc Regulation of glutamate receptor trafficking by leptin
    Peter R Moult
    Division of Neuroscience, Centre for Neuroscience, Ninewells Hospital, University of Dundee, Dundee DD1 9SY, UK
    Biochem Soc Trans 37:1364-8. 2009
    ..The impact of these leptin-driven changes on hippocampal excitatory synaptic function are discussed...
  22. ncbi request reprint Mitochondrial dysfunction and dendritic beading during neuronal toxicity
    Sam M Greenwood
    Neurosciences Institute, Ninewells Medical School, University of Dundee, Dundee DD19SY, Scotland, United Kingdom
    J Biol Chem 282:26235-44. 2007
    ..These findings suggest that the degree of calcium influx and mitochondrial depolarization inflicted by a neurotoxic challenge, determines the ability of the neuron to recover its normal morphology...
  23. pmc The aminoguanidine carboxylate BVT.12777 activates ATP-sensitive K+ channels in the rat insulinoma cell line, CRI-G1
    Jackie M Kinsella
    Division of Pathology and Neuroscience, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    BMC Pharmacol 4:17. 2004
    ..We have assessed whether one of these analogues, the aminoguanidine carboxylate BVT.12777, opens KATP channels in rat insulinoma cells, by the same mechanism as leptin...
  24. ncbi request reprint Leptin enhances NMDA receptor function and modulates hippocampal synaptic plasticity
    L J Shanley
    Department of Pharmacology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, United Kingdom
    J Neurosci 21:RC186. 2001
    ..Impairment of this process may contribute to the cognitive deficits associated with diabetes mellitus...
  25. pmc Cholinergic pesticides cause mushroom body neuronal inactivation in honeybees
    Mary J Palmer
    Division of Neuroscience, Medical Research Institute, Ninewells Medical School, University of Dundee, Dundee, UK
    Nat Commun 4:1634. 2013
    ....
  26. pmc Leptin enhances NR2B-mediated N-methyl-D-aspartate responses via a mitogen-activated protein kinase-dependent process in cerebellar granule cells
    A J Irving
    Neurosciences Institute, Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    Neuroscience 138:1137-48. 2006
    ..In addition, given that N-methyl-D-aspartate receptor activity in the cerebellum is crucial for normal locomotor function, these data also have important implications for the potential role of leptin in the control of movement...
  27. pmc Leptin inhibits epileptiform-like activity in rat hippocampal neurones via PI 3-kinase-driven activation of BK channels
    L J Shanley
    Department of Pharmacology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    J Physiol 545:933-44. 2002
    ..As uncontrolled excitability in the hippocampus is one underlying cause of temporal lobe epilepsy, this novel action of leptin could provide an alternative therapeutic target in the management of epilepsy...
  28. pmc Leptin regulation of hippocampal synaptic function in health and disease
    Andrew J Irving
    Division of Neuroscience, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    Philos Trans R Soc Lond B Biol Sci 369:20130155. 2014
    ..Here, we review the evidence supporting a cognitive enhancing role for the hormone leptin and discuss the therapeutic potential of using leptin-based agents to treat AD. ..
  29. doi request reprint Neurotrophic effects of leptin on cerebellar Purkinje but not granule neurons in vitro
    Ceri E Oldreive
    School of Biology, University of St Andrews, St Andrews, Fife KY16 9TS, UK
    Neurosci Lett 438:17-21. 2008
    ..Thus, leptin has different effects on two neighbouring populations of neurons within the cerebellum implying specificity of its actions in the central nervous system...