Genomes and Genes
Affiliation: University of Edinburgh
Location: Edinburgh, UK
- Diurnal expression of the thrombopoietin gene is regulated by CLOCKC J Tracey
University BHF Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
J Thromb Haemost 10:662-9. 2012..In addition, many cell types express endogenous circadian rhythms that affect cell-specific processes. Independent reports support the hypothesis that thrombopoietin (TPO) is under circadian control...
- The diurnal tick-tockery of platelet biologyPaul S Hartley
University BHF Centre for Cardiovascular Science, Queen s Medical Research Institute, The University of Edinburgh, Edinburgh, Scotland EH16 4TJ, UK
Platelets 23:157-60. 2012..This short review will introduce the mammalian circadian clock and discuss how circadian clocks and diurnal rhythms influence platelet production and function...
- Dietary modulation of Drosophila sleep-wake behaviourJames H Catterson
Centre for Cardiovascular Science, Queen s Medical Research Institute, The University of Edinburgh, Edinburgh, Scotland
PLoS ONE 5:e12062. 2010..Drosophila melanogaster is an important model for the study of metabolism and behaviour, however the effect of diet upon Drosophila sleep remains largely unaddressed...
- Timed feeding of mice modulates light-entrained circadian rhythms of reticulated platelet abundance and plasma thrombopoietin and affects gene expression in megakaryocytesPaul S Hartley
Centre for Cardiovascular Science, Queen s Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
Br J Haematol 146:185-92. 2009..These findings imply that circadian clock gene expression regulates platelet turnover in mammals...
- Food-entrained rhythmic expression of PER2 and BMAL1 in murine megakaryocytes does not correlate with circadian rhythms in megakaryopoiesisP S Hartley
Centre for Cardiovascular Science, Queens Medical Research Institute, The University of Edinburgh, Edinburgh, UK
J Thromb Haemost 6:1144-52. 2008..Circadian rhythms control a vast array of biological processes in a broad spectrum of organisms. The contribution of circadian rhythms to the development of megakaryocytes and the regulation of platelet biology has not been defined...
- Platelet senescence and deathPaul S Hartley
Circadian Physiology Group, Centre for Cardiovascular Science, University of Edinburgh, Queens Medical Research Institute, Edinburgh, UK
Clin Lab 53:157-66. 2007..It is unclear how senescent platelets are removed, but monocyte-macrophages are an important determinant of thrombus resolution possibly due to the phagocytosis of effete, activated platelets...
- Hypoglycaemia predisposes platelets to death by affecting calcium homeostasis and mitochondrial integrityPaul S Hartley
Inflammation Repair Group, MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh EH8 9AG, UK
Platelets 18:103-12. 2007..These data suggest that extracellular glucose is utilised by platelets for calcium homeostasis and maintenance of mitochondrial integrity and that hypoglycaemia primes platelets for death...
- The death of human platelets during incubation in citrated plasma involves shedding of CD42b and aggregation of dead plateletsPaul S Hartley
MRC Human Genetics Unit, Edinburgh EH4 2XU, UK
Thromb Haemost 95:100-6. 2006....
- Expression of activin subunits and receptors in the developing human ovary: activin A promotes germ cell survival and proliferation before primordial follicle formationS J Martins da Silva
MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, University of Edinburgh, Edinburgh EH16 4SB, UK
Dev Biol 266:334-45. 2004..These data indicate that activin may be involved in the autocrine and paracrine regulation of germ cell proliferation in the human ovary during the crucial period of development leading up to primordial follicle formation...
- Developmental changes in expression of myeloid cell leukemia-1 in human germ cells during oogenesis and early folliculogenesisP S Hartley
Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh, Scotland, UK EH3 9ET
J Clin Endocrinol Metab 87:3417-27. 2002....
- Expression and localization of inhibin alpha, inhibin/activin betaA and betaB and the activin type II and inhibin beta-glycan receptors in the developing human testisR A Anderson
MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, University of Edinburgh, 37 Chalmers Street, Edinburgh EH3 9ET, UK
Reproduction 123:779-88. 2002....
- Fermitins, the orthologs of mammalian Kindlins, regulate the development of a functional cardiac syncytium in Drosophila melanogasterJames H Catterson
The University of Edinburgh British Heart Foundation Centre for Cardiovascular Science, The University of Edinburgh, Edinburgh, Midlothian, United Kingdom
PLoS ONE 8:e62958. 2013..These findings support the concept that abnormalities in cardiomyocyte KIND2 expression or function may contribute to cardiomyopathies in humans...