Paul Hartley

Summary

Affiliation: University of Edinburgh
Location: Edinburgh, UK

Publications

  1. doi The diurnal tick-tockery of platelet biology
    Paul S Hartley
    University BHF Centre for Cardiovascular Science, Queen s Medical Research Institute, The University of Edinburgh, Edinburgh, Scotland EH16 4TJ, UK
    Platelets 23:157-60. 2012
  2. pmc Dietary modulation of Drosophila sleep-wake behaviour
    James H Catterson
    Centre for Cardiovascular Science, Queen s Medical Research Institute, The University of Edinburgh, Edinburgh, Scotland
    PLoS ONE 5:e12062. 2010
  3. doi Timed feeding of mice modulates light-entrained circadian rhythms of reticulated platelet abundance and plasma thrombopoietin and affects gene expression in megakaryocytes
    Paul S Hartley
    Centre for Cardiovascular Science, Queen s Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Br J Haematol 146:185-92. 2009
  4. doi Food-entrained rhythmic expression of PER2 and BMAL1 in murine megakaryocytes does not correlate with circadian rhythms in megakaryopoiesis
    P S Hartley
    Centre for Cardiovascular Science, Queens Medical Research Institute, The University of Edinburgh, Edinburgh, UK
    J Thromb Haemost 6:1144-52. 2008
  5. ncbi Platelet senescence and death
    Paul S Hartley
    Circadian Physiology Group, Centre for Cardiovascular Science, University of Edinburgh, Queens Medical Research Institute, Edinburgh, UK
    Clin Lab 53:157-66. 2007
  6. ncbi Hypoglycaemia predisposes platelets to death by affecting calcium homeostasis and mitochondrial integrity
    Paul S Hartley
    Inflammation Repair Group, MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh EH8 9AG, UK
    Platelets 18:103-12. 2007
  7. ncbi The death of human platelets during incubation in citrated plasma involves shedding of CD42b and aggregation of dead platelets
    Paul S Hartley
    MRC Human Genetics Unit, Edinburgh EH4 2XU, UK
    Thromb Haemost 95:100-6. 2006
  8. ncbi Expression of activin subunits and receptors in the developing human ovary: activin A promotes germ cell survival and proliferation before primordial follicle formation
    S J Martins da Silva
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, University of Edinburgh, Edinburgh EH16 4SB, UK
    Dev Biol 266:334-45. 2004
  9. ncbi Developmental changes in expression of myeloid cell leukemia-1 in human germ cells during oogenesis and early folliculogenesis
    P S Hartley
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh, Scotland, UK EH3 9ET
    J Clin Endocrinol Metab 87:3417-27. 2002
  10. ncbi Expression and localization of inhibin alpha, inhibin/activin betaA and betaB and the activin type II and inhibin beta-glycan receptors in the developing human testis
    R A Anderson
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, University of Edinburgh, 37 Chalmers Street, Edinburgh EH3 9ET, UK
    Reproduction 123:779-88. 2002

Collaborators

Detail Information

Publications12

  1. doi The diurnal tick-tockery of platelet biology
    Paul S Hartley
    University BHF Centre for Cardiovascular Science, Queen s Medical Research Institute, The University of Edinburgh, Edinburgh, Scotland EH16 4TJ, UK
    Platelets 23:157-60. 2012
    ..This short review will introduce the mammalian circadian clock and discuss how circadian clocks and diurnal rhythms influence platelet production and function...
  2. pmc Dietary modulation of Drosophila sleep-wake behaviour
    James H Catterson
    Centre for Cardiovascular Science, Queen s Medical Research Institute, The University of Edinburgh, Edinburgh, Scotland
    PLoS ONE 5:e12062. 2010
    ..Drosophila melanogaster is an important model for the study of metabolism and behaviour, however the effect of diet upon Drosophila sleep remains largely unaddressed...
  3. doi Timed feeding of mice modulates light-entrained circadian rhythms of reticulated platelet abundance and plasma thrombopoietin and affects gene expression in megakaryocytes
    Paul S Hartley
    Centre for Cardiovascular Science, Queen s Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Br J Haematol 146:185-92. 2009
    ..These findings imply that circadian clock gene expression regulates platelet turnover in mammals...
  4. doi Food-entrained rhythmic expression of PER2 and BMAL1 in murine megakaryocytes does not correlate with circadian rhythms in megakaryopoiesis
    P S Hartley
    Centre for Cardiovascular Science, Queens Medical Research Institute, The University of Edinburgh, Edinburgh, UK
    J Thromb Haemost 6:1144-52. 2008
    ..Circadian rhythms control a vast array of biological processes in a broad spectrum of organisms. The contribution of circadian rhythms to the development of megakaryocytes and the regulation of platelet biology has not been defined...
  5. ncbi Platelet senescence and death
    Paul S Hartley
    Circadian Physiology Group, Centre for Cardiovascular Science, University of Edinburgh, Queens Medical Research Institute, Edinburgh, UK
    Clin Lab 53:157-66. 2007
    ..It is unclear how senescent platelets are removed, but monocyte-macrophages are an important determinant of thrombus resolution possibly due to the phagocytosis of effete, activated platelets...
  6. ncbi Hypoglycaemia predisposes platelets to death by affecting calcium homeostasis and mitochondrial integrity
    Paul S Hartley
    Inflammation Repair Group, MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh EH8 9AG, UK
    Platelets 18:103-12. 2007
    ..These data suggest that extracellular glucose is utilised by platelets for calcium homeostasis and maintenance of mitochondrial integrity and that hypoglycaemia primes platelets for death...
  7. ncbi The death of human platelets during incubation in citrated plasma involves shedding of CD42b and aggregation of dead platelets
    Paul S Hartley
    MRC Human Genetics Unit, Edinburgh EH4 2XU, UK
    Thromb Haemost 95:100-6. 2006
    ....
  8. ncbi Expression of activin subunits and receptors in the developing human ovary: activin A promotes germ cell survival and proliferation before primordial follicle formation
    S J Martins da Silva
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, University of Edinburgh, Edinburgh EH16 4SB, UK
    Dev Biol 266:334-45. 2004
    ..These data indicate that activin may be involved in the autocrine and paracrine regulation of germ cell proliferation in the human ovary during the crucial period of development leading up to primordial follicle formation...
  9. ncbi Developmental changes in expression of myeloid cell leukemia-1 in human germ cells during oogenesis and early folliculogenesis
    P S Hartley
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh, Scotland, UK EH3 9ET
    J Clin Endocrinol Metab 87:3417-27. 2002
    ....
  10. ncbi Expression and localization of inhibin alpha, inhibin/activin betaA and betaB and the activin type II and inhibin beta-glycan receptors in the developing human testis
    R A Anderson
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, University of Edinburgh, 37 Chalmers Street, Edinburgh EH3 9ET, UK
    Reproduction 123:779-88. 2002
    ....
  11. doi Diurnal expression of the thrombopoietin gene is regulated by CLOCK
    C J Tracey
    University BHF Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    J Thromb Haemost 10:662-9. 2012
    ..In addition, many cell types express endogenous circadian rhythms that affect cell-specific processes. Independent reports support the hypothesis that thrombopoietin (TPO) is under circadian control...