Alison L Harte

Summary

Affiliation: University of Warwick
Country: UK

Publications

  1. pmc Elevated endotoxin levels in non-alcoholic fatty liver disease
    Alison L Harte
    University of Warwick, Unit for Diabetes and Metabolism, Warwick Medical School, Clinical Sciences Research Institute, UHCW, Clifford Bridge Road, Coventry, CV2 2DX, UK
    J Inflamm (Lond) 7:15. 2010
  2. pmc Acute and chronic saturated fatty acid treatment as a key instigator of the TLR-mediated inflammatory response in human adipose tissue, in vitro
    Elham M Youssef-Elabd
    Biochemistry Department, National Research Centre, Dokki, Giza, Egypt 12622
    J Nutr Biochem 23:39-50. 2012
  3. pmc Changes in endotoxin levels in T2DM subjects on anti-diabetic therapies
    Omar S Al-Attas
    Biochemistry Department, College of Science King Saud University Riyadh, KSA
    Cardiovasc Diabetol 8:20. 2009
  4. pmc Visfatin is regulated by rosiglitazone in type 2 diabetes mellitus and influenced by NFκB and JNK in human abdominal subcutaneous adipocytes
    Kirsty C McGee
    Unit for Diabetes and Metabolism, Clinical Sciences Research Institute, UHCW Trust, Walsgrave, Coventry, United Kingdom
    PLoS ONE 6:e20287. 2011
  5. doi request reprint The identification of irisin in human cerebrospinal fluid: influence of adiposity, metabolic markers, and gestational diabetes
    Milan K Piya
    Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Clinical Sciences Research Laboratories, Coventry, United Kingdom
    Am J Physiol Endocrinol Metab 306:E512-8. 2014
  6. ncbi request reprint Secretion of neuropeptide Y in human adipose tissue and its role in maintenance of adipose tissue mass
    Katarina Kos
    Unit for Diabetes and Metabolism, Clinical Sciences Research Institute, Warwick Medical School, Coventry, UK
    Am J Physiol Endocrinol Metab 293:E1335-40. 2007
  7. ncbi request reprint The in vitro effects of resistin on the innate immune signaling pathway in isolated human subcutaneous adipocytes
    Christine M Kusminski
    Unit of Diabetes and Metabolism, Clinical Sciences Research Institute, University Hospitals Coventry and Warwickshire Trust, Clifford Bridge Road, Walsgrave, Coventry CV2 2DX, United Kingdom
    J Clin Endocrinol Metab 92:270-6. 2007
  8. pmc Telomere length attrition, a marker of biological senescence, is inversely correlated with triglycerides and cholesterol in South Asian males with type 2 diabetes mellitus
    Alison L Harte
    Clinical Sciences Research Laboratories, Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, University Hospital Coventry and Warwickshire, Coventry CV2 2DX, UK
    Exp Diabetes Res 2012:895185. 2012
  9. doi request reprint GLP-1 analogue, Liraglutide protects human umbilical vein endothelial cells against high glucose induced endoplasmic reticulum stress
    Bruno Schisano
    CSRL, University of Warwick, Warwick Medical School, University Hospital, Coventry, United Kingdom
    Regul Pept 174:46-52. 2012
  10. doi request reprint NFκB as a potent regulator of inflammation in human adipose tissue, influenced by depot, adiposity, T2DM status, and TNFα
    Alison L Harte
    Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Coventry, UK
    Obesity (Silver Spring) 21:2322-30. 2013

Collaborators

Detail Information

Publications16

  1. pmc Elevated endotoxin levels in non-alcoholic fatty liver disease
    Alison L Harte
    University of Warwick, Unit for Diabetes and Metabolism, Warwick Medical School, Clinical Sciences Research Institute, UHCW, Clifford Bridge Road, Coventry, CV2 2DX, UK
    J Inflamm (Lond) 7:15. 2010
    ....
  2. pmc Acute and chronic saturated fatty acid treatment as a key instigator of the TLR-mediated inflammatory response in human adipose tissue, in vitro
    Elham M Youssef-Elabd
    Biochemistry Department, National Research Centre, Dokki, Giza, Egypt 12622
    J Nutr Biochem 23:39-50. 2012
    ....
  3. pmc Changes in endotoxin levels in T2DM subjects on anti-diabetic therapies
    Omar S Al-Attas
    Biochemistry Department, College of Science King Saud University Riyadh, KSA
    Cardiovasc Diabetol 8:20. 2009
    ..This is supported by recent studies suggesting endotoxin, derived from gut flora, may be key to the development of inflammation by stimulating the secretion of an adverse cytokine profile from adipose tissue...
  4. pmc Visfatin is regulated by rosiglitazone in type 2 diabetes mellitus and influenced by NFκB and JNK in human abdominal subcutaneous adipocytes
    Kirsty C McGee
    Unit for Diabetes and Metabolism, Clinical Sciences Research Institute, UHCW Trust, Walsgrave, Coventry, United Kingdom
    PLoS ONE 6:e20287. 2011
    ..Taken together, these findings suggest that visfatin may represent a pro-inflammatory cytokine that is influenced by insulin/insulin sensitivity via the NF-κB and JNK pathways...
  5. doi request reprint The identification of irisin in human cerebrospinal fluid: influence of adiposity, metabolic markers, and gestational diabetes
    Milan K Piya
    Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Clinical Sciences Research Laboratories, Coventry, United Kingdom
    Am J Physiol Endocrinol Metab 306:E512-8. 2014
    ..These studies indicate that irisin may have a central role in metabolism in addition to the known peripheral role. Further studies investigating the central action of irisin in human metabolic disease are required. ..
  6. ncbi request reprint Secretion of neuropeptide Y in human adipose tissue and its role in maintenance of adipose tissue mass
    Katarina Kos
    Unit for Diabetes and Metabolism, Clinical Sciences Research Institute, Warwick Medical School, Coventry, UK
    Am J Physiol Endocrinol Metab 293:E1335-40. 2007
    ..NPY's antilipolytic action may promote an increase in adipocyte size in hyperinsulinemic conditions. Adipose-derived NPY mediates reduction of leptin secretion and may have implications for central feedback of adiposity signals...
  7. ncbi request reprint The in vitro effects of resistin on the innate immune signaling pathway in isolated human subcutaneous adipocytes
    Christine M Kusminski
    Unit of Diabetes and Metabolism, Clinical Sciences Research Institute, University Hospitals Coventry and Warwickshire Trust, Clifford Bridge Road, Walsgrave, Coventry CV2 2DX, United Kingdom
    J Clin Endocrinol Metab 92:270-6. 2007
    ..The adipokine resistin has demonstrated proinflammatory properties in relation to obesity and T2DM...
  8. pmc Telomere length attrition, a marker of biological senescence, is inversely correlated with triglycerides and cholesterol in South Asian males with type 2 diabetes mellitus
    Alison L Harte
    Clinical Sciences Research Laboratories, Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, University Hospital Coventry and Warwickshire, Coventry CV2 2DX, UK
    Exp Diabetes Res 2012:895185. 2012
    ..This study highlights enhanced biological ageing among South Asian, T2DM men, which appears to be tracked by changes in lipids and BMI, suggesting that raised lipids and BMI may directly contribute to premature ageing...
  9. doi request reprint GLP-1 analogue, Liraglutide protects human umbilical vein endothelial cells against high glucose induced endoplasmic reticulum stress
    Bruno Schisano
    CSRL, University of Warwick, Warwick Medical School, University Hospital, Coventry, United Kingdom
    Regul Pept 174:46-52. 2012
    ....
  10. doi request reprint NFκB as a potent regulator of inflammation in human adipose tissue, influenced by depot, adiposity, T2DM status, and TNFα
    Alison L Harte
    Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Coventry, UK
    Obesity (Silver Spring) 21:2322-30. 2013
    ..Central obesity and sub-clinical inflammation increase metabolic risk, this study examined the intracellular inflammatory pathways in adipose tissue (AT) that contribute to this risk...
  11. pmc High fat intake leads to acute postprandial exposure to circulating endotoxin in type 2 diabetic subjects
    Alison L Harte
    Division of Metabolic and Vascular Health, University of Warwick, Coventry, UK
    Diabetes Care 35:375-82. 2012
    ..To evaluate the changes in circulating endotoxin after a high-saturated fat meal to determine whether these effects depend on metabolic disease state...
  12. ncbi request reprint Adiponectin and resistin in human cerebrospinal fluid and expression of adiponectin receptors in the human hypothalamus
    Katarina Kos
    University of Warwick, Clinical Sciences Research Institute, University Hospital Coventry and Warwickshire, Clifford Bridge Road, Coventry CV2 2DX, United Kingdom
    J Clin Endocrinol Metab 92:1129-36. 2007
    ..In contrast to some suggestion of adiponectin influencing energy homeostasis in rodents, there is no evidence for adiponectin or resistin entering the human blood-brain barrier...
  13. doi request reprint Evidence for a shift to anaerobic metabolism in adipose tissue in efavirenz-containing regimens for HIV with different nucleoside backbones
    Kirsty C McGee
    Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, UHCW, Clinical Science Research Laboratories, Coventry, UK
    Antivir Ther 17:495-507. 2012
    ..We compared patterns of gene expression in the subcutaneous adipose tissue (SAT) of HIV-positive subjects before and after 18-24 months of ARV therapy with HIV-negative controls...
  14. doi request reprint Ethnic and sex differences in circulating endotoxin levels: A novel marker of atherosclerotic and cardiovascular risk in a British multi-ethnic population
    Michelle A Miller
    Clinical Sciences Research Institute, Warwick Medical School, Coventry, UK
    Atherosclerosis 203:494-502. 2009
    ..Moreover, ethnic differences in pro-inflammatory markers may be associated with ethnic differences in atherosclerotic and cardiovascular (CVD) and coronary heart disease (CHD) risk...
  15. doi request reprint Metabolic endotoxaemia: is it more than just a gut feeling?
    Milan K Piya
    Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Clinical Sciences Research Laboratories, Coventry, UK
    Curr Opin Lipidol 24:78-85. 2013
    ..This article reviews the evidence linking gut bacteria, endotoxin, and its circulating levels with inflammatory induced obesity and metabolic disease (metabolic endotoxaemia)...
  16. pmc Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease
    Adam R Baker
    Unit for Diabetes and Metabolism, Warwick Medical School, University of Warwick, Clinical Sciences Research Institute, UHCW Campus, Coventry, CV2 2DX, UK
    Cardiovasc Diabetol 5:1. 2006
    ..Inflammation contributes to cardiovascular disease and is exacerbated with increased adiposity, particularly omental adiposity; however, the role of epicardial fat is poorly understood...