Alison L Harte
Affiliation: University of Warwick
- Elevated endotoxin levels in non-alcoholic fatty liver diseaseAlison L Harte
University of Warwick, Unit for Diabetes and Metabolism, Warwick Medical School, Clinical Sciences Research Institute, UHCW, Clifford Bridge Road, Coventry, CV2 2DX, UK
J Inflamm (Lond) 7:15. 2010....
- Acute and chronic saturated fatty acid treatment as a key instigator of the TLR-mediated inflammatory response in human adipose tissue, in vitroElham M Youssef-Elabd
Biochemistry Department, National Research Centre, Dokki, Giza, Egypt 12622
J Nutr Biochem 23:39-50. 2012....
- Changes in endotoxin levels in T2DM subjects on anti-diabetic therapiesOmar S Al-Attas
Biochemistry Department, College of Science King Saud University Riyadh, KSA
Cardiovasc Diabetol 8:20. 2009..This is supported by recent studies suggesting endotoxin, derived from gut flora, may be key to the development of inflammation by stimulating the secretion of an adverse cytokine profile from adipose tissue...
- The identification of irisin in human cerebrospinal fluid: influence of adiposity, metabolic markers, and gestational diabetesMilan K Piya
Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Clinical Sciences Research Laboratories, Coventry, United Kingdom
Am J Physiol Endocrinol Metab 306:E512-8. 2014..These studies indicate that irisin may have a central role in metabolism in addition to the known peripheral role. Further studies investigating the central action of irisin in human metabolic disease are required. ..
- Visfatin is regulated by rosiglitazone in type 2 diabetes mellitus and influenced by NFκB and JNK in human abdominal subcutaneous adipocytesKirsty C McGee
Unit for Diabetes and Metabolism, Clinical Sciences Research Institute, UHCW Trust, Walsgrave, Coventry, United Kingdom
PLoS ONE 6:e20287. 2011..Taken together, these findings suggest that visfatin may represent a pro-inflammatory cytokine that is influenced by insulin/insulin sensitivity via the NF-κB and JNK pathways...
- Secretion of neuropeptide Y in human adipose tissue and its role in maintenance of adipose tissue massKatarina Kos
Unit for Diabetes and Metabolism, Clinical Sciences Research Institute, Warwick Medical School, Coventry, UK
Am J Physiol Endocrinol Metab 293:E1335-40. 2007..NPY's antilipolytic action may promote an increase in adipocyte size in hyperinsulinemic conditions. Adipose-derived NPY mediates reduction of leptin secretion and may have implications for central feedback of adiposity signals...
- Telomere length attrition, a marker of biological senescence, is inversely correlated with triglycerides and cholesterol in South Asian males with type 2 diabetes mellitusAlison L Harte
Clinical Sciences Research Laboratories, Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, University Hospital Coventry and Warwickshire, Coventry CV2 2DX, UK
Exp Diabetes Res 2012:895185. 2012..This study highlights enhanced biological ageing among South Asian, T2DM men, which appears to be tracked by changes in lipids and BMI, suggesting that raised lipids and BMI may directly contribute to premature ageing...
- GLP-1 analogue, Liraglutide protects human umbilical vein endothelial cells against high glucose induced endoplasmic reticulum stressBruno Schisano
CSRL, University of Warwick, Warwick Medical School, University Hospital, Coventry, United Kingdom
Regul Pept 174:46-52. 2012....
- NFκB as a potent regulator of inflammation in human adipose tissue, influenced by depot, adiposity, T2DM status, and TNFαAlison L Harte
Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Coventry, UK
Obesity (Silver Spring) 21:2322-30. 2013..Central obesity and sub-clinical inflammation increase metabolic risk, this study examined the intracellular inflammatory pathways in adipose tissue (AT) that contribute to this risk...
- Adiponectin and resistin in human cerebrospinal fluid and expression of adiponectin receptors in the human hypothalamusKatarina Kos
University of Warwick, Clinical Sciences Research Institute, University Hospital Coventry and Warwickshire, Clifford Bridge Road, Coventry CV2 2DX, United Kingdom
J Clin Endocrinol Metab 92:1129-36. 2007..In contrast to some suggestion of adiponectin influencing energy homeostasis in rodents, there is no evidence for adiponectin or resistin entering the human blood-brain barrier...
- High fat intake leads to acute postprandial exposure to circulating endotoxin in type 2 diabetic subjectsAlison L Harte
Division of Metabolic and Vascular Health, University of Warwick, Coventry, UK
Diabetes Care 35:375-82. 2012..To evaluate the changes in circulating endotoxin after a high-saturated fat meal to determine whether these effects depend on metabolic disease state...
- Evidence for a shift to anaerobic metabolism in adipose tissue in efavirenz-containing regimens for HIV with different nucleoside backbonesKirsty C McGee
Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, UHCW, Clinical Science Research Laboratories, Coventry, UK
Antivir Ther 17:495-507. 2012..We compared patterns of gene expression in the subcutaneous adipose tissue (SAT) of HIV-positive subjects before and after 18-24 months of ARV therapy with HIV-negative controls...
- Metabolic endotoxaemia: is it more than just a gut feeling?Milan K Piya
Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Clinical Sciences Research Laboratories, Coventry, UK
Curr Opin Lipidol 24:78-85. 2013..This article reviews the evidence linking gut bacteria, endotoxin, and its circulating levels with inflammatory induced obesity and metabolic disease (metabolic endotoxaemia)...
- Ethnic and sex differences in circulating endotoxin levels: A novel marker of atherosclerotic and cardiovascular risk in a British multi-ethnic populationMichelle A Miller
Clinical Sciences Research Institute, Warwick Medical School, Coventry, UK
Atherosclerosis 203:494-502. 2009..Moreover, ethnic differences in pro-inflammatory markers may be associated with ethnic differences in atherosclerotic and cardiovascular (CVD) and coronary heart disease (CHD) risk...
- The in vitro effects of resistin on the innate immune signaling pathway in isolated human subcutaneous adipocytesChristine M Kusminski
Unit of Diabetes and Metabolism, Clinical Sciences Research Institute, University Hospitals Coventry and Warwickshire Trust, Clifford Bridge Road, Walsgrave, Coventry CV2 2DX, United Kingdom
J Clin Endocrinol Metab 92:270-6. 2007..The adipokine resistin has demonstrated proinflammatory properties in relation to obesity and T2DM...
- Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular diseaseAdam R Baker
Unit for Diabetes and Metabolism, Warwick Medical School, University of Warwick, Clinical Sciences Research Institute, UHCW Campus, Coventry, CV2 2DX, UK
Cardiovasc Diabetol 5:1. 2006..Inflammation contributes to cardiovascular disease and is exacerbated with increased adiposity, particularly omental adiposity; however, the role of epicardial fat is poorly understood...