Paul J Harrison

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. pmc Reduced myelin basic protein and actin-related gene expression in visual cortex in schizophrenia
    Paul R Matthews
    Department of Psychiatry, University of Oxford, Oxford, United Kingdom
    PLoS ONE 7:e38211. 2012
  2. pmc Decreased striatal dopamine in group II metabotropic glutamate receptor (mGlu2/mGlu3) double knockout mice
    Tracy A Lane
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    BMC Neurosci 14:102. 2013
  3. doi request reprint Genetic mouse models relevant to schizophrenia: taking stock and looking forward
    Paul J Harrison
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    Neuropharmacology 62:1164-7. 2012
  4. pmc Human brain weight is correlated with expression of the 'housekeeping genes' beta-2-microglobulin (β2M) and TATA-binding protein (TBP)
    P J Harrison
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    Neuropathol Appl Neurobiol 36:498-504. 2010
  5. ncbi request reprint Catechol-O-methyltransferase (COMT): a gene contributing to sex differences in brain function, and to sexual dimorphism in the predisposition to psychiatric disorders
    Paul J Harrison
    Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK
    Neuropsychopharmacology 33:3037-45. 2008
  6. ncbi request reprint The neuropathology of primary mood disorder
    Paul J Harrison
    Department of Psychiatry, University of Oxford, UK
    Brain 125:1428-49. 2002
  7. ncbi request reprint The neuropathological effects of antipsychotic drugs
    P J Harrison
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Schizophr Res 40:87-99. 1999
  8. ncbi request reprint Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence
    P J Harrison
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    Mol Psychiatry 10:40-68; image 5. 2005
  9. ncbi request reprint Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology
    Paul J Harrison
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom
    Biol Psychiatry 60:132-40. 2006
  10. doi request reprint The group II metabotropic glutamate receptor 3 (mGluR3, mGlu3, GRM3): expression, function and involvement in schizophrenia
    P J Harrison
    Department of Psychiatry, University of Oxford, Neurosciences Building, Warneford Hospital, Oxford, UK
    J Psychopharmacol 22:308-22. 2008

Collaborators

Detail Information

Publications104 found, 100 shown here

  1. pmc Reduced myelin basic protein and actin-related gene expression in visual cortex in schizophrenia
    Paul R Matthews
    Department of Psychiatry, University of Oxford, Oxford, United Kingdom
    PLoS ONE 7:e38211. 2012
    ..The findings confirm that the primary visual cortex shows molecular alterations in schizophrenia and extend the evidence for a widespread, rather than focal, cortical pathophysiology...
  2. pmc Decreased striatal dopamine in group II metabotropic glutamate receptor (mGlu2/mGlu3) double knockout mice
    Tracy A Lane
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    BMC Neurosci 14:102. 2013
    ..We also measured the same parameters in mGlu2-/- and mGlu3-/- single knockout mice...
  3. doi request reprint Genetic mouse models relevant to schizophrenia: taking stock and looking forward
    Paul J Harrison
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    Neuropharmacology 62:1164-7. 2012
    ....
  4. pmc Human brain weight is correlated with expression of the 'housekeeping genes' beta-2-microglobulin (β2M) and TATA-binding protein (TBP)
    P J Harrison
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    Neuropathol Appl Neurobiol 36:498-504. 2010
    ..Many variables affect mRNA measurements in post mortem human brain tissue. Brain weight has not hitherto been considered to be such a factor. This study examined whether there is any relationship between brain weight and mRNA abundance...
  5. ncbi request reprint Catechol-O-methyltransferase (COMT): a gene contributing to sex differences in brain function, and to sexual dimorphism in the predisposition to psychiatric disorders
    Paul J Harrison
    Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK
    Neuropsychopharmacology 33:3037-45. 2008
    ..Since sex differences in the genetic architecture of quantitative traits are the rule not the exception, we anticipate that additional evidence will emerge for sexual dimorphisms, not only in COMT but also in many other autosomal genes...
  6. ncbi request reprint The neuropathology of primary mood disorder
    Paul J Harrison
    Department of Psychiatry, University of Oxford, UK
    Brain 125:1428-49. 2002
    ..The neuropathology is postulated to contribute to the pathophysiology and dysfunction of the neural circuits which regulate mood and its associated cognitions, behaviours and somatic symptoms...
  7. ncbi request reprint The neuropathological effects of antipsychotic drugs
    P J Harrison
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Schizophr Res 40:87-99. 1999
    ..There is no good evidence that antipsychotics cause neuronal loss or gliosis, nor that they promote neurofibrillary tangle formation or other features of Alzheimer's disease...
  8. ncbi request reprint Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence
    P J Harrison
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    Mol Psychiatry 10:40-68; image 5. 2005
    ..Characterization of a core molecular pathway and a 'genetic cytoarchitecture' would be a profound advance in understanding schizophrenia, and may have equally significant therapeutic implications...
  9. ncbi request reprint Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology
    Paul J Harrison
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom
    Biol Psychiatry 60:132-40. 2006
    ..We review the structure and functions of NRG1, consider the evidence for and against it being a schizophrenia susceptibility gene, and discuss mechanisms that might underlie the contribution of NRG1 to disease pathophysiology...
  10. doi request reprint The group II metabotropic glutamate receptor 3 (mGluR3, mGlu3, GRM3): expression, function and involvement in schizophrenia
    P J Harrison
    Department of Psychiatry, University of Oxford, Neurosciences Building, Warneford Hospital, Oxford, UK
    J Psychopharmacol 22:308-22. 2008
    ..Together these data implicate mGluR3 in aetiological, pathophysiological and pharmacotherapeutic aspects of the disorder...
  11. ncbi request reprint Neuropathological studies of synaptic connectivity in the hippocampal formation in schizophrenia
    P J Harrison
    Department of Psychiatry, University of Oxford, UK
    Hippocampus 11:508-19. 2001
    ..The data, their interpretation, and their limitations are discussed, with particular emphasis upon molecular and immunological studies of synaptic protein gene expression...
  12. ncbi request reprint Meta-analysis of brain weight in schizophrenia
    Paul J Harrison
    Department of Psychiatry, Neurosciences Building, Warneford Hospital, University of Oxford, Warneford Lane, Oxford OX3 7JX, UK
    Schizophr Res 64:25-34. 2003
    ..The result encourages a continuing search for the histological and molecular correlates of schizophrenia...
  13. ncbi request reprint The hippocampus in schizophrenia: a review of the neuropathological evidence and its pathophysiological implications
    Paul J Harrison
    Department of Psychiatry, Neurosciences Building, Warneford Hospital, University of Oxford, Oxford, OX3 7JX, UK
    Psychopharmacology (Berl) 174:151-62. 2004
    ..Hippocampal involvement is likely to be associated with the neuropsychological impairments of schizophrenia rather than with its psychotic symptoms...
  14. ncbi request reprint Genes for schizophrenia? Recent findings and their pathophysiological implications
    Paul J Harrison
    University of Oxford Department of Psychiatry, Neurosciences Building, Warneford Hospital, OX3 7JX, Oxford, UK
    Lancet 361:417-9. 2003
    ..Identifying the genes is essential if the pathogenesis and pathophysiology of schizophrenia is finally to be understood, and to give the prospect of more effective treatment...
  15. ncbi request reprint Glutamate receptors and transporters in the hippocampus in schizophrenia
    Paul J Harrison
    Department of Psychiatry, Neurosciences Building, Warneford Hospital, University of Oxford, Oxford, OX3 7JX, United Kingdom
    Ann N Y Acad Sci 1003:94-101. 2003
    ..The recently described susceptibility genes for schizophrenia all act upon glutamatergic synaptic transmission, which may, therefore, be part of the core pathophysiology of the disorder...
  16. pmc Early parental deprivation in the marmoset monkey produces long-term changes in hippocampal expression of genes involved in synaptic plasticity and implicated in mood disorder
    Amanda J Law
    Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, Oxfordshire OX3 7JX, UK
    Neuropsychopharmacology 34:1381-94. 2009
    ..Equally, the negative results suggest that other features of mood disorder, such as decreased hippocampal volume and BDNF expression, are related to different aspects of the pathophysiological process...
  17. pmc Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the disease
    Amanda J Law
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, United Kingdom
    Proc Natl Acad Sci U S A 103:6747-52. 2006
    ..These data implicate variation in isoform expression as a molecular mechanism for the genetic association of NRG1 with schizophrenia...
  18. pmc Expression of kinase interacting with stathmin (KIS, UHMK1) in human brain and lymphoblasts: Effects of schizophrenia and genotype
    Greg C Bristow
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Brain Res 1301:197-206. 2009
    ....
  19. ncbi request reprint Reduced spinophilin but not microtubule-associated protein 2 expression in the hippocampal formation in schizophrenia and mood disorders: molecular evidence for a pathology of dendritic spines
    Amanda J Law
    University Department of Psychiatry, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK
    Am J Psychiatry 161:1848-55. 2004
    ..There is reasonable neuropathological evidence for a presynaptic pathology but few studies of the postsynaptic component. This study tested the hypothesis that hippocampal dendritic pathology is also present in schizophrenia...
  20. pmc Markers of glutamate synaptic transmission and plasticity are increased in the anterior cingulate cortex in bipolar disorder
    Sharon L Eastwood
    Department of Psychiatry, University of Oxford, Oxford, United Kingdom
    Biol Psychiatry 67:1010-6. 2010
    ..We also measured netrin-G1 and netrin-G2 messenger RNAs because these genes are involved in the formation and plasticity of glutamatergic connections...
  21. pmc Altered hippocampal expression of glutamate receptors and transporters in GRM2 and GRM3 knockout mice
    Louisa Lyon
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom
    Synapse 62:842-50. 2008
    ..The results show a mutual interplay between mGluR2 and mGluR3, and also provide a context in which to interpret behavioral and electrophysiological results in these mice...
  22. pmc Transgenic overexpression of the type I isoform of neuregulin 1 affects working memory and hippocampal oscillations but not long-term potentiation
    Inga H Deakin
    Department of Psychiatry, University of Oxford, Oxford, UK
    Cereb Cortex 22:1520-9. 2012
    ..However, the findings, in concert with those from other genetic and pharmacological manipulations of NRG1, emphasize the complex and pleiotropic nature of the gene, even with regard to a single isoform...
  23. ncbi request reprint Catechol-o-methyltransferase (COMT) and proline dehydrogenase (PRODH) mRNAs in the dorsolateral prefrontal cortex in schizophrenia, bipolar disorder, and major depression
    Elizabeth Tunbridge
    Department of Psychiatry, University of Oxford, Neurosciences Building, Warneford Hospital, Oxford, OX3 7JX, UK
    Synapse 51:112-8. 2004
    ....
  24. ncbi request reprint Anomalies of asymmetry of pyramidal cell density and structure in dorsolateral prefrontal cortex in schizophrenia
    Thomas J Cullen
    Prince of Wales International Centre for SANE Research, Warneford Hospital, Oxford OX3 7JX, UK
    Br J Psychiatry 188:26-31. 2006
    ..Studies suggest that neuronal density in left dorsolateral prefrontal cortex is increased in schizophrenia...
  25. ncbi request reprint Decreased hippocampal expression of the susceptibility gene PPP3CC and other calcineurin subunits in schizophrenia
    Sharon L Eastwood
    Department of Psychiatry, University of Oxford, Warneford Hospital, Headington, Oxford, United Kingdom
    Biol Psychiatry 57:702-10. 2005
    ..However, the distribution of CaN A gamma is not established, nor whether its expression changes in schizophrenia...
  26. ncbi request reprint Cerebellar synaptic protein expression in schizophrenia
    S L Eastwood
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Neuroscience 105:219-29. 2001
    ..We conclude that there is synaptic pathology in the cerebellum in schizophrenia. By disrupting neural circuits, the alterations may contribute to the cerebellar dysfunction thought to occur in the disorder...
  27. pmc Behavioural characterization of neuregulin 1 type I overexpressing transgenic mice
    Inga H Deakin
    Department of Psychiatry, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    Neuroreport 20:1523-8. 2009
    ..The pattern of results shows both similarities and differences to those reported in hypomorphic NRG1 mice, and may be relevant for interpreting the increased NRG1 type I expression observed in schizophrenia...
  28. pmc Fractionation of spatial memory in GRM2/3 (mGlu2/mGlu3) double knockout mice reveals a role for group II metabotropic glutamate receptors at the interface between arousal and cognition
    Louisa Lyon
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    Neuropsychopharmacology 36:2616-28. 2011
    ..These arousal-dependent effects may explain apparently conflicting data from previous studies, and have translational relevance for the involvement of these receptors in schizophrenia and other disorders...
  29. ncbi request reprint Altered expression of synaptic protein mRNAs in STOP (MAP6) mutant mice
    Sharon L Eastwood
    University of Oxford, Department of Psychiatry, Warneford Hospital, Oxford, UK
    J Psychopharmacol 21:635-44. 2007
    ..Together the data provide supporting evidence for a role for microtubules in synaptic function, and suggest that STOP, or other microtubule proteins, may contribute to the synaptic pathology of schizophrenia...
  30. pmc d-Amino acid oxidase and serine racemase in human brain: normal distribution and altered expression in schizophrenia
    Louise Verrall
    Department of Psychiatry, Warneford Hospital, Warneford Lane, University of Oxford, Oxford, UK
    Eur J Neurosci 26:1657-69. 2007
    ..However, they raise further questions as to the roles of D-amino acid oxidase and serine racemase in both physiological and pathophysiological processes in the brain...
  31. pmc Sexually dimorphic effects of catechol-O-methyltransferase (COMT) inhibition on dopamine metabolism in multiple brain regions
    Linda M Laatikainen
    Department of Psychiatry, University of Oxford, Oxford, United Kingdom
    PLoS ONE 8:e61839. 2013
    ..Furthermore, they suggest that the impact of tolcapone may be greater in females than males, a finding which may be of clinical significance in terms of the efficacy and dosing of COMT inhibitors...
  32. ncbi request reprint Changes in NMDA receptor subunit mRNAs and cyclophilin mRNA during development of the human hippocampus
    Amanda J Law
    Department of Psychiatry, University of Oxford, OX3 7JX, United Kingdom
    Ann N Y Acad Sci 1003:426-30. 2003
  33. pmc Decreased mRNA expression of netrin-G1 and netrin-G2 in the temporal lobe in schizophrenia and bipolar disorder
    Sharon L Eastwood
    Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK
    Neuropsychopharmacology 33:933-45. 2008
    ....
  34. ncbi request reprint Cellular basis of reduced cortical reelin expression in schizophrenia
    Sharon L Eastwood
    Department of Psychiatry, University of Oxford, Oxford OX3 7JX, UK
    Am J Psychiatry 163:540-2. 2006
    ..The authors' goals were to establish the cellular origin of the reduced cortical reelin expression that occurs in schizophrenia and to relate it to markers of synaptic pathology...
  35. ncbi request reprint Expression of multiple catechol-o-methyltransferase (COMT) mRNA variants in human brain
    Elizabeth M Tunbridge
    Department of Psychiatry, Oxford University, Oxford, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 144:834-9. 2007
    ..The alternate gene products may be of significant functional importance, and differentially impacted by polymorphisms within the COMT gene...
  36. doi request reprint Hippocampal mossy fiber long-term depression in Grm2/3 double knockout mice
    Louisa Lyon
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
    Synapse 65:945-54. 2011
    ..Two mGluR antagonists also failed to block mossy fiber LTD under 4 mM conditions in wild-type mice, strengthening the conclusion that group II mGluRs are not obligatory for mossy fiber LTD...
  37. pmc The DISC1 Ser704Cys substitution affects centrosomal localization of its binding partner PCM1 in glia in human brain
    Sharon L Eastwood
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    Hum Mol Genet 19:2487-96. 2010
    ..Whether this influence of DISC1 genotype extends to other centrosomal proteins and DISC1 binding partners remains to be determined...
  38. doi request reprint D-amino acid oxidase knockdown in the mouse cerebellum reduces NR2A mRNA
    Philip W J Burnet
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    Mol Cell Neurosci 46:167-75. 2011
    ..They also provide a tool to investigate DAO, an enzyme currently of considerable interest in the pathophysiology and therapy of schizophrenia...
  39. ncbi request reprint Synaptophysin protein and mRNA expression in the human hippocampal formation from birth to old age
    Sharon L Eastwood
    Department of Psychiatry of the University of Oxford, Neurosciences Building, Warneford Hospital, Oxford, United Kingdom
    Hippocampus 16:645-54. 2006
    ....
  40. ncbi request reprint Differential expression of calcineurin A subunit mRNA isoforms during rat hippocampal and cerebellar development
    Sharon L Eastwood
    University of Oxford, Department of Psychiatry, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK
    Eur J Neurosci 22:3017-24. 2005
    ..The data also suggest a potential importance of calcineurin Agamma in neurodevelopment, and in the genetically influenced neurodevelopmental disturbance that is thought to underlie schizophrenia...
  41. pmc Gene expression in the anterior cingulate cortex and amygdala of adolescent marmoset monkeys following parental separations in infancy
    Amanda J Law
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    Int J Neuropsychopharmacol 12:761-72. 2009
    ..The results differ from those reported in the hippocampus of the same animals, indicating the presence of limbic region-specific long-term molecular responses to early life stress...
  42. pmc Catechol-O-methyltransferase (COMT) influences the connectivity of the prefrontal cortex at rest
    Elizabeth M Tunbridge
    Department of Psychiatry, University of Oxford, Oxford, UK
    Neuroimage 68:49-54. 2013
    ....
  43. ncbi request reprint Long-term behavioural, molecular and morphological effects of neonatal NMDA receptor antagonism
    Laura Wiseman Harris
    University Department of Psychiatry, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK
    Eur J Neurosci 18:1706-10. 2003
    ....
  44. doi request reprint Polymorphisms in the catechol-O-methyltransferase (COMT) gene influence plasma total homocysteine levels
    Elizabeth M Tunbridge
    Department of Psychiatry, University of Oxford, Oxford, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 147:996-9. 2008
    ..The results also indicate that COMT activity may influence a broader range of biochemical pathways than hitherto appreciated...
  45. ncbi request reprint Antipsychotics increase microtubule-associated protein 2 mRNA but not spinophilin mRNA in rat hippocampus and cortex
    Amanda J Law
    Department of Psychiatry, University of Oxford, Neurosciences Building, Warneford Hospital, Oxford, United Kingdom
    J Neurosci Res 76:376-82. 2004
    ..Such actions may underlie their long-term effects on neural plasticity in areas of the brain implicated in the pathology of schizophrenia...
  46. ncbi request reprint Expression of serotonin 5-HT(2A) receptors in the human cerebellum and alterations in schizophrenia
    S L Eastwood
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Synapse 42:104-14. 2001
    ..Measurement of multiple parameters is necessary to give a clear picture of the normal situation and to show the profile of alterations in a disease...
  47. doi request reprint Changed relative to what? Housekeeping genes and normalization strategies in human brain gene expression studies
    Elizabeth M Tunbridge
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom
    Biol Psychiatry 69:173-9. 2011
    ..We end by making several recommendations toward a more flexible, transparent, and comprehensive approach to data presentation and analysis. We illustrate the review with examples from studies of schizophrenia and mood disorder...
  48. pmc COMT Val(158)Met genotype determines the direction of cognitive effects produced by catechol-O-methyltransferase inhibition
    Sarah M Farrell
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom
    Biol Psychiatry 71:538-44. 2012
    ..The inverted-U relationship between cortical dopamine signaling and working memory predicts that the effects of COMT inhibition will differ according to COMT genotype...
  49. ncbi request reprint Low medial and lateral right pulvinar volumes in schizophrenia: a postmortem study
    J Robin Highley
    University Department of Psychaitry, Warneford Hospital, Oxford, UK
    Am J Psychiatry 160:1177-9. 2003
    ..In this study, the volume and neuronal number of the pulvinar thalamic nucleus in schizophrenia patients were measured...
  50. pmc D-Serine metabolism in C6 glioma cells: Involvement of alanine-serine-cysteine transporter (ASCT2) and serine racemase (SRR) but not D-amino acid oxidase (DAO)
    Pilleriin Sikka
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom
    J Neurosci Res 88:1829-40. 2010
    ..The factors regulating D-serine are important for understanding normal NMDA receptor function and because D-serine, along with DAO and SRR, is implicated in the pathogenesis and treatment of schizophrenia...
  51. ncbi request reprint The axonal chemorepellant semaphorin 3A is increased in the cerebellum in schizophrenia and may contribute to its synaptic pathology
    S L Eastwood
    Departments of Psychiatry and Clinical Neurology, Warneford Hospital, University of Oxford, Oxford OX3 7JX, UK
    Mol Psychiatry 8:148-55. 2003
    ....
  52. ncbi request reprint Synaptic pathology in the anterior cingulate cortex in schizophrenia and mood disorders. A review and a Western blot study of synaptophysin, GAP-43 and the complexins
    S L Eastwood
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Brain Res Bull 55:569-78. 2001
    ..The reductions may be progressive...
  53. ncbi request reprint Deliberate self-harm is associated with allelic variation in the tryptophan hydroxylase gene (TPH A779C), but not with polymorphisms in five other serotonergic genes
    E C Pooley
    University Department of Psychiatry and Centre for Suicide Research, Warneford Hospital, University of Oxford
    Psychol Med 33:775-83. 2003
    ..In particular, several studies have reported an association with variants in the tryptophan hydroxylase (TPH) gene...
  54. ncbi request reprint The distribution and morphology of prefrontal cortex pyramidal neurons identified using anti-neurofilament antibodies SMI32, N200 and FNP7. Normative data and a comparison in subjects with schizophrenia, bipolar disorder or major depression
    Amanda J Law
    Department of Psychiatry, University of Oxford, Neurosciences Building, Warneford Hospital, OX3 7JX, Oxford, UK
    J Psychiatr Res 37:487-99. 2003
    ..However, we found no clear evidence that the prefrontal neuropathology of schizophrenia or mood disorders preferentially affects SMI32-, N200- or FNP7-immunoreactive pyramidal neurons...
  55. doi request reprint Importance of the COMT gene for sex differences in brain function and predisposition to psychiatric disorders
    Elizabeth M Tunbridge
    Department of Psychiatry, University of Oxford, Neurosciences Building, Warneford Hospital, Oxford, OX3 7JX, UK
    Curr Top Behav Neurosci 8:119-40. 2011
    ....
  56. ncbi request reprint Schizophrenia susceptibility genes and their neurodevelopmental implications: focus on neuregulin 1
    Paul J Harrison
    University of Oxford, Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK
    Novartis Found Symp 288:246-55; discussion 255-9, 276-81. 2007
    ..Here, the genetic advances and their neurodevelopmental implications are summarised, with a particular focus on neuregulin 1...
  57. doi request reprint A morphometric study of glia and neurons in the anterior cingulate cortex in mood disorder
    Rebecca A Gittins
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    J Affect Disord 133:328-32. 2011
    ..The anterior cingulate cortex (ACC) is a key region for the pathophysiology and treatment of depression. However, it remains unclear whether and how the morphology of the ACC is altered in subjects with mood disorders...
  58. ncbi request reprint A quantitative morphometric study of the human anterior cingulate cortex
    Rebecca Gittins
    Department of Psychiatry, University of Oxford, Neurosciences Building, Warneford Hospital, OX3 7JX, Oxford, UK
    Brain Res 1013:212-22. 2004
    ....
  59. ncbi request reprint An RT-PCR study of 5-HT(6) and 5-HT(7) receptor mRNAs in the hippocampal formation and prefrontal cortex in schizophrenia
    S Z East
    Department of Psychiatry, University of Oxford, Neurosciences Building, Warneford Hospital, Warneford Lane, OX3 7JX Oxford, UK
    Schizophr Res 57:15-26. 2002
    ....
  60. ncbi request reprint Distribution of kainate receptor subunit mRNAs in human hippocampus, neocortex and cerebellum, and bilateral reduction of hippocampal GluR6 and KA2 transcripts in schizophrenia
    R H Porter
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Brain Res 751:217-31. 1997
    ..These deficits are likely to contribute to the glutamatergic component of the disease pathophysiology...
  61. ncbi request reprint Evaluating the links between schizophrenia and sleep and circadian rhythm disruption
    David Pritchett
    Nuffield Department of Clinical Neurosciences Nuffield Laboratory of Ophthalmology, University of Oxford, John Radcliffe Hospital, Level 5 6 West Wing, Headley Way, Oxford OX3 9DU, UK
    J Neural Transm 119:1061-75. 2012
    ....
  62. pmc A morphometric, immunohistochemical, and in situ hybridization study of the dorsal raphe nucleus in major depression, bipolar disorder, schizophrenia, and suicide
    Paul R Matthews
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    J Affect Disord 137:125-34. 2012
    ..However, it is unclear whether these conditions include morphological involvement of the dorsal raphe nucleus (DRN), the origin of most forebrain 5-HT innervation...
  63. ncbi request reprint Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond
    Elizabeth M Tunbridge
    Department of Psychiatry, University of Oxford, Oxford, United Kingdom
    Biol Psychiatry 60:141-51. 2006
    ..We conclude by outlining preliminary data indicating that COMT is a promising therapeutic target for ameliorating the cognitive deficits associated with schizophrenia...
  64. ncbi request reprint Alternative splicing of human metabotropic glutamate receptor 3
    Leah J Sartorius
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    J Neurochem 96:1139-48. 2006
    ....
  65. ncbi request reprint A 5-HT2C receptor promoter polymorphism (HTR2C - 759C/T) is associated with obesity in women, and with resistance to weight loss in heterozygotes
    Edward C Pooley
    University Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 126:124-7. 2004
    ..Pharmacogenetic testing of HTR2C promoter variants may be valuable when evaluating anti-obesity drugs which act directly or indirectly on the receptor...
  66. ncbi request reprint Expression of 5-HT receptors and the 5-HT transporter in rat brain after electroconvulsive shock
    P W Burnet
    Department of Psychiatry, University of Oxford, Warneford Hospital, UK
    Neurosci Lett 277:79-82. 1999
    ..The other mRNAs were unchanged. The results show that ECS has subtype specific, anatomically discrete, and temporally selective effects on 5-HT receptor expression...
  67. doi request reprint Expression of D-serine and glycine transporters in the prefrontal cortex and cerebellum in schizophrenia
    P W J Burnet
    Department of Psychiatry, University of Oxford, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, United Kingdom
    Schizophr Res 102:283-94. 2008
    ..However, this interpretation remains speculative. Further investigations will be valuable in the evaluation of these transporters as potential therapeutic targets in psychosis...
  68. ncbi request reprint Amyloid precursor protein mRNAs in Alzheimer's disease
    P J Harrison
    Department of Psychiatry, University of Oxford
    Neurodegeneration 5:409-15. 1996
    ..Here we review the distribution and abundance of amyloid precursor protein mRNAs in normal and AD-afflicted brains. The expression of apolipoprotein E and presenilin mRNAs are also discussed...
  69. ncbi request reprint Schizophrenia: a disorder of neurodevelopment?
    P J Harrison
    Department of Psychiatry, Warneford Hospital, University of Oxford, OX3 7JX, UK
    Curr Opin Neurobiol 7:285-9. 1997
    ..The neurodevelopmental view of schizophrenia is supported by neuropathological, epidemiological and clinical findings. Here, the evidence in favour of the model is summarized, together with a consideration of its weaknesses...
  70. ncbi request reprint Gene expression and neuronal activity in schizophrenia: a study of polyadenylated mRNA in the hippocampal formation and cerebral cortex
    P J Harrison
    Department of Psychiatry, Warneford Hospital, University of Oxford, UK
    Schizophr Res 26:93-102. 1997
    ..It also provides a further indication that the differential expression of individual transcripts reported in the disease is not merely reflecting changes in overall gene expression...
  71. ncbi request reprint The neuropathology of schizophrenia. A critical review of the data and their interpretation
    P J Harrison
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Brain 122:593-624. 1999
    ....
  72. ncbi request reprint Hippocampal and cortical growth-associated protein-43 messenger RNA in schizophrenia
    S L Eastwood
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Neuroscience 86:437-48. 1998
    ..The data support the emerging view that the disease pathophysiology is one which affects the hippocampal and cortical circuitry and that the abnormalities are reflected in the altered expression of specific neuronal genes...
  73. ncbi request reprint Preferential involvement of excitatory neurons in medial temporal lobe in schizophrenia
    P J Harrison
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Lancet 352:1669-73. 1998
    ..These findings suggest that the complexins might be useful in the investigation of the synaptic pathology of schizophrenia...
  74. ncbi request reprint Allelic variation of the 5-HT2C receptor (HTR2C) in bulimia nervosa and binge eating disorder
    P W Burnet
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Psychiatr Genet 9:101-4. 1999
    ..We conclude that allelic variation does not account for the involvement of the 5-HT2C receptor in these eating disorders...
  75. ncbi request reprint Expression of complexin I and II mRNAs and their regulation by antipsychotic drugs in the rat forebrain
    S L Eastwood
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Synapse 36:167-77. 2000
    ..In summary, the data have implications both for understanding the effects of antipsychotic medication on synaptic organization, and for synaptic protein expression studies in patients treated with the drugs...
  76. ncbi request reprint Neuregulin-1 (NRG-1) mRNA and protein in the adult human brain
    A J Law
    Neurosciences Building, Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK
    Neuroscience 127:125-36. 2004
    ..Using these normative data, future studies can ascertain whether the role of NRG-1 in the disease is mediated, or accompanied, via alterations in its expression...
  77. ncbi request reprint Decreased expression of vesicular glutamate transporter 1 and complexin II mRNAs in schizophrenia: further evidence for a synaptic pathology affecting glutamate neurons
    S L Eastwood
    Department of Psychiatry, University of Oxford, Warneford Hospital, Neurosciences Building, Oxford OX3 7JX, UK
    Schizophr Res 73:159-72. 2005
    ..The impairment of synaptic transmission implied by the synaptic protein reductions may contribute to the dysfunction of cortical neural circuits that characterises the disorder...
  78. ncbi request reprint Interstitial white matter neurons express less reelin and are abnormally distributed in schizophrenia: towards an integration of molecular and morphologic aspects of the neurodevelopmental hypothesis
    S L Eastwood
    Department of Psychiatry, University of Oxford, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK
    Mol Psychiatry 8:769, 821-31. 2003
    ..The alterations may contribute to the aberrant synaptic connectivity seen in schizophrenia. However, the functional implications of the abnormalities, as well as the mechanisms involved, remain to be fully elucidated...
  79. ncbi request reprint Catechol-o-methyltransferase inhibition improves set-shifting performance and elevates stimulated dopamine release in the rat prefrontal cortex
    E M Tunbridge
    Department of Psychiatry, University of Oxford, Oxford, United Kingdom, OX3 7JX
    J Neurosci 24:5331-5. 2004
    ..The interaction between clozapine and tolcapone may have implications for the treatment of schizophrenia...
  80. ncbi request reprint Interstitial white matter neuron density in the dorsolateral prefrontal cortex and parahippocampal gyrus in schizophrenia
    S L Eastwood
    University of Oxford, Department of Psychiatry, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK
    Schizophr Res 79:181-8. 2005
    ..As interstitial white matter neurons are presumed to be remnants of the embryonic cortical subplate, these findings provide additional evidence supportive of an early developmental abnormality in schizophrenia...
  81. ncbi request reprint Bromocriptine use is associated with decreased smoking rates
    M F G Murphy
    University of Oxford, ICRF General Practice Research Group, Institute of Health Sciences, Oxford, UK
    Addict Biol 7:325-8. 2002
    ..0001). This observation supports the role of dopamine in nicotine addiction, and suggests that bromocriptine-like drugs could be used effectively by pregnant women to aid cessation...
  82. ncbi request reprint RNA editing of the 5-HT(2C) receptor is reduced in schizophrenia
    M S Sodhi
    University Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK
    Mol Psychiatry 6:373-9. 2001
    ..The results also illustrate that potentially important receptor alterations may occur in schizophrenia which are not detectable merely in terms of receptor abundance...
  83. ncbi request reprint Electroconvulsive shock increases tachykinin NK(1) receptors, but not the encoding mRNA, in rat cortex
    P W Burnet
    University Department of Psychiatry, Warneford Hospital, Neuroscience Building, Headington, Oxford OX3 7JX, UK
    Eur J Pharmacol 413:213-9. 2001
    ..Upregulation of receptor-binding sites without a change in mRNA indicates that translational or post-translational mechanisms underlie this process...
  84. ncbi request reprint Asymmetry of the uncinate fasciculus: a post-mortem study of normal subjects and patients with schizophrenia
    J Robin Highley
    Schizophrenia Research Group, Department of Clinical Neurology Neuropathology, Radcliffe Infirmary, Oxford, UK
    Cereb Cortex 12:1218-24. 2002
    ..The unchanged size of the fasciculus in schizophrenia contrasts with commissural tracts, which are affected in this brain series in a sex-specific manner...
  85. ncbi request reprint Laser-assisted microdissection: methods for the molecular analysis of psychiatric disorders at a cellular resolution
    Philip W J Burnet
    Department of Psychiatry, University of Oxford, Oxford, United Kingdom
    Biol Psychiatry 55:107-11. 2004
    ..Laser-assisted microdissection techniques provide such a tool. Here we briefly discuss the principles, applications, and limitations of laser-assisted microdissection in psychiatric research...
  86. ncbi request reprint Neuronal density, size and shape in the human anterior cingulate cortex: a comparison of Nissl and NeuN staining
    Rebecca Gittins
    Department of Psychiatry, University of Oxford, Warneford Hospital, Neurosciences Building, Oxford OX3 7JX, UK
    Brain Res Bull 63:155-60. 2004
    ..NeuN may be particularly useful when it is important to distinguish small neurons from glia, such as in cytoarchitectural studies of the cerebral cortex in depression and schizophrenia...
  87. ncbi request reprint Catechol-o-methyltransferase enzyme activity and protein expression in human prefrontal cortex across the postnatal lifespan
    E M Tunbridge
    Department of Psychiatry, University of Oxford, Oxford OX3 7JX, UK
    Cereb Cortex 17:1206-12. 2007
    ....
  88. ncbi request reprint A postmortem study of the mediodorsal nucleus of the thalamus in schizophrenia
    T J Cullen
    Department of Clinical Neurology Neuropathology, University of Oxford, Radcliffe Infirmary, OX2 6HE, Oxford, UK
    Schizophr Res 60:157-66. 2003
    ..Hence our negative observations, in the largest sample yet investigated, cast doubt on the robustness and/or the generalisability of MD neuropathology in schizophrenia...
  89. ncbi request reprint The met(158) allele of catechol-O-methyltransferase (COMT) is associated with obsessive-compulsive disorder in men: case-control study and meta-analysis
    E C Pooley
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    Mol Psychiatry 12:556-61. 2007
    ..The finding also extends the evidence for sexual dimorphism in COMT and in OCD...
  90. ncbi request reprint 5-HT6 receptor binding sites in schizophrenia and following antipsychotic drug administration: autoradiographic studies with [125I]SB-258585
    Simon Z East
    University of Oxford, Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK
    Synapse 45:191-9. 2002
    ....
  91. ncbi request reprint Eating disorders
    Christopher G Fairburn
    Oxford University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Lancet 361:407-16. 2003
    ..Treatment of anorexia nervosa and atypical eating disorders has received remarkably little research attention...
  92. ncbi request reprint Expression of NMDA receptor NR1, NR2A and NR2B subunit mRNAs during development of the human hippocampal formation
    Amanda J Law
    Department of Psychiatry, University of Oxford, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK
    Eur J Neurosci 18:1197-205. 2003
    ..Changes in subunit composition may thus contribute to maturational differences in human hippocampal N-methyl-d-aspartate receptor function, and to their role in the pathophysiology of schizophrenia and other neurodevelopmental disorders...
  93. ncbi request reprint Weight gain with antipsychotic drugs: the role of the 5-HT2C receptor (HTR2C) and other genes
    Paul J Harrison
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Pharmacogenet Genomics 15:193-4. 2005
  94. pmc The neurobiology of D-amino acid oxidase and its involvement in schizophrenia
    L Verrall
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom
    Mol Psychiatry 15:122-37. 2010
    ..itself: how should we weigh up convergent and cumulatively impressive, but individually inconclusive, pieces of evidence regarding the role that a given gene may have in the aetiology, pathophysiology and pharmacotherapy of schizophrenia?..
  95. ncbi request reprint In vitro evidence that 5-hydroxytryptamine increases efflux of glial glutamate via 5-HT(2A) receptor activation
    R Meller
    University Department of Clinical Pharmacology, Radcliffe Infirmary, Oxford, United Kingdom
    J Neurosci Res 67:399-405. 2002
    ..In conclusion, 5-HT stimulates the efflux of glutamate from C6 glioma cells following 5-HT(2A) receptor activation and involves a calcium-dependent mechanism...
  96. ncbi request reprint AMPA glutamate receptors and their flip and flop mRNAs in human hippocampus
    S L Eastwood
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Neuroreport 5:1325-8. 1994
    ....
  97. ncbi request reprint Schizophrenia and the frontal lobes: post-mortem stereological study of tissue volume
    J R Highley
    Schizophrenia Research Group, Department of Clinical Neurology (Neuropathology, Radcliffe Infirmary, Oxford OX3 7JX, UK
    Br J Psychiatry 178:337-43. 2001
    ..CONCLUSIONS: Such structural abnormalities as are present in the frontal lobes are more subtle than straightforward alterations in tissue volume; they may include changes in shape and the pattern of gyral folding...
  98. ncbi request reprint Schizophrenia susceptibility genes and neurodevelopment
    Paul J Harrison
    Biol Psychiatry 61:1119-20. 2007
  99. ncbi request reprint Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia
    Wei Tan
    SAIC Frederick, NCI, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 282:24343-51. 2007
    ....
  100. doi request reprint Metabotropic glutamate receptor agonists for schizophrenia
    Paul J Harrison
    Br J Psychiatry 192:86-7. 2008
    ..The finding complements accumulating evidence that glutamatergic abnormalities are important in the pathophysiology of schizophrenia...
  101. ncbi request reprint The distribution of 5-HT(6) receptors in rat brain: an autoradiographic binding study using the radiolabelled 5-HT(6) receptor antagonist [(125)I]SB-258585
    Jennifer C Roberts
    Neuroscience Research, GlaxoSmithKline, New Frontiers Science Park North, Third Avenue, Harlow, Essex CM19 5AW, UK
    Brain Res 934:49-57. 2002
    ..The high levels of binding observed in the choroid plexus in this study have not been reported before. This finding suggests that 5-HT(6) receptors could play a role in the control of cerebrospinal fluid dynamics...