Paul Harrison

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint Assessment of platelet function in the laboratory
    P Harrison
    Oxford Haemophilia and Thrombosis Centre, Churchill Hospital, Oxford, OX3 7LJ, UK
    Hamostaseologie 29:25-31. 2009
  2. ncbi request reprint Guidelines for the laboratory investigation of heritable disorders of platelet function
    Paul Harrison
    Oxford Haemophilia and Thrombosis Centre, Churchill Hospital, Oxford, UK
    Br J Haematol 155:30-44. 2011
  3. ncbi request reprint Advances in the monitoring of anti-P2Y12 therapy
    Paul Harrison
    Oxford Haemophilia and Thrombosis Centre, Churchill Hospital, Oxford, OX3 7LJ, United Kingdom
    Platelets 23:510-25. 2012
  4. ncbi request reprint Lack of reproducibility of assessment of aspirin responsiveness by optical aggregometry and two platelet function tests
    Paul Harrison
    Oxford Haemophilia and Thrombosis Centre, Oxford, UK
    Platelets 19:119-24. 2008
  5. doi request reprint Screening tests of platelet function: update on their appropriate uses for diagnostic testing
    Paul Harrison
    Oxford Haemophilia and Thrombosis Centre, Churchill Hospital, Oxford, United Kingdom
    Semin Thromb Hemost 35:150-7. 2009
  6. ncbi request reprint High incidence of defective high-shear platelet function among platelet donors
    Paul Harrison
    Oxford Haemophilia Center and Thrombosis Unit, Churchill Hospital, Headington, Oxford, UK
    Transfusion 44:764-70. 2004
  7. ncbi request reprint Impact of immunological platelet counting (by the platelet/RBC ratio) on haematological practice
    Paul Harrison
    Oxford Haemophilia Centre and Thrombosis Unit, Churchill Hospital, Headington, Oxford, United Kingdom
    Cytometry B Clin Cytom 67:1-5. 2005
  8. ncbi request reprint The role of PFA-100 testing in the investigation and management of haemostatic defects in children and adults
    Paul Harrison
    Oxford Haemophilia Centre and Thrombosis Unit, Churchill Hospital, Headington, Oxford, UK
    Br J Haematol 130:3-10. 2005
  9. ncbi request reprint Platelet function analysis
    Paul Harrison
    Oxford Haemophilia Centre and Thrombosis Unit, Churchill Hospital, Oxford OX3 7LJ, UK
    Blood Rev 19:111-23. 2005
  10. ncbi request reprint Platelet hyperactivity and risk of recurrent thrombosis
    P Harrison
    Oxford Haemophilia Centre and Thrombosis Unit, Churchill Hospital, Oxford, UK
    J Thromb Haemost 4:2544-6. 2006

Detail Information

Publications52

  1. ncbi request reprint Assessment of platelet function in the laboratory
    P Harrison
    Oxford Haemophilia and Thrombosis Centre, Churchill Hospital, Oxford, OX3 7LJ, UK
    Hamostaseologie 29:25-31. 2009
    ....
  2. ncbi request reprint Guidelines for the laboratory investigation of heritable disorders of platelet function
    Paul Harrison
    Oxford Haemophilia and Thrombosis Centre, Churchill Hospital, Oxford, UK
    Br J Haematol 155:30-44. 2011
    ..The guidance may not be appropriate to patients receiving antiplatelet therapy and in all cases individual patient circumstances may dictate an alternative approach...
  3. ncbi request reprint Advances in the monitoring of anti-P2Y12 therapy
    Paul Harrison
    Oxford Haemophilia and Thrombosis Centre, Churchill Hospital, Oxford, OX3 7LJ, United Kingdom
    Platelets 23:510-25. 2012
    ....
  4. ncbi request reprint Lack of reproducibility of assessment of aspirin responsiveness by optical aggregometry and two platelet function tests
    Paul Harrison
    Oxford Haemophilia and Thrombosis Centre, Oxford, UK
    Platelets 19:119-24. 2008
    ..Lack of consistency over time in identification of apparently non-responsiveness individuals is likely to substantially undermine any ability of these tests to predict risk of recurrent vascular events...
  5. doi request reprint Screening tests of platelet function: update on their appropriate uses for diagnostic testing
    Paul Harrison
    Oxford Haemophilia and Thrombosis Centre, Churchill Hospital, Oxford, United Kingdom
    Semin Thromb Hemost 35:150-7. 2009
    ..These tests will therefore be considered in detail in this review, and we will discuss the limitations of these methods in screening individuals for platelet disorders...
  6. ncbi request reprint High incidence of defective high-shear platelet function among platelet donors
    Paul Harrison
    Oxford Haemophilia Center and Thrombosis Unit, Churchill Hospital, Headington, Oxford, UK
    Transfusion 44:764-70. 2004
    ..There has been little previous work on PLT function in blood donors...
  7. ncbi request reprint Impact of immunological platelet counting (by the platelet/RBC ratio) on haematological practice
    Paul Harrison
    Oxford Haemophilia Centre and Thrombosis Unit, Churchill Hospital, Headington, Oxford, United Kingdom
    Cytometry B Clin Cytom 67:1-5. 2005
  8. ncbi request reprint The role of PFA-100 testing in the investigation and management of haemostatic defects in children and adults
    Paul Harrison
    Oxford Haemophilia Centre and Thrombosis Unit, Churchill Hospital, Headington, Oxford, UK
    Br J Haematol 130:3-10. 2005
    ..This review highlights the up to date, evidence-based, advantages and disadvantages of the PFA-100 test in the investigation and management of haemostatic disorders in both children and adults...
  9. ncbi request reprint Platelet function analysis
    Paul Harrison
    Oxford Haemophilia Centre and Thrombosis Unit, Churchill Hospital, Oxford OX3 7LJ, UK
    Blood Rev 19:111-23. 2005
    ..This review will highlight some of these of new tests/instruments and discuss their potential utility both within the haemostasis laboratory but also as potential point of care instruments...
  10. ncbi request reprint Platelet hyperactivity and risk of recurrent thrombosis
    P Harrison
    Oxford Haemophilia Centre and Thrombosis Unit, Churchill Hospital, Oxford, UK
    J Thromb Haemost 4:2544-6. 2006
  11. ncbi request reprint "Message in the platelet"--more than just vestigial mRNA!
    Paul Harrison
    Oxford Haemophilia and Thrombosis Centre, Churchill Hospital, Oxford, UK
    Platelets 19:395-404. 2008
    ..The full complexity of the platelet genome is now just being revealed and may open the possibility for improved diagnosis and therapy of many haemostatic and thrombotic disorders...
  12. ncbi request reprint The PFA-100: a potential rapid screening tool for the assessment of platelet dysfunction
    Paul Harrison
    Haemostasis Research, Department of Haematology, University College Hospital, London, UK
    Clin Lab Haematol 24:225-32. 2002
    ..The PFA-100 test provides a useful rapid screening tool and should increase the efficiency and reduce the cost of the routine diagnosis of platelet dysfunction...
  13. ncbi request reprint Screening for aspirin responsiveness after transient ischemic attack and stroke: comparison of 2 point-of-care platelet function tests with optical aggregometry
    Paul Harrison
    Oxford Haemophilia Centre and Thrombosis Unit, Churchill Hospital, Oxford, UK
    Stroke 36:1001-5. 2005
    ..However, there are very few data on whether the different tests produce consistent results. We therefore compared 2 POC tests (PFA-100 device and the Ultegra-RPFA [RPFA]) with conventional light transmission aggregometry (LTA)...
  14. ncbi request reprint Circulating reticulated platelets in the early and late phases after ischaemic stroke and transient ischaemic attack
    Dominick J H McCabe
    Stroke Research Group, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, University College London, London, UK
    Br J Haematol 126:861-9. 2004
    ....
  15. ncbi request reprint Platelet degranulation and monocyte-platelet complex formation are increased in the acute and convalescent phases after ischaemic stroke or transient ischaemic attack
    Dominick J H McCabe
    Stroke Research Unit, Department of Headache, Brain Injury and Rehabilitation, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, University College London, London, UK
    Br J Haematol 125:777-87. 2004
    ..This study provides evidence for ongoing excessive platelet and/or endothelial activation in ischaemic CVD patients despite treatment with antithrombotic therapy...
  16. ncbi request reprint Platelet hyper-function in acute coronary syndromes
    Paul Harrison
    Haemostasis Research Unit, Department of Haematology, University College London, UK
    Blood Coagul Fibrinolysis 16:557-62. 2005
    ..05). There is evidence for platelet hyper-function and elevated von Willebrand factor levels in the MI group that could explain their decreased responsiveness to ASA on the collagen/epinephrine cartridge...
  17. doi request reprint Evaluation of the Impact-R for monitoring the platelet storage lesion
    Abdul Majeed Albanyan
    Oxford Haemophilia and Thrombosis Centre, Churchill Hospital, Oxford, UK
    Platelets 20:1-6. 2009
    ..The Impact-R is a simple device to perform rapid test which may be useful for the assessment of platelet function within platelet concentrates...
  18. ncbi request reprint Measuring platelet function?
    Paul Harrison
    Churchill Hospital, Oxford, UK
    Hematol J 5:S164-9. 2004
  19. doi request reprint Evaluation of the INNOVANCE PFA P2Y test cartridge: sensitivity to P2Y(12) blockade and influence of anticoagulant
    Abbie Edwards
    Oxford Haemophilia and Thrombosis Centre, Churchill Hospital, Oxford OX3 7LJ, UK
    Platelets 23:106-15. 2012
    ..The sensitivity of all platelet function tests for detecting in vitro inhibition of P2Y(12) is markedly different depending on the anticoagulant used...
  20. ncbi request reprint Measuring antiplatelet drug effects in the laboratory
    Paul Harrison
    Oxford Haemophilia Centre and Thrombosis Unit, Churchill Hospital, Oxford, United Kingdom
    Thromb Res 120:323-36. 2007
    ..A clinically meaningful definition of "resistance" to antiplatelet drugs needs to be developed, based on data linking drug-dependent laboratory tests to clinical outcomes in patients...
  21. ncbi request reprint GPVI levels in platelets: relationship to platelet function at high shear
    Denise Best
    Department of Pharmacology, Oxford University, Mansfield Rd, Oxford, OX1 3QT, United Kingdom
    Blood 102:2811-8. 2003
    ..These results demonstrate that GPVI levels are tightly controlled and play a critical role in thrombus formation on collagen; nevertheless, a range of receptor densities can support platelet function under high shear...
  22. doi request reprint Measurement of phosphatidylserine exposure during storage of platelet concentrates using the novel probe lactadherin: a comparison study with annexin V
    Abdul Majeed Albanyan
    Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
    Transfusion 49:99-107. 2009
    ..The aim of this study was to compare annexin V and lactadherin labeling of PLTs in PLT concentrates (PCs)...
  23. doi request reprint Markers of platelet activation and apoptosis during storage of apheresis- and buffy coat-derived platelet concentrates for 7 days
    Abdul Majeed Albanyan
    Nuffield Department of Clinical Medicine, University of Oxford, National, Oxford, UK
    Transfusion 49:108-17. 2009
    ..The aim of this study was to compare in vitro variables of PCs produced by apheresis (AP-PC) or the buffy coat (BC-PC) method by applying a number of new and established assays...
  24. ncbi request reprint Platelet counting
    Paul Harrison
    Oxford Haemophila Centre and Thrombosis Unit, Churchill Hospital, Oxford, UK
    Methods Mol Biol 272:29-46. 2004
  25. ncbi request reprint Activation of platelets in whole blood by recombinant factor VIIa by a thrombin-dependent mechanism
    Barry Wilbourn
    Haemostasis Research Unit, Department of Haematology, University College London, 3rd Floor Jules Thorn Building, 48 Riding House Street, London W1W 7EY, UK
    Br J Haematol 122:651-61. 2003
    ..No significant difference was observed between levels of CD62P in diluted whole blood and platelet-rich plasma adjusted to an identical platelet count after their exposure to rFVIIa and calcium for 30 min...
  26. doi request reprint Measurement of circulating cell-derived microparticles by flow cytometry: sources of variability within the assay
    Lisa Ayers
    Department of Clinical Immunology, Churchill Hospital, Oxford, UK
    Thromb Res 127:370-7. 2011
    ..The aim of this study was to establish a reliable flow cytometric assay to measure distinct subtypes of MPs in disease and to identify any significant causes of variability in MP quantification...
  27. ncbi request reprint Lithium plus valproate combination therapy versus monotherapy for relapse prevention in bipolar I disorder (BALANCE): a randomised open-label trial
    John R Geddes
    Oxford Clinical Trials Unit for Mental Illness, Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    Lancet 375:385-95. 2010
    ..We aimed to establish whether lithium plus valproate was better than monotherapy with either drug alone for relapse prevention in bipolar I disorder...
  28. ncbi request reprint Effects of PTPN22 C1858T polymorphism on susceptibility and clinical characteristics of British Caucasian rheumatoid arthritis patients
    P Harrison
    Botnar Research Centre, University of Oxford, Nuffield Orthopaedic Centre, Oxford OX3 7LD, UK
    Rheumatology (Oxford) 45:1009-11. 2006
    ..To confirm the association of a functional single-nucleotide polymorphism (SNP), C1858T (rs2476601), in the PTPN22 gene of British Caucasian rheumatoid arthritis (RA) patients and to evaluate its influence on the RA phenotype...
  29. pmc Atypical antipsychotics in the treatment of schizophrenia: systematic overview and meta-regression analysis
    J Geddes
    Department of Psychiatry University of Oxford, Warneford Hospital, Oxford OX3 7JX
    BMJ 321:1371-6. 2000
    ..To develop an evidence base for recommendations on the use of atypical antipsychotics for patients with schizophrenia...
  30. ncbi request reprint MHC2TA promoter polymorphism (-168*G/A, rs3087456) is not associated with susceptibility to rheumatoid arthritis in British Caucasian rheumatoid arthritis patients
    P Harrison
    University of Oxford Institute of Musculoskeletal Sciences, Botnar Research Centre, Oxford, UK
    Rheumatology (Oxford) 46:409-11. 2007
    ....
  31. doi request reprint Interleukin-1 promoter region polymorphism role in rheumatoid arthritis: a meta-analysis of IL-1B-511A/G variant reveals association with rheumatoid arthritis
    P Harrison
    Botnar Research Centre, Nuffield Orthopaedic Centre, Windmill Road, Oxford OX3 7LD, UK
    Rheumatology (Oxford) 47:1768-70. 2008
    ..This study examined the effects of four common promoter SNPs in the IL-1 region on susceptibility and clinical characteristics of RA in British Caucasian patients and assessed the risk of RA by meta-analysis of published studies...
  32. ncbi request reprint Methods for counting platelets in severe thrombocytopenia
    Helen C Segal
    The Oxford Haemophilia Centre, Thrombosis Unit, The Churchill Hospital, Headington, Oxford, OX3 7LJ, UK
    Curr Hematol Rep 5:70-5. 2006
    ..These changes will improve clinical confidence in the accuracy of a platelet count and thus inform clinical decisions at the current level of prophylactic platelet transfusions...
  33. ncbi request reprint Prospective observational cohort study of the association between thromboelastometry, coagulation and platelet parameters and bleeding in patients with haematological malignancies- The ATHENA study
    Lise J Estcourt
    NHS Blood and Transplant, Oxford, UK Radcliffe Department of Medicine, University of Oxford, Oxford, UK
    Br J Haematol 166:581-91. 2014
    ..In a predictive model, AIPN was superior to TPC for predicting bleeding. This study indicates that AIPN may be more clinically useful than TPC at predicting bleeding. ..
  34. pmc Sizing and phenotyping of cellular vesicles using Nanoparticle Tracking Analysis
    Rebecca A Dragovic
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    Nanomedicine 7:780-8. 2011
    ..By combining NTA with fluorescence measurement we have demonstrated that vesicles can be labeled with specific antibody-conjugated quantum dots, allowing their phenotype to be determined...
  35. pmc Syncytiotrophoblast microvesicles released from pre-eclampsia placentae exhibit increased tissue factor activity
    Chris Gardiner
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Level 3, Women s Centre, John Radcliffe Hospital, Oxford, United Kingdom
    PLoS ONE 6:e26313. 2011
    ..It is caused by the placenta, which sheds increased amounts of syncytiotrophoblast microvesicles (STBM) into the maternal circulation. We hypothesized that STBM could contribute to the haemostatic activation observed in pre-eclampsia...
  36. ncbi request reprint A review of inherited platelet disorders with guidelines for their management on behalf of the UKHCDO
    Paula H B Bolton-Maggs
    Department of Haematology, Manchester Royal Infirmary, Manchester, UK
    Br J Haematol 135:603-33. 2006
    ....
  37. ncbi request reprint In vitro measurement of high-shear platelet adhesion and aggregation by the PFA-100
    Paul Harrison
    Oxford Hamophila Centre and Thrombosis Unit, Churchill Hospital, Oxford, UK
    Methods Mol Biol 272:215-23. 2004
  38. ncbi request reprint The expression of prion protein by endothelial cells: a source of the plasma form of prion protein?
    Richard Starke
    Haemostasis Research Unit, Department of Haematology, University College London, UK
    Br J Haematol 119:863-73. 2002
    ..In conclusion, endothelial cells of both macrovascular and microvascular origin expressed high levels of PrPC which can be constitutively released into the cell culture medium...
  39. ncbi request reprint Continuing developments with the automated platelet count
    C Briggs
    Department of Haematology, University College London Hospitals, London, UK
    Int J Lab Hematol 29:77-91. 2007
    ..In future, analysers may introduce additional platelet parameters; a reliable method to quantify immature or reticulated platelets would be useful...
  40. ncbi request reprint Flow cytometric analysis of reticulated platelets: evidence for a large proportion of non-specific labelling of dense granules by fluorescent dyes
    M S Robinson
    Department of Haematology, University College Hospital, London
    Br J Haematol 100:351-7. 1998
    ..clinical utilization and automation of reticulated platelet assays...
  41. ncbi request reprint Lysis of dysplastic but not normal oral keratinocytes and tissue-engineered epithelia with conditionally replicating adenoviruses
    Kamis Gaballah
    Head and Neck Cancer Unit, King s College London, Guy s, King s and St Thomas Hospitals, London, United Kingdom
    Cancer Res 67:7284-94. 2007
    ..Evidence of infection in clinical dysplastic lesions was also shown ex vivo using tissue explants. We conclude that dl922-947 may provide an efficient molecular cytotoxic to dissolve oral dysplastic lesions...
  42. ncbi request reprint Comparison of glycocalicin, thrombopoietin and reticulated platelet measurement as markers of platelet turnover in HIV+ samples
    M Robinson
    Department of Haematology, University College London, UK
    Platelets 12:108-13. 2001
    ..4, p = 0.002) in HIV+ subjects. The reticulated platelet, TPO and GCI data suggests that thrombocytopenic HIV+ subjects have normal platelet production, and increased peripheral platelet destruction...
  43. ncbi request reprint A highly unusual cluster of acute promyelocytic leukaemia: an environmental aetiology?
    R J A Murrin
    Department of Haematology, Russells Hall Hospital, Dudley, West Midlands, UK
    Clin Lab Haematol 27:71-3. 2005
    ..Our data strongly suggests that environmental agents may play a greater role in the aetiology of APML than is commonly perceived...
  44. ncbi request reprint In vivo biotinylation studies: specificity of labelling of reticulated platelets by thiazole orange and mepacrine
    M Robinson
    Department of Haematology, University College Hospital, London, UK
    Br J Haematol 108:859-64. 2000
    ..The comparative life spans and thrombin sensitivity of TO (high) and mepacrine-positive platelets suggest that TO (high) labels platelet dense granules. These data also suggest that dense granules are lost during platelet ageing...
  45. ncbi request reprint The expression of prion protein (PrP(C)) in the megakaryocyte lineage
    R Starke
    Department of Haematology, University College London, London, UK
    J Thromb Haemost 3:1266-73. 2005
    ..The majority of cellular borne PrP(C) is associated with platelets (84%). Although PrP(C) mRNA has been demonstrated in platelets, the quantity is unknown and may not reflect the total PrP(C) present...
  46. ncbi request reprint Prion protein in patients with renal failure
    R Starke
    Department of Haematology, University College London, London, UK
    Transfus Med 16:165-8. 2006
    ..The mechanism of elevated plasma PrP(C) levels in renal disease is unknown, but this shows that plasma PrP(C) is not a specific marker of neurological disease or Creutzfeldt-Jakob disease...
  47. ncbi request reprint Assessment of the antiplatelet effects of low to medium dose aspirin in the early and late phases after ischaemic stroke and TIA
    Dominick J H McCabe
    The Haemostasis Research Unit, Department of Haematology
    Platelets 16:269-80. 2005
    ..The results suggest that cyclooxygenase-independent mechanisms, including elevated von Willebrand factor antigen levels, play an important role in mediating aspirin non-responsiveness on the PFA-100...
  48. ncbi request reprint Measurement of the antiplatelet effects of aspirin in cerebrovascular disease
    Dominick J H McCabe
    Stroke 35:e146-7; author reply e146-7. 2004
  49. ncbi request reprint Hierarchy of stroma-derived factors in supporting growth of stroma-dependent hemopoietic cells: membrane-bound SCF is sufficient to confer stroma competence to epithelial cells
    Jutta Friel
    Heinrich Pette Institut for Experimental Virology and Immunology, Hamburg University, Germany
    Growth Factors 20:35-51. 2002
    ..In our model system, membrane-bound SCF expression is sufficient to confer stroma properties to an epithelial cell line but soluble SCF does not...
  50. ncbi request reprint Platelet activation can occur by shear stress alone in the PFA-100 platelet analyser
    Scott Dunkley
    Department of Haematology, Prince of Wales Hospital, Level 4 Campus Centre, Barker St, Randwick, 2031, Sydney, Australia
    Platelets 16:81-4. 2005
    ..There was no significant change in surface CD62P nor PAC-1 expression. A degree of platelet activation occurs in the PFA-100 due to shear stress alone...
  51. ncbi request reprint Current methods of assessing platelet function: relevance to transfusion medicine
    Rebecca Cardigan
    National Blood Service, Cambridge, UK
    Vox Sang 88:153-63. 2005
  52. ncbi request reprint Platelet function (measured by Platelet Function Analyser--100) and obstructive sleep apnoea
    Sophie West
    J Sleep Res 14:325-7. 2005