P J Harrison

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint Preferential involvement of excitatory neurons in medial temporal lobe in schizophrenia
    P J Harrison
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Lancet 352:1669-73. 1998
  2. ncbi request reprint Amyloid precursor protein mRNAs in Alzheimer's disease
    P J Harrison
    Department of Psychiatry, University of Oxford
    Neurodegeneration 5:409-15. 1996
  3. ncbi request reprint Schizophrenia: a disorder of neurodevelopment?
    P J Harrison
    Department of Psychiatry, Warneford Hospital, University of Oxford, OX3 7JX, UK
    Curr Opin Neurobiol 7:285-9. 1997
  4. ncbi request reprint Gene expression and neuronal activity in schizophrenia: a study of polyadenylated mRNA in the hippocampal formation and cerebral cortex
    P J Harrison
    Department of Psychiatry, Warneford Hospital, University of Oxford, UK
    Schizophr Res 26:93-102. 1997
  5. ncbi request reprint The neuropathology of schizophrenia. A critical review of the data and their interpretation
    P J Harrison
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Brain 122:593-624. 1999
  6. ncbi request reprint Decreased expression of vesicular glutamate transporter 1 and complexin II mRNAs in schizophrenia: further evidence for a synaptic pathology affecting glutamate neurons
    S L Eastwood
    Department of Psychiatry, University of Oxford, Warneford Hospital, Neurosciences Building, Oxford OX3 7JX, UK
    Schizophr Res 73:159-72. 2005
  7. pmc Modulation of hippocampal dopamine metabolism and hippocampal-dependent cognitive function by catechol-O-methyltransferase inhibition
    L M Laatikainen
    Department of Psychiatry, University of Oxford, Oxford, UK
    J Psychopharmacol 26:1561-8. 2012
  8. ncbi request reprint Expression of serotonin 5-HT(2A) receptors in the human cerebellum and alterations in schizophrenia
    S L Eastwood
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Synapse 42:104-14. 2001
  9. ncbi request reprint Expression of 5-HT receptors and the 5-HT transporter in rat brain after electroconvulsive shock
    P W Burnet
    Department of Psychiatry, University of Oxford, Warneford Hospital, UK
    Neurosci Lett 277:79-82. 1999
  10. doi request reprint Expression of D-serine and glycine transporters in the prefrontal cortex and cerebellum in schizophrenia
    P W J Burnet
    Department of Psychiatry, University of Oxford, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, United Kingdom
    Schizophr Res 102:283-94. 2008

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Preferential involvement of excitatory neurons in medial temporal lobe in schizophrenia
    P J Harrison
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Lancet 352:1669-73. 1998
    ..These findings suggest that the complexins might be useful in the investigation of the synaptic pathology of schizophrenia...
  2. ncbi request reprint Amyloid precursor protein mRNAs in Alzheimer's disease
    P J Harrison
    Department of Psychiatry, University of Oxford
    Neurodegeneration 5:409-15. 1996
    ..Here we review the distribution and abundance of amyloid precursor protein mRNAs in normal and AD-afflicted brains. The expression of apolipoprotein E and presenilin mRNAs are also discussed...
  3. ncbi request reprint Schizophrenia: a disorder of neurodevelopment?
    P J Harrison
    Department of Psychiatry, Warneford Hospital, University of Oxford, OX3 7JX, UK
    Curr Opin Neurobiol 7:285-9. 1997
    ..The neurodevelopmental view of schizophrenia is supported by neuropathological, epidemiological and clinical findings. Here, the evidence in favour of the model is summarized, together with a consideration of its weaknesses...
  4. ncbi request reprint Gene expression and neuronal activity in schizophrenia: a study of polyadenylated mRNA in the hippocampal formation and cerebral cortex
    P J Harrison
    Department of Psychiatry, Warneford Hospital, University of Oxford, UK
    Schizophr Res 26:93-102. 1997
    ..It also provides a further indication that the differential expression of individual transcripts reported in the disease is not merely reflecting changes in overall gene expression...
  5. ncbi request reprint The neuropathology of schizophrenia. A critical review of the data and their interpretation
    P J Harrison
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Brain 122:593-624. 1999
    ....
  6. ncbi request reprint Decreased expression of vesicular glutamate transporter 1 and complexin II mRNAs in schizophrenia: further evidence for a synaptic pathology affecting glutamate neurons
    S L Eastwood
    Department of Psychiatry, University of Oxford, Warneford Hospital, Neurosciences Building, Oxford OX3 7JX, UK
    Schizophr Res 73:159-72. 2005
    ..The impairment of synaptic transmission implied by the synaptic protein reductions may contribute to the dysfunction of cortical neural circuits that characterises the disorder...
  7. pmc Modulation of hippocampal dopamine metabolism and hippocampal-dependent cognitive function by catechol-O-methyltransferase inhibition
    L M Laatikainen
    Department of Psychiatry, University of Oxford, Oxford, UK
    J Psychopharmacol 26:1561-8. 2012
    ..These findings support the therapeutic candidacy of COMT inhibition as a cognitive enhancer, and suggest that, in addition to the prefrontal cortex, the hippocampus might be a key region for mediating these effects...
  8. ncbi request reprint Expression of serotonin 5-HT(2A) receptors in the human cerebellum and alterations in schizophrenia
    S L Eastwood
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Synapse 42:104-14. 2001
    ..Measurement of multiple parameters is necessary to give a clear picture of the normal situation and to show the profile of alterations in a disease...
  9. ncbi request reprint Expression of 5-HT receptors and the 5-HT transporter in rat brain after electroconvulsive shock
    P W Burnet
    Department of Psychiatry, University of Oxford, Warneford Hospital, UK
    Neurosci Lett 277:79-82. 1999
    ..The other mRNAs were unchanged. The results show that ECS has subtype specific, anatomically discrete, and temporally selective effects on 5-HT receptor expression...
  10. doi request reprint Expression of D-serine and glycine transporters in the prefrontal cortex and cerebellum in schizophrenia
    P W J Burnet
    Department of Psychiatry, University of Oxford, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, United Kingdom
    Schizophr Res 102:283-94. 2008
    ..However, this interpretation remains speculative. Further investigations will be valuable in the evaluation of these transporters as potential therapeutic targets in psychosis...
  11. ncbi request reprint Cerebellar synaptic protein expression in schizophrenia
    S L Eastwood
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Neuroscience 105:219-29. 2001
    ..We conclude that there is synaptic pathology in the cerebellum in schizophrenia. By disrupting neural circuits, the alterations may contribute to the cerebellar dysfunction thought to occur in the disorder...
  12. ncbi request reprint Interstitial white matter neurons express less reelin and are abnormally distributed in schizophrenia: towards an integration of molecular and morphologic aspects of the neurodevelopmental hypothesis
    S L Eastwood
    Department of Psychiatry, University of Oxford, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK
    Mol Psychiatry 8:769, 821-31. 2003
    ..The alterations may contribute to the aberrant synaptic connectivity seen in schizophrenia. However, the functional implications of the abnormalities, as well as the mechanisms involved, remain to be fully elucidated...
  13. ncbi request reprint Synaptic pathology in the anterior cingulate cortex in schizophrenia and mood disorders. A review and a Western blot study of synaptophysin, GAP-43 and the complexins
    S L Eastwood
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Brain Res Bull 55:569-78. 2001
    ..The reductions may be progressive...
  14. ncbi request reprint Catechol-o-methyltransferase enzyme activity and protein expression in human prefrontal cortex across the postnatal lifespan
    E M Tunbridge
    Department of Psychiatry, University of Oxford, Oxford OX3 7JX, UK
    Cereb Cortex 17:1206-12. 2007
    ....
  15. ncbi request reprint The axonal chemorepellant semaphorin 3A is increased in the cerebellum in schizophrenia and may contribute to its synaptic pathology
    S L Eastwood
    Departments of Psychiatry and Clinical Neurology, Warneford Hospital, University of Oxford, Oxford OX3 7JX, UK
    Mol Psychiatry 8:148-55. 2003
    ....
  16. ncbi request reprint Expression of complexin I and II mRNAs and their regulation by antipsychotic drugs in the rat forebrain
    S L Eastwood
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Synapse 36:167-77. 2000
    ..In summary, the data have implications both for understanding the effects of antipsychotic medication on synaptic organization, and for synaptic protein expression studies in patients treated with the drugs...
  17. ncbi request reprint RNA editing of the 5-HT(2C) receptor is reduced in schizophrenia
    M S Sodhi
    University Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK
    Mol Psychiatry 6:373-9. 2001
    ..The results also illustrate that potentially important receptor alterations may occur in schizophrenia which are not detectable merely in terms of receptor abundance...
  18. ncbi request reprint Interstitial white matter neuron density in the dorsolateral prefrontal cortex and parahippocampal gyrus in schizophrenia
    S L Eastwood
    University of Oxford, Department of Psychiatry, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK
    Schizophr Res 79:181-8. 2005
    ..As interstitial white matter neurons are presumed to be remnants of the embryonic cortical subplate, these findings provide additional evidence supportive of an early developmental abnormality in schizophrenia...
  19. ncbi request reprint Distribution of kainate receptor subunit mRNAs in human hippocampus, neocortex and cerebellum, and bilateral reduction of hippocampal GluR6 and KA2 transcripts in schizophrenia
    R H Porter
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Brain Res 751:217-31. 1997
    ..These deficits are likely to contribute to the glutamatergic component of the disease pathophysiology...
  20. ncbi request reprint Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence
    P J Harrison
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    Mol Psychiatry 10:40-68; image 5. 2005
    ..Characterization of a core molecular pathway and a 'genetic cytoarchitecture' would be a profound advance in understanding schizophrenia, and may have equally significant therapeutic implications...
  21. ncbi request reprint Allelic variation of the 5-HT2C receptor (HTR2C) in bulimia nervosa and binge eating disorder
    P W Burnet
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Psychiatr Genet 9:101-4. 1999
    ..We conclude that allelic variation does not account for the involvement of the 5-HT2C receptor in these eating disorders...
  22. ncbi request reprint Neuregulin-1 (NRG-1) mRNA and protein in the adult human brain
    A J Law
    Neurosciences Building, Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK
    Neuroscience 127:125-36. 2004
    ..Using these normative data, future studies can ascertain whether the role of NRG-1 in the disease is mediated, or accompanied, via alterations in its expression...
  23. ncbi request reprint The met(158) allele of catechol-O-methyltransferase (COMT) is associated with obsessive-compulsive disorder in men: case-control study and meta-analysis
    E C Pooley
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    Mol Psychiatry 12:556-61. 2007
    ..The finding also extends the evidence for sexual dimorphism in COMT and in OCD...
  24. ncbi request reprint Hippocampal and cortical growth-associated protein-43 messenger RNA in schizophrenia
    S L Eastwood
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Neuroscience 86:437-48. 1998
    ..The data support the emerging view that the disease pathophysiology is one which affects the hippocampal and cortical circuitry and that the abnormalities are reflected in the altered expression of specific neuronal genes...
  25. ncbi request reprint An RT-PCR study of 5-HT(6) and 5-HT(7) receptor mRNAs in the hippocampal formation and prefrontal cortex in schizophrenia
    S Z East
    Department of Psychiatry, University of Oxford, Neurosciences Building, Warneford Hospital, Warneford Lane, OX3 7JX Oxford, UK
    Schizophr Res 57:15-26. 2002
    ....
  26. ncbi request reprint The neuropathological effects of antipsychotic drugs
    P J Harrison
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Schizophr Res 40:87-99. 1999
    ..There is no good evidence that antipsychotics cause neuronal loss or gliosis, nor that they promote neurofibrillary tangle formation or other features of Alzheimer's disease...
  27. ncbi request reprint Neuropathological studies of synaptic connectivity in the hippocampal formation in schizophrenia
    P J Harrison
    Department of Psychiatry, University of Oxford, UK
    Hippocampus 11:508-19. 2001
    ..The data, their interpretation, and their limitations are discussed, with particular emphasis upon molecular and immunological studies of synaptic protein gene expression...
  28. ncbi request reprint Electroconvulsive shock increases tachykinin NK(1) receptors, but not the encoding mRNA, in rat cortex
    P W Burnet
    University Department of Psychiatry, Warneford Hospital, Neuroscience Building, Headington, Oxford OX3 7JX, UK
    Eur J Pharmacol 413:213-9. 2001
    ..Upregulation of receptor-binding sites without a change in mRNA indicates that translational or post-translational mechanisms underlie this process...
  29. pmc The neurobiology of D-amino acid oxidase and its involvement in schizophrenia
    L Verrall
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom
    Mol Psychiatry 15:122-37. 2010
    ..itself: how should we weigh up convergent and cumulatively impressive, but individually inconclusive, pieces of evidence regarding the role that a given gene may have in the aetiology, pathophysiology and pharmacotherapy of schizophrenia?..
  30. pmc Human brain weight is correlated with expression of the 'housekeeping genes' beta-2-microglobulin (β2M) and TATA-binding protein (TBP)
    P J Harrison
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    Neuropathol Appl Neurobiol 36:498-504. 2010
    ..Many variables affect mRNA measurements in post mortem human brain tissue. Brain weight has not hitherto been considered to be such a factor. This study examined whether there is any relationship between brain weight and mRNA abundance...
  31. ncbi request reprint AMPA glutamate receptors and their flip and flop mRNAs in human hippocampus
    S L Eastwood
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Neuroreport 5:1325-8. 1994
    ....
  32. ncbi request reprint A postmortem study of the mediodorsal nucleus of the thalamus in schizophrenia
    T J Cullen
    Department of Clinical Neurology Neuropathology, University of Oxford, Radcliffe Infirmary, OX2 6HE, Oxford, UK
    Schizophr Res 60:157-66. 2003
    ..Hence our negative observations, in the largest sample yet investigated, cast doubt on the robustness and/or the generalisability of MD neuropathology in schizophrenia...
  33. ncbi request reprint Deliberate self-harm is associated with allelic variation in the tryptophan hydroxylase gene (TPH A779C), but not with polymorphisms in five other serotonergic genes
    E C Pooley
    University Department of Psychiatry and Centre for Suicide Research, Warneford Hospital, University of Oxford
    Psychol Med 33:775-83. 2003
    ..In particular, several studies have reported an association with variants in the tryptophan hydroxylase (TPH) gene...
  34. doi request reprint The group II metabotropic glutamate receptor 3 (mGluR3, mGlu3, GRM3): expression, function and involvement in schizophrenia
    P J Harrison
    Department of Psychiatry, University of Oxford, Neurosciences Building, Warneford Hospital, Oxford, UK
    J Psychopharmacol 22:308-22. 2008
    ..Together these data implicate mGluR3 in aetiological, pathophysiological and pharmacotherapeutic aspects of the disorder...
  35. ncbi request reprint Catechol-o-methyltransferase inhibition improves set-shifting performance and elevates stimulated dopamine release in the rat prefrontal cortex
    E M Tunbridge
    Department of Psychiatry, University of Oxford, Oxford, United Kingdom, OX3 7JX
    J Neurosci 24:5331-5. 2004
    ..The interaction between clozapine and tolcapone may have implications for the treatment of schizophrenia...
  36. ncbi request reprint The role of catechol-O-methyltransferase in reward processing and addiction
    E M Tunbridge
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    CNS Neurol Disord Drug Targets 11:306-23. 2012
    ..In particular, it will be critical to reveal the precise neurobiological mechanisms underlying links between COMT and reward processing, and the extent to which these relate to the putative associations with addiction...
  37. ncbi request reprint A novel protein isoform of catechol O-methyltransferase (COMT): brain expression analysis in schizophrenia and bipolar disorder and effect of Val158Met genotype
    E M Tunbridge
    Mol Psychiatry 11:116-7. 2006
  38. ncbi request reprint Six degrees of separation: on the prior probability that schizophrenia susceptibility genes converge on synapses, glutamate and NMDA receptors
    P J Harrison
    Mol Psychiatry 11:981-3. 2006
  39. ncbi request reprint Bromocriptine use is associated with decreased smoking rates
    M F G Murphy
    University of Oxford, ICRF General Practice Research Group, Institute of Health Sciences, Oxford, UK
    Addict Biol 7:325-8. 2002
    ..0001). This observation supports the role of dopamine in nicotine addiction, and suggests that bromocriptine-like drugs could be used effectively by pregnant women to aid cessation...
  40. ncbi request reprint Schizophrenia and the frontal lobes: post-mortem stereological study of tissue volume
    J R Highley
    Schizophrenia Research Group, Department of Clinical Neurology (Neuropathology, Radcliffe Infirmary, Oxford OX3 7JX, UK
    Br J Psychiatry 178:337-43. 2001
    ..CONCLUSIONS: Such structural abnormalities as are present in the frontal lobes are more subtle than straightforward alterations in tissue volume; they may include changes in shape and the pattern of gyral folding...
  41. ncbi request reprint A CUB-serine protease in the olfactory organ of the spiny lobster Panulirus argus
    M Z Levine
    Department of Biology and Center for Behavioral Neuroscience, Georgia State University, Atlanta, Georgia 30303, USA
    J Neurobiol 49:277-302. 2001
    ..Possible functions in the olfactory organ and eyestalk are discussed. To our knowledge, this is the first report from any olfactory system of a gene encoding a protein with serine protease and CUB domains...
  42. pmc D-amino acid oxidase activity and expression are increased in schizophrenia
    P W J Burnet
    Mol Psychiatry 13:658-60. 2008
  43. ncbi request reprint In vitro evidence that 5-hydroxytryptamine increases efflux of glial glutamate via 5-HT(2A) receptor activation
    R Meller
    University Department of Clinical Pharmacology, Radcliffe Infirmary, Oxford, United Kingdom
    J Neurosci Res 67:399-405. 2002
    ..In conclusion, 5-HT stimulates the efflux of glutamate from C6 glioma cells following 5-HT(2A) receptor activation and involves a calcium-dependent mechanism...
  44. pmc Differential control of the scapulothoracic muscles in humans
    C Alexander
    Department of Physiotherapy, Hammersmith Hospital NHS Trust, Fulham Palace Rd, London W6 8RF, UK
    J Physiol 580:777-86. 2007
    ..The study demonstrates a contrasting bilateral control of Tr and SA. These patterns of connections are discussed in relation to the contrasting bilateral functional roles of these muscles...
  45. ncbi request reprint Allelic variation in the 5-HT2C receptor (HT2RC) and the increase in slow wave sleep produced by olanzapine
    A L Sharpley
    Psychopharmacology (Berl) 153:271-2. 2001