Christine J Harrison

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. ncbi request reprint Cytogenetics of multiple myeloma: interpretation of fluorescence in situ hybridization results
    Christine J Harrison
    Department of Haematology, Royal Free Medical School, London
    Br J Haematol 120:944-52. 2003
  2. ncbi request reprint t(14;19)(q32;q13): a recurrent translocation in B-cell precursor acute lymphoblastic leukemia
    Hazel M Robinson
    Leukaemia Research Fund Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton, UK
    Genes Chromosomes Cancer 39:88-92. 2004
  3. ncbi request reprint A diminutive chromosome 21 centromere in acute lymphoblastic leukemia
    Kathryn A Roberts
    LRF Cytogenetics Group, Cancer Sciences Division, University of Southampton, MP 822, Duthie Building, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK
    Cancer Genet Cytogenet 167:78-81. 2006
  4. pmc Complex genomic alterations and gene expression in acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21
    Jon C Strefford
    Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton SO16 6YD, United Kingdom
    Proc Natl Acad Sci U S A 103:8167-72. 2006
  5. ncbi request reprint Prognosis of children with acute lymphoblastic leukemia (ALL) and intrachromosomal amplification of chromosome 21 (iAMP21)
    Anthony V Moorman
    Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, United Kingdom
    Blood 109:2327-30. 2007
  6. ncbi request reprint Translocations of 14q32 and deletions of 13q14 are common chromosomal abnormalities in systemic amyloidosis
    Christine J Harrison
    Department of Haematology, Royal Free and University College Medical School, London, UK
    Br J Haematol 117:427-35. 2002
  7. ncbi request reprint Interphase molecular cytogenetic screening for chromosomal abnormalities of prognostic significance in childhood acute lymphoblastic leukaemia: a UK Cancer Cytogenetics Group Study
    Christine J Harrison
    Leukaemia Research Fund Cytogenetics Group, Cancer Sciences Division, University of Southampton, General Hospital, Southampton SO16 6YD, UK
    Br J Haematol 129:520-30. 2005
  8. ncbi request reprint Detection of genomic aberrations in older patients with acute myeloid leukemia
    Christine J Harrison
    Leukaemia Research Fund Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton General Hospital, Southampton, UK
    Haematologica 90:147. 2005
  9. ncbi request reprint A multicenter evaluation of comprehensive analysis of MLL translocations and fusion gene partners in acute leukemia using the MLL FusionChip device
    Christine J Harrison
    Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, MP 822 Duthie Building, Southampton General Hospital, Southampton SO16 6YD, UK
    Cancer Genet Cytogenet 173:17-22. 2007
  10. ncbi request reprint Three distinct subgroups of hypodiploidy in acute lymphoblastic leukaemia
    Christine J Harrison
    Leukaemia Research Fund Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton, UK
    Br J Haematol 125:552-9. 2004

Detail Information

Publications56

  1. ncbi request reprint Cytogenetics of multiple myeloma: interpretation of fluorescence in situ hybridization results
    Christine J Harrison
    Department of Haematology, Royal Free Medical School, London
    Br J Haematol 120:944-52. 2003
    ..Therefore, extreme caution is required in the interpretation of interphase FISH results in MM, particularly in relation to certain abnormalities, such as 13q14 deletions, which have an impact on prognosis...
  2. ncbi request reprint t(14;19)(q32;q13): a recurrent translocation in B-cell precursor acute lymphoblastic leukemia
    Hazel M Robinson
    Leukaemia Research Fund Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton, UK
    Genes Chromosomes Cancer 39:88-92. 2004
    ..This newly described translocation constitutes a distinct cytogenetic subgroup that is confined to older children and younger adults with B-cell precursor acute lymphoblastic leukemia...
  3. ncbi request reprint A diminutive chromosome 21 centromere in acute lymphoblastic leukemia
    Kathryn A Roberts
    LRF Cytogenetics Group, Cancer Sciences Division, University of Southampton, MP 822, Duthie Building, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK
    Cancer Genet Cytogenet 167:78-81. 2006
    ..The question arises, is there an association between the diminutive centromeric signals for chromosome 21 and the chromosomal instability demonstrated by the deletions of key genes from the leukemic blasts of these two patients?..
  4. pmc Complex genomic alterations and gene expression in acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21
    Jon C Strefford
    Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton SO16 6YD, United Kingdom
    Proc Natl Acad Sci U S A 103:8167-72. 2006
    ....
  5. ncbi request reprint Prognosis of children with acute lymphoblastic leukemia (ALL) and intrachromosomal amplification of chromosome 21 (iAMP21)
    Anthony V Moorman
    Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, United Kingdom
    Blood 109:2327-30. 2007
    ....
  6. ncbi request reprint Translocations of 14q32 and deletions of 13q14 are common chromosomal abnormalities in systemic amyloidosis
    Christine J Harrison
    Department of Haematology, Royal Free and University College Medical School, London, UK
    Br J Haematol 117:427-35. 2002
    ..Ten patients (27% overall and 33% of those with systemic disease) showed del(13q). The gain or loss of IGH and CCND1 signals provided evidence of numerical chromosomal changes in three patients...
  7. ncbi request reprint Interphase molecular cytogenetic screening for chromosomal abnormalities of prognostic significance in childhood acute lymphoblastic leukaemia: a UK Cancer Cytogenetics Group Study
    Christine J Harrison
    Leukaemia Research Fund Cytogenetics Group, Cancer Sciences Division, University of Southampton, General Hospital, Southampton SO16 6YD, UK
    Br J Haematol 129:520-30. 2005
    ..This study highlights the importance of iFISH as a complementary tool to cytogenetics in routine screening for significant chromosomal abnormalities in ALL...
  8. ncbi request reprint Detection of genomic aberrations in older patients with acute myeloid leukemia
    Christine J Harrison
    Leukaemia Research Fund Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton General Hospital, Southampton, UK
    Haematologica 90:147. 2005
  9. ncbi request reprint A multicenter evaluation of comprehensive analysis of MLL translocations and fusion gene partners in acute leukemia using the MLL FusionChip device
    Christine J Harrison
    Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, MP 822 Duthie Building, Southampton General Hospital, Southampton SO16 6YD, UK
    Cancer Genet Cytogenet 173:17-22. 2007
    ..The type of molecular information provided by MLL FusionChip gave an indication of the appropriate primers to design for disease monitoring of MLL patients following treatment...
  10. ncbi request reprint Three distinct subgroups of hypodiploidy in acute lymphoblastic leukaemia
    Christine J Harrison
    Leukaemia Research Fund Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton, UK
    Br J Haematol 125:552-9. 2004
    ..Thus cytogenetics, or at least a clear definition of the modal chromosome number, is essential at diagnosis in order to stratify patients with hypodiploidy into the appropriate risk group for treatment...
  11. ncbi request reprint Cytogenetics and molecular genetics of acute lymphoblastic leukemia
    Christine J Harrison
    Leukaemia Research Fund Cytogenetics Group, Cancer Sciences Division, Southampton General Hospital, Southampton, UK
    Rev Clin Exp Hematol 6:91-113; discussion 200-2. 2002
    ..In the search for new measures of prognosis, it has recently emerged that the level of minimal residual disease following induction therapy can be a reliable predictor of outcome in ALL...
  12. pmc Variable breakpoints target PAX5 in patients with dicentric chromosomes: a model for the basis of unbalanced translocations in cancer
    Qian An
    Cancer Genomics and Leukaemia Research Cytogenetics Groups, Cancer Sciences Division, University of Southampton, Southampton, SO16 6YD, United Kingdom
    Proc Natl Acad Sci U S A 105:17050-4. 2008
    ..It can be extrapolated that this strategy will reveal that the same mechanisms operate in cancer pathogenesis in general...
  13. pmc Heterogeneous breakpoints in patients with acute lymphoblastic leukemia and the dic(9;20)(p11-13;q11) show recurrent involvement of genes at 20q11.21
    Qian An
    Cancer Sciences Division, University of Southampton, Southampton, UK
    Haematologica 94:1164-9. 2009
    ..This study provides insight into the breakpoint complexity underlying dicentric chromosomal formation in acute lymphoblastic leukemia and highlights putative target gene loci...
  14. doi request reprint The complex genomic profile of ETV6-RUNX1 positive acute lymphoblastic leukemia highlights a recurrent deletion of TBL1XR1
    Helen Parker
    Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton, UK
    Genes Chromosomes Cancer 47:1118-25. 2008
    ..The target of the interaction between TBL1XR1 and the signaling pathways described here may be exploited in cancer therapy...
  15. doi request reprint Frequent upregulation of MYC in plasma cell leukemia
    Laura Chiecchio
    Leukaemia Research Fund UK Myeloma Forum Cytogenetics Group, Human Genetics Division, University of Southampton, Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, Wilts, UK
    Genes Chromosomes Cancer 48:624-36. 2009
    ..We conclude that MYC dysregulation by complex mechanisms is one of the major molecular events in the oncogenesis of PCL...
  16. pmc Genes commonly deleted in childhood B-cell precursor acute lymphoblastic leukemia: association with cytogenetics and clinical features
    Claire J Schwab
    Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
    Haematologica 98:1081-8. 2013
    ....
  17. pmc Timing of acquisition of deletion 13 in plasma cell dyscrasias is dependent on genetic context
    Laura Chiecchio
    Leukaemia Research Fund UK Myeloma Forum Cytogenetics Group, Human Genetics Division, University of Southampton, Wessex Regional Genetics Laboratory, Salisbury District Hospital, Wilts, UK
    Haematologica 94:1708-13. 2009
    ..We investigated these aspects in a large series of patients...
  18. ncbi request reprint MLL translocations with concurrent 3' deletions: interpretation of FISH results
    Kerry E Barber
    Leukaemia Research Fund Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton, United Kingdom
    Genes Chromosomes Cancer 41:266-71. 2004
    ....
  19. ncbi request reprint Molecular cytogenetic characterization of TCF3 (E2A)/19p13.3 rearrangements in B-cell precursor acute lymphoblastic leukemia
    Kerry E Barber
    Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton, UK
    Genes Chromosomes Cancer 46:478-86. 2007
    ..In addition to its role as a fusion partner gene, we propose that TCF3 can also act as a tumor suppressor gene in BCP-ALL...
  20. ncbi request reprint Cytogenetics of childhood acute myeloid leukemia: United Kingdom Medical Research Council Treatment trials AML 10 and 12
    Christine J Harrison
    Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Queen Victoria Road, Newcastle upon Tyne, UK
    J Clin Oncol 28:2674-81. 2010
    ..Because AML is rare in children, the true prognostic significance of individual chromosomal abnormalities in this age group remains unclear...
  21. ncbi request reprint ETV6/RUNX1 fusion at diagnosis and relapse: some prognostic indications
    Mary Martineau
    LRF Cytogenetics Group, Cancer Sciences Division, University of Southampton, United Kingdom
    Genes Chromosomes Cancer 43:54-71. 2005
    ..In comparing our data with previously reported cases, a picture is beginning to emerge of certain diagnostic features, which may provide circumstantial evidence of an increased risk of relapse...
  22. doi request reprint Acute lymphoblastic leukaemia
    Claire Schwab
    Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle, UK
    Methods Mol Biol 730:99-117. 2011
    ..The chapter also includes an overview of the abnormalities that are expected to be found in this disease and how the results from both cytogenetics and FISH should be interpreted...
  23. ncbi request reprint Methylation of tumour suppressor gene promoters in the presence and absence of transcriptional silencing in high hyperdiploid acute lymphoblastic leukaemia
    Kajsa Paulsson
    Cancer Research UK Medical Oncology Centre, Barts and the London School of Medicine, Queen Mary College, London, UK
    Br J Haematol 144:838-47. 2009
    ..Taken together, our findings suggest that aberrant methylation of tumour suppressor gene promoters is a common phenomenon in high hyperdiploid ALL...
  24. ncbi request reprint Cytogenetics of long-term survivors of ETV6-RUNX1 fusion positive acute lymphoblastic leukemia
    Zoe J Konn
    Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton, UK
    Genes Chromosomes Cancer 49:253-9. 2010
    ..It appears that the two groups have some distinguishing cytogenetic features at the time of diagnosis, which may provide pointers to relapse that are worthy of more detailed study...
  25. doi request reprint Cytogenetic and genomic characterization of cell line ARH77
    Helen Parker
    Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, MP822 Duthie Building, Southampton General Hospital, Southampton SO16 6YD, UK
    Cancer Genet Cytogenet 181:40-5. 2008
    ..Novel submicroscopic CNAs ( approximately 0.4 Mb) were detected by the highest resolution platform only, whereas the clones from the BAC arrays provided locus-specific FISH probes for confirmation of CNA...
  26. ncbi request reprint Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial
    Anthony V Moorman
    Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton General Hospital, Southampton, UK
    Blood 109:3189-97. 2007
    ....
  27. ncbi request reprint Complex chromosomal abnormalities in utero, 5 years before leukaemia
    Zoe J Broadfield
    Leukaemia Research Fund Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton, UK
    Br J Haematol 126:307-12. 2004
    ..There was a prolonged preleukaemic phase, which lasted well into childhood. The short time between the two diagnoses of ALL suggests a common precipitating event. The significance of the different secondary markers remains unclear...
  28. pmc The t(14;20) is a poor prognostic factor in myeloma but is associated with long-term stable disease in monoclonal gammopathies of undetermined significance
    Fiona M Ross
    LRF UKMF Cytogenetic Database, University of Southampton, Wessex Regional Genetics Laboratory, Salisbury, Wilts, UK
    Haematologica 95:1221-5. 2010
    ..None of the associated genetic abnormalities helped to predict for progression from MGUS or smoldering myeloma...
  29. ncbi request reprint Outcome heterogeneity in childhood high-hyperdiploid acute lymphoblastic leukemia
    Anthony V Moorman
    Leukaemia Research Fund Cytogenetics Group, Cancer Sciences Division, University of Southampton, MP 822, Duthie Bldg, Southampton General Hospital, Southampton, SO16 6YD, United Kingdom
    Blood 102:2756-62. 2003
    ..0001). These findings confirm that the outcome of children with HeH is heterogeneous and that specific trisomies can identify patients with the greatest and least risk of treatment failure...
  30. doi request reprint Analysis of a breakpoint cluster reveals insight into the mechanism of intrachromosomal amplification in a lymphoid malignancy
    Paul B Sinclair
    Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Hum Mol Genet 20:2591-602. 2011
    ..These findings provide insight into potential mechanisms involved in the formation of iAMP21...
  31. pmc Loss of 1p and rearrangement of MYC are associated with progression of smouldering myeloma to myeloma: sequential analysis of a single case
    Laura Chiecchio
    Leukaemia Research Fund UK Myeloma Forum Cytogenetics Group, Human Genetics Division, University of Southampton, Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, Wilts, UK
    Haematologica 94:1024-8. 2009
    ..This case report provides a unique insight into the mechanisms of disease progression from smouldering multiple myeloma to multiple myeloma...
  32. doi request reprint Demographic, clinical, and outcome features of children with acute lymphoblastic leukemia and CRLF2 deregulation: results from the MRC ALL97 clinical trial
    Hannah M Ensor
    Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
    Blood 117:2129-36. 2011
    ..69 [1.15-6.31], P = .023; OS 2.86 [1.15-6.79], P = .021). Therefore, we concluded that patients with CRLF2-d should be classified into the intermediate cytogenetic risk group...
  33. ncbi request reprint Is trisomy 5 a distinct cytogenetic subgroup in acute lymphoblastic leukemia?
    Rachel L Harris
    Cancer Sciences Division, University of Southampton, MP 822, Duthie Building, Southampton General Hospital, SO16 6YD Southampton, UK
    Cancer Genet Cytogenet 148:159-62. 2004
    ..We conclude that trisomy 5 as the sole numerical abnormality occurs predominantly in older children, may be associated with a poor outcome, and may represent a distinct, albeit rare, cytogenetic subgroup in ALL...
  34. doi request reprint Abnormalities of the der(12)t(12;21) in ETV6-RUNX1 acute lymphoblastic leukemia
    Halima Al-Shehhi
    Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
    Genes Chromosomes Cancer 52:202-13. 2013
    ..In conclusion, this study has defined novel abnormalities in ETV6-RUNX1 BCP-ALL, which implicate new genes involved in leukemogenesis...
  35. doi request reprint Results of a randomized trial in children with Acute Myeloid Leukaemia: medical research council AML12 trial
    Brenda E S Gibson
    Department of Haematology, Royal Hospital for Sick Children, Glasgow G3 8SJ, Scotland, UK
    Br J Haematol 155:366-76. 2011
    ..EFS was superior compared to the preceding trial AML10, partly due to fewer deaths in remission, highlighting the importance of supportive care...
  36. doi request reprint Fluorescence In situ hybridization (FISH) as a tool for the detection of significant chromosomal abnormalities in childhood leukaemia
    Zoe J Konn
    Cancer Sciences Division, University of Southampton, Southampton, UK
    Methods Mol Biol 538:29-55. 2009
    ..The range of procedures necessary for the successful application of FISH in the accurate detection of significant chromosomal abnormalities in childhood acute leukaemia is described here...
  37. ncbi request reprint Prognostic effect of chromosomal abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: results from the UK Medical Research Council ALL97/99 randomised trial
    Anthony V Moorman
    Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
    Lancet Oncol 11:429-38. 2010
    ..Also, little is known about the association between cytogenetics and the characteristics of relapse (eg, time and site of relapse) that are known to predict outcome after relapse...
  38. doi request reprint Cytogenetics of paediatric and adolescent acute lymphoblastic leukaemia
    Christine J Harrison
    Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
    Br J Haematol 144:147-56. 2009
    ..In this molecular era, cytogenetics continues to be integral to our understanding of the genetics of this disease...
  39. ncbi request reprint Modeling the molecular consequences of unbalanced translocations in cancer: lessons from acute lymphoblastic leukemia
    Jonathan C Strefford
    Cancer Genomics Group, Cancer Sciences Division, University of Southampton, Southampton, UK
    Cell Cycle 8:2175-84. 2009
    ..The application of the same strategy to their analysis will lead to the discovery of novel cancer genes and improve our understanding of the genetic basis of tumorigenesis...
  40. ncbi request reprint t(6;14)(p22;q32): a new recurrent IGH@ translocation involving ID4 in B-cell precursor acute lymphoblastic leukemia (BCP-ALL)
    Lisa J Russell
    Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    Blood 111:387-91. 2008
    ..This study defines a new subgroup of BCP-ALL characterized by ID4 over-expression and CDKN2A and PAX5 deletions. Preliminary survival data suggest that this subgroup may be associated with a good response to therapy...
  41. ncbi request reprint Intrachromosomal amplification of chromosome 21 (iAMP21) may arise from a breakage-fusion-bridge cycle
    Hazel M Robinson
    Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton, UK
    Genes Chromosomes Cancer 46:318-26. 2007
    ..These findings suggested that iAMP21 had arisen from a breakage-fusion-bridge cycle: a mechanism previously described in tumors, which we report for the first time in ALL...
  42. doi request reprint Detection of prognostically relevant genetic abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: recommendations from the Biology and Diagnosis Committee of the International Berlin-Frankfürt-Münster study group
    Christine J Harrison
    Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
    Br J Haematol 151:132-42. 2010
    ..However, cytogenetics, particularly fluorescence in situ hybridization may provide reliable alternative detection methods dependent upon the preferred technical approach within each protocol...
  43. doi request reprint Acute lymphoblastic leukemia
    Christine J Harrison
    Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Level 5 Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Clin Lab Med 31:631-47, ix. 2011
    ..A number of new biomarkers provide the potential for molecular targets for therapy with promise for further improvements in survival and quality of life for ALL sufferers...
  44. ncbi request reprint Molecular cytogenetics in childhood leukemia
    Christine J Harrison
    Leukaemia Research Fund Cytogenetics Group, University of Southampton, UK
    Methods Mol Med 91:123-37. 2004
  45. ncbi request reprint A fluorescence in situ hybridization map of 6q deletions in acute lymphocytic leukemia: identification and analysis of a candidate tumor suppressor gene
    Paul B Sinclair
    Haematology Department, Royal Free and University College School of Medicine, London, United Kingdom
    Cancer Res 64:4089-98. 2004
    ..Finally, we detected significant levels of GRIK2 expression in prostate, kidney, trachea, and lung, raising the possibility that this gene may be protective against multiple tumor types...
  46. ncbi request reprint Analysis of balanced rearrangements of chromosome 6 in acute leukemia: clustered breakpoints in q22-q23 and possible involvement of c-MYB in a new recurrent translocation, t(6;7)(q23;q32 through 36)
    Paul Sinclair
    Haematology Department, Royal Free and University College School of Medicine, Rowland Hill Street, London NW3 2PF, UK
    Haematologica 90:602-11. 2005
    ..In this study we investigated the significance of novel translocations and inversions of 6q in acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML)...
  47. ncbi request reprint Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL)
    Takashi Akasaka
    Toxicology Unit, Medical Research Council, University of Leicester, Lancaster Road, Leicester, UK
    Blood 109:3451-61. 2007
    ..Our findings implicate the CEBP gene family as novel oncogenes in BCP-ALL, and suggest opposing functions of CEBP dysregulation in myeloid and lymphoid leukemogenesis...
  48. ncbi request reprint Involvement of the MLL gene in T-lineage acute lymphoblastic leukemia
    Anthony V Moorman
    Blood 100:2273-4. 2002
  49. ncbi request reprint Monosomy 7 and deletion 7q in children and adolescents with acute myeloid leukemia: an international retrospective study
    Henrik Hasle
    Department of Pediatrics, Aarhus University Hospital Skejby, Aarhus, Denmark
    Blood 109:4641-7. 2007
    ..Childhood AML with chromosome 7 aberrations represents a heterogeneous group of disorders with additional cytogenetic aberrations having a major prognostic impact which should be reflected in future risk-group stratification...
  50. ncbi request reprint Comparative expressed sequence hybridization studies of high-hyperdiploid childhood acute lymphoblastic leukemia
    Alicja M Gruszka-Westwood
    Section of Haematological Oncology, Institute of Cancer Research, London, United Kingdom
    Genes Chromosomes Cancer 41:191-202. 2004
    ..In conclusion, we have shown that tri-/tetrasomies in hyperdiploid ALL lead to an increase in the expression of associated sequences. The choice of a biologically relevant reference is crucial for data interpretation...
  51. pmc Outcome of treatment in children with hypodiploid acute lymphoblastic leukemia
    James B Nachman
    The University of Chicago Comer Children s Hospital, IL 60637, USA
    Blood 110:1112-5. 2007
    ..Children and adolescents with ALL and hypodiploidy with fewer than 44 chromosomes have a poor outcome despite contemporary therapy...
  52. ncbi request reprint Cytogenetic features of acute lymphoblastic and myeloid leukemias in pediatric patients with Down syndrome: an iBFM-SG study
    Erik Forestier
    Pediatrics Unit, Department of Clinical Sciences, University of Umea, Umea, Sweden
    Blood 111:1575-83. 2008
    ....
  53. ncbi request reprint Mutation of genes affecting the RAS pathway is common in childhood acute lymphoblastic leukemia
    Marian Case
    Northern Institute for Cancer Research, Newcastle upon Tyne, Tyne and Wear, United Kingdom
    Cancer Res 68:6803-9. 2008
    ..Inhibitors of the pathway, which are currently undergoing clinical trial, may be a novel therapeutic option for cALL, particularly at relapse...
  54. ncbi request reprint Overexpression of CEBPA resulting from the translocation t(14;19)(q32;q13) of human precursor B acute lymphoblastic leukemia
    Elise Chapiro
    Assistance Publique Hôpitaux de Paris AP HP Service d Hématologie Biologique, Hopital Pitie Salpetriere, Paris, France
    Blood 108:3560-3. 2006
    ..Overexpression of apparently normal CEBPA RNA or protein was observed in 6 patients. These data indicate that CEBPA may exhibit oncogenic as well as tumor suppressor properties in human leukemogenesis...
  55. ncbi request reprint Karyotyping lymph node biopsies in non-Hodgkin's lymphoma
    Fiona M Ross
    Wessex Regional Genetics Laboratory, Salisbury District Hospital, UK
    Methods Mol Med 115:93-107. 2005
    ....
  56. ncbi request reprint Successful treatment without cranial radiotherapy of children receiving intensified chemotherapy for acute lymphoblastic leukaemia: results of the risk-stratified randomized central nervous system treatment trial MRC UKALL XI (ISRC TN 16757172)
    Frank G H Hill
    Department of Clinical and Laboratory Haematology, The Children s Hospital NHS Trust, Birmingham, UK
    Br J Haematol 124:33-46. 2004
    ..EFS was not significantly different, being 55.2% (95% CI 47.8-62.6) at 10 years with XRT and 52.1% (95% CI 44.8-59.4) with HDMTX plus ITMTX...