Christine J Harrison

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. doi request reprint Genomic analysis drives tailored therapy in poor risk childhood leukemia
    Christine J Harrison
    Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
    Cancer Cell 22:139-40. 2012
  2. doi request reprint Cytogenetics of paediatric and adolescent acute lymphoblastic leukaemia
    Christine J Harrison
    Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
    Br J Haematol 144:147-56. 2009
  3. doi request reprint Detection of prognostically relevant genetic abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: recommendations from the Biology and Diagnosis Committee of the International Berlin-Frankfürt-Münster study group
    Christine J Harrison
    Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
    Br J Haematol 151:132-42. 2010
  4. doi request reprint Cytogenetics of childhood acute myeloid leukemia: United Kingdom Medical Research Council Treatment trials AML 10 and 12
    Christine J Harrison
    Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Queen Victoria Road, Newcastle upon Tyne, UK
    J Clin Oncol 28:2674-81. 2010
  5. doi request reprint Acute lymphoblastic leukemia
    Christine J Harrison
    Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Level 5 Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Clin Lab Med 31:631-47, ix. 2011
  6. doi request reprint IGH@ translocations, CRLF2 deregulation, and microdeletions in adolescents and adults with acute lymphoblastic leukemia
    Anthony V Moorman
    Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Level 5, Sir James Spence Institute, Royal Victoria Infirmary, Queen Victoria Rd, Newcastle upon Tyne, NE1 4LP, United Kingdom
    J Clin Oncol 30:3100-8. 2012
  7. doi request reprint Genomic characterization implicates iAMP21 as a likely primary genetic event in childhood B-cell precursor acute lymphoblastic leukemia
    Vikki Rand
    Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
    Blood 117:6848-55. 2011
  8. doi request reprint A comprehensive analysis of the CDKN2A gene in childhood acute lymphoblastic leukemia reveals genomic deletion, copy number neutral loss of heterozygosity, and association with specific cytogenetic subgroups
    Sarina Sulong
    Northern Institute for Cancer Research, Newcastle University, Queen Victoria Road, Newcastle upon Tyne, UK
    Blood 113:100-7. 2009
  9. pmc Genes commonly deleted in childhood B-cell precursor acute lymphoblastic leukemia: association with cytogenetics and clinical features
    Claire J Schwab
    Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
    Haematologica 98:1081-8. 2013
  10. doi request reprint Analysis of a breakpoint cluster reveals insight into the mechanism of intrachromosomal amplification in a lymphoid malignancy
    Paul B Sinclair
    Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Hum Mol Genet 20:2591-602. 2011

Collaborators

Detail Information

Publications23

  1. doi request reprint Genomic analysis drives tailored therapy in poor risk childhood leukemia
    Christine J Harrison
    Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
    Cancer Cell 22:139-40. 2012
    ..describe the identification of genetic alterations that lead to activated kinase and cytokine receptor signaling in Ph-like ALL and demonstrate that this aberrant signaling can be inhibited effectively...
  2. doi request reprint Cytogenetics of paediatric and adolescent acute lymphoblastic leukaemia
    Christine J Harrison
    Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
    Br J Haematol 144:147-56. 2009
    ..In this molecular era, cytogenetics continues to be integral to our understanding of the genetics of this disease...
  3. doi request reprint Detection of prognostically relevant genetic abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: recommendations from the Biology and Diagnosis Committee of the International Berlin-Frankfürt-Münster study group
    Christine J Harrison
    Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
    Br J Haematol 151:132-42. 2010
    ..However, cytogenetics, particularly fluorescence in situ hybridization may provide reliable alternative detection methods dependent upon the preferred technical approach within each protocol...
  4. doi request reprint Cytogenetics of childhood acute myeloid leukemia: United Kingdom Medical Research Council Treatment trials AML 10 and 12
    Christine J Harrison
    Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Queen Victoria Road, Newcastle upon Tyne, UK
    J Clin Oncol 28:2674-81. 2010
    ..Because AML is rare in children, the true prognostic significance of individual chromosomal abnormalities in this age group remains unclear...
  5. doi request reprint Acute lymphoblastic leukemia
    Christine J Harrison
    Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Level 5 Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Clin Lab Med 31:631-47, ix. 2011
    ..A number of new biomarkers provide the potential for molecular targets for therapy with promise for further improvements in survival and quality of life for ALL sufferers...
  6. doi request reprint IGH@ translocations, CRLF2 deregulation, and microdeletions in adolescents and adults with acute lymphoblastic leukemia
    Anthony V Moorman
    Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Level 5, Sir James Spence Institute, Royal Victoria Infirmary, Queen Victoria Rd, Newcastle upon Tyne, NE1 4LP, United Kingdom
    J Clin Oncol 30:3100-8. 2012
    ....
  7. doi request reprint Genomic characterization implicates iAMP21 as a likely primary genetic event in childhood B-cell precursor acute lymphoblastic leukemia
    Vikki Rand
    Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
    Blood 117:6848-55. 2011
    ....
  8. doi request reprint A comprehensive analysis of the CDKN2A gene in childhood acute lymphoblastic leukemia reveals genomic deletion, copy number neutral loss of heterozygosity, and association with specific cytogenetic subgroups
    Sarina Sulong
    Northern Institute for Cancer Research, Newcastle University, Queen Victoria Road, Newcastle upon Tyne, UK
    Blood 113:100-7. 2009
    ..The variation in the incidence of CDKN2A deletions by cytogenetic subgroup may explain its inconsistent association with outcome. CNN LOH without apparent CDKN2A inactivation suggests the presence of other relevant genes in this region...
  9. pmc Genes commonly deleted in childhood B-cell precursor acute lymphoblastic leukemia: association with cytogenetics and clinical features
    Claire J Schwab
    Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
    Haematologica 98:1081-8. 2013
    ....
  10. doi request reprint Analysis of a breakpoint cluster reveals insight into the mechanism of intrachromosomal amplification in a lymphoid malignancy
    Paul B Sinclair
    Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Hum Mol Genet 20:2591-602. 2011
    ..These findings provide insight into potential mechanisms involved in the formation of iAMP21...
  11. doi request reprint Demographic, clinical, and outcome features of children with acute lymphoblastic leukemia and CRLF2 deregulation: results from the MRC ALL97 clinical trial
    Hannah M Ensor
    Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
    Blood 117:2129-36. 2011
    ..69 [1.15-6.31], P = .023; OS 2.86 [1.15-6.79], P = .021). Therefore, we concluded that patients with CRLF2-d should be classified into the intermediate cytogenetic risk group...
  12. doi request reprint Cytogenetics of long-term survivors of ETV6-RUNX1 fusion positive acute lymphoblastic leukemia
    Zoe J Konn
    Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton, UK
    Genes Chromosomes Cancer 49:253-9. 2010
    ..It appears that the two groups have some distinguishing cytogenetic features at the time of diagnosis, which may provide pointers to relapse that are worthy of more detailed study...
  13. doi request reprint Cytogenetic and genomic characterization of cell line ARH77
    Helen Parker
    Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, MP822 Duthie Building, Southampton General Hospital, Southampton SO16 6YD, UK
    Cancer Genet Cytogenet 181:40-5. 2008
    ..Novel submicroscopic CNAs ( approximately 0.4 Mb) were detected by the highest resolution platform only, whereas the clones from the BAC arrays provided locus-specific FISH probes for confirmation of CNA...
  14. doi request reprint Acute lymphoblastic leukaemia
    Claire Schwab
    Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle, UK
    Methods Mol Biol 730:99-117. 2011
    ..The chapter also includes an overview of the abnormalities that are expected to be found in this disease and how the results from both cytogenetics and FISH should be interpreted...
  15. doi request reprint Abnormalities of the der(12)t(12;21) in ETV6-RUNX1 acute lymphoblastic leukemia
    Halima Al-Shehhi
    Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
    Genes Chromosomes Cancer 52:202-13. 2013
    ..In conclusion, this study has defined novel abnormalities in ETV6-RUNX1 BCP-ALL, which implicate new genes involved in leukemogenesis...
  16. doi request reprint The complex genomic profile of ETV6-RUNX1 positive acute lymphoblastic leukemia highlights a recurrent deletion of TBL1XR1
    Helen Parker
    Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton, UK
    Genes Chromosomes Cancer 47:1118-25. 2008
    ..The target of the interaction between TBL1XR1 and the signaling pathways described here may be exploited in cancer therapy...
  17. ncbi request reprint Molecular cytogenetic characterization of TCF3 (E2A)/19p13.3 rearrangements in B-cell precursor acute lymphoblastic leukemia
    Kerry E Barber
    Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton, UK
    Genes Chromosomes Cancer 46:478-86. 2007
    ..In addition to its role as a fusion partner gene, we propose that TCF3 can also act as a tumor suppressor gene in BCP-ALL...
  18. doi request reprint Prognostic effect of chromosomal abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: results from the UK Medical Research Council ALL97/99 randomised trial
    Anthony V Moorman
    Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
    Lancet Oncol 11:429-38. 2010
    ..Also, little is known about the association between cytogenetics and the characteristics of relapse (eg, time and site of relapse) that are known to predict outcome after relapse...
  19. ncbi request reprint A multicenter evaluation of comprehensive analysis of MLL translocations and fusion gene partners in acute leukemia using the MLL FusionChip device
    Christine J Harrison
    Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, MP 822 Duthie Building, Southampton General Hospital, Southampton SO16 6YD, UK
    Cancer Genet Cytogenet 173:17-22. 2007
    ..The type of molecular information provided by MLL FusionChip gave an indication of the appropriate primers to design for disease monitoring of MLL patients following treatment...
  20. ncbi request reprint Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial
    Anthony V Moorman
    Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton General Hospital, Southampton, UK
    Blood 109:3189-97. 2007
    ....
  21. doi request reprint Mutation of genes affecting the RAS pathway is common in childhood acute lymphoblastic leukemia
    Marian Case
    Northern Institute for Cancer Research, Newcastle upon Tyne, Tyne and Wear, United Kingdom
    Cancer Res 68:6803-9. 2008
    ..Inhibitors of the pathway, which are currently undergoing clinical trial, may be a novel therapeutic option for cALL, particularly at relapse...
  22. doi request reprint Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia
    Lisa J Russell
    Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle, United Kingdom
    Blood 114:2688-98. 2009
    ....
  23. ncbi request reprint Intrachromosomal amplification of chromosome 21 (iAMP21) may arise from a breakage-fusion-bridge cycle
    Hazel M Robinson
    Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton, UK
    Genes Chromosomes Cancer 46:318-26. 2007
    ..These findings suggested that iAMP21 had arisen from a breakage-fusion-bridge cycle: a mechanism previously described in tumors, which we report for the first time in ALL...