William A Harris
Affiliation: University of Cambridge
Boije H, MacDonald R, Harris W. Reconciling competence and transcriptional hierarchies with stochasticity in retinal lineages. Curr Opin Neurobiol. 2014;27:68-74 pubmed publisher
..that also influence cell division and cell fate in the developing retina? Where may stochasticity arise in the system and how do we make progress in this field when we may never fully explain the behavior of individual progenitor cells? ..
Piper M, Lee A, van Horck F, McNeilly H, Lu T, Harris W, et al
. Differential requirement of F-actin and microtubule cytoskeleton in cue-induced local protein synthesis in axonal growth cones. Neural Dev. 2015;10:3 pubmed publisher
Wang X, Lupo G, He R, Barsacchi G, Harris W, Liu Y. Dorsoventral patterning of the Xenopus eye involves differential temporal changes in the response of optic stalk and retinal progenitors to Hh signalling. Neural Dev. 2015;10:7 pubmed publisher
..We speculate that this temporal regulation is important to coordinate dorsoventral patterning with morphogenesis and differentiation processes during eye development. ..
Boije H, Rulands S, Dudczig S, Simons B, Harris W. The Independent Probabilistic Firing of Transcription Factors: A Paradigm for Clonal Variability in the Zebrafish Retina. Dev Cell. 2015;34:532-43 pubmed publisher
Wan Y, Almeida A, Rulands S, Chalour N, Muresan L, Wu Y, et al
. The ciliary marginal zone of the zebrafish retina: clonal and time-lapse analysis of a continuously growing tissue. Development. 2016;143:1099-107 pubmed publisher
..These results link embryonic and postembryonic cell behaviour, and help to explain the constancy of tissue architecture that has been generated over a lifetime. ..
Eldred M, Charlton Perkins M, Muresan L, Harris W. Self-organising aggregates of zebrafish retinal cells for investigating mechanisms of neural lamination. Development. 2017;144:1097-1106 pubmed publisher
..Image analysis allowed us to derive quantitative measures of lamination, which we then used to find that Müller glia, but not RPE cells, are essential for this process. ..
MacDonald R, Charlton Perkins M, Harris W. Mechanisms of Müller glial cell morphogenesis. Curr Opin Neurobiol. 2017;47:31-37 pubmed publisher
..Uncovering the mechanisms governing glial morphogenesis, using transcriptomics and imaging, may provide shed new light on the pathophysiology and treatment of human neurological disorders. ..