Affiliation: University of Birmingham
- Effects of endocrine disruptors on dehydroepiandrosterone sulfotransferase and enzymes involved in PAPS synthesis: genomic and nongenomic pathwaysRobert Harris
School of Biosciences, The University of Birmingham, Edgbaston, Birmingham, United Kingdom
Environ Health Perspect 115:51-4. 2007..Studies in rodents have shown that the conversion of dehydroepiandrosterone (DHEA) to DHEA-sulfate is involved in learning and the memory process...
- Sulfotransferase inhibition: potential impact of diet and environmental chemicals on steroid metabolism and drug detoxificationR M Harris
School of Biosciences, University of Birmingham, Birmingham, UK
Curr Drug Metab 9:269-75. 2008....
- Phytoestrogens are potent inhibitors of estrogen sulfation: implications for breast cancer risk and treatmentR M Harris
School of Biosciences and Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
J Clin Endocrinol Metab 89:1779-87. 2004..Hence, dietary flavonoids may be able to influence the bioavailability of endogenous estrogens, and disrupt endocrine balance, by increasing the ratio of active estrogens to inactive estrogen sulfates in human tissues...
- Phytoestrogens and xenoestrogens: the contribution of diet and environment to endocrine disruptionR H Waring
School of Biosciences, University of Birmingham, Birmingham, United Kingdom
J Steroid Biochem Mol Biol 108:213-20. 2008..Endocrine disrupting effects in man may be multifactorial when components from both the diet and the environment act at the same point in steroid metabolism...
- Endocrine disrupters: a human risk?R H Waring
School of Biosciences, University of Birmingham, UK
Mol Cell Endocrinol 244:2-9. 2005..This may be of long-term concern since traces of EDs such as plasticisers, brominated fire retardants, sunscreen agents and cosmetic ingredients are widely distributed in the environment and in human biofluids...
- Sulfation of "estrogenic" alkylphenols and 17beta-estradiol by human platelet phenol sulfotransferasesR M Harris
School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
J Biol Chem 275:159-66. 2000..We conclude that by acting either as substrates or inhibitors of SULT1A1/2, alkylphenols may influence the sulfation, and hence the excretion, of estrogens and other phenol sulfotransferase substrates in humans...
- Do dietary phytoestrogens influence susceptibility to hormone-dependent cancer by disrupting the metabolism of endogenous oestrogens?C J Kirk
School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U K
Biochem Soc Trans 29:209-16. 2001..Hence the inhibition of sulphotransferases by dietary phytoestrogens may have complex effects upon human susceptibility to breast cancer...
- Effects of culture with TNF-alpha, TGF-beta and insulin on sulphotransferase (SULT 1A1 and 1A3) activity in human colon and neuronal cell linesE Davies
School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
Toxicol In Vitro 18:749-54. 2004....
- Non-genomic effects of endocrine disrupters: inhibition of estrogen sulfotransferase by phenols and chlorinated phenolsR M Harris
School of Biosciences, The University of Birmingham, Edgbaston, UK
Mol Cell Endocrinol 244:72-4. 2005..Our results demonstrate a potential non-genomic mechanism of action for these compounds and suggest that, where viable alternatives exist, both phenols substituted in the 2-position and their metabolic precursors should be avoided...
- Bone marrow-derived cells contribute to epithelial engraftment during wound healingXenia Borue
Department of Laboratory Medicine, Yale University School of Medicine, 333 Cedar Street, P.O. Box 208035, New Haven, CT 06520-8035, USA
Am J Pathol 165:1767-72. 2004....