Lorna W Harries

Summary

Affiliation: University of Exeter
Country: UK

Publications

  1. Morrison F, Locke J, Wood A, Tuke M, Pasko D, Murray A, et al. The splice site variant rs11078928 may be associated with a genotype-dependent alteration in expression of GSDMB transcripts. BMC Genomics. 2013;14:627 pubmed publisher
  2. Meerson A, Eliraz Y, Yehuda H, Knight B, Crundwell M, Ferguson D, et al. Obesity impacts the regulation of miR-10b and its targets in primary breast tumors. BMC Cancer. 2019;19:86 pubmed publisher
    ..MiR-10b expression may have diagnostic and therapeutic implications for the incidence and prognosis of BC in obese women. ..
  3. Holly A, Pilling L, Hernandez D, Lee B, Singleton A, Ferrucci L, et al. Splicing factor 3B1 hypomethylation is associated with altered SF3B1 transcript expression in older humans. Mech Ageing Dev. 2014;135:50-6 pubmed publisher
    ..SF3B1 encodes a critical component of the U2 snRNP; altered expression of this gene may therefore contribute to the loss of regulated mRNA splicing that occurs with age. ..
  4. Harries L. MicroRNAs as Mediators of the Ageing Process. Genes (Basel). 2014;5:656-70 pubmed publisher
    ..Definition of the factors involved in degeneration of organismal, tissue and cellular homeostasis may provide biomarkers for healthy ageing and increase understanding of the processes that underpin the ageing process itself. ..
  5. Galloway T, Fletcher T, Thomas O, Lee B, Pilling L, Harries L. PFOA and PFOS are associated with reduced expression of the parathyroid hormone 2 receptor (PTH2R) gene in women. Chemosphere. 2015;120:555-62 pubmed publisher
    ..41, p=0.046). As the parathyroid signalling cascade is a known candidate for osteoarthritis risk and our findings raise the possibility that exposure to these chemicals may contribute to the pathogenesis of OA in some individuals. ..
  6. Latorre E, Harries L. Splicing regulatory factors, ageing and age-related disease. Ageing Res Rev. 2017;36:165-170 pubmed publisher
    ..These important splicing regulators have been implicated in age-related disease, and in the ageing process itself. This review will outline the important contribution of splicing regulator proteins to ageing and age-related disease. ..
  7. Lee B, Lloyd Laney H, Locke J, McCulloch L, Knight B, Yaghootkar H, et al. Functional characterisation of ADIPOQ variants using individuals recruited by genotype. Mol Cell Endocrinol. 2016;428:49-57 pubmed publisher
    ..These studies illustrate the utility of recruit-by-genotype studies in relevant human tissues in functional interpretation of GWAS signals. ..
  8. Locke J, Hysenaj G, Wood A, Weedon M, Harries L. Targeted allelic expression profiling in human islets identifies cis-regulatory effects for multiple variants identified by type 2 diabetes genome-wide association studies. Diabetes. 2015;64:1484-91 pubmed publisher
    ..The results of this study support the hypothesis that changes to cis-regulation of gene expression are involved in a large proportion of SNP associations with type 2 diabetes susceptibility. ..
  9. Latorre E, Pilling L, Lee B, Bandinelli S, Melzer D, Ferrucci L, et al. The VEGFA156b isoform is dysregulated in senescent endothelial cells and may be associated with prevalent and incident coronary heart disease. Clin Sci (Lond). 2018;132:313-325 pubmed publisher
    ..Dysregulated splicing factor expression is a key feature of senescent cardiomyocytes and endothelial cells. Altered splicing of key cardiac or endothelial genes may contribute to the risk of CHD in the human population. ..

More Information

Publications18

  1. request reprint
    Harries L, Ellard S, Stride A, Morgan N, Hattersley A. Isomers of the TCF1 gene encoding hepatocyte nuclear factor-1 alpha show differential expression in the pancreas and define the relationship between mutation position and clinical phenotype in monogenic diabetes. Hum Mol Genet. 2006;15:2216-24 pubmed
    ..We conclude that all three isomers may be critical for beta-cell function and could play a role in both the developing and mature beta cell. ..
  2. Harries L, McCulloch L, Holley J, Rawling T, Welters H, Kos K. A role for SPARC in the moderation of human insulin secretion. PLoS ONE. 2013;8:e68253 pubmed publisher
  3. Harries L, Sloman M, Sellers E, Hattersley A, Ellard S. Diabetes susceptibility in the Canadian Oji-Cree population is moderated by abnormal mRNA processing of HNF1A G319S transcripts. Diabetes. 2008;57:1978-82 pubmed publisher
    ..A combination of abnormal splicing and reduced activity of the G319S protein may explain the diabetes susceptibility. ..
  4. Harries L, Locke J, Shields B, Hanley N, Hanley K, Steele A, et al. The diabetic phenotype in HNF4A mutation carriers is moderated by the expression of HNF4A isoforms from the P1 promoter during fetal development. Diabetes. 2008;57:1745-52 pubmed publisher
  5. Harries L, Perry J, McCullagh P, Crundwell M. Alterations in LMTK2, MSMB and HNF1B gene expression are associated with the development of prostate cancer. BMC Cancer. 2010;10:315 pubmed publisher
    ..The alterations in isoform usage we detect highlights the potential importance of alternative mRNA processing and moderation of mRNA stability as potentially important disease mechanisms. ..
  6. Latorre E, Birar V, Sheerin A, Jeynes J, Hooper A, Dawe H, et al. Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence. BMC Cell Biol. 2017;18:31 pubmed publisher
    ..Small molecule modulators of such targets may therefore represent promising novel anti-degenerative therapies. ..
  7. Haque S, Harries L. Circular RNAs (circRNAs) in Health and Disease. Genes (Basel). 2017;8: pubmed publisher
    ..In this review, we explore the state of knowledge on this exciting class of transcripts in regulating gene expression and discuss their emerging role in health and disease. ..
  8. Harries L, Brown J, Gloyn A. Species-specific differences in the expression of the HNF1A, HNF1B and HNF4A genes. PLoS ONE. 2009;4:e7855 pubmed publisher
    ..We conclude that alterations to expression of HNF isoforms may underlie some of the phenotypic variation caused by mutations in these genes. ..
  9. Jeffery N, Richardson S, Beall C, Harries L. The species origin of the cellular microenvironment influences markers of beta cell fate and function in EndoC-βH1 cells. Exp Cell Res. 2017;361:284-291 pubmed publisher