Steven J Harper

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. ncbi request reprint Expression of neuropilin-1 by human glomerular epithelial cells in vitro and in vivo
    S J Harper
    Academic Renal Unit, University of Bristol, Southmead Hospital, Westbury on Trym, Bristol B10 5NB, U K
    Clin Sci (Lond) 101:439-46. 2001
  2. ncbi request reprint Elevated plasma vascular endothelial growth factor levels in non-diabetic predialysis uraemia
    Steven J Harper
    Academic Renal Laboratories, University of Bristol, Westbury on Trym, Bristol, UK
    Nephron 90:341-3. 2002
  3. pmc VEGF-A splicing: the key to anti-angiogenic therapeutics?
    Steven J Harper
    Microvascular Research Laboratories, Department of Physiology and Pharmacology, Bristol Heart Institute, School of Veterinary Science, University of Bristol, Southwell Street, Bristol BS2 8EJ, UK
    Nat Rev Cancer 8:880-7. 2008
  4. pmc Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors
    Dawid G Nowak
    Microvascular Research Laboratories, Bristol Heart Institute, Department of Physiology and Pharmacology, School of Veterinary Sciences, University of Bristol, Southwell Street, Bristol BS2 8EJ, UK
    J Cell Sci 121:3487-95. 2008
  5. pmc Regulation of vascular endothelial growth factor (VEGF) splicing from pro-angiogenic to anti-angiogenic isoforms: a novel therapeutic strategy for angiogenesis
    Dawid G Nowak
    Microvascular Research Laboratories, Bristol Heart Institute, Department of Physiology and Pharmacology, School of Veterinary Sciences, University of Bristol, Bristol BS2 8EJ, United Kingdom
    J Biol Chem 285:5532-40. 2010
  6. pmc VEGF-A165b is cytoprotective and antiangiogenic in the retina
    Anette L Magnussen
    Microvascular Research Laboratories, Bristol Heart Institute, Department of Physiology and Pharmacology, School of Veterinary Sciences, University of Bristol, Bristol, UK
    Invest Ophthalmol Vis Sci 51:4273-81. 2010
  7. pmc Recombinant human VEGF165b inhibits experimental choroidal neovascularization
    Jing Hua
    Microvascular Research Laboratories, Department of Physiology and Pharmacology, Bristol Heart Institute, School of Veterinary Sciences, University of Bristol, Bristol, UK
    Invest Ophthalmol Vis Sci 51:4282-8. 2010
  8. pmc Balance of pro- versus anti-angiogenic splice isoforms of vascular endothelial growth factor as a regulator of neuroblastoma growth
    Maria Peiris-Pagès
    Cellular and Molecular Medicine, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    J Pathol 222:138-47. 2010
  9. pmc WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing
    Elianna M Amin
    Centre for Research in Biomedicine, University of the West of England, Bristol, UK
    Cancer Cell 20:768-80. 2011
  10. pmc VEGF-C induced angiogenesis preferentially occurs at a distance from lymphangiogenesis
    Andrew V Benest
    Microvascular Research Laboratories, Department of Physiology, University of Bristol, BS2 8EJ Bristol, UK
    Cardiovasc Res 78:315-23. 2008

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Expression of neuropilin-1 by human glomerular epithelial cells in vitro and in vivo
    S J Harper
    Academic Renal Unit, University of Bristol, Southmead Hospital, Westbury on Trym, Bristol B10 5NB, U K
    Clin Sci (Lond) 101:439-46. 2001
    ..Functional studies will be required to address the potential significance of this finding in terms of an autocrine loop or VEGF sequestration...
  2. ncbi request reprint Elevated plasma vascular endothelial growth factor levels in non-diabetic predialysis uraemia
    Steven J Harper
    Academic Renal Laboratories, University of Bristol, Westbury on Trym, Bristol, UK
    Nephron 90:341-3. 2002
    ..002. In conclusion, free plasma VEGF levels are high in chronic renal impairment. We hypothesise that this potent growth and permeability factor may contribute to the endothelial dysfunction of uraemia...
  3. pmc VEGF-A splicing: the key to anti-angiogenic therapeutics?
    Steven J Harper
    Microvascular Research Laboratories, Department of Physiology and Pharmacology, Bristol Heart Institute, School of Veterinary Science, University of Bristol, Southwell Street, Bristol BS2 8EJ, UK
    Nat Rev Cancer 8:880-7. 2008
    ....
  4. pmc Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors
    Dawid G Nowak
    Microvascular Research Laboratories, Bristol Heart Institute, Department of Physiology and Pharmacology, School of Veterinary Sciences, University of Bristol, Southwell Street, Bristol BS2 8EJ, UK
    J Cell Sci 121:3487-95. 2008
    ....
  5. pmc Regulation of vascular endothelial growth factor (VEGF) splicing from pro-angiogenic to anti-angiogenic isoforms: a novel therapeutic strategy for angiogenesis
    Dawid G Nowak
    Microvascular Research Laboratories, Bristol Heart Institute, Department of Physiology and Pharmacology, School of Veterinary Sciences, University of Bristol, Bristol BS2 8EJ, United Kingdom
    J Biol Chem 285:5532-40. 2010
    ..Injection of an SRPK1/2 inhibitor reduced angiogenesis in a mouse model of retinal neovascularization, suggesting that regulation of alternative splicing could be a potential therapeutic strategy in angiogenic pathologies...
  6. pmc VEGF-A165b is cytoprotective and antiangiogenic in the retina
    Anette L Magnussen
    Microvascular Research Laboratories, Bristol Heart Institute, Department of Physiology and Pharmacology, School of Veterinary Sciences, University of Bristol, Bristol, UK
    Invest Ophthalmol Vis Sci 51:4273-81. 2010
    ..Here the authors investigate the antiangiogenic activity of VEGF(165)b and its effect on retinal epithelial and endothelial cell survival...
  7. pmc Recombinant human VEGF165b inhibits experimental choroidal neovascularization
    Jing Hua
    Microvascular Research Laboratories, Department of Physiology and Pharmacology, Bristol Heart Institute, School of Veterinary Sciences, University of Bristol, Bristol, UK
    Invest Ophthalmol Vis Sci 51:4282-8. 2010
    ..It is the proangiogenic family that is responsible for the blood vessel growth seen in AMD...
  8. pmc Balance of pro- versus anti-angiogenic splice isoforms of vascular endothelial growth factor as a regulator of neuroblastoma growth
    Maria Peiris-Pagès
    Cellular and Molecular Medicine, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    J Pathol 222:138-47. 2010
    ..In conclusion, VEGF(165)b is an effective inhibitor of NB growth. These findings provide the rationale for further investigation of VEGF(165)b in NB and other paediatric malignancies...
  9. pmc WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing
    Elianna M Amin
    Centre for Research in Biomedicine, University of the West of England, Bristol, UK
    Cancer Cell 20:768-80. 2011
    ..Altered VEGF splicing was reversed by wild-type WT1, knockdown of SRSF1, or SRPK1 and inhibition of SRPK1, which prevented in vitro and in vivo angiogenesis and associated tumor growth...
  10. pmc VEGF-C induced angiogenesis preferentially occurs at a distance from lymphangiogenesis
    Andrew V Benest
    Microvascular Research Laboratories, Department of Physiology, University of Bristol, BS2 8EJ Bristol, UK
    Cardiovasc Res 78:315-23. 2008
    ....
  11. ncbi request reprint Differentiated human podocytes endogenously express an inhibitory isoform of vascular endothelial growth factor (VEGF165b) mRNA and protein
    Tai Gen Cui
    Microvascula Research Laboratories, Dept of Physiology, Preclinical Veterinary School, Univ of Bristol, Southwell St, Bristol BS2 8EJ, UK
    Am J Physiol Renal Physiol 286:F767-73. 2004
    ....
  12. ncbi request reprint The endogenous anti-angiogenic family of splice variants of VEGF, VEGFxxxb, are down-regulated in pre-eclamptic placentae at term
    David O Bates
    Microvascular Research Laboratories, Department of Physiology, Preclinical Veterinary School, University of Bristol, Bristol BS2 8EJ, UK
    Clin Sci (Lond) 110:575-85. 2006
    ....
  13. pmc Angiopoietin-1 alters microvascular permeability coefficients in vivo via modification of endothelial glycocalyx
    Andrew H J Salmon
    Department of Physiology and Pharmacology, Preclinical Veterinary School, Microvascular Research Laboratories, Bristol Heart Institute, University of Bristol, Southwell Street, Bristol, UK
    Cardiovasc Res 83:24-33. 2009
    ..In this study, we wished to determine whether angiopoietin-1 (Ang1) modified the permeability coefficients of non-inflamed, intact continuous, and fenestrated microvessels in vivo and to elucidate the underlying cellular mechanisms...
  14. pmc The anti-angiogenic isoforms of VEGF in health and disease
    Yan Qiu
    Department of Physiology and Pharmacology, Microvascular Research Laboratories, Bristol Heart Institute, School of Veterinary Sciences, University of Bristol, Southwell Street, Bristol BS2 8EJ, UK
    Biochem Soc Trans 37:1207-13. 2009
    ....
  15. ncbi request reprint Nephrotic plasma alters slit diaphragm-dependent signaling and translocates nephrin, Podocin, and CD2 associated protein in cultured human podocytes
    Richard J M Coward
    Academic and Children s Renal Unit, Southmead Hospital, University of Bristol, Bristol, UK
    J Am Soc Nephrol 16:629-37. 2005
    ..This work demonstrates that nephrotic plasma seems to be deficient in factors that act via the podocyte SD complex, which are essential in maintaining its physiologic function...
  16. ncbi request reprint VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, is down-regulated in renal cell carcinoma
    David O Bates
    Microvascular Research Laboratories, Department of Physiology, Preclinical Veterinary School, University of Bristol, Bristol BS2 8EJ, United Kingdom
    Cancer Res 62:4123-31. 2002
    ..This novel isoform VEGF165b is therefore an endogenous inhibitory form of VEGF that is down-regulated in renal tumors and, therefore, may be anti-angiogenesis...
  17. ncbi request reprint Functional evidence that vascular endothelial growth factor may act as an autocrine factor on human podocytes
    Rebecca R Foster
    Microvascular Research Laboratories, Department of Physiology, University of Bristol, Preclinical Veterinary School, United Kingdom
    Am J Physiol Renal Physiol 284:F1263-73. 2003
    ..These results indicate that one of the functions of VEGF secreted from podocytes may be to act as an autocrine factor on calcium homeostasis and cell survival...
  18. ncbi request reprint Vascular endothelial growth factor and nephrin interact and reduce apoptosis in human podocytes
    Rebecca R Foster
    Microvascular Research Laboratories, Department of Physiology, University of Bristol, Preclinical Veterinary School, Southwell St, Bristol BS2 8EJ, UK
    Am J Physiol Renal Physiol 288:F48-57. 2005
    ..However, the involvement of AKT in this survival response in normal human podocytes is not clear...
  19. pmc Association between VEGF splice isoforms and progression-free survival in metastatic colorectal cancer patients treated with bevacizumab
    David O Bates
    Microvascular Research Laboratories, Department of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom
    Clin Cancer Res 18:6384-91. 2012
    ..We tested the hypothesis that prolonged progression-free survival (PFS) would occur only in patients with low relative VEGF(165)b levels treated with bevacizumab...
  20. pmc VEGF165b overexpression restores normal glomerular water permeability in VEGF164-overexpressing adult mice
    Sebastian Oltean
    Microvascular Research Laboratories, School of Physiology and Pharmacology, Univ of Bristol, Preclinical Veterinary School, Southwell St, Bristol, United Kingdom BS2 8EJ
    Am J Physiol Renal Physiol 303:F1026-36. 2012
    ..VEGF(165)b is capable of preventing VEGF(164)-induced changes in glomerular permeability and ultrastructure in vivo...
  21. pmc Loss of the endothelial glycocalyx links albuminuria and vascular dysfunction
    Andrew H J Salmon
    Microvascular Research Laboratories, School of Physiology and Pharmacology, University of Bristol, Southwell Street, Bristol, UK
    J Am Soc Nephrol 23:1339-50. 2012
    ..Taken together, these results suggest that widespread loss of the endothelial surface layer links albuminuric kidney disease with systemic vascular dysfunction, providing a potential therapeutic target for proteinuric kidney disease...
  22. pmc Molecular diversity of VEGF-A as a regulator of its biological activity
    Jeanette Woolard
    Department of Physiology and Pharmacology, Bristol Heart Institute, School of Veterinary Sciences, University of Bristol, Bristol, UK
    Microcirculation 16:572-92. 2009
    ..Here, we examine the molecular diversity of VEGF-A as a regulator of its biological activity and compare the role of the pro- and antiangiogenic VEGF-A splice isoforms in both normal and pathophysiological processes...
  23. pmc Therapeutic potential of manipulating VEGF splice isoforms in oncology
    Emma S Rennel
    Microvascular Research Laboratories, Department of Physiology and Pharmacology, School of Veterinary Sciences, University of Bristol, Bristol, UK
    Future Oncol 5:703-12. 2009
    ..The concept here is to target the splicing mechanisms that control splice site choice in the VEGF-A mRNA. Recent evidence on the pharmacological possibilities of such splice factors is described...
  24. pmc The alternatively spliced anti-angiogenic family of VEGF isoforms VEGFxxxb in human kidney development
    Heather S Bevan
    Microvascular Research Laboratories, Department of Physiology, University of Bristol, Bristol, UK
    Nephron Physiol 110:p57-67. 2008
    ..VEGF(165)b, the first described exon 8b-containing isoform, antagonises VEGF(165) and is anti-angiogenic in vivo...
  25. pmc Failure to up-regulate VEGF165b in maternal plasma is a first trimester predictive marker for pre-eclampsia
    Victoria L Bills
    Microvascular Research Laboratories, Department of Physiology, Preclinical Veterinary School, University of Bristol, Bristol BS2 8EJ, U K
    Clin Sci (Lond) 116:265-72. 2009
    ..In conclusion, low VEGF(165)b may therefore be a clinically useful first trimester plasma marker for increased risk of pre-eclampsia...
  26. pmc VEGF in the lung: a role for novel isoforms
    Julia Varet
    Lung Research Group, Department of Clinical Science at North Bristol, University of Bristol Paul O Gorman Lifeline Centre, Southmead Hospital, Westbury on Trym, United Kingdom
    Am J Physiol Lung Cell Mol Physiol 298:L768-74. 2010
    ..A specific functional effect on primary human endothelial and alveolar epithelial cells has also been shown. These data suggest that the VEGF(xxx)b family may have a role in repair after lung injury...
  27. pmc Vascular endothelial growth factor increases the ultrafiltration coefficient in isolated intact Wistar rat glomeruli
    Andrew H J Salmon
    Microvascular Research Laboratories, Department of Physiology, School of Veterinary Sciences, University of Bristol, Southwell Street, Bristol BS2 8EJ, UK
    J Physiol 570:141-56. 2006
    ..We suggest that glomerular VEGF contributes to the high physiological permeability of mammalian glomeruli to water through an action on endothelial cells...
  28. pmc Arteriolar genesis and angiogenesis induced by endothelial nitric oxide synthase overexpression results in a mature vasculature
    Andrew V Benest
    Microvascular Research Laboratories, Bristol Heart Institute, Department of Physiology, University of Bristol, Southwell Street, Bristol BS2 8EJ, United Kingdom
    Arterioscler Thromb Vasc Biol 28:1462-8. 2008
    ..Generation of physiologically active vascular beds by delivery of combinations of growth factors offers promise for vascular gene therapy...
  29. ncbi request reprint Mammary alveolar development during lactation is inhibited by the endogenous antiangiogenic growth factor isoform, VEGF165b
    Yan Qiu
    Microvascular Research Laboratories, School of Veterinary Sciences, University of Bristol, Bristol, UK
    FASEB J 22:1104-12. 2008
    ..This study provides the first evidence for the role of endogenous antiangiogenic VEGF isoforms in normal physiology--their down-regulation is required for effective milk production...
  30. ncbi request reprint Hyperglycemia stimulates a sustained increase in hydraulic conductivity in vivo without any change in reflection coefficient
    Rachel M Perrin
    Microvascular Research Laboratories, Department of Physiology, University of Bristol, Preclinical Veterinary School, Bristol, UK
    Microcirculation 14:683-96. 2007
    ..The mechanisms underlying increased permeability, however, are poorly understood...
  31. ncbi request reprint Therapeutic potential of inhibitory VEGF splice variants
    David O Bates
    University of Bristol, Microvascular Research Laboratories, Department of Physiology, Preclinical Veterinary School, Southwell Street, Bristol, BS2 8EJ, UK
    Future Oncol 1:467-73. 2005
    ..The discovery, mechanism of action, preclinical evaluation, and the potential uses of these isoforms in future cancer therapy will be discussed herein...
  32. pmc Detection of VEGF-Axxxb Isoforms in Human Tissues
    David O Bates
    Microvascular Research Laboratories, School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom
    PLoS ONE 8:e68399. 2013
    ....
  33. ncbi request reprint Glomerular filtration into the subpodocyte space is highly restricted under physiological perfusion conditions
    Christopher R Neal
    Dept of Physiology, Univ of Bristol, Southwell St, Bristol BS2 8EJ, UK
    Am J Physiol Renal Physiol 293:F1787-98. 2007
    ..This suggests a physiological role of the podocyte in the regulation of glomerular fluid flux across most of the GFB...
  34. pmc Recombinant human VEGF165b protein is an effective anti-cancer agent in mice
    Emma S Rennel
    Microvascular Research Laboratories, Department of Physiology and Pharmacology, School of Veterinary Science, University of Bristol, Southwell Street, Bristol BS2 8EJ, United Kingdom
    Eur J Cancer 44:1883-94. 2008
    ....
  35. ncbi request reprint VEGF165b, an inhibitory vascular endothelial growth factor splice variant: mechanism of action, in vivo effect on angiogenesis and endogenous protein expression
    Jeanette Woolard
    Microvascular Research Laboratories, Department of Physiology, Preclinical Veterinary School, University of Bristol, Southwell Street, Bristol, United Kingdom
    Cancer Res 64:7822-35. 2004
    ..These results suggest that regulation of VEGF splicing may be a critical switch from an antiangiogenic to a proangiogenic phenotype...
  36. doi request reprint New aspects of glomerular filtration barrier structure and function: five layers (at least) not three
    Andrew H J Salmon
    Microvascular Research Laboratories, Bristol Heart Institute, Department of Physiology and Pharmacology, School of Veterinary Sciences, Southwell Street, University of Bristol, Bristol, UK
    Curr Opin Nephrol Hypertens 18:197-205. 2009
    ..We review recent work demonstrating the functional importance of two additional layers: the endothelial surface layer (ESL) and the subpodocyte space (SPS)...
  37. ncbi request reprint VEGF and angiopoietin-1 stimulate different angiogenic phenotypes that combine to enhance functional neovascularization in adult tissue
    Andrew V Benest
    Microvascular Research Laboratories, Department of Physiology, University of Bristol, Bristol, UK
    Microcirculation 13:423-37. 2006
    ..This study determined the physiological mechanism by which adenoviral delivery of growth factor combinations alter vascular phenotype and functionality...
  38. ncbi request reprint Three-dimensional reconstruction of glomeruli by electron microscopy reveals a distinct restrictive urinary subpodocyte space
    Christopher R Neal
    Microvascular Research Laboratories, Department of Physiology, Preclinical Veterinary School, University of Bristol, Southwell Street, Bristol BS2 8EJ, UK
    J Am Soc Nephrol 16:1223-35. 2005
    ..The physiologic role of the restrictive SPS is yet to be determined but likely possibilities include regulation of glomerular filtration and cleaning of the glomerular filtration barrier...
  39. doi request reprint A human neutralizing antibody specific to Ang-2 inhibits ocular angiogenesis
    Emma S Rennel
    Microvascular Research Laboratories, Bristol Heart Institute, School of Physiology and Pharmacology, Veterinary Sciences Building, University of Bristol, Bristol, UK
    Microcirculation 18:598-607. 2011
    ..Our objective was to determine the requirement of ocular angiogenesis for Ang2 in animal models of disease...
  40. ncbi request reprint An adenovirus-mediated gene-transfer model of angiogenesis in rat mesentery
    Wen Ying Wang
    Microvascular Research Laboratories, Department of Physiology, Preclinical Veterinary School, University of Bristol, Bristol, UK
    Microcirculation 11:361-75. 2004
    ..To develop an adenovirus-mediated angiogenesis model, dependent on VEGF, in a system amenable to functional characterization...
  41. pmc VEGF-A165b Is an Endogenous Neuroprotective Splice Isoform of Vascular Endothelial Growth Factor A in Vivo and in Vitro
    Nicholas Beazley-Long
    Microvascular Research Laboratories, School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom
    Am J Pathol 183:918-29. 2013
    ..The endogenous nature of VEGF-A165b expression suggests that non-isoform-specific inhibition of VEGF-A (for antiangiogenic reasons) may be damaging to retinal and sensory neurons. ..
  42. pmc Topical Antiangiogenic SRPK1 Inhibitors Reduce Choroidal Neovascularization in Rodent Models of Exudative AMD
    Melissa V Gammons
    Microvascular Research Laboratories, School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom
    Invest Ophthalmol Vis Sci 54:6052-62. 2013
    ..We tested the hypothesis that topical (eye drop) SRPK1-selective inhibitors could be generated that reduce pro-angiogenic isoforms, and prevent choroidal neovascularization in vivo...
  43. ncbi request reprint Plasma from women with severe pre-eclampsia increases microvascular permeability in an animal model in vivo
    Christopher R Neal
    Microvascular Research Laboratories, Department of Physiology, Preclinical Veterinary School, University of Bristol, Bristol, BS2 8EJ, UK
    Clin Sci (Lond) 107:399-405. 2004
    ..The nature of the circulating macromolecule is not known, except that it is, or is bound to, a molecule greater than 12 kDa...
  44. doi request reprint SRPK1 Inhibition Modulates VEGF Splicing to Reduce Pathological Neovascularization in a Rat Model of Retinopathy of Prematurity
    Melissa V R Gammons
    Microvascular Research Laboratories, School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom
    Invest Ophthalmol Vis Sci 54:5797-806. 2013
    ....
  45. ncbi request reprint Human uremic plasma increases microvascular permeability to water and proteins in vivo
    Steven J Harper
    Academic Renal Laboratories, University of Bristol, Southmead Hospital, Bristol, England, United Kingdom
    Kidney Int 61:1416-22. 2002
    ..Transvascular transport of lipids and other macromolecules in both large vessels and the microcirculation has been implicated in generation of cardiovascular disease...
  46. ncbi request reprint Evidence for restriction of fluid and solute movement across the glomerular capillary wall by the subpodocyte space
    Andrew H J Salmon
    ZNI 335, Zilkha Neurogenetic Institute, 1501 San Pablo St, Keck School of Medicine, Univ of Southern California, Los Angeles, CA 90089, USA
    Am J Physiol Renal Physiol 293:F1777-86. 2007
    ..These observations indicate both ultrafiltration and hydraulic resistance imparted by the SPS, demonstrating the potential physiological contribution of the SPS to glomerular permeability...
  47. ncbi request reprint Alternative splicing in angiogenesis: the vascular endothelial growth factor paradigm
    Michael R Ladomery
    Centre for Research in Biomedicine, Bristol Genomics Research Institute, Faculty of Applied Sciences, University of the West of England, Coldharbour Lane, Bristol BS16 1QY, UK
    Cancer Lett 249:133-42. 2007
    ..Understanding what regulates VEGF(xxx)b alternative splicing, and therefore the balance of pro- and antiangiogenic isoforms is of great importance and will be explored in detail over the next few years...
  48. doi request reprint Vascular endothelial growth factor (VEGF)-A165b is a weak in vitro agonist for VEGF receptor-2 due to lack of coreceptor binding and deficient regulation of kinase activity
    Harukiyo Kawamura
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Cancer Res 68:4683-92. 2008
    ..Our data indicate that loss of VEGFR-2/NRP1 complex formation and Y1052 phosphorylation contribute to the lack of angiogenic properties of VEGF-A165b...