Lorraine Harper

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. doi request reprint Pulse versus daily oral cyclophosphamide for induction of remission in ANCA-associated vasculitis: long-term follow-up
    Lorraine Harper
    School of Immunity and Infection, University of Birmingham, Birmingham, UK
    Ann Rheum Dis 71:955-60. 2012
  2. pmc Long- term outcome of paediatric patients with ANCA vasculitis
    Nishkantha Arulkumaran
    Renal Section, Division of Medicine, Imperial College London, Hammersmith Hospital, DuCane Road, London W12 0NN, UK
    Pediatr Rheumatol Online J 9:12. 2011
  3. pmc Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis
    Edward J Carr
    Cambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Hills Road, Cambridge CB20XY, UK
    BMC Med Genet 10:121. 2009
  4. doi request reprint Recent advances to achieve remission induction in antineutrophil cytoplasmic antibody-associated vasculitis
    Lorraine Harper
    School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK
    Curr Opin Rheumatol 22:37-42. 2010
  5. ncbi request reprint ANCA-associated renal vasculitis at the end of the twentieth century--a disease of older patients
    L Harper
    Division of Immunlogy and Infection, The Medical School, University of Birmingham, Edgbaston, UK
    Rheumatology (Oxford) 44:495-501. 2005
  6. ncbi request reprint Propylthiouracil and carbimazole associated-antineutrophil cytoplasmic antibodies (ANCA) in patients with Graves' disease
    L Harper
    Division of Medical Sciences, University of Birmingham, Edgbaston, Birmingham, UK
    Clin Endocrinol (Oxf) 60:671-5. 2004
  7. ncbi request reprint The importance of resolution of inflammation in the pathogenesis of ANCA-associated vasculitis
    L Harper
    Division of Medical Sciences, University of Birmingham, Birmingham B15 2TT, UK
    Biochem Soc Trans 32:502-6. 2004
  8. ncbi request reprint ANCA-associated vasculitis: is there a role for neutrophil apoptosis in autoimmunity?
    Lorraine Harper
    Renal Immunobiology, Division of Infection and Immunity, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Expert Rev Clin Immunol 2:237-44. 2006
  9. ncbi request reprint Leukocyte-endothelial interactions in antineutrophil cytoplasmic antibody-associated systemic vasculitis
    L Harper
    Department of Renal Immunobiology, Medical Research Council Center for Immune Regulation, University of Birmingham Medical School, Edgbaston, Birmingham, United Kingdom
    Rheum Dis Clin North Am 27:887-903. 2001
  10. pmc Cytomegalovirus seropositivity is associated with increased arterial stiffness in patients with chronic kidney disease
    Nadezhda A Wall
    School of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom
    PLoS ONE 8:e55686. 2013

Detail Information

Publications57

  1. doi request reprint Pulse versus daily oral cyclophosphamide for induction of remission in ANCA-associated vasculitis: long-term follow-up
    Lorraine Harper
    School of Immunity and Infection, University of Birmingham, Birmingham, UK
    Ann Rheum Dis 71:955-60. 2012
    ..The study had limited power to detect a difference in relapse. This study describes the long-term outcomes of patients in the CYCLOPS study...
  2. pmc Long- term outcome of paediatric patients with ANCA vasculitis
    Nishkantha Arulkumaran
    Renal Section, Division of Medicine, Imperial College London, Hammersmith Hospital, DuCane Road, London W12 0NN, UK
    Pediatr Rheumatol Online J 9:12. 2011
    ..abstract:..
  3. pmc Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis
    Edward J Carr
    Cambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Hills Road, Cambridge CB20XY, UK
    BMC Med Genet 10:121. 2009
    ..We studied ten candidate loci on the basis of their immunoregulatory role and prior associations with type 1 diabetes (T1D). These included PTPN22, CTLA4 and CD226, which have previously been associated with AAV...
  4. doi request reprint Recent advances to achieve remission induction in antineutrophil cytoplasmic antibody-associated vasculitis
    Lorraine Harper
    School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK
    Curr Opin Rheumatol 22:37-42. 2010
    ..Significant advances in the treatment of antineutrophil cytoplasmic antibody-associated vasculitis have been made in the past 10 years. This review aims to detail advances in treatment aimed at induction of remission...
  5. ncbi request reprint ANCA-associated renal vasculitis at the end of the twentieth century--a disease of older patients
    L Harper
    Division of Immunlogy and Infection, The Medical School, University of Birmingham, Edgbaston, UK
    Rheumatology (Oxford) 44:495-501. 2005
    ..We aimed to examine the presentation, response to treatment and outcome of patients over 65 yr of age compared with a younger cohort...
  6. ncbi request reprint Propylthiouracil and carbimazole associated-antineutrophil cytoplasmic antibodies (ANCA) in patients with Graves' disease
    L Harper
    Division of Medical Sciences, University of Birmingham, Edgbaston, Birmingham, UK
    Clin Endocrinol (Oxf) 60:671-5. 2004
    ..We aimed to investigate whether carbimazole therapy was also associated with increased risk of ANCA...
  7. ncbi request reprint The importance of resolution of inflammation in the pathogenesis of ANCA-associated vasculitis
    L Harper
    Division of Medical Sciences, University of Birmingham, Birmingham B15 2TT, UK
    Biochem Soc Trans 32:502-6. 2004
    ..The autoimmune response may be promoted by aberrant phagocytosis of apoptotic neutrophils by dendritic cells. Understanding the pathogenesis can help to rationalize existing therapies and indicate new approaches to therapy...
  8. ncbi request reprint ANCA-associated vasculitis: is there a role for neutrophil apoptosis in autoimmunity?
    Lorraine Harper
    Renal Immunobiology, Division of Infection and Immunity, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Expert Rev Clin Immunol 2:237-44. 2006
    ..The autoimmune response may be promoted by aberrant phagocytosis of apoptotic neutrophils by dendritic cells. Understanding pathogenesis can help to rationalize existing therapies and indicate new approaches to therapy...
  9. ncbi request reprint Leukocyte-endothelial interactions in antineutrophil cytoplasmic antibody-associated systemic vasculitis
    L Harper
    Department of Renal Immunobiology, Medical Research Council Center for Immune Regulation, University of Birmingham Medical School, Edgbaston, Birmingham, United Kingdom
    Rheum Dis Clin North Am 27:887-903. 2001
    ....
  10. pmc Cytomegalovirus seropositivity is associated with increased arterial stiffness in patients with chronic kidney disease
    Nadezhda A Wall
    School of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom
    PLoS ONE 8:e55686. 2013
    ..We examined whether CMV seropositivity was associated with increased arterial stiffness in patients with chronic kidney disease...
  11. doi request reprint Neutrophil serine proteases mediate inflammatory cell recruitment by glomerular endothelium and progression towards dysfunction
    Sahithi J Kuravi
    Schools of Immunity and Infection, University of Birmingham, Birmingham, UK
    Nephrol Dial Transplant 27:4331-8. 2012
    ..This study investigated the stages and mechanisms through which neutrophil serine proteases (SPs), proteinase 3 (PR3) or elastase contribute to endothelial dysfunction...
  12. ncbi request reprint ANCA-associated vasculitis: new options beyond steroids and cytotoxic drugs
    Umut Selamet
    University of Birmingham, Division of Immunity and Infection, The Medical School, Edgbaston, Birmingham, B15 2TT, UK
    Expert Opin Investig Drugs 16:689-703. 2007
    ..Gene therapy with targeted delivery of specific proteins is an exciting future prospect...
  13. pmc Cardiovascular effects of sevelamer in stage 3 CKD
    Colin D Chue
    Schools of Clinical and Experimental Medicine, University of Birmingham, Birmingham, United Kingdom
    J Am Soc Nephrol 24:842-52. 2013
    ..In conclusion, this study does not provide evidence that sevelamer carbonate improves LV mass, LV function, or arterial stiffness in stage 3 nondiabetic CKD...
  14. ncbi request reprint Early mortality in systemic vasculitis: relative contribution of adverse events and active vasculitis
    Mark A Little
    Renal Institute of Birmingham, School of Infection, Immunity and Inflammation, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK
    Ann Rheum Dis 69:1036-43. 2010
    ..To contrast the effect of the burden of vasculitis activity with the burden of adverse events on 1-year mortality of patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV)...
  15. ncbi request reprint ANCA-positive vasculitis
    Lavanya Kamesh
    Renal Immunobiology, Division of Medical Sciences, The Medical School, University of Birmingham, Birmingham B15 277, UK
    J Am Soc Nephrol 13:1953-60. 2002
  16. doi request reprint Increased incidence of cardiovascular events in patients with antineutrophil cytoplasmic antibody-associated vasculitides: a matched-pair cohort study
    Matthew D Morgan
    University of Birmingham, Birmingham, UK
    Arthritis Rheum 60:3493-500. 2009
    ..To explore the risk of cardiovascular disease in patients with antineutrophil cytoplasmic antibody-associated vasculitides (AAVs) and to assess contributing risk factors...
  17. ncbi request reprint Recurrences and infections during continuous immunosuppressive therapy after beginning dialysis in ANCA-associated vasculitis
    Frauke Weidanz
    Division of Immunity and Infection, University of Birmingham, Edgbaston, Birmingham, UK
    Am J Kidney Dis 50:36-46. 2007
    ..It is not clear whether continuation of immunosuppression, with its associated risks, is beneficial because relapse rates after the development of ESRF are reported to be low...
  18. doi request reprint Adverse effects of therapy for ANCA-associated vasculitis
    Jennifer Turnbull
    Renal Immunobiology, Division of Immunity and Infection, University of Birmingham, Birmingham, UK
    Best Pract Res Clin Rheumatol 23:391-401. 2009
    ..In addition, disease damage, particularly renal failure, increases the risk of toxicity. Improvements in disease management should include the increased awareness of treatment-related toxicity and its prevention...
  19. doi request reprint ANCA-associated vasculitis: from bench research to novel treatments
    Lalit Pallan
    University of Birmingham and University Hospital Birmingham NHS Foundation Trust, Birmingham, UK
    Nat Rev Nephrol 5:278-86. 2009
    ..Future potential therapies include molecules that block signaling pathways that are essential in the pathogenesis of these diseases...
  20. doi request reprint Vasculitic IgA nephropathy: prognosis and outcome
    Tanya Pankhurst
    Department of Immunity and Infection, Institute of Biomedical Research Medical School, University of Birmingham, Edgbaston Birmingham, UK
    Nephron Clin Pract 112:c16-24. 2009
    ..A vasculitic glomerulonephritis is seen in both IgA nephropathy and Henoch-Schonlein purpura. No study has examined prognostic factors in vasculitic IgA nephropathy...
  21. pmc Caveolin-1 single nucleotide polymorphism in antineutrophil cytoplasmic antibody associated vasculitis
    Sourabh Chand
    Centre for Translational Inflammation Research, University of Birmingham, Birmingham, United Kingdom
    PLoS ONE 8:e69022. 2013
    ..Its functional role has been associated with these complications. For the first time, caveolin-1 (CAV1) gene variation is studied in AAV...
  22. pmc Podocytes Regulate Neutrophil Recruitment by Glomerular Endothelial Cells via IL-6-Mediated Crosstalk
    Sahithi J Kuravi
    Centre for Translational Inflammation Research, School of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Immunol 193:234-43. 2014
    ..In summary, these studies reveal that podocytes can negatively regulate neutrophil recruitment to inflamed GEnCs by modulating IL-6 signaling, identifying a potential novel anti-inflammatory role of IL-6 in renal glomeruli. ..
  23. pmc PR3 and elastase alter PAR1 signaling and trigger vWF release via a calcium-independent mechanism from glomerular endothelial cells
    Samantha P Tull
    Schools of Immunity and Infection, College of Medicine and Dentistry, University of Birmingham, Birmingham, United Kingdom
    PLoS ONE 7:e43916. 2012
    ..Neither protease induced a calcium response in GEC. Therefore, PAR signaling and serine protease-induced alterations in endothelial function modulate glomerular inflammation via parallel but independent pathways...
  24. doi request reprint Complications of long-term therapy for ANCA-associated systemic vasculitis
    Nadezhda Wall
    University of Birmingham Medical School, Division of Infection and Immunity, Edgbaston, Birmingham B15 2TT, UK
    Nat Rev Nephrol 8:523-32. 2012
    ..The challenge for the future is to develop specific therapies with improved safety profiles that can cure these diseases...
  25. doi request reprint Addition of infliximab to standard therapy for ANCA-associated vasculitis
    Matthew D Morgan
    Renal Immunobiology, School of Immunity and Infection, The Medical School, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK m d morgan bham ac uk
    Nephron Clin Pract 117:c89-97. 2011
    ....
  26. doi request reprint Does immunosuppressant medication lower blood pressure and arterial stiffness in patients with chronic kidney disease? An observational study
    Charles J Ferro
    Department of Nephrology, University of Birmingham and University Hospital Birmingham, Birmingham, UK
    Hypertens Res 34:113-9. 2011
    ..5 ± 1.8 vs. 8.8 ± 1.9 m s(-1); P = 0.02). This study suggests that immunosuppression might be a method of reducing blood pressure and arterial stiffness in patients with chronic kidney disease...
  27. doi request reprint CT60 and +49 polymorphisms of CTLA 4 are associated with ANCA-positive small vessel vasculitis
    Lavanya Kamesh
    Renal Unit, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
    Rheumatology (Oxford) 48:1502-5. 2009
    ..To investigate whether single nucleotide polymorphisms (SNPs) within cytotoxic T-lymphocyte antigen-4 (CTLA-4) are associated with ANCA-associated small vessel vasculitis (SVV)...
  28. ncbi request reprint Neutrophil priming and apoptosis in anti-neutrophil cytoplasmic autoantibody-associated vasculitis
    L Harper
    Renal Immunobiology, MRC Centre for Immune Regulation, The Medical School, University of Birmingham, Birmingham, England, United Kingdom
    Kidney Int 59:1729-38. 2001
    ..These antigens may then provide targets for ANCA. Opsonization of apoptotic PMN will enhance clearance by macrophages but will also trigger the release of pro-inflammatory cytokines that may contribute to chronic inflammation...
  29. pmc A dual role for diacylglycerol kinase generated phosphatidic acid in autoantibody-induced neutrophil exocytosis
    Neil J Holden
    Renal Immunobiology, School of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom
    Mol Med 17:1242-52. 2011
    ..PA and its associated pathways may represent viable drug targets to reduce tissue injury associated with ANCA-associated vasculitic diseases and other neutrophilic inflammatory disorders...
  30. pmc Patients with Wegener's granulomatosis demonstrate a relative deficiency and functional impairment of T-regulatory cells
    Matthew D Morgan
    Renal Immunobiology, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
    Immunology 130:64-73. 2010
    ..This information is of value in understanding the pathogenesis and potential treatment of this disease...
  31. ncbi request reprint Pulmonary infection in Wegener granulomatosis and idiopathic pulmonary fibrosis
    A G Richter
    Lung Investigation Unit, 1st floor Nuffield House, Birmingham, UK
    Thorax 64:692-7. 2009
    ..Wegener granulomatosis (WG) has previously been associated with increased nasal carriage of Staphylococcus aureus, but no studies have investigated the occurrence of pathogen growth in the lower airways...
  32. pmc Hypogalactosylation of serum IgG in patients with ANCA-associated systemic vasculitis
    M Holland
    MRC Centre for Immune Regulation, The Medical School, University of Birmingham, UK
    Clin Exp Immunol 129:183-90. 2002
    ..Both of these activities could impact on the processing and presentation of self-antigens in autoimmune disease...
  33. ncbi request reprint IgG from myeloperoxidase-antineutrophil cytoplasmic antibody-positive patients stimulates greater activation of primed neutrophils than IgG from proteinase 3-antineutrophil cytosplasmic antibody-positive patients
    L Harper
    University of Birmingham, Edgbaston, UK
    Arthritis Rheum 44:921-30. 2001
    ..Differences in activation of PMN by these antibodies may determine some differences between WG and MPA...
  34. ncbi request reprint Treatment of vasculitic IgA nephropathy
    L Harper
    Department of Nephrology, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK
    J Nephrol 13:360-6. 2000
    ..We performed a retrospective study to assess whether treatment with steroids and immunosuppressants would preserve renal function by healing these lesions and thereby prevent progression to glomerular sclerosis and renal failure...
  35. ncbi request reprint Pulmonary manifestations of anti-neutrophil cytoplasmic antibody (ANCA)-positive vasculitis
    D R Thickett
    Lung Injury and Fibrosis Treatment Programme, Department of Medical Sciences, Division of Infection and Immunity, Medical School, University of Birmingham, Birmingham, UK
    Rheumatology (Oxford) 45:261-8. 2006
  36. ncbi request reprint IL-18 is upregulated in the kidney and primes neutrophil responsiveness in ANCA-associated vasculitis
    P Hewins
    Renal Immunobiology, Medical School, University of Birmingham, Birmingham, UK
    Kidney Int 69:605-15. 2006
    ..We conclude that IL-18 is likely to be important for neutrophil recruitment and priming in ASV. Therapies targeting single priming agents may have limited efficacy in controlling disease...
  37. ncbi request reprint Mannose-binding lectin gene polymorphisms in a cohort study of ANCA-associated small vessel vasculitis
    L Kamesh
    Division of Immunity and Infection, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Rheumatology (Oxford) 46:1076-8. 2007
    ....
  38. doi request reprint CD4+CD28- T cell expansion in granulomatosis with polyangiitis (Wegener's) is driven by latent cytomegalovirus infection and is associated with an increased risk of infection and mortality
    Matthew D Morgan
    University of Birmingham, Birmingham, UK
    Arthritis Rheum 63:2127-37. 2011
    ..We undertook this study to investigate whether CMV infection may be responsible for driving the expansion of CD4+CD28- T cells in GPA patients and how this might relate to clinical features...
  39. ncbi request reprint New findings in pathogenesis of antineutrophil cytoplasm antibody-associated vasculitis
    Caroline O S Savage
    Division of Medical Sciences, The Medical School, University of Birmingham, Edgbaston, Birmingham, United Kingdom
    Curr Opin Rheumatol 14:15-22. 2002
    ..It is likely that environmental factors operate against a background genetic susceptibility, and polymorphisms in genes for proteins associated with inflammation are being tested for possible links with small vessel vasculitides...
  40. doi request reprint Renal transplantation in systemic vasculitis: when is it safe?
    Mark A Little
    Renal Institute of Birmingham, School of Immunity, Infection and Inflammation, University of Birmingham, Birmingham, UK
    Nephrol Dial Transplant 24:3219-25. 2009
    ..There are no clear guidelines on renal transplantation in patients with antineutrophil cytoplasmic antibody (ANCA)-positive vasculitis...
  41. ncbi request reprint ANCA-associated vasculitides-lessons from the adult literature
    Joannis Vamvakopoulos
    School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK
    Pediatr Nephrol 25:1397-407. 2010
    ..Meeting this challenge will require international collaboration, not only among paediatricians but also with the specialists taking over care of these patients as they reach adulthood...
  42. ncbi request reprint Anti-neutrophil cytoplasm-associated glomerulonephritis
    Matthew David Morgan
    Division of Immunity and Infection, The Medical School, University of Birmingham, Vincent Drive, Birmingham, United Kingdom
    J Am Soc Nephrol 17:1224-34. 2006
    ..Consideration is given to recent clinical trials in the management of anti-neutrophil cytoplasm antibodies (ANCA)-associated vasculitides...
  43. ncbi request reprint Impairment of lung function, health status and functional capacity in patients with ANCA-associated vasculitis
    C Newall
    Division of Immunity and Infection, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Rheumatology (Oxford) 44:623-8. 2005
    ..To determine the effects of lung involvement on respiratory function in patients with ANCA-associated vasculitis and the relation to impaired health status...
  44. doi request reprint Predictors and consequences of fatigue in prevalent kidney transplant recipients
    Winnie Chan
    1 Department of Nephrology and Kidney Transplantation, Queen Elizabeth Hospital Birmingham, Birmingham, UK 2 Department of Nutrition and Dietetics, Queen Elizabeth Hospital Birmingham, Birmingham, UK 3 School of Sport and Exercise Sciences, The University of Birmingham, Birmingham, UK 4 Division of Metabolic and Vascular Health, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry, UK 5 Centre for Translational Inflammation Research, University of Birmingham Research Laboratories, Queen Elizabeth Hospital Birmingham, Birmingham, UK 6 Address correspondence to Richard Borrows, M A, Department of Nephrology and Kidney Transplantation, Queen Elizabeth Hospital Birmingham, Area 5, Level 7, Mindelsohn Way, Edgbaston, Birmingham B15 2WB, UK
    Transplantation 96:987-94. 2013
    ....
  45. ncbi request reprint Effect of verocytotoxins (Shiga-like toxins) on human neutrophils in vitro
    Julie U Holle
    Department of Renal Immunobiology, The Medical School, University of Birmingham, Birmingham, B15 2TT, UK
    Pediatr Nephrol 20:1237-44. 2005
    ..In conclusion, VT1 and VT2 do not activate primed neutrophils in vitro. Nor do they affect chemotaxis towards fMLP. They may impair neutrophil priming...
  46. ncbi request reprint Dendritic cell uptake of human apoptotic and necrotic neutrophils inhibits CD40, CD80, and CD86 expression and reduces allogeneic T cell responses: relevance to systemic vasculitis
    Abigail R Clayton
    MRC Centre for Immune Regulation, University of Birmingham Medical School, Birmingham B15 2TT, UK
    Arthritis Rheum 48:2362-74. 2003
    ..This study was undertaken to investigate the effects of human apoptotic and necrotic neutrophils on human dendritic cell (DC) phenotype and ability to stimulate allogeneic T cell proliferation...
  47. doi request reprint Soluble endostatin is a novel inhibitor of epithelial repair in idiopathic pulmonary fibrosis
    A G Richter
    Lung Injury and Fibrosis Treatment Programme, Department of Medical Sciences, Medical School, University of Birmingham, Birmingham, UK
    Thorax 64:156-61. 2009
    ..This study aimed to establish the levels of endostatin in the bronchoalveolar lavage fluid (BALF) in IPF and to investigate its actions on distal lung epithelial cells (DLEC) and primary type II cells...
  48. ncbi request reprint Adjuvant treatment of patients with antineutrophil cytoplasmic antibody-associated vasculitis with vitamins E and C reduces superoxide production by neutrophils
    L Harper
    MRC Centre for Immune Regulation, Department of Medicine, The Medical School, Birmingham University, Edgbaston, Birmingham B15 2TT, UK
    Rheumatology (Oxford) 41:274-8. 2002
    ....
  49. ncbi request reprint Malignancy is increased in ANCA-associated vasculitis
    T Pankhurst
    Division of Medical Sciences, The Medical School, University of Birmingham, Birmingham, UK
    Rheumatology (Oxford) 43:1532-5. 2004
    ....
  50. ncbi request reprint Plasmapheresis in nephrology: an update
    Tahmina Rahman
    Division of Medical Sciences, University of Birmingham, Edgbaston, Birmingham, UK
    Curr Opin Nephrol Hypertens 15:603-9. 2006
    ..In the past, recommendations for the use of plasmapheresis were based on findings reported from pilot studies or anecdotes. New results from several randomized controlled trials have changed the indications for the use of plasma exchange...
  51. doi request reprint ANCA-associated vasculitis is linked to carriage of the Z allele of α₁ antitrypsin and its polymers
    H Morris
    School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
    Ann Rheum Dis 70:1851-6. 2011
    ..Small studies have linked α1 antitrypsin (α1AT) deficiency to patients with antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV)...
  52. ncbi request reprint Anti-endothelial cell antibodies from lupus patients bind to apoptotic endothelial cells promoting macrophage phagocytosis but do not induce apoptosis
    J M Williams
    Division of Immunity and Infection, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Rheumatology (Oxford) 44:879-84. 2005
    ..Anti-endothelial cell antibodies (AECA) have been reported to induce apoptosis. We investigated the induction of apoptosis by these autoantibodies and their involvement in the removal of apoptotic cells...
  53. ncbi request reprint Translational research in autoimmunity: aims of therapy in vasculitis
    R Watts
    Rheumatology (Oxford) 44:573-6. 2005
  54. ncbi request reprint Interest of laparoscopy in polysplenia syndrome
    L Harper
    Department of Paediatric Surgery, centre hospitalier départemental Félix Guyon, Saint Denis de La Réunion, France
    Eur J Pediatr Surg 13:417-20. 2003
    ..We performed a laparoscopic Ladd's procedure followed by fixation of the accessory spleen and resection of Meckel's diverticulum through a short left-flank incision...
  55. pmc Proximal femoral structure and the prediction of hip fracture in men: a large prospective study using QCT
    Dennis M Black
    Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94107, USA
    J Bone Miner Res 23:1326-33. 2008
    ....
  56. ncbi request reprint The parapelvic renal cyst. A rare aetiology of blood hypertension in children
    E Dobremez
    Department of Paediatric Surgery, Hôpital Pellegrin Enfants, Bordeaux, France
    Eur J Pediatr Surg 16:61-3. 2006
    ..Surgical resection was performed. Normotension returned within 3 months, and the obstruction disappeared. A renovascular mechanism can be evoked to explain hypertension...
  57. pmc Beta blocker treatment is associated with improvement in renal function and anaemia in patients with heart failure
    W Khan
    Heart 92:1856-7. 2006