Margaret M Harnett

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. ncbi request reprint Antigen receptor signaling is subverted by an immunomodulatory product secreted by a filarial nematode
    M M Harnett
    Department of Immunology, University of Glasgow, UK
    Arch Immunol Ther Exp (Warsz) 49:263-9. 2001
  2. pmc The therapeutic potential of the filarial nematode-derived immunodulator, ES-62 in inflammatory disease
    M M Harnett
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Centre, University of Glasgow, Glasgow, UK
    Clin Exp Immunol 159:256-67. 2010
  3. ncbi request reprint Differential signalling during B-cell maturation
    Margaret M Harnett
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow G116NT, UK
    Immunol Lett 98:33-44. 2005
  4. ncbi request reprint Laser scanning cytometry: understanding the immune system in situ
    Margaret M Harnett
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, G12 8TA, UK
    Nat Rev Immunol 7:897-904. 2007
  5. ncbi request reprint CD40: a growing cytoplasmic tale
    Margaret M Harnett
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow G11 6NT, UK
    Sci STKE 2004:pe25. 2004
  6. ncbi request reprint Immunology. B cells spread and gather
    Margaret M Harnett
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK
    Science 312:709-10. 2006
  7. pmc In vivo exposure of murine dendritic cell and macrophage bone marrow progenitors to the phosphorylcholine-containing filarial nematode glycoprotein ES-62 polarizes their differentiation to an anti-inflammatory phenotype
    Helen S Goodridge
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, United Kingdom
    Immunology 113:491-8. 2004
  8. pmc Effect of activated antigen-specific B cells on ES-62-mediated modulation of effector function of heterologous antigen-specific T cells in vivo
    Fraser A Marshall
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
    Immunology 123:411-25. 2008
  9. ncbi request reprint Immunomodulation via novel use of TLR4 by the filarial nematode phosphorylcholine-containing secreted product, ES-62
    Helen S Goodridge
    Division of Immunology, Infection, and Inflammation, University of Glasgow, Western Infirmary, Dumbarton Road, Glasgow G11 6NT, Scotland, UK
    J Immunol 174:284-93. 2005
  10. ncbi request reprint FcgammaRIIb-mediated negative regulation of BCR signalling is associated with the recruitment of the MAPkinase-phosphatase, Pac-1, and the 3'-inositol phosphatase, PTEN
    Kirsty S Brown
    Division of Immunology, Infection and Inflammation, University of Glasgow, Western Infirmary, Dumbarton Road, Glasgow G11 6NT, Scotland, UK
    Cell Signal 16:71-80. 2004

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Antigen receptor signaling is subverted by an immunomodulatory product secreted by a filarial nematode
    M M Harnett
    Department of Immunology, University of Glasgow, UK
    Arch Immunol Ther Exp (Warsz) 49:263-9. 2001
    ....
  2. pmc The therapeutic potential of the filarial nematode-derived immunodulator, ES-62 in inflammatory disease
    M M Harnett
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Centre, University of Glasgow, Glasgow, UK
    Clin Exp Immunol 159:256-67. 2010
    ....
  3. ncbi request reprint Differential signalling during B-cell maturation
    Margaret M Harnett
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow G116NT, UK
    Immunol Lett 98:33-44. 2005
    ..Thus, the combined signature of BCR signalling is likely to dictate the functional response and act as a developmental checkpoint for B-cell maturation...
  4. ncbi request reprint Laser scanning cytometry: understanding the immune system in situ
    Margaret M Harnett
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, G12 8TA, UK
    Nat Rev Immunol 7:897-904. 2007
    ..This article describes the technology and its potential for delineating the molecular and cellular events underpinning the immune response in health and disease...
  5. ncbi request reprint CD40: a growing cytoplasmic tale
    Margaret M Harnett
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow G11 6NT, UK
    Sci STKE 2004:pe25. 2004
    ..The roles of the phosphoinositide 3-kinase, mitogen-activated protein kinase, and nuclear factor kappaB pathways in mediating CD40 stimulation of the cell cycle are described...
  6. ncbi request reprint Immunology. B cells spread and gather
    Margaret M Harnett
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK
    Science 312:709-10. 2006
  7. pmc In vivo exposure of murine dendritic cell and macrophage bone marrow progenitors to the phosphorylcholine-containing filarial nematode glycoprotein ES-62 polarizes their differentiation to an anti-inflammatory phenotype
    Helen S Goodridge
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, United Kingdom
    Immunology 113:491-8. 2004
    ..Such a finding could have important implications for the use of pathogen products or their derivatives for immunotherapy...
  8. pmc Effect of activated antigen-specific B cells on ES-62-mediated modulation of effector function of heterologous antigen-specific T cells in vivo
    Fraser A Marshall
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
    Immunology 123:411-25. 2008
    ..Collectively, these results suggest that whilst ES-62 can target B-T-cell co-operation, this does not promote polarizing of T-cell responses towards a Th2-type phenotype...
  9. ncbi request reprint Immunomodulation via novel use of TLR4 by the filarial nematode phosphorylcholine-containing secreted product, ES-62
    Helen S Goodridge
    Division of Immunology, Infection, and Inflammation, University of Glasgow, Western Infirmary, Dumbarton Road, Glasgow G11 6NT, Scotland, UK
    J Immunol 174:284-93. 2005
    ....
  10. ncbi request reprint FcgammaRIIb-mediated negative regulation of BCR signalling is associated with the recruitment of the MAPkinase-phosphatase, Pac-1, and the 3'-inositol phosphatase, PTEN
    Kirsty S Brown
    Division of Immunology, Infection and Inflammation, University of Glasgow, Western Infirmary, Dumbarton Road, Glasgow G11 6NT, Scotland, UK
    Cell Signal 16:71-80. 2004
    ....
  11. ncbi request reprint In vivo activation of murine peritoneal B1 cells by the filarial nematode phosphorylcholine-containing glycoprotein ES-62
    Emma H Wilson
    Department of Immunology, Strathclyde Institute of Biomedical Sciences, University of Strathclyde, Glasgow, UK
    Parasite Immunol 25:463-6. 2003
    ....
  12. pmc Signalling mechanisms underlying subversion of the immune response by the filarial nematode secreted product ES-62
    Helen S Goodridge
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow G11 6NT, UK
    Immunology 115:296-304. 2005
    ..In this review we discuss the immunomodulatory effects of the phosphorylcholine-containing filarial nematode-secreted glycoprotein ES-62 and describe the intracellular signal transduction pathways it targets to achieve these effects...
  13. pmc Hyporesponsiveness of murine B lymphocytes exposed to the filarial nematode secreted product ES-62 in vivo
    Emma H Wilson
    Department of Immunology, University of Strathclyde, Glasgow, UK
    Immunology 109:238-45. 2003
    ..This finding considerably strengthens the idea that ES-62 plays a role in evasion of the immune response during parasitism...
  14. ncbi request reprint Filarial nematode secreted product ES-62 is an anti-inflammatory agent: therapeutic potential of small molecule derivatives and ES-62 peptide mimetics
    William Harnett
    Department of Immunology, University of Strathclyde, Glasgow, UK
    Clin Exp Pharmacol Physiol 33:511-8. 2006
    ....
  15. ncbi request reprint ES-62, an immunomodulator secreted by filarial nematodes, suppresses clonal expansion and modifies effector function of heterologous antigen-specific T cells in vivo
    Fraser A Marshall
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, United Kingdom
    J Immunol 175:5817-26. 2005
    ....
  16. pmc Protection against collagen-induced arthritis in mice afforded by the parasitic worm product, ES-62, is associated with restoration of the levels of interleukin-10-producing B cells and reduced plasma cell infiltration of the joints
    David T Rodgers
    Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK
    Immunology 141:457-66. 2014
    ....
  17. ncbi request reprint Differences in the kinetics, amplitude, and localization of ERK activation in anergy and priming revealed at the level of individual primary T cells by laser scanning cytometry
    Claire L Adams
    Division of Immunology, Infection and Inflammation, University of Glasgow, Western Infirmary, Glasgow, United Kingdom
    J Immunol 173:1579-86. 2004
    ..These data suggest that the different consequences of Ag recognition by T cells are associated with distinctive kinetics, amplitude, and localization of MAPK signaling...
  18. pmc Differential regulation of interleukin-12 p40 and p35 induction via Erk mitogen-activated protein kinase-dependent and -independent mechanisms and the implications for bioactive IL-12 and IL-23 responses
    Helen S Goodridge
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
    Immunology 109:415-25. 2003
    ....
  19. ncbi request reprint Direct quantitation of T cell signaling by laser scanning cytometry
    Angela M Grierson
    Division of Immunology, Infection and Inflammation, Western Infirmary, University of Glasgow, Glasgow, G11 6NT, UK
    J Immunol Methods 301:140-53. 2005
    ..The purpose of this protocol is to describe in vitro and ex vivo methods for quantifying cell signaling molecule expression and activation within antigen-specific T cells by laser scanning cytometry...
  20. ncbi request reprint Inverse Rap1 and phospho-ERK expression discriminate the maintenance phase of tolerance and priming of antigen-specific CD4+ T cells in vitro and in vivo
    Angela M Morton
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
    J Immunol 179:8026-34. 2007
    ....
  21. ncbi request reprint Bcl-(xL) antagonism of BCR-coupled mitochondrial phospholipase A(2) signaling correlates with protection from apoptosis in WEHI-231 B cells
    Elad Katz
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, United Kingdom
    Blood 103:168-76. 2004
    ....
  22. ncbi request reprint Subversion of immunological signalling by a filarial nematode phosphorylcholine-containing secreted product
    Helen S Goodridge
    Division of Immunology, Infection and Inflammation, University of Glasgow, Western Infirmary, Dumbarton Road, Glasgow G11 6NT, UK
    Cell Signal 17:11-6. 2005
    ....
  23. ncbi request reprint ES-62, a filarial nematode-derived immunomodulator with anti-inflammatory potential
    William Harnett
    Department of Immunology, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, UK
    Immunol Lett 94:27-33. 2004
    ..The nematode product was also able to suppress pro-inflammatory cytokine release in vitro in synovial cells derived from RA patients. ES-62 thus constitutes a pathogen-derived immunomodulator with significant therapeutic potential...
  24. doi request reprint The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17-producing cellular network at multiple sites
    Miguel A Pineda
    University of Glasgow, Glasgow, UK
    Arthritis Rheum 64:3168-78. 2012
    ..Since interleukin-17 (IL-17) has been reported to play a pathogenic role in the development of RA, this study was undertaken to investigate whether targeting of IL-17 may explain the protection against CIA afforded by ES-62...
  25. doi request reprint Laser scanning cytometry: capturing the immune system in situ
    Mairi A McGrath
    Institute of Infection, Immunity and Inflammation, College of Medical Veterinary and Life Sciences, Glasgow Biomedical Research Centre, University of Glasgow, Scotland, UK
    Methods Cell Biol 102:231-60. 2011
    ....
  26. ncbi request reprint Differential polarization of immune responses by plant 2S seed albumins, Ber e 1, and SFA8
    Dorothy E Kean
    Division of Immunology, Infection, and Inflammation, University of Glasgow, Glasgow, UK
    J Immunol 177:1561-6. 2006
    ..Overall, our data are consistent with the idea that the ability of Ber e 1, but not SFA8, to act as a potent allergen may reflect differences in their ability to induce IL-12 production...
  27. ncbi request reprint Immunomodulatory activity and therapeutic potential of the filarial nematode secreted product, ES-62
    William Harnett
    Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK
    Adv Exp Med Biol 666:88-94. 2009
    ..As a consequence of this, ES-62 demonstrates striking drug-like activity in models of disease associated with aberrant inflammation, in particular those associated with autoimmunity and allergy...
  28. ncbi request reprint What causes lymphocyte hyporesponsiveness during filarial nematode infection?
    William Harnett
    Department of Immunology, University of Strathclyde, Glasgow, UK
    Trends Parasitol 22:105-10. 2006
    ..The consistency of this observation, allied to the ease of measurement of lymphocyte hyporesponsiveness, has resulted in many attempts to understand its cause...
  29. ncbi request reprint The anti-inflammatory potential of the filarial nematode secreted product, ES-62
    William Harnett
    Department of Immunology, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, UK
    Curr Top Med Chem 4:553-9. 2004
    ..The nematode product was also found to inhibit pro-inflammatory cytokine release in vitro in synovial cells derived from RA patients. ES-62 thus represents a parasite-derived immunomodulator with significant therapeutic potential...
  30. ncbi request reprint ES-62 protects against collagen-induced arthritis by resetting interleukin-22 toward resolution of inflammation in the joints
    Miguel A Pineda
    University of Glasgow, Glasgow, UK
    Arthritis Rheumatol 66:1492-503. 2014
    ..The present study was undertaken to investigate whether the protection against joint damage afforded by ES-62 also reflects suppression of IL-22...
  31. doi request reprint Immune complex-mediated co-ligation of the BCR with FcγRIIB results in homeostatic apoptosis of B cells involving Fas signalling that is defective in the MRL/Lpr model of systemic lupus erythematosus
    Verica Paunovic
    Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow G12 8TA, UK
    J Autoimmun 39:332-46. 2012
    ..As these mice develop spontaneous, immune complex-driven lupus-like glomerulonephritis, targeting this FcγRIIB-mediated apoptotic pathway may therefore have novel therapeutic implications for systemic autoimmune disease...
  32. doi request reprint Helminth-derived immunomodulators: can understanding the worm produce the pill?
    William Harnett
    Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK
    Nat Rev Immunol 10:278-84. 2010
    ....
  33. ncbi request reprint Immunomodulatory properties of Ascaris suum glycosphingolipids - phosphorylcholine and non-phosphorylcholine-dependent effects
    Maureen R Deehan
    Department of Immunology, University of Glasgow, UK
    Parasite Immunol 24:463-9. 2002
    ..Overall these data indicate that PC-containing glycosphingolipids of A. suum appear to have at least two immunomodulatory constituents - PC and an as yet unknown component...
  34. ncbi request reprint Therapeutic immunomodulators from nematode parasites
    William Harnett
    Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK
    Expert Rev Mol Med 10:e18. 2008
    ..The recent and future use of nematodes and their products in treating human disease are also discussed...
  35. pmc Mast Cell Subsets and Their Functional Modulation by the Acanthocheilonema viteae Product ES-62
    Dimity H Ball
    Centre for Immunobiology, Glasgow Biomedical Research Centre, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK
    J Parasitol Res 2013:961268. 2013
    ....
  36. ncbi request reprint ES-62, a therapeutic anti-inflammatory agent evolved by the filarial nematode Acanthocheilonema viteae
    Miguel A Pineda
    Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow G12 8TA, UK
    Mol Biochem Parasitol 194:1-8. 2014
    ..Finally, we discuss recent results showing that it is possible to synthetise small molecule analogues (SMAs) that mimic the anti-inflammatory properties of ES-62, opening an exciting new drug development field in translational medicine. ..
  37. ncbi request reprint Mitogen-activated protein kinases as therapeutic targets for rheumatoid arthritis
    Verica Paunovic
    Institute of Infection, Immunity and Inflammation, College of Medical Veterinary and Life Sciences, MVLS, University of Glasgow, Glasgow G12 8TA, UK
    Drugs 73:101-15. 2013
    ..Their potential as therapies in the management of RA is also discussed...
  38. ncbi request reprint Differential roles for extracellularly regulated kinase-mitogen-activated protein kinase in B cell antigen receptor-induced apoptosis and CD40-mediated rescue of WEHI-231 immature B cells
    Stephen B Gauld
    Department of Immunology and Bacteriology, University of Glasgow, Glasgow, United Kingdom
    J Immunol 168:3855-64. 2002
    ..Erk-MAP kinase can therefore induce diverse biological responses in WEHI-231 cells depending on the context and kinetics of activation...
  39. ncbi request reprint Differentiation of the human monocyte cell line, U937, with dibutyryl cyclicAMP induces the expression of the inhibitory Fc receptor, FcgammaRIIb
    Angus J M Cameron
    Department of Medicine and Therapeutics, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
    Immunol Lett 83:171-9. 2002
    ..These data define a role for FcgammaRIIb in the modulation of immune complex mediated macrophage activation in a human model system...
  40. ncbi request reprint A novel MyD-1 (SIRP-1alpha) signaling pathway that inhibits LPS-induced TNFalpha production by monocytes
    Rosemary E Smith
    Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, United Kingdom
    Blood 102:2532-40. 2003
    ..MyD-1-coupling to this PI 3-kinase-dependent signaling pathway may therefore present a novel target for the development of therapeutic strategies for combating TNFalpha production and consequent inflammatory disease...