Margaret M Harnett

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. ncbi Antigen receptor signaling is subverted by an immunomodulatory product secreted by a filarial nematode
    M M Harnett
    Department of Immunology, University of Glasgow, UK
    Arch Immunol Ther Exp (Warsz) 49:263-9. 2001
  2. ncbi Differential signalling during B-cell maturation
    Margaret M Harnett
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow G116NT, UK
    Immunol Lett 98:33-44. 2005
  3. ncbi Immunology. B cells spread and gather
    Margaret M Harnett
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK
    Science 312:709-10. 2006
  4. ncbi Laser scanning cytometry: understanding the immune system in situ
    Margaret M Harnett
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, G12 8TA, UK
    Nat Rev Immunol 7:897-904. 2007
  5. ncbi The therapeutic potential of the filarial nematode-derived immunodulator, ES-62 in inflammatory disease
    M M Harnett
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Centre, University of Glasgow, Glasgow, UK
    Clin Exp Immunol 159:256-67. 2010
  6. ncbi CD40: a growing cytoplasmic tale
    Margaret M Harnett
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow G11 6NT, UK
    Sci STKE 2004:pe25. 2004
  7. ncbi In vivo exposure of murine dendritic cell and macrophage bone marrow progenitors to the phosphorylcholine-containing filarial nematode glycoprotein ES-62 polarizes their differentiation to an anti-inflammatory phenotype
    Helen S Goodridge
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, United Kingdom
    Immunology 113:491-8. 2004
  8. ncbi Effect of activated antigen-specific B cells on ES-62-mediated modulation of effector function of heterologous antigen-specific T cells in vivo
    Fraser A Marshall
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
    Immunology 123:411-25. 2008
  9. ncbi Immunomodulation via novel use of TLR4 by the filarial nematode phosphorylcholine-containing secreted product, ES-62
    Helen S Goodridge
    Division of Immunology, Infection, and Inflammation, University of Glasgow, Western Infirmary, Dumbarton Road, Glasgow G11 6NT, Scotland, UK
    J Immunol 174:284-93. 2005
  10. ncbi FcgammaRIIb-mediated negative regulation of BCR signalling is associated with the recruitment of the MAPkinase-phosphatase, Pac-1, and the 3'-inositol phosphatase, PTEN
    Kirsty S Brown
    Division of Immunology, Infection and Inflammation, University of Glasgow, Western Infirmary, Dumbarton Road, Glasgow G11 6NT, Scotland, UK
    Cell Signal 16:71-80. 2004

Collaborators

Detail Information

Publications37

  1. ncbi Antigen receptor signaling is subverted by an immunomodulatory product secreted by a filarial nematode
    M M Harnett
    Department of Immunology, University of Glasgow, UK
    Arch Immunol Ther Exp (Warsz) 49:263-9. 2001
    ....
  2. ncbi Differential signalling during B-cell maturation
    Margaret M Harnett
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow G116NT, UK
    Immunol Lett 98:33-44. 2005
    ..Thus, the combined signature of BCR signalling is likely to dictate the functional response and act as a developmental checkpoint for B-cell maturation...
  3. ncbi Immunology. B cells spread and gather
    Margaret M Harnett
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK
    Science 312:709-10. 2006
  4. ncbi Laser scanning cytometry: understanding the immune system in situ
    Margaret M Harnett
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, G12 8TA, UK
    Nat Rev Immunol 7:897-904. 2007
    ..This article describes the technology and its potential for delineating the molecular and cellular events underpinning the immune response in health and disease...
  5. ncbi The therapeutic potential of the filarial nematode-derived immunodulator, ES-62 in inflammatory disease
    M M Harnett
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Centre, University of Glasgow, Glasgow, UK
    Clin Exp Immunol 159:256-67. 2010
    ....
  6. ncbi CD40: a growing cytoplasmic tale
    Margaret M Harnett
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow G11 6NT, UK
    Sci STKE 2004:pe25. 2004
    ..The roles of the phosphoinositide 3-kinase, mitogen-activated protein kinase, and nuclear factor kappaB pathways in mediating CD40 stimulation of the cell cycle are described...
  7. ncbi In vivo exposure of murine dendritic cell and macrophage bone marrow progenitors to the phosphorylcholine-containing filarial nematode glycoprotein ES-62 polarizes their differentiation to an anti-inflammatory phenotype
    Helen S Goodridge
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, United Kingdom
    Immunology 113:491-8. 2004
    ..Such a finding could have important implications for the use of pathogen products or their derivatives for immunotherapy...
  8. ncbi Effect of activated antigen-specific B cells on ES-62-mediated modulation of effector function of heterologous antigen-specific T cells in vivo
    Fraser A Marshall
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
    Immunology 123:411-25. 2008
    ..Collectively, these results suggest that whilst ES-62 can target B-T-cell co-operation, this does not promote polarizing of T-cell responses towards a Th2-type phenotype...
  9. ncbi Immunomodulation via novel use of TLR4 by the filarial nematode phosphorylcholine-containing secreted product, ES-62
    Helen S Goodridge
    Division of Immunology, Infection, and Inflammation, University of Glasgow, Western Infirmary, Dumbarton Road, Glasgow G11 6NT, Scotland, UK
    J Immunol 174:284-93. 2005
    ....
  10. ncbi FcgammaRIIb-mediated negative regulation of BCR signalling is associated with the recruitment of the MAPkinase-phosphatase, Pac-1, and the 3'-inositol phosphatase, PTEN
    Kirsty S Brown
    Division of Immunology, Infection and Inflammation, University of Glasgow, Western Infirmary, Dumbarton Road, Glasgow G11 6NT, Scotland, UK
    Cell Signal 16:71-80. 2004
    ....
  11. ncbi In vivo activation of murine peritoneal B1 cells by the filarial nematode phosphorylcholine-containing glycoprotein ES-62
    Emma H Wilson
    Department of Immunology, Strathclyde Institute of Biomedical Sciences, University of Strathclyde, Glasgow, UK
    Parasite Immunol 25:463-6. 2003
    ....
  12. ncbi Signalling mechanisms underlying subversion of the immune response by the filarial nematode secreted product ES-62
    Helen S Goodridge
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow G11 6NT, UK
    Immunology 115:296-304. 2005
    ..In this review we discuss the immunomodulatory effects of the phosphorylcholine-containing filarial nematode-secreted glycoprotein ES-62 and describe the intracellular signal transduction pathways it targets to achieve these effects...
  13. ncbi Hyporesponsiveness of murine B lymphocytes exposed to the filarial nematode secreted product ES-62 in vivo
    Emma H Wilson
    Department of Immunology, University of Strathclyde, Glasgow, UK
    Immunology 109:238-45. 2003
    ..This finding considerably strengthens the idea that ES-62 plays a role in evasion of the immune response during parasitism...
  14. ncbi Filarial nematode secreted product ES-62 is an anti-inflammatory agent: therapeutic potential of small molecule derivatives and ES-62 peptide mimetics
    William Harnett
    Department of Immunology, University of Strathclyde, Glasgow, UK
    Clin Exp Pharmacol Physiol 33:511-8. 2006
    ....
  15. ncbi ES-62, an immunomodulator secreted by filarial nematodes, suppresses clonal expansion and modifies effector function of heterologous antigen-specific T cells in vivo
    Fraser A Marshall
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, United Kingdom
    J Immunol 175:5817-26. 2005
    ....
  16. ncbi Differences in the kinetics, amplitude, and localization of ERK activation in anergy and priming revealed at the level of individual primary T cells by laser scanning cytometry
    Claire L Adams
    Division of Immunology, Infection and Inflammation, University of Glasgow, Western Infirmary, Glasgow, United Kingdom
    J Immunol 173:1579-86. 2004
    ..These data suggest that the different consequences of Ag recognition by T cells are associated with distinctive kinetics, amplitude, and localization of MAPK signaling...
  17. ncbi Differential regulation of interleukin-12 p40 and p35 induction via Erk mitogen-activated protein kinase-dependent and -independent mechanisms and the implications for bioactive IL-12 and IL-23 responses
    Helen S Goodridge
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
    Immunology 109:415-25. 2003
    ....
  18. ncbi Direct quantitation of T cell signaling by laser scanning cytometry
    Angela M Grierson
    Division of Immunology, Infection and Inflammation, Western Infirmary, University of Glasgow, Glasgow, G11 6NT, UK
    J Immunol Methods 301:140-53. 2005
    ..The purpose of this protocol is to describe in vitro and ex vivo methods for quantifying cell signaling molecule expression and activation within antigen-specific T cells by laser scanning cytometry...
  19. ncbi Inverse Rap1 and phospho-ERK expression discriminate the maintenance phase of tolerance and priming of antigen-specific CD4+ T cells in vitro and in vivo
    Angela M Morton
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
    J Immunol 179:8026-34. 2007
    ....
  20. ncbi ES-62, a filarial nematode-derived immunomodulator with anti-inflammatory potential
    William Harnett
    Department of Immunology, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, UK
    Immunol Lett 94:27-33. 2004
    ..The nematode product was also able to suppress pro-inflammatory cytokine release in vitro in synovial cells derived from RA patients. ES-62 thus constitutes a pathogen-derived immunomodulator with significant therapeutic potential...
  21. ncbi Bcl-(xL) antagonism of BCR-coupled mitochondrial phospholipase A(2) signaling correlates with protection from apoptosis in WEHI-231 B cells
    Elad Katz
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, United Kingdom
    Blood 103:168-76. 2004
    ....
  22. ncbi Subversion of immunological signalling by a filarial nematode phosphorylcholine-containing secreted product
    Helen S Goodridge
    Division of Immunology, Infection and Inflammation, University of Glasgow, Western Infirmary, Dumbarton Road, Glasgow G11 6NT, UK
    Cell Signal 17:11-6. 2005
    ....
  23. ncbi The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17-producing cellular network at multiple sites
    Miguel A Pineda
    University of Glasgow, Glasgow, UK
    Arthritis Rheum 64:3168-78. 2012
    ..Since interleukin-17 (IL-17) has been reported to play a pathogenic role in the development of RA, this study was undertaken to investigate whether targeting of IL-17 may explain the protection against CIA afforded by ES-62...
  24. ncbi Laser scanning cytometry: capturing the immune system in situ
    Mairi A McGrath
    Institute of Infection, Immunity and Inflammation, College of Medical Veterinary and Life Sciences, Glasgow Biomedical Research Centre, University of Glasgow, Scotland, UK
    Methods Cell Biol 102:231-60. 2011
    ....
  25. ncbi Differential polarization of immune responses by plant 2S seed albumins, Ber e 1, and SFA8
    Dorothy E Kean
    Division of Immunology, Infection, and Inflammation, University of Glasgow, Glasgow, UK
    J Immunol 177:1561-6. 2006
    ..Overall, our data are consistent with the idea that the ability of Ber e 1, but not SFA8, to act as a potent allergen may reflect differences in their ability to induce IL-12 production...
  26. ncbi The anti-inflammatory potential of the filarial nematode secreted product, ES-62
    William Harnett
    Department of Immunology, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, UK
    Curr Top Med Chem 4:553-9. 2004
    ..The nematode product was also found to inhibit pro-inflammatory cytokine release in vitro in synovial cells derived from RA patients. ES-62 thus represents a parasite-derived immunomodulator with significant therapeutic potential...
  27. ncbi What causes lymphocyte hyporesponsiveness during filarial nematode infection?
    William Harnett
    Department of Immunology, University of Strathclyde, Glasgow, UK
    Trends Parasitol 22:105-10. 2006
    ..The consistency of this observation, allied to the ease of measurement of lymphocyte hyporesponsiveness, has resulted in many attempts to understand its cause...
  28. ncbi Immunomodulatory activity and therapeutic potential of the filarial nematode secreted product, ES-62
    William Harnett
    Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK
    Adv Exp Med Biol 666:88-94. 2009
    ..As a consequence of this, ES-62 demonstrates striking drug-like activity in models of disease associated with aberrant inflammation, in particular those associated with autoimmunity and allergy...
  29. ncbi Immune complex-mediated co-ligation of the BCR with FcγRIIB results in homeostatic apoptosis of B cells involving Fas signalling that is defective in the MRL/Lpr model of systemic lupus erythematosus
    Verica Paunovic
    Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow G12 8TA, UK
    J Autoimmun 39:332-46. 2012
    ..As these mice develop spontaneous, immune complex-driven lupus-like glomerulonephritis, targeting this FcγRIIB-mediated apoptotic pathway may therefore have novel therapeutic implications for systemic autoimmune disease...
  30. ncbi Immunomodulatory properties of Ascaris suum glycosphingolipids - phosphorylcholine and non-phosphorylcholine-dependent effects
    Maureen R Deehan
    Department of Immunology, University of Glasgow, UK
    Parasite Immunol 24:463-9. 2002
    ..Overall these data indicate that PC-containing glycosphingolipids of A. suum appear to have at least two immunomodulatory constituents - PC and an as yet unknown component...
  31. ncbi Helminth-derived immunomodulators: can understanding the worm produce the pill?
    William Harnett
    Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK
    Nat Rev Immunol 10:278-84. 2010
    ....
  32. ncbi Therapeutic immunomodulators from nematode parasites
    William Harnett
    Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK
    Expert Rev Mol Med 10:e18. 2008
    ..The recent and future use of nematodes and their products in treating human disease are also discussed...
  33. ncbi Mast Cell Subsets and Their Functional Modulation by the Acanthocheilonema viteae Product ES-62
    Dimity H Ball
    Centre for Immunobiology, Glasgow Biomedical Research Centre, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK
    J Parasitol Res 2013:961268. 2013
    ....
  34. ncbi Mitogen-activated protein kinases as therapeutic targets for rheumatoid arthritis
    Verica Paunovic
    Institute of Infection, Immunity and Inflammation, College of Medical Veterinary and Life Sciences, MVLS, University of Glasgow, Glasgow G12 8TA, UK
    Drugs 73:101-15. 2013
    ..Their potential as therapies in the management of RA is also discussed...
  35. ncbi Differential roles for extracellularly regulated kinase-mitogen-activated protein kinase in B cell antigen receptor-induced apoptosis and CD40-mediated rescue of WEHI-231 immature B cells
    Stephen B Gauld
    Department of Immunology and Bacteriology, University of Glasgow, Glasgow, United Kingdom
    J Immunol 168:3855-64. 2002
    ..Erk-MAP kinase can therefore induce diverse biological responses in WEHI-231 cells depending on the context and kinetics of activation...
  36. ncbi Differentiation of the human monocyte cell line, U937, with dibutyryl cyclicAMP induces the expression of the inhibitory Fc receptor, FcgammaRIIb
    Angus J M Cameron
    Department of Medicine and Therapeutics, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
    Immunol Lett 83:171-9. 2002
    ..These data define a role for FcgammaRIIb in the modulation of immune complex mediated macrophage activation in a human model system...
  37. ncbi A novel MyD-1 (SIRP-1alpha) signaling pathway that inhibits LPS-induced TNFalpha production by monocytes
    Rosemary E Smith
    Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, United Kingdom
    Blood 102:2532-40. 2003
    ..MyD-1-coupling to this PI 3-kinase-dependent signaling pathway may therefore present a novel target for the development of therapeutic strategies for combating TNFalpha production and consequent inflammatory disease...