M I Hariz

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Deep brain stimulation in Parkinson's disease
    Marwan I Hariz
    N Engl J Med 346:452-3. 2002
  2. pmc Confirmation of functional zones within the human subthalamic nucleus: patterns of connectivity and sub-parcellation using diffusion weighted imaging
    Christian Lambert
    Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, UK
    Neuroimage 60:83-94. 2012
  3. ncbi request reprint A quick and universal method for stereotactic visualization of the subthalamic nucleus before and after implantation of deep brain stimulation electrodes
    Marwan I Hariz
    Department of Neurosurgery, Umea, Sweden
    Stereotact Funct Neurosurg 80:96-101. 2003
  4. ncbi request reprint [Capsulotomy in obsessive syndromes: medical matter-of-fact arguments or a forced neglect of the reality?]
    Marwan I Hariz
    Institute of Neurology and National Hospital for Neurology and Neurosurgery, London
    Lakartidningen 100:2705-8. 2003
  5. ncbi request reprint From functional neurosurgery to "interventional" neurology: survey of publications on thalamotomy, pallidotomy, and deep brain stimulation for Parkinson's disease from 1966 to 2001
    Marwan I Hariz
    Department of Clinical Neuroscience, University Hospital, Umea, Sweden
    Mov Disord 18:845-53. 2003
  6. ncbi request reprint Multicenter study on deep brain stimulation in Parkinson's disease: an independent assessment of reported adverse events at 4 years
    Marwan I Hariz
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 23:416-21. 2008
  7. ncbi request reprint Multicentre European study of thalamic stimulation for parkinsonian tremor: a 6 year follow-up
    M I Hariz
    Department of Neurosurgery, University Hospital of Northern Sweden, Umea, Sweden
    J Neurol Neurosurg Psychiatry 79:694-9. 2008
  8. doi request reprint Deep brain stimulation between 1947 and 1987: the untold story
    Marwan I Hariz
    Unit of Functional Neurosurgery, UCL Institute of Neurology, Queen Square, London, UK
    Neurosurg Focus 29:E1. 2010
  9. doi request reprint Gilles de la Tourette syndrome and deep brain stimulation
    Marwan I Hariz
    Unit of Functional Neurosurgery, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Eur J Neurosci 32:1128-34. 2010
  10. ncbi request reprint Air-ventriculography provokes an anterior displacement of the third ventricle during functional stereotactic procedures
    M I Hariz
    Department of Neurosurgery, University Hospital, Umea, Sweden
    Acta Neurochir (Wien) 123:147-52. 1993

Detail Information

Publications54

  1. ncbi request reprint Deep brain stimulation in Parkinson's disease
    Marwan I Hariz
    N Engl J Med 346:452-3. 2002
  2. pmc Confirmation of functional zones within the human subthalamic nucleus: patterns of connectivity and sub-parcellation using diffusion weighted imaging
    Christian Lambert
    Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, UK
    Neuroimage 60:83-94. 2012
    ....
  3. ncbi request reprint A quick and universal method for stereotactic visualization of the subthalamic nucleus before and after implantation of deep brain stimulation electrodes
    Marwan I Hariz
    Department of Neurosurgery, Umea, Sweden
    Stereotact Funct Neurosurg 80:96-101. 2003
    ..Postoperatively, the same imaging protocol permitted visualization of the target area and DBS electrodes with minimum artifacts. This imaging technique may contribute to a decrease in the number of electrode passes at surgery...
  4. ncbi request reprint [Capsulotomy in obsessive syndromes: medical matter-of-fact arguments or a forced neglect of the reality?]
    Marwan I Hariz
    Institute of Neurology and National Hospital for Neurology and Neurosurgery, London
    Lakartidningen 100:2705-8. 2003
  5. ncbi request reprint From functional neurosurgery to "interventional" neurology: survey of publications on thalamotomy, pallidotomy, and deep brain stimulation for Parkinson's disease from 1966 to 2001
    Marwan I Hariz
    Department of Clinical Neuroscience, University Hospital, Umea, Sweden
    Mov Disord 18:845-53. 2003
    ..The fact that the first author of surgical publications on PD is often a non-neurosurgeon may have some bearing on the reported results of surgery...
  6. ncbi request reprint Multicenter study on deep brain stimulation in Parkinson's disease: an independent assessment of reported adverse events at 4 years
    Marwan I Hariz
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 23:416-21. 2008
    ..When comparing patients who exhibited AEs with those who did not, it was found that in the STN DBS group, the patients with AEs had a longer disease duration, as well as more gait disorders and psychiatric disturbances at baseline...
  7. ncbi request reprint Multicentre European study of thalamic stimulation for parkinsonian tremor: a 6 year follow-up
    M I Hariz
    Department of Neurosurgery, University Hospital of Northern Sweden, Umea, Sweden
    J Neurol Neurosurg Psychiatry 79:694-9. 2008
    ..To evaluate the results of ventral intermediate (Vim) thalamic deep brain stimulation (DBS) in patients with tremor predominant Parkinson's disease (PD) at 6 years post surgery...
  8. doi request reprint Deep brain stimulation between 1947 and 1987: the untold story
    Marwan I Hariz
    Unit of Functional Neurosurgery, UCL Institute of Neurology, Queen Square, London, UK
    Neurosurg Focus 29:E1. 2010
    ..Some of the questionable behavior in surgery for psychiatric illness, including the bygone era of DBS, was at the hands of nonneurosurgeons. These practices have been deemed as "dubious and precarious by yesterday's standards."..
  9. doi request reprint Gilles de la Tourette syndrome and deep brain stimulation
    Marwan I Hariz
    Unit of Functional Neurosurgery, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Eur J Neurosci 32:1128-34. 2010
    ..This paper reviews critically and in detail all studies published to date. Only two studies on just a few patients fulfil some of the evidence-based criteria. DBS for GTS is therefore still highly experimental...
  10. ncbi request reprint Air-ventriculography provokes an anterior displacement of the third ventricle during functional stereotactic procedures
    M I Hariz
    Department of Neurosurgery, University Hospital, Umea, Sweden
    Acta Neurochir (Wien) 123:147-52. 1993
    ..This anterior dislocation of the commissures was presumably due to the insufflation of air into the ventricles of patients being in the supine position during surgery...
  11. pmc Effects of subthalamic stimulation on speech of consecutive patients with Parkinson disease
    E Tripoliti
    Sobell Department, Unit of Functional Neurosurgery, UCL Institute of Neurology, Box 146, Queen Square, London, WC1N 3BG, UK
    Neurology 76:80-6. 2011
    ..Here we prospectively examined the short- and long-term speech response to STN-DBS in a consecutive series of patients to identify clinical and surgical factors associated with speech change...
  12. ncbi request reprint Variability of the subthalamic nucleus: the case for direct MRI guided targeting
    K Ashkan
    Functional Neurosurgery Unit, Institute of Neurology, London, UK
    Br J Neurosurg 21:197-200. 2007
    ..The coordinates of the directly visualised STN were significantly different from those of the atlas target. Variability of the position of the STN may render direct visualisation a more accurate means of targeting this nucleus...
  13. ncbi request reprint Tolerance and tremor rebound following long-term chronic thalamic stimulation for Parkinsonian and essential tremor
    M I Hariz
    Department of Neurosurgery, University Hospital, Umea, Sweden
    Stereotact Funct Neurosurg 72:208-18. 1999
    ..07) in the PD group, requiring continuous 24-hour stimulation in some patients. Permanent non-adjustable ataxia was induced by stimulation in 2 PD patients...
  14. ncbi request reprint Do microelectrode techniques increase accuracy or decrease risks in pallidotomy and deep brain stimulation? A critical review of the literature
    M I Hariz
    Department of Neurosurgery, University Hospital, Umea, Sweden
    Stereotact Funct Neurosurg 72:157-69. 1999
    ....
  15. doi request reprint Parkinsonian impairment correlates with spatially extensive subthalamic oscillatory synchronization
    A Pogosyan
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, WC1N 3BG UK
    Neuroscience 171:245-57. 2010
    ..In addition, they strengthen the link between pathological synchronization and the different motor features of Parkinsonism...
  16. doi request reprint Minimizing brain shift in stereotactic functional neurosurgery
    Erika A Petersen
    Unit of Functional Neurosurgery, Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London, UK
    Neurosurgery 67:ons213-21; discussion ons221. 2010
    ..Stereotactic functional neurosurgical interventions depend on precise anatomic targeting before lesioning or deep brain stimulation (DBS) electrode placement...
  17. ncbi request reprint Intra-operative recordings of local field potentials can help localize the subthalamic nucleus in Parkinson's disease surgery
    Chiung Chu Chen
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WCIN 3BG, UK
    Exp Neurol 198:214-21. 2006
    ..Functional physiological localization of STN by the on-line spectral analysis of LFPs is quick to perform and may provide information directly relevant to the position of the electrode contact actually used for DBS...
  18. ncbi request reprint Dopaminergic therapy promotes lateralized motor activity in the subthalamic area in Parkinson's disease
    Alexandros G Androulidakis
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
    Brain 130:457-68. 2007
    ..These findings suggest that dopaminergic therapy restores a more physiological pattern of reactivity in the STN of patients with Parkinson's disease...
  19. ncbi request reprint Cortico-cortical coupling in Parkinson's disease and its modulation by therapy
    Paul Silberstein
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
    Brain 128:1277-91. 2005
    ..This mechanistic similarity may underscore the strong clinical correlation between the therapeutic effects of these treatment modalities...
  20. ncbi request reprint Is there a relationship between size and site of the stereotactic lesion and symptomatic results of pallidotomy and thalamotomy?
    M I Hariz
    Department of Neurosurgery, University of Umea, Sweden
    Stereotact Funct Neurosurg 69:28-45. 1997
    ....
  21. ncbi request reprint Thalamic deep brain stimulation in the treatment of essential tremor: a long-term follow-up
    P Blomstedt
    Department of Neurosurgery, University Hospital of Umea, Umea, Sweden
    Br J Neurosurg 21:504-9. 2007
    ..7 to 4.1 and 8.2, respectively. Vim-DBS is an efficient treatment for ET, also after many years of treatment. There is, however, a decreasing effect over time, most noticeable concerning tremor of action...
  22. ncbi request reprint Can chronic subthalamic nucleus stimulation induce de novo tremor in Parkinson's disease?
    Stephane Thobois
    Sobell Department of Motor Neurosciences and Movement Disorders, Unit of Functional Neurosurgery, Institute of Neurology, London, United Kingdom
    Mov Disord 20:1066-9. 2005
    ..We report on the cases of 3 patients who developed such modification of their parkinsonian symptomatology. Physiopathological hypotheses are discussed...
  23. ncbi request reprint Modulation of beta oscillations in the subthalamic area during motor imagery in Parkinson's disease
    Andrea A Kuhn
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
    Brain 129:695-706. 2006
    ....
  24. ncbi request reprint Does the ADL part of the unified Parkinson's disease rating scale measure ADL? An evaluation in patients after pallidotomy and thalamic deep brain stimulation
    Gun Marie Hariz
    Department of Clinical Neuroscience, University Hospital of Northern Sweden, Umea, Sweden
    Mov Disord 18:373-81. 2003
    ..The ADL part of the UPDRS contains a mixture of impairment- and disability-related items. This mixture may confound results when evaluating the impact of surgery on ADL...
  25. doi request reprint Stereotactic localization of the human pedunculopontine nucleus: atlas-based coordinates and validation of a magnetic resonance imaging protocol for direct localization
    Ludvic Zrinzo
    Unit of Functional Neurosurgery, Institute of Neurology, University College London, UK
    Brain 131:1588-98. 2008
    ..Direct MRI localization may allow greater individual accuracy than that afforded by atlas-based coordinates when localizing the human PPN and may be relevant to groups evaluating the clinical role of PPN DBS...
  26. doi request reprint Effects of contact location and voltage amplitude on speech and movement in bilateral subthalamic nucleus deep brain stimulation
    Elina Tripoliti
    Unit of Functional Neurosurgery, Sobell Department, Institute of Neurology, London, United Kingdom
    Mov Disord 23:2377-83. 2008
    ....
  27. doi request reprint Avoiding the ventricle: a simple step to improve accuracy of anatomical targeting during deep brain stimulation
    Ludvic Zrinzo
    Unit of Functional Neurosurgery, Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London
    J Neurosurg 110:1283-90. 2009
    ..Special attention was focused on the impact that ventricular involvement of the electrode trajectory had on targeting accuracy...
  28. pmc Optimized beamforming for simultaneous MEG and intracranial local field potential recordings in deep brain stimulation patients
    Vladimir Litvak
    UCL Institute of Neurology, Queen Square, WC1N 3BG, London, UK
    Neuroimage 50:1578-88. 2010
    ..Our findings demonstrate that physiologically meaningful information can be extracted from heavily contaminated MEG signals and pave the way for further analysis of combined MEG-LFP recordings in DBS patients...
  29. doi request reprint Surgical management of Parkinson's disease
    Thomas Foltynie
    UCL Institute of Neurology, Queen Square, London, UK
    Expert Rev Neurother 10:903-14. 2010
    ..We also provide details of our practice, including patient selection, surgical technique and postoperative stimulation programming and medication adjustment. Current and possible future alternatives to DBS of the STN are also discussed...
  30. ncbi request reprint Complications of deep brain stimulation surgery
    Marwan I Hariz
    Department of Neurosurgery, University Hospital, Umea, Sweden
    Mov Disord 17:S162-6. 2002
    ....
  31. ncbi request reprint The physiological effects of pallidal deep brain stimulation in dystonia
    Stephen Tisch
    Unit of Functional Neurosurgery, Sobell Department of Motor Neuroscience, Institute of Neurology, London WC1N 3BG, UK
    IEEE Trans Neural Syst Rehabil Eng 15:166-72. 2007
    ....
  32. doi request reprint An approach to deep brain stimulation for severe treatment-refractory Tourette syndrome: the UK perspective
    Andrea E Cavanna
    Department of Neuropsychiatry, University of Birmingham and BSMHFT, Birmingham, UK
    Br J Neurosurg 25:38-44. 2011
    ..The present article illustrates the UK perspective on DBS in TS and proposes consensus-based recommendations for double-blind controlled trials...
  33. ncbi request reprint Activation of the subthalamic region during emotional processing in Parkinson disease
    A A Kühn
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, WC1N 3BG, UK
    Neurology 65:707-13. 2005
    ..To elucidate the involvement of the human subthalamic nucleus (STN) region in the processing or transmission of emotional information...
  34. ncbi request reprint A 10-year follow-up review of patients who underwent Leksell's posteroventral pallidotomy for Parkinson disease
    M I Hariz
    Department of Neurosurgery, University Hospital of Northern Sweden, Umea
    J Neurosurg 94:552-8. 2001
    ..These patients were part of a larger series described in the first paper on Leksell's PVP that was published in 1992...
  35. doi request reprint Pallidal deep brain stimulation in the treatment of Meige syndrome
    P Blomstedt
    Department of Neurosurgery, University Hospital of Northern Sweden, Umea, Sweden
    Acta Neurol Scand 118:198-202. 2008
    ..The experience is however limited concerning focal dystonias and to date only a few cases of pallidal DBS in the treatment of Meige syndrome have been published...
  36. doi request reprint High-frequency stimulation of the subthalamic nucleus suppresses oscillatory beta activity in patients with Parkinson's disease in parallel with improvement in motor performance
    Andrea A Kuhn
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London WC1N 3BG, United Kingdom
    J Neurosci 28:6165-73. 2008
    ..Our findings suggest that HFS may act by modulating pathological patterns of synchronized oscillations, specifically by reduction of pathological beta activity in PD...
  37. ncbi request reprint Pallidotomy versus pallidal stimulation
    Patric Blomstedt
    Department of Neurosurgery, University Hospital of Umea, SE 90185 Umeå, Sweden
    Parkinsonism Relat Disord 12:296-301. 2006
    ....
  38. doi request reprint High resolution MR anatomy of the subthalamic nucleus: imaging at 9.4 T with histological validation
    L A Massey
    Sara Koe PSP Research Centre, UCL Institute of Neurology, London, UK
    Neuroimage 59:2035-44. 2012
    ..Direct visualisation of the STN is possible using high field MRI and this is particularly relevant, given its anatomical variability, for planning deep brain stimulation...
  39. ncbi request reprint Changes in forearm reciprocal inhibition following pallidal stimulation for dystonia
    S Tisch
    obell Department Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square London, United Kingdom
    Neurology 66:1091-3. 2006
    ..The authors conclude that pallidal DBS for dystonia results in functional reorganization of the nervous system, which includes a long-term increase in spinal inhibition...
  40. doi request reprint Deep brain stimulation in the treatment of depression
    P Blomstedt
    Department of Neurosurgery, University Hospital of Umea, Sweden
    Acta Psychiatr Scand 123:4-11. 2011
    ..To present the technique of deep brain stimulation (DBS) and to evaluate the studies conducted on DBS in the treatment of therapy-refractory major depressive disorder (MDD)...
  41. doi request reprint Deep brain stimulation for movement disorders before DBS for movement disorders
    Patric Blomstedt
    Department of Neurosurgery, University Hospital of Umea, Sweden
    Parkinsonism Relat Disord 16:429-33. 2010
    ..It is to the credit of the Grenoble Group to have reinvented, modernised and expanded modern DBS in surgical treatment of movement disorders...
  42. ncbi request reprint Safety and risk of microelectrode recording in surgery for movement disorders
    Marwan I Hariz
    Department of Clinical Neuroscience, University Hospital, Umea, Sweden
    Stereotact Funct Neurosurg 78:146-57. 2002
    ..In terms of safety for the patients, however, MER techniques are relatively safe, but non-Mer techniques, based on macrostimulation-guided surgery, are at least five times safer...
  43. doi request reprint A family with a hereditary form of torsion dystonia from northern Sweden treated with bilateral pallidal deep brain stimulation
    Patric Blomstedt
    Department of Neurosurgery, University Hospital of Northern Sweden, Umea, Sweden
    Mov Disord 24:2415-9. 2009
    ..The present study confirms the effectiveness of pallidal DBS in a new family with hereditary primary segmental and generalized dystonia...
  44. ncbi request reprint Gender differences in disability and health-related quality of life in patients with Parkinson's disease treated with stereotactic surgery
    Gun Marie Hariz
    Department of Clinical Neuroscience, Section of Neurosurgery, University Hospital of Northern Sweden, Umea, Sweden
    Acta Neurol Scand 108:28-37. 2003
    ..To investigate eventual differences between women and men with Parkinson's disease (PD) before and after surgery, with respect to clinical status, disability and health-related quality of life (HRQoL)...
  45. ncbi request reprint Are complications less common in deep brain stimulation than in ablative procedures for movement disorders?
    Patric Blomstedt
    Department of Neurosurgery, University Hospital of Northern Sweden, Umea, Sweden
    Stereotact Funct Neurosurg 84:72-81. 2006
    ..Some of the side effects following lesioning are transient and most but not all DBS side effects are reversible. In the Vim DBS is safer than lesioning, while in the pallidum, unilateral lesions are well tolerated...
  46. ncbi request reprint Hardware-related complications of deep brain stimulation: a ten year experience
    P Blomstedt
    Department of Neurosurgery, University Hospital, Umea, Sweden
    Acta Neurochir (Wien) 147:1061-4; discussion 1064. 2005
    ..To analyse the occurrence of hardware-related complications in patients with deep brain stimulation (DBS), over a long period of time...
  47. ncbi request reprint Acute severe depression induced by intraoperative stimulation of the substantia nigra: a case report
    Patric Blomstedt
    Department of Neurosurgery, University Hospital of Northern Sweden, Umea, Sweden
    Parkinsonism Relat Disord 14:253-6. 2008
    ..Repeated blinded stimulations resulted in the same response. Immediate postoperative magnetic resonance imaging (MRI) revealed that the lowest contact of the right electrode was located in the substantia nigra...
  48. ncbi request reprint Dittmar and the history of stereotaxy; or rats, rabbits, and references
    Patric Blomstedt
    Department of Neurosurgery, University Hospital, Umea, Sweden
    Neurosurgery 60:198-201; discussion 201-2. 2007
    ..quot; In our opinion, it can most properly be classified as a supportive arm...
  49. ncbi request reprint Hypofractionated conformal stereotactic radiotherapy for arteriovenous malformations
    Peter Lindvall
    Department of Neurosurgery, University Hospital, Umea, Sweden
    Neurosurgery 53:1036-42; discussion 1042-3. 2003
    ..There are several options for treatment, including radiotherapy. Safe and effective single-fraction radiotherapy for patients with large AVMs has been considered difficult...
  50. ncbi request reprint Stereotactic imaging of the pallidal target
    Hidehiro Hirabayashi
    Department of Neurosurgery, Nara Medical University, Nara, Japan
    Mov Disord 17:S130-4. 2002
    ....
  51. ncbi request reprint Intracerebral microvascular measurements during deep brain stimulation implantation using laser Doppler perfusion monitoring
    Karin Wårdell
    Department of Biomedical Engineering, Linkoping University, Linkoping, Sweden
    Stereotact Funct Neurosurg 85:279-86. 2007
    ..005) and the perfusion significantly lower (p < 0.005) in positions identified as white matter in the respective MRI batch. The measurements imply that LDPM has the potential to be used as an intracerebral guidance tool...
  52. ncbi request reprint What is deep brain stimulation "failure" and how do we manage our own failures?
    Marwan I Hariz
    Arch Neurol 62:1938; author reply 1938-9. 2005
  53. ncbi request reprint The effect of cystic cavities on deep brain stimulation in the basal ganglia: a simulation-based study
    Mattias Aström
    Department of Biomedical Engineering, Linkoping University, Sweden
    J Neural Eng 3:132-8. 2006
    ....
  54. ncbi request reprint Anterior capsulotomy for treatment of refractory obsessive-compulsive disorder: results in a young and an old patient
    Daniel D Christensen
    University of Utah Neuropsychiatric Institute, Salt Lake City, Utah, USA
    Stereotact Funct Neurosurg 79:234-44. 2002
    ..We conclude that treatment-refractory OCD may be alleviated by anterior radiofrequency capsulotomy in the young and the old patient. This study expands the documented age range of response from 18 to 64...