K G Hardwick

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc MAD3 encodes a novel component of the spindle checkpoint which interacts with Bub3p, Cdc20p, and Mad2p
    K G Hardwick
    Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom
    J Cell Biol 148:871-82. 2000
  2. ncbi request reprint Complex formation between Mad1p, Bub1p and Bub3p is crucial for spindle checkpoint function
    D M Brady
    Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, UK
    Curr Biol 10:675-8. 2000
  3. ncbi request reprint The spindle checkpoint
    K G Hardwick
    Institute of Cell and Molecular Biology, University of Edinburgh, UK
    Trends Genet 14:1-4. 1998
  4. pmc The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins
    R H Chen
    Department of Physiology, University of California, San Francisco, San Francisco, California 94143 0444, USA
    Mol Biol Cell 10:2607-18. 1999
  5. pmc Lesions in many different spindle components activate the spindle checkpoint in the budding yeast Saccharomyces cerevisiae
    K G Hardwick
    Department of Physiology, University of California, San Francisco, California 94143 0444, USA
    Genetics 152:509-18. 1999
  6. ncbi request reprint Budding yeast Cdc20: a target of the spindle checkpoint
    L H Hwang
    Department of Physiology, University of California at San Francisco, San Francisco, CA 94143 0444, USA
    Science 279:1041-4. 1998
  7. pmc Cdc28 activates exit from mitosis in budding yeast
    A D Rudner
    Department of Physiology, University of California, San Francisco, California 94143 0444, USA
    J Cell Biol 149:1361-76. 2000
  8. ncbi request reprint Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption
    K G Hardwick
    Department of Physiology, University of California, San Francisco, CA 94143 0444, USA
    Science 273:953-6. 1996
  9. pmc Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast
    K G Hardwick
    Department of Physiology, University of California, San Francisco 94143 0444, USA
    J Cell Biol 131:709-20. 1995
  10. pmc ERD1, a yeast gene required for the retention of luminal endoplasmic reticulum proteins, affects glycoprotein processing in the Golgi apparatus
    K G Hardwick
    MRC Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 9:623-30. 1990

Collaborators

Detail Information

Publications13

  1. pmc MAD3 encodes a novel component of the spindle checkpoint which interacts with Bub3p, Cdc20p, and Mad2p
    K G Hardwick
    Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom
    J Cell Biol 148:871-82. 2000
    ..We discuss roles for Mad3p and its interactions with other spindle checkpoint proteins and with Cdc20p, the target of the checkpoint...
  2. ncbi request reprint Complex formation between Mad1p, Bub1p and Bub3p is crucial for spindle checkpoint function
    D M Brady
    Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, UK
    Curr Biol 10:675-8. 2000
    ..Mutation of this motif abolishes checkpoint function, indicating that formation of the Mad1p-Bub1p-Bub3p complex is a crucial step in the spindle checkpoint mechanism...
  3. ncbi request reprint The spindle checkpoint
    K G Hardwick
    Institute of Cell and Molecular Biology, University of Edinburgh, UK
    Trends Genet 14:1-4. 1998
  4. pmc The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins
    R H Chen
    Department of Physiology, University of California, San Francisco, San Francisco, California 94143 0444, USA
    Mol Biol Cell 10:2607-18. 1999
    ..Deletion and mutational analysis of both proteins indicate that association of Mad2p with Mad1p is critical for checkpoint function and for hyperphosphorylation of Mad1p...
  5. pmc Lesions in many different spindle components activate the spindle checkpoint in the budding yeast Saccharomyces cerevisiae
    K G Hardwick
    Department of Physiology, University of California, San Francisco, California 94143 0444, USA
    Genetics 152:509-18. 1999
    ..In contrast, the cell cycle arrest caused by mutations that induce DNA damage (cdc13), inactivate the cyclin proteolysis machinery (cdc16 and cdc23), or arrest cells in anaphase (cdc15) is independent of the spindle checkpoint...
  6. ncbi request reprint Budding yeast Cdc20: a target of the spindle checkpoint
    L H Hwang
    Department of Physiology, University of California at San Francisco, San Francisco, CA 94143 0444, USA
    Science 279:1041-4. 1998
    ..Mutants in Cdc20 that were resistant to the spindle checkpoint no longer bound Mad proteins, suggesting that Cdc20 is the target of the spindle checkpoint...
  7. pmc Cdc28 activates exit from mitosis in budding yeast
    A D Rudner
    Department of Physiology, University of California, San Francisco, California 94143 0444, USA
    J Cell Biol 149:1361-76. 2000
    ..The defects of CDC28-VF suggest that Cdc28 activity is required to induce the metaphase to anaphase transition and initiate the transition from anaphase to G1 in budding yeast...
  8. ncbi request reprint Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption
    K G Hardwick
    Department of Physiology, University of California, San Francisco, CA 94143 0444, USA
    Science 273:953-6. 1996
    ..Ectopic activation of cell-cycle checkpoints might be used to exploit the differences in checkpoint status between normal and tumor cells and thus improve the selectivity of chemotherapy...
  9. pmc Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast
    K G Hardwick
    Department of Physiology, University of California, San Francisco 94143 0444, USA
    J Cell Biol 131:709-20. 1995
    ..We discuss the possible functions of Mad1p at this cell cycle checkpoint...
  10. pmc ERD1, a yeast gene required for the retention of luminal endoplasmic reticulum proteins, affects glycoprotein processing in the Golgi apparatus
    K G Hardwick
    MRC Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 9:623-30. 1990
    ..The sequence of ERD1 predicts a membrane protein with several transmembrane domains, a conclusion supported by analysis of ERD1-SUC2 fusion proteins...
  11. ncbi request reprint ERD2, a yeast gene required for the receptor-mediated retrieval of luminal ER proteins from the secretory pathway
    J C Semenza
    MRC Laboratory of Molecular Biology, Cambridge, England
    Cell 61:1349-57. 1990
    ..The gene is also required, perhaps indirectly, for normal protein transport through the Golgi, and hence for growth. We discuss possible roles for ERD2 in the secretory pathway...
  12. pmc SED5 encodes a 39-kD integral membrane protein required for vesicular transport between the ER and the Golgi complex
    K G Hardwick
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    J Cell Biol 119:513-21. 1992
    ..We suggest that Sed5p has an essential role in vesicular transport between ER and Golgi compartments and that it may itself cycle between these organelles...
  13. pmc Genes that allow yeast cells to grow in the absence of the HDEL receptor
    K G Hardwick
    MRC Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 11:4187-95. 1992
    ....