David Harding

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. ncbi request reprint Does interleukin-6 genotype influence cerebral injury or developmental progress after preterm birth?
    David R Harding
    Department of Child Health, University of Bristol, Bristol, United Kingdom
    Pediatrics 114:941-7. 2004
  2. ncbi request reprint Is interleukin-6 -174 genotype associated with the development of septicemia in preterm infants?
    David Harding
    Department of Child Health, University of Bristol, Bristol, United Kingdom
    Pediatrics 112:800-3. 2003
  3. ncbi request reprint Angiotensin-converting enzyme DD genotype is associated with worse perinatal cardiorespiratory adaptation in preterm infants
    David Harding
    Division of Child Health, University of Bristol, United Kingdom
    J Pediatr 143:746-9. 2003
  4. ncbi request reprint Variation in the interleukin-6 gene is associated with impaired cognitive development in children born prematurely: a preliminary study
    David Harding
    Department of Child Health, University of Bristol, St Michael s Hospital, Bristol BS8 2JZ, UK
    Pediatr Res 58:117-20. 2005
  5. pmc Cognitive outcome and cyclo-oxygenase-2 gene (-765 G/C) variation in the preterm infant
    D R Harding
    Neonatal Intensive Care Unit, University of Bristol, D Level, St Michael s Hospital, Bristol BS2 8EG, UK
    Arch Dis Child Fetal Neonatal Ed 92:F108-12. 2007
  6. pmc Impact of common genetic variation on neonatal disease and outcome
    David Harding
    University of Bristol, D Level, St Michael s Hospital, Bristol BS2 8EG, UK
    Arch Dis Child Fetal Neonatal Ed 92:F408-13. 2007
  7. ncbi request reprint Severity of meningococcal disease in children and the angiotensin-converting enzyme insertion/deletion polymorphism
    David Harding
    Peter Dunn Neonatal Intensive Care Unit and Department of Child Health, University of Bristol, Bristol, United Kingdom
    Am J Respir Crit Care Med 165:1103-6. 2002

Detail Information

Publications7

  1. ncbi request reprint Does interleukin-6 genotype influence cerebral injury or developmental progress after preterm birth?
    David R Harding
    Department of Child Health, University of Bristol, Bristol, United Kingdom
    Pediatrics 114:941-7. 2004
    ..Our objective was to determine whether the CC genotype is associated with worse early illness severity, neurologic injury, and lower developmental scores among surviving preterm children...
  2. ncbi request reprint Is interleukin-6 -174 genotype associated with the development of septicemia in preterm infants?
    David Harding
    Department of Child Health, University of Bristol, Bristol, United Kingdom
    Pediatrics 112:800-3. 2003
    ..We tested the hypothesis that the IL-6 -174 GG genotype, associated with lower IL-6 response to inflammation, is also associated with the development of septicemia in preterm infants...
  3. ncbi request reprint Angiotensin-converting enzyme DD genotype is associated with worse perinatal cardiorespiratory adaptation in preterm infants
    David Harding
    Division of Child Health, University of Bristol, United Kingdom
    J Pediatr 143:746-9. 2003
    ..Intensive care data were prospectively obtained. Primary analysis was by Mann-Whitney U and chi(2) tests...
  4. ncbi request reprint Variation in the interleukin-6 gene is associated with impaired cognitive development in children born prematurely: a preliminary study
    David Harding
    Department of Child Health, University of Bristol, St Michael s Hospital, Bristol BS8 2JZ, UK
    Pediatr Res 58:117-20. 2005
    ..These data support a role for IL-6 in the genesis of neurologic impairment in such children...
  5. pmc Cognitive outcome and cyclo-oxygenase-2 gene (-765 G/C) variation in the preterm infant
    D R Harding
    Neonatal Intensive Care Unit, University of Bristol, D Level, St Michael s Hospital, Bristol BS2 8EG, UK
    Arch Dis Child Fetal Neonatal Ed 92:F108-12. 2007
    ..The inducible form of the COX2 gene is polymorphic: the -765 C (rather than G) variant of the gene is associated with reduced COX2 activity...
  6. pmc Impact of common genetic variation on neonatal disease and outcome
    David Harding
    University of Bristol, D Level, St Michael s Hospital, Bristol BS2 8EG, UK
    Arch Dis Child Fetal Neonatal Ed 92:F408-13. 2007
    ..The shortcomings of published association studies and the place of such studies in future research are also discussed...
  7. ncbi request reprint Severity of meningococcal disease in children and the angiotensin-converting enzyme insertion/deletion polymorphism
    David Harding
    Peter Dunn Neonatal Intensive Care Unit and Department of Child Health, University of Bristol, Bristol, United Kingdom
    Am J Respir Crit Care Med 165:1103-6. 2002
    ..DD genotype frequency was 6% (1 case) for the 18 children who did not require PICU care, 33% for the 84 PICU survivors, and 45% for those who died (p = 0.01). ACE DD is associated with increased illness severity in meningococcal disease...