Roger C Hardie

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi In vivo light-induced and basal phospholipase C activity in Drosophila photoreceptors measured with genetically targeted phosphatidylinositol 4,5-bisphosphate-sensitive ion channels (Kir2.1)
    Roger C Hardie
    Department of Anatomy, Cambridge University, Downing St, Cambridge CB2 3DY, United Kingdom
    J Biol Chem 279:47773-82. 2004
  2. pmc Stochastic, adaptive sampling of information by microvilli in fly photoreceptors
    Zhuoyi Song
    Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK
    Curr Biol 22:1371-80. 2012
  3. doi Regulation of arrestin translocation by Ca2+ and myosin III in Drosophila photoreceptors
    Roger C Hardie
    Department of Physiology, Development and Neuroscience, Cambridge University, Cambridge CB2 3EG, United Kingdom
    J Neurosci 32:9205-16. 2012
  4. doi Photomechanical responses in Drosophila photoreceptors
    Roger C Hardie
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK
    Science 338:260-3. 2012
  5. doi Polarization vision: Drosophila enters the arena
    Roger C Hardie
    Cambridge University Department of Physiology Development and Neuroscience, Cambridge CB2 3EG, UK
    Curr Biol 22:R12-4. 2012
  6. doi Lipids in Ca2+ signalling--an introduction
    Roger C Hardie
    Department of Physiology Development and Neuroscience, Cambridge University, Downing St, Cambridge, United Kingdom
    Cell Calcium 45:517-20. 2009
  7. doi A brief history of trp: commentary and personal perspective
    Roger C Hardie
    Department of Physiology, Development and Neuroscience, Cambridge University, Downing Street, Cambridge, CB2 3DY, UK
    Pflugers Arch 461:493-8. 2011
  8. pmc Ca2+-dependent metarhodopsin inactivation mediated by calmodulin and NINAC myosin III
    Che Hsiung Liu
    Department of Physiology, Development and Neuroscience, Cambridge University, Cambridge CB23DY, UK
    Neuron 59:778-89. 2008
  9. ncbi Functional INAD complexes are required to mediate degeneration in photoreceptors of the Drosophila rdgA mutant
    Plamen Georgiev
    The Inositide Laboratory, Babraham Institute, Babraham Research Campus, Cambridge, CB2 4AT, UK
    J Cell Sci 118:1373-84. 2005
  10. ncbi Mechanisms of light adaptation in Drosophila photoreceptors
    Yuchun Gu
    Department of Anatomy, Cambridge University, Downing Street, Cambridge CB2 3DY, United Kingdom
    Curr Biol 15:1228-34. 2005

Collaborators

Detail Information

Publications25

  1. ncbi In vivo light-induced and basal phospholipase C activity in Drosophila photoreceptors measured with genetically targeted phosphatidylinositol 4,5-bisphosphate-sensitive ion channels (Kir2.1)
    Roger C Hardie
    Department of Anatomy, Cambridge University, Downing St, Cambridge CB2 3DY, United Kingdom
    J Biol Chem 279:47773-82. 2004
    ....
  2. pmc Stochastic, adaptive sampling of information by microvilli in fly photoreceptors
    Zhuoyi Song
    Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK
    Curr Biol 22:1371-80. 2012
    ....
  3. doi Regulation of arrestin translocation by Ca2+ and myosin III in Drosophila photoreceptors
    Roger C Hardie
    Department of Physiology, Development and Neuroscience, Cambridge University, Cambridge CB2 3EG, United Kingdom
    J Neurosci 32:9205-16. 2012
    ..We propose that rapid Ca(2+)/CaM-dependent release of Arr2 from NINAC upon Ca(2+) influx accounts for the acceleration of translocation by phototransduction...
  4. doi Photomechanical responses in Drosophila photoreceptors
    Roger C Hardie
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK
    Science 338:260-3. 2012
    ....
  5. doi Polarization vision: Drosophila enters the arena
    Roger C Hardie
    Cambridge University Department of Physiology Development and Neuroscience, Cambridge CB2 3EG, UK
    Curr Biol 22:R12-4. 2012
    ..Two new studies introduce the power of Drosophila genetics to polarization vision, revealing distinct photoreceptor inputs to polarotactic behaviour mediated by dorsal and ventral eye regions...
  6. doi Lipids in Ca2+ signalling--an introduction
    Roger C Hardie
    Department of Physiology Development and Neuroscience, Cambridge University, Downing St, Cambridge, United Kingdom
    Cell Calcium 45:517-20. 2009
    ..Although appreciated individually, it seems timely to highlight the overall impact of lipids as signalling molecules and their role in Ca(2+) signalling, and this is the aim of this special issue of Cell Calcium...
  7. doi A brief history of trp: commentary and personal perspective
    Roger C Hardie
    Department of Physiology, Development and Neuroscience, Cambridge University, Downing Street, Cambridge, CB2 3DY, UK
    Pflugers Arch 461:493-8. 2011
    ..Three years later, in 1995, the labs of Montell and Birnbaumer independently cloned TRPC1, the first of 29 vertebrate TRP isoforms distributed amongst seven subfamilies...
  8. pmc Ca2+-dependent metarhodopsin inactivation mediated by calmodulin and NINAC myosin III
    Che Hsiung Liu
    Department of Physiology, Development and Neuroscience, Cambridge University, Cambridge CB23DY, UK
    Neuron 59:778-89. 2008
    ..Our results indicate that this strategy promotes quantum efficiency, temporal resolution, and fidelity of visual signaling...
  9. ncbi Functional INAD complexes are required to mediate degeneration in photoreceptors of the Drosophila rdgA mutant
    Plamen Georgiev
    The Inositide Laboratory, Babraham Institute, Babraham Research Campus, Cambridge, CB2 4AT, UK
    J Cell Sci 118:1373-84. 2005
    ..They also suggest a key role for the lipid products of phosphoinositide hydrolysis in the activation of TRP channels in vivo...
  10. ncbi Mechanisms of light adaptation in Drosophila photoreceptors
    Yuchun Gu
    Department of Anatomy, Cambridge University, Downing Street, Cambridge CB2 3DY, United Kingdom
    Curr Biol 15:1228-34. 2005
    ....
  11. doi Activation of TRP channels by protons and phosphoinositide depletion in Drosophila photoreceptors
    Jiehong Huang
    Department of Physiology, Development, and Neuroscience, Cambridge University, Cambridge CB2 3DY, UK
    Curr Biol 20:189-97. 2010
    ..The fact that hydrolysis of the phosphodiester bond in PIP(2) by PLC also releases a proton is seldom recognized and has neither been measured in vivo nor implicated previously in a signaling context...
  12. ncbi In vivo identification and manipulation of the Ca2+ selectivity filter in the Drosophila transient receptor potential channel
    Che H Liu
    Department of Physiology Development and Neuroscience, Cambridge University, Cambridge CB2 3DY, United Kingdom
    J Neurosci 27:604-15. 2007
    ..We found that Asp621 mutations profoundly affected several key aspects of the light response and caused light-dependent retinal degeneration...
  13. ncbi Phototransduction: shedding light on translocation
    Roger C Hardie
    Cambridge University Department of Anatomy, Downing Street, Cambridge CB2 3DY, UK
    Curr Biol 13:R775-7. 2003
    ..New work has identified a phosphoinositide lipid binding domain in Drosophila arrestin and implicates PIP(3) in control of arrestin translocation...
  14. ncbi Regulation of Drosophila TRP channels by lipid messengers
    Roger C Hardie
    Cambridge University Department of Anatomy, Downing Street, Cambridge CB2 3DY, UK
    Novartis Found Symp 258:160-7; discussion 167-71, 263-6. 2004
    ..Together with evidence from several mammalian TRP homologues, these results suggest that regulation by lipids may be a defining feature of many TRP channels...
  15. doi Regulation of Drosophila TRPC channels by lipid messengers
    Padinjat Raghu
    Inositide Laboratory, Babraham Institute, Cambridge, United Kingdom
    Cell Calcium 45:566-73. 2009
    ..Evidence on the role of these lipid elements in regulating TRP and TRPL activity is discussed in this review...
  16. doi Distinct roles for two histamine receptors (hclA and hclB) at the Drosophila photoreceptor synapse
    Antonios Pantazis
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge CB2 3DY, United Kingdom
    J Neurosci 28:7250-9. 2008
    ..Our results suggest that the native receptor at the LMC synapse is an HCLA homomer, whereas HCLB signaling via the lamina glia plays a previously unrecognized role in shaping the LMC postsynaptic response...
  17. ncbi Inhibition of phospholipase C activity in Drosophila photoreceptors by 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid (BAPTA) and di-bromo BAPTA
    Roger C Hardie
    Cambridge University, Department of Anatomy, Downing St, Cambridge CB2 3DY, UK
    Cell Calcium 38:547-56. 2005
    ..The results indicate that both BAPTA and DBB inhibit PLC activity independently of their role as Ca2+ chelators, whilst non-physiologically low (<100 nM) levels of Ca2+ suppress both basal and light-induced PLC activity...
  18. ncbi Regulation of TRP channels via lipid second messengers
    Roger C Hardie
    Department of Anatomy, Cambridge University, Downing St Cambridge CB2 3DY, United Kingdom
    Annu Rev Physiol 65:735-59. 2003
    ..Recent evidence indicates that a growing number of mammalian TRP homologues are also regulated by lipid messengers, including DAG, arachidonic acid, and PIP2...
  19. ncbi TRP channels in Drosophila photoreceptors: the lipid connection
    Roger C Hardie
    Department of Anatomy, Cambridge University, Downing Street, Cambridge CB2 3DY, UK
    Cell Calcium 33:385-93. 2003
    ..The rdgA mutation leads to constitutive activation of both TRP and TRPL channels and dramatically increases sensitivity to light in hypomorphic mutations of PLC and G protein...
  20. ncbi Rescue of light responses in the Drosophila "null" phospholipase C mutant, norpAP24, by the diacylglycerol kinase mutant, rdgA, and by metabolic inhibition
    Roger C Hardie
    Cambridge University Department of Anatomy, Cambridge CB2 3DY, United Kingdom
    J Biol Chem 278:18851-8. 2003
    ....
  21. pmc TRP channels and lipids: from Drosophila to mammalian physiology
    Roger C Hardie
    Department of Physiology Development and Neuroscience, Cambridge University, Downing Street, Cambridge CB2 3DY, UK
    J Physiol 578:9-24. 2007
    ..Although compelling evidence for a direct interaction of DAG with the TRPC channels is lacking, mutagenesis studies have identified putative PIP2-interacting domains in the C-termini of several TRPV and TRPM channels...
  22. pmc Common mechanisms regulating dark noise and quantum bump amplification in Drosophila photoreceptors
    Brian Chu
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom
    J Neurophysiol 109:2044-55. 2013
    ..By contrast, quantum bump generation is reliable but delayed until sufficient G proteins and PLC are activated to overcome threshold, thereby ensuring generation of full-size bumps with high quantum efficiency...
  23. pmc Fractional Ca(2+) currents through TRP and TRPL channels in Drosophila photoreceptors
    Brian Chu
    Department of Physiology, Development and Neuroscience, Cambridge University, Cambridge, UK
    Biophys J 104:1905-16. 2013
    ....
  24. pmc Depletion of PtdIns(4,5)P₂ underlies retinal degeneration in Drosophila trp mutants
    Sukanya Sengupta
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK
    J Cell Sci 126:1247-59. 2013
    ....
  25. ncbi The contribution of Shaker K+ channels to the information capacity of Drosophila photoreceptors
    Jeremy E Niven
    Physiological Laboratory, University of Cambridge, Cambridge CB2 3EG, UK
    Nature 421:630-4. 2003
    ....