R C Hardie


Affiliation: University of Cambridge
Country: UK


  1. request reprint
    Hardie R. Phototransduction: shedding light on translocation. Curr Biol. 2003;13:R775-7 pubmed
    ..New work has identified a phosphoinositide lipid binding domain in Drosophila arrestin and implicates PIP(3) in control of arrestin translocation. ..
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    Hardie R, Reuss H, Lansdell S, Millar N. Functional equivalence of native light-sensitive channels in the Drosophila trp301 mutant and TRPL cation channels expressed in a stably transfected Drosophila cell line. Cell Calcium. 1997;21:431-40 pubmed
    ..These findings indicate that channels encoded by the trpl gene can completely account for the component of the light-sensitive conductance remaining in the trp mutant. ..
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    Hardie R, Raghu P, Moore S, Juusola M, Baines R, Sweeney S. Calcium influx via TRP channels is required to maintain PIP2 levels in Drosophila photoreceptors. Neuron. 2001;30:149-59 pubmed
    ..Without this feedback one photon appears sufficient to deplete the phosphoinositide pool of approximately 4 microvilli. ..
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    Hardie R, Raghu P. Visual transduction in Drosophila. Nature. 2001;413:186-93 pubmed
    ..Analysis in Drosophila has revealed many of the underlying molecular strategies, leading to the discovery and characterization of signalling molecules of widespread importance. ..
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    Hardie R. Phototransduction in Drosophila melanogaster. J Exp Biol. 2001;204:3403-9 pubmed
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    Hardie R, Martin F, Chyb S, Raghu P. Rescue of light responses in the Drosophila "null" phospholipase C mutant, norpAP24, by the diacylglycerol kinase mutant, rdgA, and by metabolic inhibition. J Biol Chem. 2003;278:18851-8 pubmed
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    Hardie R, Gu Y, Martin F, Sweeney S, Raghu P. In vivo light-induced and basal phospholipase C activity in Drosophila photoreceptors measured with genetically targeted phosphatidylinositol 4,5-bisphosphate-sensitive ion channels (Kir2.1). J Biol Chem. 2004;279:47773-82 pubmed
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    Gu Y, Oberwinkler J, Postma M, Hardie R. Mechanisms of light adaptation in Drosophila photoreceptors. Curr Biol. 2005;15:1228-34 pubmed