Hardie R. Phototransduction: shedding light on translocation. Curr Biol. 2003;13:R775-7 pubmed
..New work has identified a phosphoinositide lipid binding domain in Drosophila arrestin and implicates PIP(3) in control of arrestin translocation. ..
Hardie R, Reuss H, Lansdell S, Millar N. Functional equivalence of native light-sensitive channels in the Drosophila trp301 mutant and TRPL cation channels expressed in a stably transfected Drosophila cell line. Cell Calcium. 1997;21:431-40 pubmed
..These findings indicate that channels encoded by the trpl gene can completely account for the component of the light-sensitive conductance remaining in the trp mutant. ..
Hardie R, Raghu P, Moore S, Juusola M, Baines R, Sweeney S. Calcium influx via TRP channels is required to maintain PIP2 levels in Drosophila photoreceptors. Neuron. 2001;30:149-59 pubmed
..Without this feedback one photon appears sufficient to deplete the phosphoinositide pool of approximately 4 microvilli. ..
Hardie R, Raghu P. Visual transduction in Drosophila. Nature. 2001;413:186-93 pubmed
..Analysis in Drosophila has revealed many of the underlying molecular strategies, leading to the discovery and characterization of signalling molecules of widespread importance. ..
Hardie R. Phototransduction in Drosophila melanogaster. J Exp Biol. 2001;204:3403-9 pubmed
Hardie R, Martin F, Chyb S, Raghu P. Rescue of light responses in the Drosophila "null" phospholipase C mutant, norpAP24, by the diacylglycerol kinase mutant, rdgA, and by metabolic inhibition. J Biol Chem. 2003;278:18851-8 pubmed
Hardie R, Gu Y, Martin F, Sweeney S, Raghu P. In vivo light-induced and basal phospholipase C activity in Drosophila photoreceptors measured with genetically targeted phosphatidylinositol 4,5-bisphosphate-sensitive ion channels (Kir2.1). J Biol Chem. 2004;279:47773-82 pubmed
Gu Y, Oberwinkler J, Postma M, Hardie R. Mechanisms of light adaptation in Drosophila photoreceptors. Curr Biol. 2005;15:1228-34 pubmed