Research Topics
Species | Roger M HarbordSummaryAffiliation: University of Bristol Country: UK Publications
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Detail Information
Publications
No role for quality scores in systematic reviews of diagnostic accuracy studiesPenny Whiting
MRC Health Services Research Collaboration, Department of Social Medicine, University of Bristol, Bristol, UK
BMC Med Res Methodol 5:19. 2005....- Graphical presentation of diagnostic informationPenny F Whiting
Department of Social Medicine, Canynge Hall, Whiteladies Road, Bristol, BS8 2PR, UK
BMC Med Res Methodol 8:20. 2008..Diagnostic information should be presented in an easily interpretable way, which conveys both test characteristics (diagnostic accuracy) and the potential for use in clinical practice (predictive value)... 
A modified test for small-study effects in meta-analyses of controlled trials with binary endpointsRoger M Harbord
MRC Health Services Research Collaboration, Department of Social Medicine, University of Bristol, UK
Stat Med 25:3443-57. 2006..When the degree of between-trial heterogeneity is large, none of the tests that have been proposed has uniformly good properties...- A unification of models for meta-analysis of diagnostic accuracy studiesRoger M Harbord
Medical Research Council Health Services Research Collaboration, Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, UK
Biostatistics 8:239-51. 2007..We discuss the different forms of summary model output suggested by the two approaches, including summary ROC curves, summary points, confidence regions, and prediction regions... 
An empirical comparison of methods for meta-analysis of diagnostic accuracy showed hierarchical models are necessaryRoger M Harbord
MRC Health Services Research Collaboration, Department of Social Medicine, University of Bristol, Bristol, UK
J Clin Epidemiol 61:1095-103. 2008..Statistically rigorous hierarchical models require expertise and sophisticated software. We assessed whether any of the simpler methods can in practice give adequately accurate and reliable results...- Instrumental variable estimation of causal risk ratios and causal odds ratios in Mendelian randomization analysesTom M Palmer
MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
Am J Epidemiol 173:1392-403. 2011..Based on the theoretical properties of the estimators, structural mean models make weaker assumptions than other IV estimators and can therefore be expected to be consistent in a wider range of situations... - Using genetic loci to understand the relationship between adiposity and psychological distress: a Mendelian Randomization study in the Copenhagen General Population Study of 53,221 adultsDebbie A Lawlor
MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, UK
J Intern Med 269:525-37. 2011..We used genetic variants that are robustly associated with adiposity to examine the causal association of adiposity with psychological distress... - The association of C-reactive protein and CRP genotype with coronary heart disease: findings from five studies with 4,610 cases amongst 18,637 participantsDebbie A Lawlor
MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom
PLoS ONE 3:e3011. 2008..Our objective was to examine the association between CRP genetic variant +1444C>T (rs1130864) and CHD risk in the largest study to date of this association... - Exploring the developmental overnutrition hypothesis using parental-offspring associations and FTO as an instrumental variableDebbie A Lawlor
Medical Research Council Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom
PLoS Med 5:e33. 2008..If true, this would result in the obesity epidemic progressing across generations irrespective of environmental or genetic changes. It is therefore important to robustly test this hypothesis... - Mendelian randomization: using genes as instruments for making causal inferences in epidemiologyDebbie A Lawlor
Department of Social Medicine, University of Bristol, U K
Stat Med 27:1133-63. 2008..This paper outlines Mendelian randomization, draws parallels with IV methods, provides examples of implementation of the approach and discusses limitations of the approach and some methods for dealing with these... - Meta-analyses of observational and genetic association studies of folate intakes or levels and breast cancer riskSarah J Lewis
Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
J Natl Cancer Inst 98:1607-22. 2006.... - C-reactive protein and its role in metabolic syndrome: mendelian randomisation studyNicholas J Timpson
Department of Social Medicine, University of Bristol, Canynge Hall, Bristol BS8 2PR, UK
Lancet 366:1954-9. 2005..Our aim was to generate estimates of the association between plasma CRP and metabolic syndrome phenotypes that were free from confounding and reverse causation, to assess the causal role of this protein... - Genetic variation at the SLC23A1 locus is associated with circulating concentrations of L-ascorbic acid (vitamin C): evidence from 5 independent studies with >15,000 participantsNicholas J Timpson
Medical Research Council Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Department of Social Medicine, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, United Kingdom
Am J Clin Nutr 92:375-82. 2010..To date, there are no confirmed genetic correlates of circulating concentrations of L-ascorbic acid... - How much of the data published in observational studies of the association between diet and prostate or bladder cancer is usable for meta-analysis?Geertruida E Bekkering
Department of Social Medicine, University of Bristol, Bristol, United Kingdom
Am J Epidemiol 167:1017-26. 2008..Results providing evidence of associations may be overrepresented in meta-analyses of observational studies... - Can lactase persistence genotype be used to reassess the relationship between renal cell carcinoma and milk drinking? Potentials and problems in the application of Mendelian randomizationNicholas J Timpson
MRC Centre for Causal Analysis in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, United Kingdom
Cancer Epidemiol Biomarkers Prev 19:1341-8. 2010..Whether this represents a causal association or is a result of confounding or bias is unclear. We assessed the potential for using genetic variation in lactase persistence as a tool for the study of this relationship... - Alcohol intake and blood pressure: a systematic review implementing a Mendelian randomization approachLina Chen
Department of Social Medicine, University of Bristol, Bristol, United Kingdom
PLoS Med 5:e52. 2008..We hypothesise that this polymorphism may influence the risk of hypertension by affecting alcohol drinking behaviour... - Likelihood-based estimation of microsatellite mutation ratesJohn C Whittaker
School of Applied Statistics, University of Reading, United Kingdom
Genetics 164:781-7. 2003..This would lead to a stationary distribution for allele length maintained by mutational balance. There is no evidence that contractions and expansions differ in their step size distributions...