Roger M Harbord

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. pmc No role for quality scores in systematic reviews of diagnostic accuracy studies
    Penny Whiting
    MRC Health Services Research Collaboration, Department of Social Medicine, University of Bristol, Bristol, UK
    BMC Med Res Methodol 5:19. 2005
  2. pmc Graphical presentation of diagnostic information
    Penny F Whiting
    Department of Social Medicine, Canynge Hall, Whiteladies Road, Bristol, BS8 2PR, UK
    BMC Med Res Methodol 8:20. 2008
  3. doi request reprint An empirical comparison of methods for meta-analysis of diagnostic accuracy showed hierarchical models are necessary
    Roger M Harbord
    MRC Health Services Research Collaboration, Department of Social Medicine, University of Bristol, Bristol, UK
    J Clin Epidemiol 61:1095-103. 2008
  4. ncbi request reprint A modified test for small-study effects in meta-analyses of controlled trials with binary endpoints
    Roger M Harbord
    MRC Health Services Research Collaboration, Department of Social Medicine, University of Bristol, UK
    Stat Med 25:3443-57. 2006
  5. ncbi request reprint A unification of models for meta-analysis of diagnostic accuracy studies
    Roger M Harbord
    Medical Research Council Health Services Research Collaboration, Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, UK
    Biostatistics 8:239-51. 2007
  6. doi request reprint Severity of bias of a simple estimator of the causal odds ratio in Mendelian randomization studies
    Roger M Harbord
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Stat Med 32:1246-58. 2013
  7. pmc Using multiple genetic variants as instrumental variables for modifiable risk factors
    Tom M Palmer
    MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK
    Stat Methods Med Res 21:223-42. 2012
  8. ncbi request reprint Instrumental variable estimation of causal risk ratios and causal odds ratios in Mendelian randomization analyses
    Tom M Palmer
    MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
    Am J Epidemiol 173:1392-403. 2011
  9. ncbi request reprint Mendelian randomization: using genes as instruments for making causal inferences in epidemiology
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, U K
    Stat Med 27:1133-63. 2008
  10. ncbi request reprint C-reactive protein and its role in metabolic syndrome: mendelian randomisation study
    Nicholas J Timpson
    Department of Social Medicine, University of Bristol, Canynge Hall, Bristol BS8 2PR, UK
    Lancet 366:1954-9. 2005

Detail Information

Publications20

  1. pmc No role for quality scores in systematic reviews of diagnostic accuracy studies
    Penny Whiting
    MRC Health Services Research Collaboration, Department of Social Medicine, University of Bristol, Bristol, UK
    BMC Med Res Methodol 5:19. 2005
    ....
  2. pmc Graphical presentation of diagnostic information
    Penny F Whiting
    Department of Social Medicine, Canynge Hall, Whiteladies Road, Bristol, BS8 2PR, UK
    BMC Med Res Methodol 8:20. 2008
    ..Diagnostic information should be presented in an easily interpretable way, which conveys both test characteristics (diagnostic accuracy) and the potential for use in clinical practice (predictive value)...
  3. doi request reprint An empirical comparison of methods for meta-analysis of diagnostic accuracy showed hierarchical models are necessary
    Roger M Harbord
    MRC Health Services Research Collaboration, Department of Social Medicine, University of Bristol, Bristol, UK
    J Clin Epidemiol 61:1095-103. 2008
    ..Statistically rigorous hierarchical models require expertise and sophisticated software. We assessed whether any of the simpler methods can in practice give adequately accurate and reliable results...
  4. ncbi request reprint A modified test for small-study effects in meta-analyses of controlled trials with binary endpoints
    Roger M Harbord
    MRC Health Services Research Collaboration, Department of Social Medicine, University of Bristol, UK
    Stat Med 25:3443-57. 2006
    ..When the degree of between-trial heterogeneity is large, none of the tests that have been proposed has uniformly good properties...
  5. ncbi request reprint A unification of models for meta-analysis of diagnostic accuracy studies
    Roger M Harbord
    Medical Research Council Health Services Research Collaboration, Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, UK
    Biostatistics 8:239-51. 2007
    ..We discuss the different forms of summary model output suggested by the two approaches, including summary ROC curves, summary points, confidence regions, and prediction regions...
  6. doi request reprint Severity of bias of a simple estimator of the causal odds ratio in Mendelian randomization studies
    Roger M Harbord
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Stat Med 32:1246-58. 2013
    ..The Wald-type estimator may retain a role as an approximate method for meta-analysis based on summary data...
  7. pmc Using multiple genetic variants as instrumental variables for modifiable risk factors
    Tom M Palmer
    MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK
    Stat Methods Med Res 21:223-42. 2012
    ..Under the correct conditions, multiple instrument analyses are a promising approach for Mendelian randomisation studies. Further research is required into multiple imputation methods to address missing data issues in IV estimation...
  8. ncbi request reprint Instrumental variable estimation of causal risk ratios and causal odds ratios in Mendelian randomization analyses
    Tom M Palmer
    MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
    Am J Epidemiol 173:1392-403. 2011
    ..Based on the theoretical properties of the estimators, structural mean models make weaker assumptions than other IV estimators and can therefore be expected to be consistent in a wider range of situations...
  9. ncbi request reprint Mendelian randomization: using genes as instruments for making causal inferences in epidemiology
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, U K
    Stat Med 27:1133-63. 2008
    ..This paper outlines Mendelian randomization, draws parallels with IV methods, provides examples of implementation of the approach and discusses limitations of the approach and some methods for dealing with these...
  10. ncbi request reprint C-reactive protein and its role in metabolic syndrome: mendelian randomisation study
    Nicholas J Timpson
    Department of Social Medicine, University of Bristol, Canynge Hall, Bristol BS8 2PR, UK
    Lancet 366:1954-9. 2005
    ..Our aim was to generate estimates of the association between plasma CRP and metabolic syndrome phenotypes that were free from confounding and reverse causation, to assess the causal role of this protein...
  11. pmc The association of C-reactive protein and CRP genotype with coronary heart disease: findings from five studies with 4,610 cases amongst 18,637 participants
    Debbie A Lawlor
    MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom
    PLoS ONE 3:e3011. 2008
    ..Our objective was to examine the association between CRP genetic variant +1444C>T (rs1130864) and CHD risk in the largest study to date of this association...
  12. ncbi request reprint Meta-analyses of observational and genetic association studies of folate intakes or levels and breast cancer risk
    Sarah J Lewis
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    J Natl Cancer Inst 98:1607-22. 2006
    ....
  13. pmc Exploring the developmental overnutrition hypothesis using parental-offspring associations and FTO as an instrumental variable
    Debbie A Lawlor
    Medical Research Council Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom
    PLoS Med 5:e33. 2008
    ..If true, this would result in the obesity epidemic progressing across generations irrespective of environmental or genetic changes. It is therefore important to robustly test this hypothesis...
  14. pmc Genetic variation at the SLC23A1 locus is associated with circulating concentrations of L-ascorbic acid (vitamin C): evidence from 5 independent studies with >15,000 participants
    Nicholas J Timpson
    Medical Research Council Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Department of Social Medicine, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, United Kingdom
    Am J Clin Nutr 92:375-82. 2010
    ..To date, there are no confirmed genetic correlates of circulating concentrations of L-ascorbic acid...
  15. pmc Is MRI better than CT for detecting a vascular component to dementia? A systematic review and meta-analysis
    Rebecca Beynon
    School of Social and Community Medicine, University of Bristol, Canynge Hall, Bristol, BS8 2PS, UK
    BMC Neurol 12:33. 2012
    ..We conducted a systematic review and meta-analysis to investigate this question...
  16. doi request reprint Using genetic loci to understand the relationship between adiposity and psychological distress: a Mendelian Randomization study in the Copenhagen General Population Study of 53,221 adults
    Debbie A Lawlor
    MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, UK
    J Intern Med 269:525-37. 2011
    ..We used genetic variants that are robustly associated with adiposity to examine the causal association of adiposity with psychological distress...
  17. doi request reprint Can lactase persistence genotype be used to reassess the relationship between renal cell carcinoma and milk drinking? Potentials and problems in the application of Mendelian randomization
    Nicholas J Timpson
    MRC Centre for Causal Analysis in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, United Kingdom
    Cancer Epidemiol Biomarkers Prev 19:1341-8. 2010
    ..Whether this represents a causal association or is a result of confounding or bias is unclear. We assessed the potential for using genetic variation in lactase persistence as a tool for the study of this relationship...
  18. doi request reprint How much of the data published in observational studies of the association between diet and prostate or bladder cancer is usable for meta-analysis?
    Geertruida E Bekkering
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    Am J Epidemiol 167:1017-26. 2008
    ..Results providing evidence of associations may be overrepresented in meta-analyses of observational studies...
  19. pmc Alcohol intake and blood pressure: a systematic review implementing a Mendelian randomization approach
    Lina Chen
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    PLoS Med 5:e52. 2008
    ..We hypothesise that this polymorphism may influence the risk of hypertension by affecting alcohol drinking behaviour...
  20. pmc Likelihood-based estimation of microsatellite mutation rates
    John C Whittaker
    School of Applied Statistics, University of Reading, United Kingdom
    Genetics 164:781-7. 2003
    ..This would lead to a stationary distribution for allele length maintained by mutational balance. There is no evidence that contractions and expansions differ in their step size distributions...