Ihtshamul Haq

Summary

Affiliation: University of Sheffield
Country: UK

Publications

  1. ncbi Thermodynamics of drug-DNA interactions
    Ihtshamul Haq
    Centre for Chemical Biology, Department of Chemistry, Krebs Institute, The University of Sheffield, Dainton Building, Brook Hill, Sheffield S3 7HF, UK
    Arch Biochem Biophys 403:1-15. 2002
  2. ncbi Dinuclear monointercalating RuII complexes that display high affinity binding to duplex and quadruplex DNA
    Chatna Rajput
    Department of Chemistry, University of Sheffield, Sheffield S3 7HF, UK
    Chemistry 12:4611-9. 2006
  3. ncbi Calorimetric and spectroscopic studies of Hoechst 33258: self-association and binding to non-cognate DNA
    Niklaas J Buurma
    Centre for Chemical Biology, The Department of Chemistry, The University of Sheffield, Dainton Building, Brook Hill, Sheffield, South Yorkshire, S3 7HF, UK
    J Mol Biol 381:607-21. 2008
  4. ncbi DNA binding of an organic dppz-based intercalator
    Tim Phillips
    Department of Chemistry, University of Sheffield, Sheffield S3 7HF, UK
    Biochemistry 43:13657-65. 2004
  5. ncbi Advances in the analysis of isothermal titration calorimetry data for ligand-DNA interactions
    Niklaas J Buurma
    School of Chemistry, Cardiff University, Cardiff CF10 3AT, UK
    Methods 42:162-72. 2007
  6. ncbi Roles of divalent metal ions in flap endonuclease-substrate interactions
    Min Feng
    University of Sheffield School of Medicine and Biomedical Science, Division of Genomic Medicine, Beech Hill Road, Sheffield, S10 2RX, UK
    Nat Struct Mol Biol 11:450-6. 2004
  7. ncbi Expression and characterization of the two flavodoxin proteins of Bacillus subtilis, YkuN and YkuP: biophysical properties and interactions with cytochrome P450 BioI
    Rachel J Lawson
    Department of Biochemistry, University of Leicester, UK
    Biochemistry 43:12390-409. 2004
  8. ncbi Thermodynamic and biophysical characterization of cytochrome P450 BioI from Bacillus subtilis
    Rachel J Lawson
    Department of Biochemistry, University of Leicester, UK
    Biochemistry 43:12410-26. 2004
  9. ncbi The dichotomy in the DNA-binding behaviour of ruthenium(II) complexes bearing benzoxazole and benzothiazole groups
    Catriona B Spillane
    The School of Chemistry and Chemical Engineering, Queen s University Belfast, Belfast BT9 5AG, Northern Ireland, United Kingdom
    J Inorg Biochem 102:673-83. 2008

Collaborators

  • Jim A Thomas
  • Niklaas J Buurma
  • Matthew J Sykes
  • David Leys
  • Rachel J Lawson
  • Catriona B Spillane
  • Chatna Rajput
  • Linda Swanson
  • Tim Phillips
  • Andrew W Munro
  • Min Feng
  • Marième N V Dabo
  • Joy L Morgan
  • F Richard Keene
  • Nicholas C Fletcher
  • Ramune Rutkaite
  • Anthony J H M Meijer
  • Jon R Sayers
  • John Clarkson
  • Dipak Patel
  • Harry Adams
  • Ian Soutar
  • Myles R Cheesman
  • Susan J Smith
  • Claes von Wachenfeldt
  • John Perkins
  • Carol A Kemp
  • Joe J Dervan
  • W Ewen Smith
  • Dietrich Suck
  • Thomas Ceska
  • Michael J Sutcliffe
  • John B Perkins

Detail Information

Publications9

  1. ncbi Thermodynamics of drug-DNA interactions
    Ihtshamul Haq
    Centre for Chemical Biology, Department of Chemistry, Krebs Institute, The University of Sheffield, Dainton Building, Brook Hill, Sheffield S3 7HF, UK
    Arch Biochem Biophys 403:1-15. 2002
    ..Finally some aspects of cooperativity in drug-DNA interactions are described and the importance of considering cooperative effects when examining these reactions is highlighted...
  2. ncbi Dinuclear monointercalating RuII complexes that display high affinity binding to duplex and quadruplex DNA
    Chatna Rajput
    Department of Chemistry, University of Sheffield, Sheffield S3 7HF, UK
    Chemistry 12:4611-9. 2006
    ..Calorimetry studies reveal that the thermodynamics of duplex and quadruplex binding is distinctly different, with the former being entirely entropically driven and the latter being both enthalpically and entropically favored...
  3. ncbi Calorimetric and spectroscopic studies of Hoechst 33258: self-association and binding to non-cognate DNA
    Niklaas J Buurma
    Centre for Chemical Biology, The Department of Chemistry, The University of Sheffield, Dainton Building, Brook Hill, Sheffield, South Yorkshire, S3 7HF, UK
    J Mol Biol 381:607-21. 2008
    ..Here, this numerical analysis, which uses simulated annealing of complex calorimetric data representing multiple coupled equilibria, is described...
  4. ncbi DNA binding of an organic dppz-based intercalator
    Tim Phillips
    Department of Chemistry, University of Sheffield, Sheffield S3 7HF, UK
    Biochemistry 43:13657-65. 2004
    ..poly(dT). A variety of techniques reveal that the cation binds to DNA with an affinity comparable to those of many metal dppz complexes, via an intercalative binding mode...
  5. ncbi Advances in the analysis of isothermal titration calorimetry data for ligand-DNA interactions
    Niklaas J Buurma
    School of Chemistry, Cardiff University, Cardiff CF10 3AT, UK
    Methods 42:162-72. 2007
    ..Models dealing with such data are now appearing in literature and we summarise examples relevant for the study of ligand-DNA interactions...
  6. ncbi Roles of divalent metal ions in flap endonuclease-substrate interactions
    Min Feng
    University of Sheffield School of Medicine and Biomedical Science, Division of Genomic Medicine, Beech Hill Road, Sheffield, S10 2RX, UK
    Nat Struct Mol Biol 11:450-6. 2004
    ..These results raise the possibility that local concentrations of free cofactor could influence the endo- or exonucleolytic pathway in vivo...
  7. ncbi Expression and characterization of the two flavodoxin proteins of Bacillus subtilis, YkuN and YkuP: biophysical properties and interactions with cytochrome P450 BioI
    Rachel J Lawson
    Department of Biochemistry, University of Leicester, UK
    Biochemistry 43:12390-409. 2004
    ..YkuN and YkuP supported monohydroxylation of lauric acid and myristic acid, but secondary oxygenation of the primary product was observed with both palmitic acid and palmitoleic acid as substrates...
  8. ncbi Thermodynamic and biophysical characterization of cytochrome P450 BioI from Bacillus subtilis
    Rachel J Lawson
    Department of Biochemistry, University of Leicester, UK
    Biochemistry 43:12410-26. 2004
    ..Calorimetry shows that structural stability of the protein was altered by addition of the reductant dithiothreitol, suggesting that the disulfide is important to integrity of BioI structure...
  9. ncbi The dichotomy in the DNA-binding behaviour of ruthenium(II) complexes bearing benzoxazole and benzothiazole groups
    Catriona B Spillane
    The School of Chemistry and Chemical Engineering, Queen s University Belfast, Belfast BT9 5AG, Northern Ireland, United Kingdom
    J Inorg Biochem 102:673-83. 2008
    ....