Mark A Hanson

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. pmc Relationship between placental expression of the imprinted PHLDA2 gene, intrauterine skeletal growth and childhood bone mass
    R M Lewis
    Institute of Developmental Sciences, University of Southampton and Southampton University Hospitals NHS Trust, UK
    Bone 50:337-42. 2012
  2. doi request reprint Developmental origins of health and disease: moving from biological concepts to interventions and policy
    Mark A Hanson
    Institute of Developmental Sciences, University of Southampton, Southampton, UK
    Int J Gynaecol Obstet 115:S3-5. 2011
  3. pmc Developmental origins of non-communicable disease: implications for research and public health
    Robert Barouki
    INSERM UMR S, Universite Paris Descartes, France
    Environ Health 11:42. 2012
  4. pmc Developmental origins of health and disease: reducing the burden of chronic disease in the next generation
    Peter D Gluckman
    Liggins Institute, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
    Genome Med 2:14. 2010
  5. pmc Fetal size in the second trimester is associated with the duration of pregnancy, small fetuses having longer pregnancies
    Synnøve L Johnsen
    Department of Obstetrics and Gynaecology, Haukeland University Hospital, Bergen, Norway
    BMC Pregnancy Childbirth 8:25. 2008
  6. pmc Maternal high fat diet during pregnancy and lactation alters hepatic expression of insulin like growth factor-2 and key microRNAs in the adult offspring
    Junlong Zhang
    Clinical Science Research Institute, Warwick Medical School, Clinical Sciences Building, University Hospital, Walsgrave Campus, Coventry, UK
    BMC Genomics 10:478. 2009
  7. pmc Developmental processes and the induction of cardiovascular function: conceptual aspects
    Mark A Hanson
    Centre for Developmental Origins of Health and Disease, University of Southampton, Princess Anne Hospital Level F 887, Coxford Road, Southampton S016 5YA, UK
    J Physiol 565:27-34. 2005
  8. pmc Endothelial dysfunction and cardiovascular disease: the role of predictive adaptive responses
    M Hanson
    Centre for Developmental Origins of Health and Disease, University of Southampton, Princess Anne Hospital, Coxford Road, Southampton, S016 5YA, UK
    Heart 91:864-6. 2005
  9. doi request reprint Epigenetic epidemiology: the rebirth of soft inheritance
    Mark A Hanson
    Institute of Developmental Sciences, University of Southampton, Southampton, UK
    Ann Nutr Metab 58:8-15. 2011
  10. doi request reprint Developmental origins of health and disease: new insights
    Mark A Hanson
    Division of Developmental Origins of Health and Disease, University of Southampton, Southampton, UK
    Basic Clin Pharmacol Toxicol 102:90-3. 2008

Detail Information

Publications105 found, 100 shown here

  1. pmc Relationship between placental expression of the imprinted PHLDA2 gene, intrauterine skeletal growth and childhood bone mass
    R M Lewis
    Institute of Developmental Sciences, University of Southampton and Southampton University Hospitals NHS Trust, UK
    Bone 50:337-42. 2012
    ..The results suggest that placental PHLDA2 may provide a biomarker for suboptimal skeletal growth in pregnancies uncomplicated by overt fetal growth restriction...
  2. doi request reprint Developmental origins of health and disease: moving from biological concepts to interventions and policy
    Mark A Hanson
    Institute of Developmental Sciences, University of Southampton, Southampton, UK
    Int J Gynaecol Obstet 115:S3-5. 2011
    ..A new focus on interventions to promote a good start to life in at-risk populations necessitates revision of public health policy, with implications for the health, education, and empowerment of women and children in particular...
  3. pmc Developmental origins of non-communicable disease: implications for research and public health
    Robert Barouki
    INSERM UMR S, Universite Paris Descartes, France
    Environ Health 11:42. 2012
    ....
  4. pmc Developmental origins of health and disease: reducing the burden of chronic disease in the next generation
    Peter D Gluckman
    Liggins Institute, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
    Genome Med 2:14. 2010
    ....
  5. pmc Fetal size in the second trimester is associated with the duration of pregnancy, small fetuses having longer pregnancies
    Synnøve L Johnsen
    Department of Obstetrics and Gynaecology, Haukeland University Hospital, Bergen, Norway
    BMC Pregnancy Childbirth 8:25. 2008
    ..Here we test the hypothesis that in low-risk pregnancies fetal growth (expressed by fetal size in the second trimester) is itself a determinant for pregnancy duration with the slower growing fetuses having a longer pregnancy...
  6. pmc Maternal high fat diet during pregnancy and lactation alters hepatic expression of insulin like growth factor-2 and key microRNAs in the adult offspring
    Junlong Zhang
    Clinical Science Research Institute, Warwick Medical School, Clinical Sciences Building, University Hospital, Walsgrave Campus, Coventry, UK
    BMC Genomics 10:478. 2009
    ....
  7. pmc Developmental processes and the induction of cardiovascular function: conceptual aspects
    Mark A Hanson
    Centre for Developmental Origins of Health and Disease, University of Southampton, Princess Anne Hospital Level F 887, Coxford Road, Southampton S016 5YA, UK
    J Physiol 565:27-34. 2005
    ....
  8. pmc Endothelial dysfunction and cardiovascular disease: the role of predictive adaptive responses
    M Hanson
    Centre for Developmental Origins of Health and Disease, University of Southampton, Princess Anne Hospital, Coxford Road, Southampton, S016 5YA, UK
    Heart 91:864-6. 2005
  9. doi request reprint Epigenetic epidemiology: the rebirth of soft inheritance
    Mark A Hanson
    Institute of Developmental Sciences, University of Southampton, Southampton, UK
    Ann Nutr Metab 58:8-15. 2011
    ..This may pave the way to much more effective, customised interventions to promote health across the life course...
  10. doi request reprint Developmental origins of health and disease: new insights
    Mark A Hanson
    Division of Developmental Origins of Health and Disease, University of Southampton, Southampton, UK
    Basic Clin Pharmacol Toxicol 102:90-3. 2008
    ..Appropriate interventions may have long-term multigenerational effects to reduce the risk of chronic disease...
  11. doi request reprint Commentary: Maternal constraint is a pre-eminent regulator of fetal growth
    Mark A Hanson
    Institute of Developmental Sciences, Southampton General Hospital Mailpoint 887, Tremona Road, Southampton SO16 6YD, UK
    Int J Epidemiol 37:252-4. 2008
  12. ncbi request reprint Report on the 2nd World Congress on Fetal Origins of Adult Disease, Brighton, U.K., June 7-10, 2003
    Mark Hanson
    Centre for Developmental Origins of Health and Disease, University of Southampton, Princess Anne Hospital, Southampton, S016 5YA, UK
    Pediatr Res 55:894-7. 2004
    ..Both have been characterized by a unique multidisciplinary attendance ranging from molecular, experimental, and developmental biologists to epidemiologists and health economists...
  13. doi request reprint Developmental origins of noncommunicable disease: population and public health implications
    Mark Hanson
    University of Southampton, Institute of Developmental Sciences, Southampton General Hospital, Southampton, United Kingdom
    Am J Clin Nutr 94:1754S-1758S. 2011
    ..We highlight the biomedical implications of this developmental origins of health and disease (DOHaD) concept of NCDs and discuss the implications for health policy...
  14. doi request reprint Developmental plasticity and developmental origins of non-communicable disease: theoretical considerations and epigenetic mechanisms
    Mark Hanson
    DOHaD Centre, University of Southampton, Southampton SO166YD, United Kingdom
    Prog Biophys Mol Biol 106:272-80. 2011
    ..Elucidation of epigenetic processes may permit perinatal identification of individuals most at risk of later NCD and enable early intervention strategies to reduce such risk...
  15. doi request reprint Maternal low-protein diet during mouse pre-implantation development induces vascular dysfunction and altered renin-angiotensin-system homeostasis in the offspring
    Adam J Watkins
    School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, UK
    Br J Nutr 103:1762-70. 2010
    ....
  16. pmc Sex- and age-specific effects of nutrition in early gestation and early postnatal life on hypothalamo-pituitary-adrenal axis and sympathoadrenal function in adult sheep
    Kirsten R Poore
    Institute of Developmental Sciences, Developmental Origins of Health and Disease Division, University of Southampton, Southampton, UK
    J Physiol 588:2219-37. 2010
    ..With altered glucose tolerance previously reported in this model, this may have long-term detrimental effects on metabolic homeostasis and cardiovascular function...
  17. doi request reprint Effects of pre- and periconceptional undernutrition on arterial function in adult female sheep are vascular bed dependent
    Christopher Torrens
    Institute of Developmental Sciences, School of Medicine, University of Southampton, Southampton SO16 6YD, UK
    Exp Physiol 94:1024-33. 2009
    ..The effect depends on the timing of the insult, but also on the vascular bed studied and vessel hierarchy in the vascular tree...
  18. doi request reprint Maternal protein restriction with or without folic acid supplementation during pregnancy alters the hepatic transcriptome in adult male rats
    Karen A Lillycrop
    Development and Cell Biology, University of Southampton, Bassett Crescent East, Southampton, UK
    Br J Nutr 103:1711-9. 2010
    ..The present findings show that the pattern of induced changes in the adult liver transcriptome were dependent on maternal protein and folic acid intakes during pregnancy...
  19. pmc Interaction between maternal and offspring diet to impair vascular function and oxidative balance in high fat fed male mice
    Christopher Torrens
    Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
    PLoS ONE 7:e50671. 2012
    ..To determine the impact of maternal and post-weaning consumption of a high fat diet on endothelium-dependent vasorelaxation and redox regulation in adult male mouse offspring...
  20. pmc Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and
    Karen A Lillycrop
    Development and Cell Biology, Biomedical Sciences Building, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Br J Nutr 97:1064-73. 2007
    ..These findings suggest that induction in the offspring of altered epigenetic regulation of the hepatic GR1(10) promoter, and hence metabolic phenotype, may be due to reduced Dnmt1 expression...
  21. pmc Vascular dysfunction induced in offspring by maternal dietary fat involves altered arterial polyunsaturated fatty acid biosynthesis
    Christopher J Kelsall
    Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Hampshire, United Kingdom
    PLoS ONE 7:e34492. 2012
    ....
  22. doi request reprint Appetite regulatory mechanisms and food intake in mice are sensitive to mismatch in diets between pregnancy and postnatal periods
    Dyan Sellayah
    Institute of Developmental Sciences, Developmental Origins of Health and Disease Division, University of Southampton School of Medicine, Southampton General Hospital, Southampton, UK
    Brain Res 1237:146-52. 2008
    ....
  23. pmc Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generations
    Graham C Burdge
    Developmental Origins of Health and Disease Division, University of Southampton, Southampton, UK
    Br J Nutr 97:435-9. 2007
    ..This may represent a mechanism for the transmission of induced phenotypes between generations..
  24. ncbi request reprint The effect of maternal undernutrition in early gestation on gestation length and fetal and postnatal growth in sheep
    Jane K Cleal
    Centre for Developmental Origins of Health and Disease, University of Southampton, Southampton, SO16 5YA United Kingdom
    Pediatr Res 62:422-7. 2007
    ..e. growth rate or length of time in utero) adopted by the fetus to enhance immediate survival depends on offspring number and sex. This is likely to reflect the degree of constraint imposed on the fetus...
  25. pmc Mismatched pre- and postnatal nutrition leads to cardiovascular dysfunction and altered renal function in adulthood
    Jane K Cleal
    Institute of Developmental Sciences, University of Southampton, Tremona Road, Southampton SO16 6YD, United Kingdom
    Proc Natl Acad Sci U S A 104:9529-33. 2007
    ..Our findings have substantial implications for devising strategies to reduce the impact of a mismatch in nutrition levels in humans undergoing rapid socio-economic transitions in both developing and developed societies...
  26. pmc The nature of the growth pattern and of the metabolic response to fasting in the rat are dependent upon the dietary protein and folic acid intakes of their pregnant dams and post-weaning fat consumption
    Graham C Burdge
    Institute of Human Nutrition, University of Southampton, Southampton, SO16 6YD, UK
    Br J Nutr 99:540-9. 2008
    ..Prevention by increased folic acid intake of an altered metabolic phenotype by maternal protein-restriction may be at the expense of somatic growth...
  27. doi request reprint Long-term maternal high-fat feeding from weaning through pregnancy and lactation predisposes offspring to hypertension, raised plasma lipids and fatty liver in mice
    Maqsood M Elahi
    Institute of Developmental Sciences, Developmental Origins of Health and Disease Division, University of Southampton School of Medicine, Southampton General Hospital, Mailpoint 887, Southampton SO16 6YD, UK
    Br J Nutr 102:514-9. 2009
    ....
  28. doi request reprint Transmission of raised blood pressure and endothelial dysfunction to the F2 generation induced by maternal protein restriction in the F0, in the absence of dietary challenge in the F1 generation
    Christopher Torrens
    Maternal, Fetal and Neonatal Physiology, Institute of Developmental Sciences, School of Medicine, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO166YD, UK
    Br J Nutr 100:760-6. 2008
    ..Risk factors for chronic disease may therefore be heritable by non-genomic processes...
  29. pmc The late gestation fetal cardiovascular response to hypoglycaemia is modified by prior peri-implantation undernutrition in sheep
    Deborah M Burrage
    Institute of Developmental Sciences, Southampton General Hospital, Tremona Road, Southampton, UK
    J Physiol 587:611-24. 2009
    ..One element of the peripheral vascular response was modified by peri-implantation nutrient restriction, indicating that nutritional challenges early in gestation can have an enduring impact on cardiovascular control...
  30. pmc Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha promoter of the offspring
    Karen A Lillycrop
    Development and Cell Biology, Biomedical Sciences Building, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Br J Nutr 100:278-82. 2008
    ..These data show for the first time that prenatal nutrition induces differential changes to the methylation of individual CpG dinucleotides in juvenile rats which persist in adults...
  31. pmc Maternal fat intake in rats alters 20:4n-6 and 22:6n-3 status and the epigenetic regulation of Fads2 in offspring liver
    Samuel P Hoile
    Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK
    J Nutr Biochem 24:1213-20. 2013
    ..Thus, epigenetic regulation of Fads2 may contribute to short- and long-term regulation of PUFA synthesis...
  32. pmc Progressive, transgenerational changes in offspring phenotype and epigenotype following nutritional transition
    Graham C Burdge
    Academic Unit of Human Development and Health, Faculty of Medicine, Institute of Developmental Sciences, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    PLoS ONE 6:e28282. 2011
    ..The transgenerational effects on phenotype were associated with altered DNA methylation of specific genes in a manner consistent with induction de novo of epigenetic marks in each generation...
  33. pmc Endothelial dysfunction and reduced antioxidant protection in an animal model of the developmental origins of cardiovascular disease
    Joanne L Rodford
    Institute of Developmental Sciences, University of Southampton, Southampton, UK
    J Physiol 586:4709-20. 2008
    ..Our findings have established that PR induces significant phenotypic changes in male offspring that may be indicative of an adaptive response during development...
  34. doi request reprint Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression
    Kimberley D Bruce
    Institute of Developmental Sciences, University of Southampton, Southampton General Hospital, Southampton, UK
    Hepatology 50:1796-808. 2009
    ..In addition, measurement of hepatic gene expression indicated that lipogenesis, oxidative stress, and inflammatory pathways were up-regulated in the 15-week-old HF/C and HF/HF offspring...
  35. ncbi request reprint Folate supplementation during pregnancy improves offspring cardiovascular dysfunction induced by protein restriction
    Christopher Torrens
    Centre for Developmental Origins of Health and Disease, University of Southampton, Princess Anne Hospital, Southampton S016 5YA, United Kingdom
    Hypertension 47:982-7. 2006
    ..The concept of developmental origins of adult disease focuses predominately on fetal life but must also include a role for maternal cardiovascular function...
  36. pmc Dietary protein restriction during F0 pregnancy in rats induces transgenerational changes in the hepatic transcriptome in female offspring
    Samuel P Hoile
    Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Hampshire, United Kingdom
    PLoS ONE 6:e21668. 2011
    ..Such variation may reflect differences between generations in the signals received by the fetus from the mother as a consequence of changes in the interaction between her phenotype and the environment...
  37. doi request reprint Non-imprinted epigenetics in fetal and postnatal development and growth
    Keith M Godfrey
    MRC Lifecourse Epidemiology Unit, Southampton General Hospital, Southampton, UK
    Nestle Nutr Inst Workshop Ser 71:57-63. 2013
    ..Elucidation of epigenetic processes may enable early intervention strategies to improve early development and growth...
  38. doi request reprint Atorvastatin restores endothelial function in offspring of protein-restricted rats in a cholesterol-independent manner
    Christopher Torrens
    Vascular Biology Group, Institute of Developmental Sciences 887, University of Southampton, School of Medicine, Southampton General Hospital, Tremona Rd, Southampton S016 6YD, United Kingdom
    Hypertension 53:661-7. 2009
    ..These data suggest that atorvastatin can restore endothelial function in this model, but its effects are gender specific and dependent on the vascular bed...
  39. ncbi request reprint Effects of pre-natal and early post-natal undernutrition on adult internal thoracic artery function
    Omar A Khan
    Department of Cardiothoracic Surgery, Southampton General Hospital, UK
    Eur J Cardiothorac Surg 28:811-5. 2005
    ..We investigated the effect of pre- and post-natal nutrient restriction on the vascular reactivity of the left internal thoracic artery using a sheep model...
  40. pmc Low protein diet fed exclusively during mouse oocyte maturation leads to behavioural and cardiovascular abnormalities in offspring
    Adam J Watkins
    School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    J Physiol 586:2231-44. 2008
    ..Similar and distinct postnatal outcomes were observed here compared with maternal LPD treatment during post-fertilization preimplantation development which may reflect the relative contribution of the paternal genome...
  41. doi request reprint Increasing the folic acid content of maternal or post-weaning diets induces differential changes in phosphoenolpyruvate carboxykinase mRNA expression and promoter methylation in rats
    Samuel P Hoile
    Academic Unit of Human Development and Health, Faculty of Medicine, Institute of Developmental Sciences, Southampton General Hospital, Tremona Road, Southampton, UK
    Br J Nutr 108:852-7. 2012
    ..Together, these findings show that both the period during the life course and sex influence the effect of increased exposure to folic acid on the epigenetic regulation of PEPCK and glucose homeostasis...
  42. ncbi request reprint Epigenetic mechanisms and the mismatch concept of the developmental origins of health and disease
    Keith M Godfrey
    Centre for Developmental Origins of Health and Disease, University of Southampton, UK
    Pediatr Res 61:5R-10R. 2007
    ..Future research into epigenetic processes may permit us to develop intervention strategies...
  43. pmc Epigenetic regulation of transcription: a mechanism for inducing variations in phenotype (fetal programming) by differences in nutrition during early life?
    Graham C Burdge
    DOHaD Research Division, University of Southampton, Bassett Cresent East, Southampton, UK
    Br J Nutr 97:1036-46. 2007
    ..The demonstration of altered epigenetic regulation of genes in phenotype induction suggests the possibility of interventions to modify long-term disease risk associated with unbalanced nutrition in early life...
  44. pmc Effect of sex and dietary fat intake on the fatty acid composition of phospholipids and triacylglycerol in rat heart
    Joanne L Slater-Jefferies
    Institute of Human Nutrition, University of Southampton School of Medicine, Institute of Developmental Sciences Building, MP887, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Prostaglandins Leukot Essent Fatty Acids 83:219-23. 2010
    ..These findings suggest that sex is an important factor in determining the incorporation of dietary fatty acids into cardiac lipids. This may have implications for sex differences in susceptibility to heart disease...
  45. ncbi request reprint Vasodilation to vascular endothelial growth factor in the uterine artery of the pregnant rat is blunted by low dietary protein intake
    Shigeru Itoh
    Centre for Fetal Origins of Adult Disease, Princess Anne Hospital, University of Southampton, Southampton SO16 5YA, UK
    Pediatr Res 51:485-91. 2002
    ..These results show an attenuated uterine artery vasodilator response to VEGF produced by a low-protein diet in pregnancy, partly because of a reduction of the nitric oxide component of VEGF-mediated relaxation...
  46. pmc Tissue-specific 5' heterogeneity of PPARα transcripts and their differential regulation by leptin
    Emma S Garratt
    Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
    PLoS ONE 8:e67483. 2013
    ..Such complexity in the regulation of PPARα may allow the expression of PPARα to be finely regulated in response to environmental factors. ..
  47. pmc Fetal liver blood flow distribution: role in human developmental strategy to prioritize fat deposition versus brain development
    Keith M Godfrey
    Institute of Developmental Sciences, University of Southampton, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom
    PLoS ONE 7:e41759. 2012
    ..Prenatal developmental influences play important roles in the human propensity to deposit fat...
  48. ncbi request reprint Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring
    Karen A Lillycrop
    Development and Cell Biology, University of Southampton, UK
    J Nutr 135:1382-6. 2005
    ..Epigenetic regulation of gene transcription provides a strong candidate mechanism for fetal programming...
  49. pmc Epigenetic gene promoter methylation at birth is associated with child's later adiposity
    Keith M Godfrey
    Institute of Developmental Sciences, University of Southampton, Southampton, UK
    Diabetes 60:1528-34. 2011
    ..In animal models, maternal diet alters offspring body composition, accompanied by epigenetic changes in metabolic control genes. Little is known about whether such processes operate in humans...
  50. doi request reprint Umbilical venous-arterial plasma composition differences suggest differential incorporation of fatty acids in NEFA and cholesteryl ester pools
    Rohan M Lewis
    Institute of Developmental Sciences, Faculty of Medicine, University of Southampton, UK
    Br J Nutr 106:463-7. 2011
    ..The present study demonstrates differential enrichment across the placenta of fatty acids into specific lipid pools in the fetal circulation. Such partitioning may facilitate supply of individual fatty acids to specific fetal tissues...
  51. pmc The long-term effects of prenatal development on growth and metabolism
    Keith M Godfrey
    Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom
    Semin Reprod Med 29:257-65. 2011
    ..This mismatch may arise through unbalanced diet or body composition of the mother or a change in lifestyle factors between generations. These insights offer new possibilities for the early diagnosis and prevention of chronic disease...
  52. pmc Modification of fetal plasma amino acid composition by placental amino acid exchangers in vitro
    Jane K Cleal
    DOHaD Division, University of Southampton, Southampton, UK
    J Physiol 582:871-82. 2007
    ..This study demonstrates that these transporters have the capacity to exchange micromolar amounts of specific amino acids, and suggests that they play an important role in regulating fetal plasma amino acid composition...
  53. ncbi request reprint Low serine hydroxymethyltransferase activity in the human placenta has important implications for fetal glycine supply
    Rohan M Lewis
    Centre for the Developmental Origins of Health and Disease, University of Southampton, Princess Anne Hospital, SO16 5YA Southampton, United Kingdom
    J Clin Endocrinol Metab 90:1594-8. 2005
    ..The low activity of SHMT in the human and rat placenta suggests that, unlike in the sheep, placental conversion of serine to glycine is not a major source of fetal glycine in these species...
  54. ncbi request reprint Nutritional challenges during development induce sex-specific changes in glucose homeostasis in the adult sheep
    Kirsten R Poore
    Centre for DOHaD, University of Southampton, Princess Anne Hospital, Level F MP 887 Coxford Road, Southampton SO16 5YA, UK
    Am J Physiol Endocrinol Metab 292:E32-9. 2007
    ..Improved glucose utilization may aid weight recovery but have negative implications for glucose homeostasis and body composition over the longer term...
  55. doi request reprint Developmental origins of metabolic disease: life course and intergenerational perspectives
    Keith M Godfrey
    University of Southampton School of Medicine, Southampton, UK
    Trends Endocrinol Metab 21:199-205. 2010
    ..Adopting a life course approach that takes into account intergenerational effects has important implications for prevention of non-communicable diseases, particularly in populations undergoing rapid economic transition...
  56. pmc Peri-implantation and late gestation maternal undernutrition differentially affect fetal sheep skeletal muscle development
    Paula M Costello
    Institute of Developmental Sciences, Developmental Origins of Health and Disease Division, MP 887, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    J Physiol 586:2371-9. 2008
    ..However, together these adaptations may influence the risk of later metabolic disease and thus our findings have implications for future strategies aimed at improving maternal diet...
  57. pmc Transgenerational effects of prenatal nutrient restriction on cardiovascular and hypothalamic-pituitary-adrenal function
    Caroline Bertram
    1Centre for Developmental Origins of Health and Disease, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, UK
    J Physiol 586:2217-29. 2008
    ..In conclusion, moderate maternal undernutrition profoundly modifies heart structure and HPA function in adult male offspring for two generations...
  58. doi request reprint Statin treatment in hypercholesterolemic pregnant mice reduces cardiovascular risk factors in their offspring
    Maqsood M Elahi
    Institute of Developmental Sciences, Developmental Origins of Health and Disease Division, University of Southampton School of Medicine, Southampton General Hospital, Southampton, United Kingdom
    Hypertension 51:939-44. 2008
    ..These findings indicate that the cholesterol-lowering effect of statins in pregnant dams consuming a high-fat, high-cholesterol diet leads to reduced cardiovascular risk factors in offspring that are sustained into adulthood...
  59. doi request reprint Sensitivity of housekeeping genes in the hypothalamus to mismatch in diets between pre- and postnatal periods in mice
    Dyan Sellayah
    Developmental Origins of Health and Disease Division, Institute of Developmental Sciences, University of Southampton School of Medicine, Southampton General Hospital, Southampton, United Kingdom
    Neurosci Lett 447:54-7. 2008
    ....
  60. pmc Lower maternal body condition during pregnancy affects skeletal muscle structure and glut-4 protein levels but not glucose tolerance in mature adult sheep
    Paula M Costello
    Institute of Developmental Sciences, University of Southampton, Southampton, UK
    Reprod Sci 20:1144-55. 2013
    ..However, such adaptations may lead to complications in metabolic control in an overabundant postnatal nutrient environment. ..
  61. doi request reprint The developmental origins, mechanisms, and implications of metabolic syndrome
    Kimberley D Bruce
    Developmental Origins of Health and Disease Division, Institute of Developmental Sciences, University of Southampton School of Medicine, Southampton General Hospital, Southampton, UK
    J Nutr 140:648-52. 2010
    ..A continued and greater understanding of these mechanisms will eventually allow specific interventions, with a favorable impact on the global incidence of cardiovascular disease and type 2 diabetes in the future...
  62. doi request reprint Developmental origins of the metabolic syndrome: body clocks and stress responses
    Felino R Cagampang
    Institute of Developmental Sciences, School of Medicine, University of Southampton, Southampton, UK
    Brain Behav Immun 25:214-20. 2011
    ..These effects can operate within the normal range and are not in themselves pathological, but can nevertheless affect an individual's response to environmental challenges in adult life and thus their risk of the metabolic syndrome...
  63. pmc Early life opportunities for prevention of diabetes in low and middle income countries
    Mark A Hanson
    Institute of Developmental Sciences, Faculty of Medicine, University of Southampton, Mailpoint 887, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK
    BMC Public Health 12:1025. 2012
    ..However, interventions to promote diet and lifestyle in prospective parents before conception have not received sufficient attention, especially in low- and middle-income countries undergoing socio-economic transition...
  64. ncbi request reprint Mechanisms of disease: in utero programming in the pathogenesis of hypertension
    David J P Barker
    Developmental Origins of Health and Disease Division MP 887, University of Southampton, Princess Anne Hospital, Southampton SO16 5YA, UK
    Nat Clin Pract Nephrol 2:700-7. 2006
    ..By monitoring blood pressure, weight, and renal function in children, it might be possible to reduce the risk of cardiovascular and renal disease in later life...
  65. ncbi request reprint Fetal origins of coronary heart disease-implications for cardiothoracic surgery?
    Omar A Khan
    Department of Cardiothoracic Surgery, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Eur J Cardiothorac Surg 27:1036-42. 2005
    ..Finally, the potential relevance of the theory to cardiac surgical practice will be evaluated...
  66. ncbi request reprint Expression of agouti-related peptide, neuropeptide Y, pro-opiomelanocortin and the leptin receptor isoforms in fetal mouse brain from pregnant dams on a protein-restricted diet
    Paul L Terroni
    Centre for Developmental Origins of Health and Disease, University of Southampton, School of Medicine, Princess Anne Hospital, Level F mailpoint 887, Coxford Road, Southampton, UK
    Brain Res Mol Brain Res 140:111-5. 2005
    ..Levels of expression for these genes were altered in brains of E12 fetuses from pregnant dams on a protein-restricted diet, suggesting that the fetal brain is responsive to changes in maternal nutrition prior to birth...
  67. doi request reprint Association of adult height and leg length with fasting plasma cortisol concentrations: evidence for an effect of normal variation in adrenocortical activity on growth
    D I W Phillips
    MRC Epidemiology Resource Centre, Mpt 95, Southampton General Hospital, Southampton, United Kingdom
    Am J Hum Biol 20:712-5. 2008
    ..They also raise the possibility that the HPA axis may be involved in mediating resource allocation decisions and trade-offs during development perhaps by limiting physical growth to enable other competing processes...
  68. doi request reprint Gestational diabetes, maternal obesity, and the NCD burden
    Ronald C W Ma
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong
    Clin Obstet Gynecol 56:633-41. 2013
    ..We use an evolutionary perspective to elucidate the origins of gestational diabetes. Focusing efforts on maternal health is an important approach to combating the growing burden of diabetes and other noncommunicable diseases. ..
  69. ncbi request reprint Prenatal programming of postnatal endocrine responses by glucocorticoids
    Caroline E Bertram
    Centre for Fetal Origins of Adult Disease, Mailpoint 887, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, UK
    Reproduction 124:459-67. 2002
    ..Current data indicate that key targets for programming may include not only the HPA axis but also glucocorticoid receptor gene and 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2) gene expression in a range of tissues...
  70. ncbi request reprint Adaptive responses by mouse early embryos to maternal diet protect fetal growth but predispose to adult onset disease
    Adam J Watkins
    School of Biological Sciences, University of Southampton, Southampton SO16 7PX, United Kingdom
    Biol Reprod 78:299-306. 2008
    ..However, activation of such responses may also lead to adult excess growth and cardiovascular and behavioral diseases...
  71. ncbi request reprint Effect of reduced maternal protein intake in pregnancy in the rat on the fatty acid composition of brain, liver, plasma, heart and lung phospholipids of the offspring after weaning
    Graham C Burdge
    Institute of Human Nutrition, Biomedical Sciences Building 62, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Br J Nutr 90:345-52. 2003
    ..These results suggest that restricted maternal protein intake during pregnancy results in persistent alterations to membrane fatty acid content...
  72. doi request reprint Angiotensin II receptor antagonist reduces subsequent uterine arterial dysfunction in pregnant offspring of protein-restricted rat dams
    Tomomi Saito
    Department of Obstetrics and Gynecology, School of Medicine, Juntendo University, Tokyo, Japan
    J Obstet Gynaecol Res 38:483-9. 2012
    ....
  73. pmc Maternal protein restriction in the rat impairs resistance artery but not conduit artery function in pregnant offspring
    Christopher Torrens
    Centre for Fetal Origins of Adult Disease, University of Southampton, Southampton, SO16 5YA, UK
    J Physiol 547:77-84. 2003
    ..We conclude that dietary protein restriction in pregnancy programmes vasodilator dysfunction in isolated resistance arteries of female offspring when they become pregnant, but does not affect conduit arteries...
  74. ncbi request reprint Does estrogen affect the development of abnormal vascular function in offspring of rats fed a low-protein diet in pregnancy?
    Yuka Musha
    Department of Obstetrics and Gynecology, School of Medicine Juntendo University 2 1 1 Hongo, Bunkyo ku Tokyo, Japan 113 8421
    Pediatr Res 59:784-9. 2006
    ..The processes may underlie gender and life course patterns of hypertension and also the developmental origins of this disease...
  75. ncbi request reprint Metabolic disease: evolutionary, developmental and transgenerational influences
    Peter D Gluckman
    Liggins Institute, University of Auckland and National Research Centre for Growth and Development, Grafton, New Zealand
    Nestle Nutr Workshop Ser Pediatr Program 55:17-27. 2005
  76. ncbi request reprint Effects of chronic hypoxia and protein malnutrition on growth in the developing chick
    Suzanne L Miller
    Departments of Obstetrics and Gynaecology, University College London, UK
    Am J Obstet Gynecol 186:261-7. 2002
    ..The purpose of this study was to determine how chronic hypoxia and/or protein malnutrition in ovo affect growth in developing chicks...
  77. ncbi request reprint Maternal constraint of fetal growth and its consequences
    Peter D Gluckman
    Liggins Institute, University of Auckland and National Research Centre for Growth and Development, 2 6 Park Avenue, Grafton, Private Bag 92019, Auckland, New Zealand
    Semin Fetal Neonatal Med 9:419-25. 2004
    ..Changing demography means that maternal constraint must increasingly be considered as a significant factor in determining the pattern of disease...
  78. ncbi request reprint The fetal, neonatal, and infant environments-the long-term consequences for disease risk
    Peter D Gluckman
    Liggins Institute and National Research Centre for Growth and Development, University of Auckland, 2 6 Park Avenue, Grafton, Private Bag 92019, Auckland, New Zealand
    Early Hum Dev 81:51-9. 2005
    ..There is increasing evidence that prematurity can be associated with long-term consequences, and this is to be anticipated from conceptual considerations. Different preventative strategies may be relevant in different populations...
  79. ncbi request reprint The effect of dietary supplementation with linoleic acid to late gestation ewes on the fatty acid composition of maternal and fetal plasma and tissues and the synthetic capacity of the placenta for 2-series prostaglandins
    Matthew Elmes
    Reproduction and Development Group, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Herts, AL9 7TA, UK
    Biochim Biophys Acta 1686:139-47. 2004
    ..Variations in the extent to which the diet altered the polyunsaturated fatty acid (PUFA) content of the different tissues indicated complex interactions between nutrient availability and metabolic adaptation...
  80. pmc Environmental influences during development and their later consequences for health and disease: implications for the interpretation of empirical studies
    Peter D Gluckman
    Liggins Institute, University of Auckland and National Research Centre for Growth and Development, 2 6 Park Avenue, Grafton, Private Bag 92019, Auckland, New Zealand
    Proc Biol Sci 272:671-7. 2005
    ..The paper reviews these concepts and explores ways in which such distinctions may be made in practice...
  81. ncbi request reprint Vasodilator tone in the llama fetus: the role of nitric oxide during normoxemia and hypoxemia
    Emilia M Sanhueza
    Programa de Fisiopatología, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Casilla 16038, Santiago 9, Chile
    Am J Physiol Regul Integr Comp Physiol 289:R776-83. 2005
    ....
  82. ncbi request reprint The developmental origins of the metabolic syndrome
    Peter D Gluckman
    Liggins Institute, University of Auckland and National Research Centre for Growth and Development, 2 6 Park Avenue, Grafton, Private Bag 92019, Auckland, New Zealand
    Trends Endocrinol Metab 15:183-7. 2004
    ..In this article, we review the clinical and experimental perspectives on the "developmental origins of disease" model in the context of these new concepts...
  83. ncbi request reprint Impaired glucose homeostasis and mitochondrial abnormalities in offspring of rats fed a fat-rich diet in pregnancy
    Paul D Taylor
    Division of Reproductive Health, Endocrinology and Development, King s College London, United Kingdom
    Am J Physiol Regul Integr Comp Physiol 288:R134-9. 2005
    ....
  84. ncbi request reprint The developmental origins of adult disease
    Peter D Gluckman
    Liggins Institute, University of Auckland, 2 6 Park Avenue, Grafton, Private Bag 92019, Auckland, New Zealand
    Matern Child Nutr 1:130-41. 2005
    ..These experimental, clinical and conceptual considerations have important implications for prevention and intervention in the current epidemic of childhood obesity and adult metabolic and cardiovascular disorders...
  85. ncbi request reprint Gender-linked hypertension in offspring of lard-fed pregnant rats
    Imran Y Khan
    Maternal and Fetal Research Unit, GKT Department of Women s Health, St Thomas Hospital, London, UK
    Hypertension 41:168-75. 2003
    ..Feeding a diet rich in lard to pregnant rats leads to gender-related cardiovascular dysfunction in normally fed offspring...
  86. ncbi request reprint Cardiovascular and endocrine responses to cutaneous electrical stimulation after fentanyl in the ovine fetus
    Richard P Smith
    Department of Maternal and Fetal Medicine, Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Royal Free and University College Medical School, London, UK
    Am J Obstet Gynecol 190:836-42. 2004
    ....
  87. ncbi request reprint Carbon monoxide: a novel pulmonary artery vasodilator in neonatal llamas of the Andean altiplano
    Emilio A Herrera
    Programa de Fisiopatología, ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Cardiovasc Res 77:197-201. 2008
    ..To study the nitric oxide (NO) and carbon monoxide roles in the regulation of the pulmonary circulation in lowland and highland newborn sheep and llamas...
  88. pmc Metabolic plasticity during mammalian development is directionally dependent on early nutritional status
    Peter D Gluckman
    Liggins Institute, University of Auckland, Private Bag 92019, Auckland 1023, New Zealand
    Proc Natl Acad Sci U S A 104:12796-800. 2007
    ....
  89. doi request reprint Predictive adaptive responses in perspective
    Peter D Gluckman
    Trends Endocrinol Metab 19:109-10; author reply 112. 2008
  90. doi request reprint The effect of maternal body condition score before and during pregnancy on the glucose tolerance of adult sheep offspring
    Roselle L Cripps
    Department of Clinical Biochemistry, University of Cambridge, Cambridge, UK
    Reprod Sci 15:448-56. 2008
    ..These findings suggest that altered maternal body composition and an imbalance between the fetal and postnatal environment influence offspring glucose tolerance...
  91. doi request reprint Effect of in utero and early-life conditions on adult health and disease
    Peter D Gluckman
    Liggins Institute, University of Auckland, and National Research Centre for Growth and Development, Auckland, New Zealand
    N Engl J Med 359:61-73. 2008
  92. doi request reprint Developmental perspectives on individual variation: implications for understanding nutritional needs
    Peter D Gluckman
    Liggins Institute, University of Auckland, Auckland, New Zealand
    Nestle Nutr Workshop Ser Pediatr Program 62:1-9; disucssion 9-12. 2008
    ..Epigenetic biomarkers may be able to identify a risk of developmental mismatch and thus offer the opportunity for nutritional or other intervention...
  93. ncbi request reprint High-altitude chronic hypoxia during gestation and after birth modifies cardiovascular responses in newborn sheep
    Emilio A Herrera
    Laboratorio de Fisiología y Fisiopatología del Desarrollo, Programa de Fisiopatología, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Am J Physiol Regul Integr Comp Physiol 292:R2234-40. 2007
    ..These responses determined in intrauterine life and early after birth could be adaptive to chronic hypoxia in the Andean altiplano...
  94. ncbi request reprint Living with the past: evolution, development, and patterns of disease
    Peter D Gluckman
    Liggins Institute, University of Auckland and National Research Centre for Growth and Development, 2 6 Park Avenue, Grafton, Private Bag 92019, Auckland, New Zealand
    Science 305:1733-6. 2004
    ..This "developmental origins of health and disease" concept may have important biological, medical, and socioeconomic implications...
  95. ncbi request reprint Life-long echoes--a critical analysis of the developmental origins of adult disease model
    Peter D Gluckman
    Liggins Institute, University of Auckland, Grafton, Private Bag 92019, Auckland, New Zealand
    Biol Neonate 87:127-39. 2005
    ..A model of the relationship between the developmental and mature environment is proposed and suggests interventional strategies that will vary in different population settings...
  96. pmc The fetal dilemma: spare the brain and spoil the liver
    Peter W Nathanielsz
    J Physiol 548:333. 2003
  97. ncbi request reprint The fetal llama versus the fetal sheep: different strategies to withstand hypoxia
    Anibal J Llanos
    Laboratorio de Fisiología y Fisiopatología del Desarrollo, Programa de Fisiopatología, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    High Alt Med Biol 4:193-202. 2003
    ..These results suggest that the llama fetus responds to acute hypoxia with hypometabolism. How this reduction in metabolism is produced and how the cells are preserved during this condition remain to be elucidated...
  98. ncbi request reprint Early life events and their consequences for later disease: a life history and evolutionary perspective
    Peter D Gluckman
    Liggins Institute, University of Auckland, and National Research Centre for Growth and Development, Private Bag 92019, Auckland, New Zealand
    Am J Hum Biol 19:1-19. 2007
    ..This view of human disease from the perspectives of life history biology and evolutionary theory offers new approaches to prevention, diagnosis and intervention...
  99. pmc Effect of nutritional restriction in early pregnancy on isolated femoral artery function in mid-gestation fetal sheep
    Hidenori Nishina
    Department of Obstetrics and Gynaecology, University College London, 86 96 Chenies Mews, London WC1 6HX, UK
    J Physiol 553:637-47. 2003
    ..These changes may precede perturbed late-gestation fetal and postnatal cardiovascular control...
  100. ncbi request reprint Non-genomic transgenerational inheritance of disease risk
    Peter D Gluckman
    Liggins Institute and National Research Centre for Growth and Development, University of Auckland, Auckland, New Zealand
    Bioessays 29:145-54. 2007
    ....
  101. ncbi request reprint Developmental origins of disease paradigm: a mechanistic and evolutionary perspective
    Peter D Gluckman
    Liggins Institute, University of Auckland and National Research Centre for Growth and Development, Private Bag 92019, Auckland, New Zealand
    Pediatr Res 56:311-7. 2004
    ..The developmental origins paradigm and its underlying mechanistic and evolutionary basis have major implications for addressing the increasing burden of metabolic and cardiovascular disease...