Research Topics
Genomes and Genes | Mark A HansonSummaryAffiliation: University of Southampton Country: UK Publications
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Publications
Developmental origins of health and disease: moving from biological concepts to interventions and policyMark A Hanson
Institute of Developmental Sciences, University of Southampton, Southampton, UK
Int J Gynaecol Obstet 115:S3-5. 2011..A new focus on interventions to promote a good start to life in at-risk populations necessitates revision of public health policy, with implications for the health, education, and empowerment of women and children in particular...
Developmental origins of non-communicable disease: implications for research and public healthRobert Barouki
INSERM UMR S, Universite Paris Descartes, France
Environ Health 11:42. 2012....- Developmental origins of health and disease: reducing the burden of chronic disease in the next generationPeter D Gluckman
Liggins Institute, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
Genome Med 2:14. 2010.... - Fetal size in the second trimester is associated with the duration of pregnancy, small fetuses having longer pregnanciesSynnøve L Johnsen
Department of Obstetrics and Gynaecology, Haukeland University Hospital, Bergen, Norway
BMC Pregnancy Childbirth 8:25. 2008..Here we test the hypothesis that in low-risk pregnancies fetal growth (expressed by fetal size in the second trimester) is itself a determinant for pregnancy duration with the slower growing fetuses having a longer pregnancy... - Maternal high fat diet during pregnancy and lactation alters hepatic expression of insulin like growth factor-2 and key microRNAs in the adult offspringJunlong Zhang
Clinical Science Research Institute, Warwick Medical School, Clinical Sciences Building, University Hospital, Walsgrave Campus, Coventry, UK
BMC Genomics 10:478. 2009.... - Developmental plasticity and developmental origins of non-communicable disease: theoretical considerations and epigenetic mechanismsMark Hanson
DOHaD Centre, University of Southampton, Southampton SO166YD, United Kingdom
Prog Biophys Mol Biol 106:272-80. 2011..Elucidation of epigenetic processes may permit perinatal identification of individuals most at risk of later NCD and enable early intervention strategies to reduce such risk... - Developmental processes and the induction of cardiovascular function: conceptual aspectsMark A Hanson
Centre for Developmental Origins of Health and Disease, University of Southampton, Princess Anne Hospital Level F 887, Coxford Road, Southampton S016 5YA, UK
J Physiol 565:27-34. 2005.... 
Report on the 2nd World Congress on Fetal Origins of Adult Disease, Brighton, U.K., June 7-10, 2003Mark Hanson
Centre for Developmental Origins of Health and Disease, University of Southampton, Princess Anne Hospital, Southampton, S016 5YA, UK
Pediatr Res 55:894-7. 2004..Both have been characterized by a unique multidisciplinary attendance ranging from molecular, experimental, and developmental biologists to epidemiologists and health economists...- Epigenetic epidemiology: the rebirth of soft inheritanceMark A Hanson
Institute of Developmental Sciences, University of Southampton, Southampton, UK
Ann Nutr Metab 58:8-15. 2011..This may pave the way to much more effective, customised interventions to promote health across the life course... - Developmental origins of noncommunicable disease: population and public health implicationsMark Hanson
University of Southampton, Institute of Developmental Sciences, Southampton General Hospital, Southampton, United Kingdom
Am J Clin Nutr 94:1754S-1758S. 2011..We highlight the biomedical implications of this developmental origins of health and disease (DOHaD) concept of NCDs and discuss the implications for health policy... - Developmental origins of health and disease: new insightsMark A Hanson
Division of Developmental Origins of Health and Disease, University of Southampton, Southampton, UK
Basic Clin Pharmacol Toxicol 102:90-3. 2008..Appropriate interventions may have long-term multigenerational effects to reduce the risk of chronic disease... - Endothelial dysfunction and cardiovascular disease: the role of predictive adaptive responsesM Hanson
Centre for Developmental Origins of Health and Disease, University of Southampton, Princess Anne Hospital, Coxford Road, Southampton, S016 5YA, UK
Heart 91:864-6. 2005 - Commentary: Maternal constraint is a pre-eminent regulator of fetal growthMark A Hanson
Institute of Developmental Sciences, Southampton General Hospital (Mailpoint 887, Tremona Road, Southampton SO16 6YD, UK
Int J Epidemiol 37:252-4. 2008 - Maternal low-protein diet during mouse pre-implantation development induces vascular dysfunction and altered renin-angiotensin-system homeostasis in the offspringAdam J Watkins
School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, UK
Br J Nutr 103:1762-70. 2010.... - Sex- and age-specific effects of nutrition in early gestation and early postnatal life on hypothalamo-pituitary-adrenal axis and sympathoadrenal function in adult sheepKirsten R Poore
Institute of Developmental Sciences, Developmental Origins of Health and Disease Division, University of Southampton, Southampton, UK
J Physiol 588:2219-37. 2010..With altered glucose tolerance previously reported in this model, this may have long-term detrimental effects on metabolic homeostasis and cardiovascular function... - Effects of pre- and periconceptional undernutrition on arterial function in adult female sheep are vascular bed dependentChristopher Torrens
Institute of Developmental Sciences, School of Medicine, University of Southampton, Southampton SO16 6YD, UK
Exp Physiol 94:1024-33. 2009..The effect depends on the timing of the insult, but also on the vascular bed studied and vessel hierarchy in the vascular tree... - Maternal protein restriction with or without folic acid supplementation during pregnancy alters the hepatic transcriptome in adult male ratsKaren A Lillycrop
Development and Cell Biology, University of Southampton, Bassett Crescent East, Southampton, UK
Br J Nutr 103:1711-9. 2010..The present findings show that the pattern of induced changes in the adult liver transcriptome were dependent on maternal protein and folic acid intakes during pregnancy... - Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and Karen A Lillycrop
Development and Cell Biology, Biomedical Sciences Building, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
Br J Nutr 97:1064-73. 2007..These findings suggest that induction in the offspring of altered epigenetic regulation of the hepatic GR1(10) promoter, and hence metabolic phenotype, may be due to reduced Dnmt1 expression... - Vascular dysfunction induced in offspring by maternal dietary fat involves altered arterial polyunsaturated fatty acid biosynthesisChristopher J Kelsall
Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Hampshire, United Kingdom
PLoS ONE 7:e34492. 2012.... - Appetite regulatory mechanisms and food intake in mice are sensitive to mismatch in diets between pregnancy and postnatal periodsDyan Sellayah
Institute of Developmental Sciences, Developmental Origins of Health and Disease Division, University of Southampton School of Medicine, Southampton General Hospital, Southampton, UK
Brain Res 1237:146-52. 2008.... - Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generationsGraham C Burdge
Developmental Origins of Health and Disease Division, University of Southampton, Southampton, UK
Br J Nutr 97:435-9. 2007..This may represent a mechanism for the transmission of induced phenotypes between generations.. - The effect of maternal undernutrition in early gestation on gestation length and fetal and postnatal growth in sheepJane K Cleal
Centre for Developmental Origins of Health and Disease, University of Southampton, Southampton, SO16 5YA United Kingdom
Pediatr Res 62:422-7. 2007..e. growth rate or length of time in utero) adopted by the fetus to enhance immediate survival depends on offspring number and sex. This is likely to reflect the degree of constraint imposed on the fetus... - Long-term maternal high-fat feeding from weaning through pregnancy and lactation predisposes offspring to hypertension, raised plasma lipids and fatty liver in miceMaqsood M Elahi
Institute of Developmental Sciences, Developmental Origins of Health and Disease Division, University of Southampton School of Medicine, Southampton General Hospital, Mailpoint 887, Southampton SO16 6YD, UK
Br J Nutr 102:514-9. 2009.... - Mismatched pre- and postnatal nutrition leads to cardiovascular dysfunction and altered renal function in adulthoodJane K Cleal
Institute of Developmental Sciences, University of Southampton, Tremona Road, Southampton SO16 6YD, United Kingdom
Proc Natl Acad Sci U S A 104:9529-33. 2007..Our findings have substantial implications for devising strategies to reduce the impact of a mismatch in nutrition levels in humans undergoing rapid socio-economic transitions in both developing and developed societies... - The nature of the growth pattern and of the metabolic response to fasting in the rat are dependent upon the dietary protein and folic acid intakes of their pregnant dams and post-weaning fat consumptionGraham C Burdge
Institute of Human Nutrition, University of Southampton, Southampton, SO16 6YD, UK
Br J Nutr 99:540-9. 2008..Prevention by increased folic acid intake of an altered metabolic phenotype by maternal protein-restriction may be at the expense of somatic growth... - The late gestation fetal cardiovascular response to hypoglycaemia is modified by prior peri-implantation undernutrition in sheepDeborah M Burrage
Institute of Developmental Sciences, Southampton General Hospital, Tremona Road, Southampton, UK
J Physiol 587:611-24. 2009..One element of the peripheral vascular response was modified by peri-implantation nutrient restriction, indicating that nutritional challenges early in gestation can have an enduring impact on cardiovascular control... - Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha promoter of the offspringKaren A Lillycrop
Development and Cell Biology, Biomedical Sciences Building, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
Br J Nutr 100:278-82. 2008..These data show for the first time that prenatal nutrition induces differential changes to the methylation of individual CpG dinucleotides in juvenile rats which persist in adults... - Transmission of raised blood pressure and endothelial dysfunction to the F2 generation induced by maternal protein restriction in the F0, in the absence of dietary challenge in the F1 generationChristopher Torrens
Maternal, Fetal and Neonatal Physiology, Institute of Developmental Sciences, School of Medicine, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO166YD, UK
Br J Nutr 100:760-6. 2008..Risk factors for chronic disease may therefore be heritable by non-genomic processes... - Progressive, transgenerational changes in offspring phenotype and epigenotype following nutritional transitionGraham C Burdge
Academic Unit of Human Development and Health, Faculty of Medicine, Institute of Developmental Sciences, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
PLoS ONE 6:e28282. 2011..The transgenerational effects on phenotype were associated with altered DNA methylation of specific genes in a manner consistent with induction de novo of epigenetic marks in each generation... - Folate supplementation during pregnancy improves offspring cardiovascular dysfunction induced by protein restrictionChristopher Torrens
Centre for Developmental Origins of Health and Disease, University of Southampton, Princess Anne Hospital, Southampton S016 5YA, United Kingdom
Hypertension 47:982-7. 2006..The concept of developmental origins of adult disease focuses predominately on fetal life but must also include a role for maternal cardiovascular function... - Dietary protein restriction during F0 pregnancy in rats induces transgenerational changes in the hepatic transcriptome in female offspringSamuel P Hoile
Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Hampshire, United Kingdom
PLoS ONE 6:e21668. 2011..Such variation may reflect differences between generations in the signals received by the fetus from the mother as a consequence of changes in the interaction between her phenotype and the environment... - Endothelial dysfunction and reduced antioxidant protection in an animal model of the developmental origins of cardiovascular diseaseJoanne L Rodford
Institute of Developmental Sciences, University of Southampton, Southampton, UK
J Physiol 586:4709-20. 2008..Our findings have established that PR induces significant phenotypic changes in male offspring that may be indicative of an adaptive response during development... - Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expressionKimberley D Bruce
Institute of Developmental Sciences, University of Southampton, Southampton General Hospital, Southampton, UK
Hepatology 50:1796-808. 2009..CONCLUSION: Maternal fat intake contributes toward the NAFLD progression in adult offspring, which is mediated through impaired hepatic mitochondrial metabolism and up-regulated hepatic lipogenesis... - Atorvastatin restores endothelial function in offspring of protein-restricted rats in a cholesterol-independent mannerChristopher Torrens
Vascular Biology Group, Institute of Developmental Sciences 887, University of Southampton, School of Medicine, Southampton General Hospital, Tremona Rd, Southampton S016 6YD, United Kingdom
Hypertension 53:661-7. 2009..These data suggest that atorvastatin can restore endothelial function in this model, but its effects are gender specific and dependent on the vascular bed... - Low protein diet fed exclusively during mouse oocyte maturation leads to behavioural and cardiovascular abnormalities in offspringAdam J Watkins
School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
J Physiol 586:2231-44. 2008..Similar and distinct postnatal outcomes were observed here compared with maternal LPD treatment during post-fertilization preimplantation development which may reflect the relative contribution of the paternal genome... - Effects of pre-natal and early post-natal undernutrition on adult internal thoracic artery functionOmar A Khan
Department of Cardiothoracic Surgery, Southampton General Hospital, UK
Eur J Cardiothorac Surg 28:811-5. 2005..This effect is significantly attenuated by continued undernutrition in early post-natal life. These experiments suggest that in utero and early post-natal undernutrition may be important determinants of graft function in later life... - Increasing the folic acid content of maternal or post-weaning diets induces differential changes in phosphoenolpyruvate carboxykinase mRNA expression and promoter methylation in ratsSamuel P Hoile
Academic Unit of Human Development and Health, Faculty of Medicine, Institute of Developmental Sciences, Southampton General Hospital, Tremona Road, Southampton, UK
Br J Nutr 108:852-7. 2012..Together, these findings show that both the period during the life course and sex influence the effect of increased exposure to folic acid on the epigenetic regulation of PEPCK and glucose homeostasis... - Effect of sex and dietary fat intake on the fatty acid composition of phospholipids and triacylglycerol in rat heartJoanne L Slater-Jefferies
Institute of Human Nutrition, University of Southampton School of Medicine, Institute of Developmental Sciences Building, MP887, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
Prostaglandins Leukot Essent Fatty Acids 83:219-23. 2010..These findings suggest that sex is an important factor in determining the incorporation of dietary fatty acids into cardiac lipids. This may have implications for sex differences in susceptibility to heart disease... - Epigenetic regulation of transcription: a mechanism for inducing variations in phenotype (fetal programming) by differences in nutrition during early life?Graham C Burdge
DOHaD Research Division, University of Southampton, Bassett Cresent East, Southampton, UK
Br J Nutr 97:1036-46. 2007..The demonstration of altered epigenetic regulation of genes in phenotype induction suggests the possibility of interventions to modify long-term disease risk associated with unbalanced nutrition in early life... - Epigenetic mechanisms and the mismatch concept of the developmental origins of health and diseaseKeith M Godfrey
Centre for Developmental Origins of Health and Disease, University of Southampton, UK
Pediatr Res 61:5R-10R. 2007..Future research into epigenetic processes may permit us to develop intervention strategies... - Vasodilation to vascular endothelial growth factor in the uterine artery of the pregnant rat is blunted by low dietary protein intakeShigeru Itoh
Centre for Fetal Origins of Adult Disease, Princess Anne Hospital, University of Southampton, Southampton SO16 5YA, UK
Pediatr Res 51:485-91. 2002..These results show an attenuated uterine artery vasodilator response to VEGF produced by a low-protein diet in pregnancy, partly because of a reduction of the nitric oxide component of VEGF-mediated relaxation... - Fetal liver blood flow distribution: role in human developmental strategy to prioritize fat deposition versus brain developmentKeith M Godfrey
Institute of Developmental Sciences, University of Southampton, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom
PLoS ONE 7:e41759. 2012..Prenatal developmental influences play important roles in the human propensity to deposit fat... - The long-term effects of prenatal development on growth and metabolismKeith M Godfrey
Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom
Semin Reprod Med 29:257-65. 2011..This mismatch may arise through unbalanced diet or body composition of the mother or a change in lifestyle factors between generations. These insights offer new possibilities for the early diagnosis and prevention of chronic disease... - Modification of fetal plasma amino acid composition by placental amino acid exchangers in vitroJane K Cleal
DOHaD Division, University of Southampton, Southampton, UK
J Physiol 582:871-82. 2007..This study demonstrates that these transporters have the capacity to exchange micromolar amounts of specific amino acids, and suggests that they play an important role in regulating fetal plasma amino acid composition... - Low serine hydroxymethyltransferase activity in the human placenta has important implications for fetal glycine supplyRohan M Lewis
Centre for the Developmental Origins of Health and Disease, University of Southampton, Princess Anne Hospital, SO16 5YA Southampton, United Kingdom
J Clin Endocrinol Metab 90:1594-8. 2005..The low activity of SHMT in the human and rat placenta suggests that, unlike in the sheep, placental conversion of serine to glycine is not a major source of fetal glycine in these species... - Umbilical venous-arterial plasma composition differences suggest differential incorporation of fatty acids in NEFA and cholesteryl ester poolsRohan M Lewis
Institute of Developmental Sciences, Faculty of Medicine, University of Southampton, UK
Br J Nutr 106:463-7. 2011..The present study demonstrates differential enrichment across the placenta of fatty acids into specific lipid pools in the fetal circulation. Such partitioning may facilitate supply of individual fatty acids to specific fetal tissues... - Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspringKaren A Lillycrop
Development and Cell Biology, University of Southampton, UK
J Nutr 135:1382-6. 2005..Epigenetic regulation of gene transcription provides a strong candidate mechanism for fetal programming... - Epigenetic gene promoter methylation at birth is associated with child's later adiposityKeith M Godfrey
Institute of Developmental Sciences, University of Southampton, Southampton, UK
Diabetes 60:1528-34. 2011..In animal models, maternal diet alters offspring body composition, accompanied by epigenetic changes in metabolic control genes. Little is known about whether such processes operate in humans... - Interaction between maternal and offspring diet to impair vascular function and oxidative balance in high fat fed male miceChristopher Torrens
Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
PLoS ONE 7:e50671. 2012..To determine the impact of maternal and post-weaning consumption of a high fat diet on endothelium-dependent vasorelaxation and redox regulation in adult male mouse offspring... - Nutritional challenges during development induce sex-specific changes in glucose homeostasis in the adult sheepKirsten R Poore
Centre for DOHaD, University of Southampton, Princess Anne Hospital, Level F MP 887 Coxford Road, Southampton SO16 5YA, UK
Am J Physiol Endocrinol Metab 292:E32-9. 2007..Improved glucose utilization may aid weight recovery but have negative implications for glucose homeostasis and body composition over the longer term... - Peri-implantation and late gestation maternal undernutrition differentially affect fetal sheep skeletal muscle developmentPaula M Costello
Institute of Developmental Sciences, Developmental Origins of Health and Disease Division, MP 887, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
J Physiol 586:2371-9. 2008..However, together these adaptations may influence the risk of later metabolic disease and thus our findings have implications for future strategies aimed at improving maternal diet... - Developmental origins of metabolic disease: life course and intergenerational perspectivesKeith M Godfrey
University of Southampton School of Medicine, Southampton, UK
Trends Endocrinol Metab 21:199-205. 2010..Adopting a life course approach that takes into account intergenerational effects has important implications for prevention of non-communicable diseases, particularly in populations undergoing rapid economic transition... - Statin treatment in hypercholesterolemic pregnant mice reduces cardiovascular risk factors in their offspringMaqsood M Elahi
Institute of Developmental Sciences, Developmental Origins of Health and Disease Division, University of Southampton School of Medicine, Southampton General Hospital, Southampton, United Kingdom
Hypertension 51:939-44. 2008..These findings indicate that the cholesterol-lowering effect of statins in pregnant dams consuming a high-fat, high-cholesterol diet leads to reduced cardiovascular risk factors in offspring that are sustained into adulthood... - Sensitivity of housekeeping genes in the hypothalamus to mismatch in diets between pre- and postnatal periods in miceDyan Sellayah
Developmental Origins of Health and Disease Division, Institute of Developmental Sciences, University of Southampton School of Medicine, Southampton General Hospital, Southampton, United Kingdom
Neurosci Lett 447:54-7. 2008.... - Transgenerational effects of prenatal nutrient restriction on cardiovascular and hypothalamic-pituitary-adrenal functionCaroline Bertram
1Centre for Developmental Origins of Health and Disease, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, UK
J Physiol 586:2217-29. 2008..In conclusion, moderate maternal undernutrition profoundly modifies heart structure and HPA function in adult male offspring for two generations... - Non-imprinted epigenetics in fetal and postnatal development and growthKeith M Godfrey
MRC Lifecourse Epidemiology Unit, Southampton General Hospital, Southampton, UK
Nestle Nutr Inst Workshop Ser 71:57-63. 2013..Elucidation of epigenetic processes may enable early intervention strategies to improve early development and growth... - Developmental origins of the metabolic syndrome: body clocks and stress responsesFelino R Cagampang
Institute of Developmental Sciences, School of Medicine, University of Southampton, Southampton, UK
Brain Behav Immun 25:214-20. 2011..These effects can operate within the normal range and are not in themselves pathological, but can nevertheless affect an individual's response to environmental challenges in adult life and thus their risk of the metabolic syndrome... - The developmental origins, mechanisms, and implications of metabolic syndromeKimberley D Bruce
Developmental Origins of Health and Disease Division, Institute of Developmental Sciences, University of Southampton School of Medicine, Southampton General Hospital, Southampton, UK
J Nutr 140:648-52. 2010..A continued and greater understanding of these mechanisms will eventually allow specific interventions, with a favorable impact on the global incidence of cardiovascular disease and type 2 diabetes in the future... - Early life opportunities for prevention of diabetes in low and middle income countriesMark A Hanson
Institute of Developmental Sciences, Faculty of Medicine, University of Southampton, Mailpoint 887, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK
BMC Public Health 12:1025. 2012..However, interventions to promote diet and lifestyle in prospective parents before conception have not received sufficient attention, especially in low- and middle-income countries undergoing socio-economic transition... - Fetal origins of coronary heart disease-implications for cardiothoracic surgery?Omar A Khan
Department of Cardiothoracic Surgery, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
Eur J Cardiothorac Surg 27:1036-42. 2005..Finally, the potential relevance of the theory to cardiac surgical practice will be evaluated... - Expression of agouti-related peptide, neuropeptide Y, pro-opiomelanocortin and the leptin receptor isoforms in fetal mouse brain from pregnant dams on a protein-restricted dietPaul L Terroni
Centre for Developmental Origins of Health and Disease, University of Southampton, School of Medicine, Princess Anne Hospital, Level F mailpoint 887, Coxford Road, Southampton, UK
Brain Res Mol Brain Res 140:111-5. 2005..Levels of expression for these genes were altered in brains of E12 fetuses from pregnant dams on a protein-restricted diet, suggesting that the fetal brain is responsive to changes in maternal nutrition prior to birth... - Mechanisms of disease: in utero programming in the pathogenesis of hypertensionDavid J P Barker
Developmental Origins of Health and Disease Division MP 887, University of Southampton, Princess Anne Hospital, Southampton SO16 5YA, UK
Nat Clin Pract Nephrol 2:700-7. 2006..By monitoring blood pressure, weight, and renal function in children, it might be possible to reduce the risk of cardiovascular and renal disease in later life... - Association of adult height and leg length with fasting plasma cortisol concentrations: evidence for an effect of normal variation in adrenocortical activity on growthD I W Phillips
MRC Epidemiology Resource Centre, Mpt 95, Southampton General Hospital, Southampton, United Kingdom
Am J Hum Biol 20:712-5. 2008..They also raise the possibility that the HPA axis may be involved in mediating resource allocation decisions and trade-offs during development perhaps by limiting physical growth to enable other competing processes... - Adaptive responses by mouse early embryos to maternal diet protect fetal growth but predispose to adult onset diseaseAdam J Watkins
School of Biological Sciences, University of Southampton, Southampton SO16 7PX, United Kingdom
Biol Reprod 78:299-306. 2008..However, activation of such responses may also lead to adult excess growth and cardiovascular and behavioral diseases... - Effect of reduced maternal protein intake in pregnancy in the rat on the fatty acid composition of brain, liver, plasma, heart and lung phospholipids of the offspring after weaningGraham C Burdge
Institute of Human Nutrition, Biomedical Sciences Building 62, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
Br J Nutr 90:345-52. 2003..These results suggest that restricted maternal protein intake during pregnancy results in persistent alterations to membrane fatty acid content... - Prenatal programming of postnatal endocrine responses by glucocorticoidsCaroline E Bertram
Centre for Fetal Origins of Adult Disease, Mailpoint 887, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, UK
Reproduction 124:459-67. 2002..Current data indicate that key targets for programming may include not only the HPA axis but also glucocorticoid receptor gene and 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2) gene expression in a range of tissues... - Angiotensin II receptor antagonist reduces subsequent uterine arterial dysfunction in pregnant offspring of protein-restricted rat damsTomomi Saito
Department of Obstetrics and Gynecology, School of Medicine, Juntendo University, Tokyo, Japan
J Obstet Gynaecol Res 38:483-9. 2012.... - Maternal protein restriction in the rat impairs resistance artery but not conduit artery function in pregnant offspringChristopher Torrens
Centre for Fetal Origins of Adult Disease, University of Southampton, Southampton, SO16 5YA, UK
J Physiol 547:77-84. 2003..We conclude that dietary protein restriction in pregnancy programmes vasodilator dysfunction in isolated resistance arteries of female offspring when they become pregnant, but does not affect conduit arteries... - Life-long echoes--a critical analysis of the developmental origins of adult disease modelPeter D Gluckman
Liggins Institute, University of Auckland, Grafton, Private Bag 92019, Auckland, New Zealand
Biol Neonate 87:127-39. 2005..A model of the relationship between the developmental and mature environment is proposed and suggests interventional strategies that will vary in different population settings... - Impaired glucose homeostasis and mitochondrial abnormalities in offspring of rats fed a fat-rich diet in pregnancyPaul D Taylor
Division of Reproductive Health, Endocrinology and Development, King s College London, United Kingdom
Am J Physiol Regul Integr Comp Physiol 288:R134-9. 2005.... - Living with the past: evolution, development, and patterns of diseasePeter D Gluckman
Liggins Institute, University of Auckland and National Research Centre for Growth and Development, 2 6 Park Avenue, Grafton, Private Bag 92019, Auckland, New Zealand
Science 305:1733-6. 2004..This "developmental origins of health and disease" concept may have important biological, medical, and socioeconomic implications... - Developmental origins of disease paradigm: a mechanistic and evolutionary perspectivePeter D Gluckman
Liggins Institute, University of Auckland and National Research Centre for Growth and Development, Private Bag 92019, Auckland, New Zealand
Pediatr Res 56:311-7. 2004..The developmental origins paradigm and its underlying mechanistic and evolutionary basis have major implications for addressing the increasing burden of metabolic and cardiovascular disease... - The effect of dietary supplementation with linoleic acid to late gestation ewes on the fatty acid composition of maternal and fetal plasma and tissues and the synthetic capacity of the placenta for 2-series prostaglandinsMatthew Elmes
Reproduction and Development Group, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Herts, AL9 7TA, UK
Biochim Biophys Acta 1686:139-47. 2004..Variations in the extent to which the diet altered the polyunsaturated fatty acid (PUFA) content of the different tissues indicated complex interactions between nutrient availability and metabolic adaptation... - Cardiovascular and endocrine responses to cutaneous electrical stimulation after fentanyl in the ovine fetusRichard P Smith
Department of Maternal and Fetal Medicine, Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Royal Free and University College Medical School, London, UK
Am J Obstet Gynecol 190:836-42. 2004..Fentanyl itself has significant effects on the cardiovascular and endocrine system, which might adversely affect the fetus... - The developmental origins of the metabolic syndromePeter D Gluckman
Liggins Institute, University of Auckland and National Research Centre for Growth and Development, 2 6 Park Avenue, Grafton, Private Bag 92019, Auckland, New Zealand
Trends Endocrinol Metab 15:183-7. 2004..In this article, we review the clinical and experimental perspectives on the "developmental origins of disease" model in the context of these new concepts... - Effect of nutritional restriction in early pregnancy on isolated femoral artery function in mid-gestation fetal sheepHidenori Nishina
Department of Obstetrics and Gynaecology, University College London, 86-96 Chenies Mews, London WC1 6HX, UK
J Physiol 553:637-47. 2003..These changes may precede perturbed late-gestation fetal and postnatal cardiovascular control... - The fetal llama versus the fetal sheep: different strategies to withstand hypoxiaAnibal J Llanos
Laboratorio de Fisiología y Fisiopatología del Desarrollo, Programa de Fisiopatología, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
High Alt Med Biol 4:193-202. 2003..These results suggest that the llama fetus responds to acute hypoxia with hypometabolism. How this reduction in metabolism is produced and how the cells are preserved during this condition remain to be elucidated... - The fetal dilemma: spare the brain and spoil the liverPeter W Nathanielsz
J Physiol 548:333. 2003 - Gender-linked hypertension in offspring of lard-fed pregnant ratsImran Y Khan
Maternal and Fetal Research Unit, GKT Department of Women s Health, St Thomas Hospital, London, UK
Hypertension 41:168-75. 2003..Feeding a diet rich in lard to pregnant rats leads to gender-related cardiovascular dysfunction in normally fed offspring... - Maternal constraint of fetal growth and its consequencesPeter D Gluckman
Liggins Institute, University of Auckland and National Research Centre for Growth and Development, 2 6 Park Avenue, Grafton, Private Bag 92019, Auckland, New Zealand
Semin Fetal Neonatal Med 9:419-25. 2004..Changing demography means that maternal constraint must increasingly be considered as a significant factor in determining the pattern of disease... - The fetal, neonatal, and infant environments-the long-term consequences for disease riskPeter D Gluckman
Liggins Institute and National Research Centre for Growth and Development, University of Auckland, 2 6 Park Avenue, Grafton, Private Bag 92019, Auckland, New Zealand
Early Hum Dev 81:51-9. 2005..There is increasing evidence that prematurity can be associated with long-term consequences, and this is to be anticipated from conceptual considerations. Different preventative strategies may be relevant in different populations... - Environmental influences during development and their later consequences for health and disease: implications for the interpretation of empirical studiesPeter D Gluckman
Liggins Institute, University of Auckland and National Research Centre for Growth and Development, 2-6 Park Avenue, Grafton, Private Bag 92019, Auckland, New Zealand
Proc Biol Sci 272:671-7. 2005..The paper reviews these concepts and explores ways in which such distinctions may be made in practice... - The effect of maternal body condition score before and during pregnancy on the glucose tolerance of adult sheep offspringRoselle L Cripps
Department of Clinical Biochemistry, University of Cambridge, Cambridge, UK
Reprod Sci 15:448-56. 2008..These findings suggest that altered maternal body composition and an imbalance between the fetal and postnatal environment influence offspring glucose tolerance... - Carbon monoxide: a novel pulmonary artery vasodilator in neonatal llamas of the Andean altiplanoEmilio A Herrera
Programa de Fisiopatología, ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile
Cardiovasc Res 77:197-201. 2008..To study the nitric oxide (NO) and carbon monoxide roles in the regulation of the pulmonary circulation in lowland and highland newborn sheep and llamas... - Effect of in utero and early-life conditions on adult health and diseasePeter D Gluckman
Liggins Institute, University of Auckland, and National Research Centre for Growth and Development, Auckland, New Zealand
N Engl J Med 359:61-73. 2008 - Developmental perspectives on individual variation: implications for understanding nutritional needsPeter D Gluckman
Liggins Institute, University of Auckland, Auckland, New Zealand
Nestle Nutr Workshop Ser Pediatr Program 62:1-9; disucssion 9-12. 2008..Epigenetic biomarkers may be able to identify a risk of developmental mismatch and thus offer the opportunity for nutritional or other intervention... - Metabolic plasticity during mammalian development is directionally dependent on early nutritional statusPeter D Gluckman
Liggins Institute, University of Auckland, Private Bag 92019, Auckland 1023, New Zealand
Proc Natl Acad Sci U S A 104:12796-800. 2007.... - Predictive adaptive responses in perspectivePeter D Gluckman
Trends Endocrinol Metab 19:109-10; author reply 112. 2008 - High-altitude chronic hypoxia during gestation and after birth modifies cardiovascular responses in newborn sheepEmilio A Herrera
Laboratorio de Fisiología y Fisiopatología del Desarrollo, Programa de Fisiopatología, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
Am J Physiol Regul Integr Comp Physiol 292:R2234-40. 2007..These responses determined in intrauterine life and early after birth could be adaptive to chronic hypoxia in the Andean altiplano... - Non-genomic transgenerational inheritance of disease riskPeter D Gluckman
Liggins Institute and National Research Centre for Growth and Development, University of Auckland, Auckland, New Zealand
Bioessays 29:145-54. 2007.... - Effects of chronic hypoxia and protein malnutrition on growth in the developing chickSuzanne L Miller
Departments of Obstetrics and Gynaecology, University College London, UK
Am J Obstet Gynecol 186:261-7. 2002..Early growth restriction that was induced by hypoxia from the beginning of incubation is reversed by the restoration of normoxia at mid incubation... - Vasodilator tone in the llama fetus: the role of nitric oxide during normoxemia and hypoxemiaEmilia M Sanhueza
Programa de Fisiopatología, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Casilla 16038, Santiago 9, Chile
Am J Physiol Regul Integr Comp Physiol 289:R776-83. 2005.... - Metabolic disease: evolutionary, developmental and transgenerational influencesPeter D Gluckman
Liggins Institute, University of Auckland and National Research Centre for Growth and Development, Grafton, New Zealand
Nestle Nutr Workshop Ser Pediatr Program 55:17-27. 2005 - Does estrogen affect the development of abnormal vascular function in offspring of rats fed a low-protein diet in pregnancy?Yuka Musha
Department of Obstetrics and Gynecology, School of Medicine Juntendo University 2 1 1 Hongo, Bunkyo ku Tokyo, Japan 113 8421
Pediatr Res 59:784-9. 2006..The processes may underlie gender and life course patterns of hypertension and also the developmental origins of this disease... - The developmental origins of adult diseasePeter D Gluckman
Liggins Institute, University of Auckland, 2 6 Park Avenue, Grafton, Private Bag 92019, Auckland, New Zealand
Matern Child Nutr 1:130-41. 2005..These experimental, clinical and conceptual considerations have important implications for prevention and intervention in the current epidemic of childhood obesity and adult metabolic and cardiovascular disorders... - Early life events and their consequences for later disease: a life history and evolutionary perspectivePeter D Gluckman
Liggins Institute, University of Auckland, and National Research Centre for Growth and Development, Private Bag 92019, Auckland, New Zealand
Am J Hum Biol 19:1-19. 2007..This view of human disease from the perspectives of life history biology and evolutionary theory offers new approaches to prevention, diagnosis and intervention... - The effect of systemic administration of lipopolysaccharide on cerebral haemodynamics and oxygenation in the 0.65 gestation ovine fetus in uteroDonald M Peebles
Department of Obstetrics and Gynaecology, University College London, 86-96 Chenies Mews, London WC1E 6HX, UK
BJOG 110:735-43. 2003..Fetal tachycardia and cerebral vasodilation may indicate endotoxaemia in fetuses exposed to prenatal infection... - Hepatic artery hemodynamics suggest operation of a buffer response in the human fetusCathrine Ebbing
Department of Clinical Medicine, University of Bergen, Norway
Reprod Sci 15:166-78. 2008..0001). The authors establish a method for measuring fetal hepatic arterial blood velocity, provide reference ranges, and show that the hepatic artery buffer response operates prenatally... - Nitric oxide plays a role in the regulation of adrenal blood flow and adrenocorticomedullary functions in the llama fetusRaquel A Riquelme
, , Universidad de Chile, Santiago, Chile
J Physiol 544:267-76. 2002..These data support the hypothesis that nitric oxide has important roles in the regulation of adrenal blood flow and adrenal corticomedullary functions during normoxaemia and hypoxaemia functions in the late gestation llama fetus... - Evolving in thin air--lessons from the llama fetus in the altiplanoAnibal J Llanos
Laboratorio de Fisiología y Fisiopatología del Desarrollo, Programa de Fisiopatología, Instituto de Ciencias Biomedicas ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile
Respir Physiol Neurobiol 158:298-306. 2007..These strategies may have evolved to prevent hypoxic injury to the brain or other organs in the face of the persistent hypobaric hypoxia of life in the Andean altiplano...