Richard D Handy

Summary

Affiliation: University of Plymouth
Country: UK

Publications

  1. ncbi request reprint Histopathologic biomarkers in three spined sticklebacks, Gasterosteus aculeatus, from several rivers in Southern England that meet the freshwater fisheries directive
    R D Handy
    Department of Biological Sciences, The University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK
    Ecotoxicology 11:467-79. 2002
  2. pmc The antibacterial effects of silver, titanium dioxide and silica dioxide nanoparticles compared to the dental disinfectant chlorhexidine on Streptococcus mutans using a suite of bioassays
    Alexandros Besinis
    School of Biomedical and Biological Sciences, The University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK
    Nanotoxicology 8:1-16. 2014
  3. pmc Practical considerations for conducting ecotoxicity test methods with manufactured nanomaterials: what have we learnt so far?
    Richard D Handy
    Ecotoxicology Research and Innovation Centre, School of Biomedical and Biological Sciences, University of Plymouth, Plymouth, UK
    Ecotoxicology 21:933-72. 2012
  4. doi request reprint Ecotoxicity test methods for engineered nanomaterials: practical experiences and recommendations from the bench
    Richard D Handy
    Ecotoxicology Research and Innovation Centre, School of Biomedical and Biological Sciences, University of Plymouth, Plymouth, UK
    Environ Toxicol Chem 31:15-31. 2012
  5. doi request reprint Effects of manufactured nanomaterials on fishes: a target organ and body systems physiology approach
    R D Handy
    School of Biomedical and Biological Sciences, University of Plymouth, Drake Circus, PL4 8AA Plymouth, UK
    J Fish Biol 79:821-53. 2011
  6. doi request reprint Manufactured nanoparticles: their uptake and effects on fish--a mechanistic analysis
    Richard D Handy
    Ecotoxicology and Stress Biology Research Group, School of Biological Sciences, University of Plymouth, Drake Circus, Plymouth, UK
    Ecotoxicology 17:396-409. 2008
  7. doi request reprint The ecotoxicology of nanoparticles and nanomaterials: current status, knowledge gaps, challenges, and future needs
    Richard D Handy
    Ecotoxicology and Stress Biology Research Group, School of Biological Sciences, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK
    Ecotoxicology 17:315-25. 2008
  8. doi request reprint The ecotoxicology and chemistry of manufactured nanoparticles
    Richard D Handy
    School of Biological Sciences, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK
    Ecotoxicology 17:287-314. 2008
  9. ncbi request reprint Chronic diazinon exposure: pathologies of spleen, thymus, blood cells, and lymph nodes are modulated by dietary protein or lipid in the mouse
    R D Handy
    Department of Biological Sciences and Plymouth Environmental Research Centre, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK
    Toxicology 172:13-34. 2002
  10. ncbi request reprint Ecotoxicity of nanomaterials to fish: challenges for ecotoxicity testing
    Richard D Handy
    University of Plymouth, Plymouth, UK
    Integr Environ Assess Manag 3:458-60. 2007

Detail Information

Publications41

  1. ncbi request reprint Histopathologic biomarkers in three spined sticklebacks, Gasterosteus aculeatus, from several rivers in Southern England that meet the freshwater fisheries directive
    R D Handy
    Department of Biological Sciences, The University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK
    Ecotoxicology 11:467-79. 2002
    ..We propose histopathologic biomarkers of the three spined stickleback for routine monitoring of fish health in EU freshwaters...
  2. pmc The antibacterial effects of silver, titanium dioxide and silica dioxide nanoparticles compared to the dental disinfectant chlorhexidine on Streptococcus mutans using a suite of bioassays
    Alexandros Besinis
    School of Biomedical and Biological Sciences, The University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK
    Nanotoxicology 8:1-16. 2014
    ..Dialysis experiments showed negligible silver dissolution. Overall, Ag NPs were the best disinfectant and performed better than chlorhexidine. Improvements to the MIC assay are suggested...
  3. pmc Practical considerations for conducting ecotoxicity test methods with manufactured nanomaterials: what have we learnt so far?
    Richard D Handy
    Ecotoxicology Research and Innovation Centre, School of Biomedical and Biological Sciences, University of Plymouth, Plymouth, UK
    Ecotoxicology 21:933-72. 2012
    ..In conclusion, most protocols will require some modifications and recommendations are made to aid the researcher at the bench...
  4. doi request reprint Ecotoxicity test methods for engineered nanomaterials: practical experiences and recommendations from the bench
    Richard D Handy
    Ecotoxicology Research and Innovation Centre, School of Biomedical and Biological Sciences, University of Plymouth, Plymouth, UK
    Environ Toxicol Chem 31:15-31. 2012
    ..The existing bioaccumulation tests are conceptually flawed and require considerable modification, or a new test, to work for ENMs. Overall, most methodologies need some amendments, and recommendations are made to assist researchers...
  5. doi request reprint Effects of manufactured nanomaterials on fishes: a target organ and body systems physiology approach
    R D Handy
    School of Biomedical and Biological Sciences, University of Plymouth, Drake Circus, PL4 8AA Plymouth, UK
    J Fish Biol 79:821-53. 2011
    ..g. some dissolved metals) and the innovative, responsible, development of nanotechnology should continue, with potential benefits for aquaculture, fisheries and fish health diagnostics...
  6. doi request reprint Manufactured nanoparticles: their uptake and effects on fish--a mechanistic analysis
    Richard D Handy
    Ecotoxicology and Stress Biology Research Group, School of Biological Sciences, University of Plymouth, Drake Circus, Plymouth, UK
    Ecotoxicology 17:396-409. 2008
    ..There are also opportunities to apply existing tools and techniques to fundamental studies of fish toxicology with NPs, such as perfused organs and fish cell culture systems...
  7. doi request reprint The ecotoxicology of nanoparticles and nanomaterials: current status, knowledge gaps, challenges, and future needs
    Richard D Handy
    Ecotoxicology and Stress Biology Research Group, School of Biological Sciences, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK
    Ecotoxicology 17:315-25. 2008
    ....
  8. doi request reprint The ecotoxicology and chemistry of manufactured nanoparticles
    Richard D Handy
    School of Biological Sciences, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK
    Ecotoxicology 17:287-314. 2008
    ..We conclude with a consideration of implications for environmental risk assessment of manufactured nanoparticles...
  9. ncbi request reprint Chronic diazinon exposure: pathologies of spleen, thymus, blood cells, and lymph nodes are modulated by dietary protein or lipid in the mouse
    R D Handy
    Department of Biological Sciences and Plymouth Environmental Research Centre, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK
    Toxicology 172:13-34. 2002
    ..We conclude that the immunotoxicity of diazinon is exacerbated by excess dietary protein or lipid. The limited recovery and post-exposure histochemical changes imply deleterious effects on metabolism with oxidative stress after exposure...
  10. ncbi request reprint Ecotoxicity of nanomaterials to fish: challenges for ecotoxicity testing
    Richard D Handy
    University of Plymouth, Plymouth, UK
    Integr Environ Assess Manag 3:458-60. 2007
  11. ncbi request reprint Sodium-dependent copper uptake across epithelia: a review of rationale with experimental evidence from gill and intestine
    R D Handy
    Department of Biological Sciences, The University of Plymouth, Drake Circus, Plymouth, UK
    Biochim Biophys Acta 1566:104-15. 2002
    ..However, effects of intracellular chloride on the Cu-ATPase or ENaC indicate that Na(+) might indirectly alter Cu flux. Conversely, Cu ions inhibit basolateral Na(+)K(+)-ATPase and may increase [Na(+)](i)...
  12. ncbi request reprint Chronic effects of copper exposure versus endocrine toxicity: two sides of the same toxicological process?
    Richard D Handy
    School of Biological Sciences, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK
    Comp Biochem Physiol A Mol Integr Physiol 135:25-38. 2003
    ..We conclude that the chronic physiological effects of Cu and apparent endocrine disrupting effects of Cu are two sides of the same toxicological process...
  13. ncbi request reprint A proposal for the use of biomarkers for the assessment of chronic pollution and in regulatory toxicology
    Richard D Handy
    Plymouth Environmental Research Centre, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK
    Ecotoxicology 12:331-43. 2003
    ..We propose a regulatory framework for biomarkers based on a weight of evidence approach that can integrate biomarkers in risk assessment and long-term monitoring programmes...
  14. ncbi request reprint Toxicity of titanium dioxide nanoparticles to rainbow trout (Oncorhynchus mykiss): gill injury, oxidative stress, and other physiological effects
    Gillian Federici
    Ecotoxicology and Stress Biology Research Group, School of Biological Sciences, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK
    Aquat Toxicol 84:415-30. 2007
    ..Respiratory distress is a concern and sub-lethal toxicity involves oxidative stress, organ pathologies, and the induction of anti-oxidant defences, such as glutathione...
  15. doi request reprint Dietary exposure to titanium dioxide nanoparticles in rainbow trout, (Oncorhynchus mykiss): no effect on growth, but subtle biochemical disturbances in the brain
    Christopher S Ramsden
    Ecotoxicology and Stress Biology Research Group, School of Biological Sciences, University of Plymouth, Drake Circus, Plymouth, PL4 8AA, UK
    Ecotoxicology 18:939-51. 2009
    ....
  16. ncbi request reprint Dietary copper exposure and recovery in Nile tilapia, Oreochromis niloticus
    Benjamin J Shaw
    School of Biological Sciences, University of Plymouth, Drake Circus, UK
    Aquat Toxicol 76:111-21. 2006
    ..However, the liver of the Cu-fed fish showed a further 1.7-fold rise in Cu content and marked hepatic lipidosis (increased intracellular fat stores) post-exposure, suggesting redistribution of Cu to the liver and delayed hepatotoxicity...
  17. doi request reprint Minimal effects of waterborne exposure to single-walled carbon nanotubes on behaviour and physiology of juvenile rainbow trout (Oncorhynchus mykiss)
    David Boyle
    Ecotoxicology Research and Innovation Centre, School of Biomedical and Biological Sciences, University of Plymouth, Devon, UK
    Aquat Toxicol 146:154-64. 2014
    ....
  18. ncbi request reprint Uptake of different crystal structures of TiO₂ nanoparticles by Caco-2 intestinal cells
    Constantinos Gitrowski
    School of Biomedical and Biological Sciences, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK Electronic address
    Toxicol Lett 226:264-76. 2014
    ..Overall, the data shows that Ti accumulation for TiO2 NP exposure in Caco-2 cells is crystal structure-dependent, and that the mechanism(s) involves endocytosis of intact particles...
  19. doi request reprint Critical comparison of intravenous injection of TiO2 nanoparticles with waterborne and dietary exposures concludes minimal environmentally-relevant toxicity in juvenile rainbow trout Oncorhynchus mykiss
    David Boyle
    Ecotoxicology Research and Innovation Centre, School of Biomedical and Biological Sciences, University of Plymouth, Devon PL4 8AA, UK Electronic address
    Environ Pollut 182:70-9. 2013
    ....
  20. doi request reprint Subtle alterations in swimming speed distributions of rainbow trout exposed to titanium dioxide nanoparticles are associated with gill rather than brain injury
    David Boyle
    Ecotoxicology Research and Innovation Centre, School of Biomedical and Biological Sciences, University of Plymouth, Devon, UK
    Aquat Toxicol 126:116-27. 2013
    ..Whole brain homogenates showed a statistically significant increase in oxidative stress defences such as the total glutathione pool, but without loss of Na(+)K(+)-ATPase or acetylcholinesterase activities...
  21. ncbi request reprint Toxicity of single walled carbon nanotubes to rainbow trout, (Oncorhynchus mykiss): respiratory toxicity, organ pathologies, and other physiological effects
    Catherine J Smith
    Ecotoxicology and Stress Biology Research Group, School of Biological Sciences, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK
    Aquat Toxicol 82:94-109. 2007
    ....
  22. doi request reprint Dietary toxicity of single-walled carbon nanotubes and fullerenes (C60) in rainbow trout (Oncorhynchus mykiss)
    Thomas W K Fraser
    School of Biomedical and Biological Sciences, University of Plymouth, Devon, UK
    Nanotoxicology 5:98-108. 2011
    ..28 ± 0.56 nmol mg(-1) protein). No other significant treatment-related differences were observed. Results indicate that dietary exposure to SWCNTs and C(60) in rainbow trout did not result in overt toxicity...
  23. doi request reprint A simplified method for determining titanium from TiO2 nanoparticles in fish tissue with a concomitant multi-element analysis
    Benjamin J Shaw
    Ecotoxicology Research and Innovation Centre, School of Biomedical and Biological Sciences, Plymouth University, Drake Circus, Plymouth, PL4 8AA, UK
    Chemosphere 92:1136-44. 2013
    ..This improved method is simple with high throughput and represents a marked improvement for routine determination Ti from TiO2 NPs in fish tissues. ..
  24. doi request reprint Histopathological effects of waterborne copper nanoparticles and copper sulphate on the organs of rainbow trout (Oncorhynchus mykiss)
    Genan A Al-Bairuty
    Ecotoxicology Research and Innovation Centre, School of Biomedical and Biological Sciences, University of Plymouth, UK
    Aquat Toxicol 126:104-15. 2013
    ....
  25. doi request reprint Effects of waterborne copper nanoparticles and copper sulphate on rainbow trout, (Oncorhynchus mykiss): physiology and accumulation
    Benjamin J Shaw
    School of Biomedical and Biological Sciences, Plymouth University, Drake Circus, Plymouth PL4 8AA, UK
    Aquat Toxicol 116:90-101. 2012
    ..Overall, these data show that Cu-NPs have similar types of toxic effects to CuSO₄, which can occur at lower tissue Cu concentrations than expected for the dissolved metal...
  26. ncbi request reprint Uptake of titanium from TiO₂ nanoparticle exposure in the isolated perfused intestine of rainbow trout: nystatin, vanadate and novel CO₂-sensitive components
    Aliaa R Al-Jubory
    School of Biomedical and Biological Sciences, University of Plymouth, Drake Circus, Plymouth, PL4 8AA, UK
    Nanotoxicology 7:1282-301. 2013
    ..The data demonstrate Ti uptake across the intestine from TiO₂ NP exposures, involving CO₂-dependent and nystatin-sensitive mechanisms...
  27. doi request reprint Physiological effects of nanoparticles on fish: a comparison of nanometals versus metal ions
    Benjamin J Shaw
    Ecotoxicology Research and Innovation Centre, School of Biomedical and Biological Sciences, University of Plymouth, Drake Circus, Plymouth, UK
    Environ Int 37:1083-97. 2011
    ..We conclude that nanometals do have adverse physiological effects on fish, and the hazard for some metal NPs will be different to the traditional dissolved forms of metals...
  28. ncbi request reprint Differentiating copper and arsenic toxicity using biochemical biomarkers in Asellus aquaticus and Dreissena polymorpha
    Nicolas J Bouskill
    Plymouth Environmental Research Centre and School of Biological Sciences, University of Plymouth, Drakes Circus, Plymouth PL4 8AA, UK
    Ecotoxicol Environ Saf 65:342-9. 2006
    ..aquaticus, 1.1 micromol Pi/mg/h, and for D. polymorpha, 0.38 micromol Pi/mg/h, are probably the first reported for these species...
  29. doi request reprint Comparison of intermittent and continuous exposures to cadmium in the blue mussel, Mytilus edulis: accumulation and sub-lethal physiological effects
    Dokuboba Amachree
    Ecotoxicology Research and Innovation Centre, School of Biomedical and Biological Sciences, University of Plymouth, Plymouth, UK
    Ecotoxicol Environ Saf 95:19-26. 2013
    ..Overall, the data showed that the Cd accumulation was generally greater in the continuous exposure regime, but despite this, most of the biological responses being similar in both regimes...
  30. doi request reprint Ingestion of metal-nanoparticle contaminated food disrupts endogenous microbiota in zebrafish (Danio rerio)
    Daniel L Merrifield
    School of Biomedical and Biological Sciences, Plymouth University, 401 Davy Building, Drake Circus, Plymouth PL4 8AA, Devon, UK
    Environ Pollut 174:157-63. 2013
    ..Unique changes in zebrafish microbiome caused by exposure to Ag-NP and Cu-NP indicate that NP ingestion could affect digestive system function and organism health...
  31. doi request reprint Effect of nanomaterials on the compound action potential of the shore crab, Carcinus maenas
    Kirsten M Windeatt
    Ecotoxicology Research and Innovation Centre, School of Biomedical and Biological Sciences, University of Plymouth, Drake Circus, Plymouth, UK
    Nanotoxicology 7:378-88. 2013
    ..Overall, the study concludes that there were no effects of the materials at the concentrations tested on the compound action potential of the shore crab in physiological saline...
  32. doi request reprint Tissue injury and cellular immune responses to mercuric chloride exposure in the common mussel Mytilus edulis: modulation by lipopolysaccharide
    Sherin K Sheir
    School of Biomedical and Biological Science, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK
    Ecotoxicol Environ Saf 73:1338-44. 2010
    ..We conclude that Hg can cause inflammation in mussels in vivo, and that stimulation with LPS can greatly increase Hg-dependent immunotoxicity...
  33. doi request reprint Inhibition of biofilm formation and antibacterial properties of a silver nano-coating on human dentine
    Alexandros Besinis
    School of Biomedical and Biological Sciences, The University of Plymouth, Plymouth PL4 8AA, UK
    Nanotoxicology 8:745-54. 2014
    ....
  34. ncbi request reprint Impaired behavioural response to alarm substance in rainbow trout exposed to copper nanoparticles
    Tereza Sovová
    Ecotoxicology Research and Innovation Centre, School of Biomedical and Biological Sciences, Plymouth University, Devon, UK Department of Environmental Chemistry, Faculty of Environmental Technology, Institute of Chemical Technology, Prague, Czech Republic
    Aquat Toxicol 152:195-204. 2014
    ..Overall, the study showed that the olfactory mediated behaviours of fish were potentially more sensitive to Cu NPs than CuSO4 and NPs elicited effects via a mechanism that is distinct from that of the metal salt. ..
  35. doi request reprint Are reproduction impairments of free spawning marine invertebrates exposed to zero-valent nano-iron associated with dissolution of nanoparticles?
    Eniko Kadar
    Plymouth Marine Laboratory, Prospect Place, The Hoe, Plymouth, UK
    Nanotoxicology 7:135-43. 2013
    ..We provide in vitro evidence for the rapid dissolution (within 2 h) of nZVI in seawater to a degree that concentration of total solute Fe released from the coated ZVI particles exceeds safe limits of NOECs established for dissolved Fe...
  36. ncbi request reprint Effects of nitrate and atrazine on larval development and sexual differentiation in the northern leopard frog Rana pipiens
    Frances Orton
    School of Biological Sciences, University of Plymouth, Plymouth, Devon PL4 8AA, United Kingdom
    Environ Toxicol Chem 25:65-71. 2006
    ..Histological evidence suggests that premature maturation of gonad may occur as a result of nitrate and/or atrazine exposure during larval development...
  37. ncbi request reprint Effect of low salinity on cadmium accumulation and calcium homeostasis in the shore crab (Carcinus maenas) at fixed free Cd2+ concentrations
    Jonathan Burke
    School of Biological Sciences, University of Plymouth, Drake Circus, Plymouth PL4 8AA, United Kingdom
    Environ Toxicol Chem 22:2761-7. 2003
    ..Physiological responses are therefore important during low-level Cd exposure in dilute seawater...
  38. ncbi request reprint Assessing the sensitivity of Atlantic salmon (Salmo salar) to dietary endosulfan exposure using tissue biochemistry and histology
    Chris N Glover
    National Institute of Nutrition and Seafood Research NIFES, Bergen, Norway
    Aquat Toxicol 84:346-55. 2007
    ....
  39. ncbi request reprint Quantification of changing Pseudomonas aeruginosa sodA, htpX and mt gene abundance in response to trace metal toxicity: a potential in situ biomarker of environmental health
    Nicolas J Bouskill
    Department of Microbiology, Montana State University, Bozeman, MT 59717, USA
    FEMS Microbiol Ecol 60:276-86. 2007
    ..The development of rapid microbial biomarker tools represents a significant advance in the field of environmental biomonitoring and the prediction of metal bioavailability...
  40. doi request reprint Ecotoxicity test methods and environmental hazard assessment for engineered nanoparticles
    Mark Crane
    WCA Environment Limited, 23 London Street, Faringdon, Oxfordshire SN7 7AG, UK
    Ecotoxicology 17:421-37. 2008
    ....
  41. ncbi request reprint Chronic dietary mercury exposure causes oxidative stress, brain lesions, and altered behaviour in Atlantic salmon (Salmo salar) parr
    Marc H G Berntssen
    National Institute for Nutrition and Seafood Research, P O Box 176, N 5804 Bergen, Norway
    Aquat Toxicol 65:55-72. 2003
    ..However, above a threshold of 10 mg kg(-1) methylmercury these defences are overcome and lipid peroxidative injury (TBARS) as well as severe pathological damage and adverse behaviour become apparent...