Research Topics
| Richard D HandySummaryAffiliation: University of Plymouth Country: UK Publications
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Publications
Practical considerations for conducting ecotoxicity test methods with manufactured nanomaterials: what have we learnt so far?Richard D Handy
Ecotoxicology Research and Innovation Centre, School of Biomedical and Biological Sciences, University of Plymouth, Plymouth, UK
Ecotoxicology 21:933-72. 2012..In conclusion, most protocols will require some modifications and recommendations are made to aid the researcher at the bench...
Chronic diazinon exposure: pathologies of spleen, thymus, blood cells, and lymph nodes are modulated by dietary protein or lipid in the mouseR D Handy
Department of Biological Sciences and Plymouth Environmental Research Centre, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK
Toxicology 172:13-34. 2002..We conclude that the immunotoxicity of diazinon is exacerbated by excess dietary protein or lipid. The limited recovery and post-exposure histochemical changes imply deleterious effects on metabolism with oxidative stress after exposure...
Ecotoxicity test methods for engineered nanomaterials: practical experiences and recommendations from the benchRichard D Handy
Ecotoxicology Research and Innovation Centre, School of Biomedical and Biological Sciences, University of Plymouth, Plymouth, UK
Environ Toxicol Chem 31:15-31. 2012..The existing bioaccumulation tests are conceptually flawed and require considerable modification, or a new test, to work for ENMs. Overall, most methodologies need some amendments, and recommendations are made to assist researchers...- Effects of manufactured nanomaterials on fishes: a target organ and body systems physiology approachR D Handy
School of Biomedical and Biological Sciences, University of Plymouth, Drake Circus, PL4 8AA Plymouth, UK
J Fish Biol 79:821-53. 2011..g. some dissolved metals) and the innovative, responsible, development of nanotechnology should continue, with potential benefits for aquaculture, fisheries and fish health diagnostics... - Manufactured nanoparticles: their uptake and effects on fish--a mechanistic analysisRichard D Handy
Ecotoxicology and Stress Biology Research Group, School of Biological Sciences, University of Plymouth, Drake Circus, Plymouth, UK
Ecotoxicology 17:396-409. 2008..There are also opportunities to apply existing tools and techniques to fundamental studies of fish toxicology with NPs, such as perfused organs and fish cell culture systems... - The ecotoxicology of nanoparticles and nanomaterials: current status, knowledge gaps, challenges, and future needsRichard D Handy
Ecotoxicology and Stress Biology Research Group, School of Biological Sciences, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK
Ecotoxicology 17:315-25. 2008.... - The ecotoxicology and chemistry of manufactured nanoparticlesRichard D Handy
School of Biological Sciences, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK
Ecotoxicology 17:287-314. 2008..We conclude with a consideration of implications for environmental risk assessment of manufactured nanoparticles... - Ecotoxicity of nanomaterials to fish: challenges for ecotoxicity testingRichard D Handy
University of Plymouth, Plymouth, UK
Integr Environ Assess Manag 3:458-60. 2007 - Sodium-dependent copper uptake across epithelia: a review of rationale with experimental evidence from gill and intestineR D Handy
Department of Biological Sciences, The University of Plymouth, Drake Circus, Plymouth, UK
Biochim Biophys Acta 1566:104-15. 2002..However, effects of intracellular chloride on the Cu-ATPase or ENaC indicate that Na(+) might indirectly alter Cu flux. Conversely, Cu ions inhibit basolateral Na(+)K(+)-ATPase and may increase [Na(+)](i)... - Histopathologic biomarkers in three spined sticklebacks, Gasterosteus aculeatus, from several rivers in Southern England that meet the freshwater fisheries directiveR D Handy
Department of Biological Sciences, The University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK
Ecotoxicology 11:467-79. 2002..We propose histopathologic biomarkers of the three spined stickleback for routine monitoring of fish health in EU freshwaters... - Chronic effects of copper exposure versus endocrine toxicity: two sides of the same toxicological process?Richard D Handy
School of Biological Sciences, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK
Comp Biochem Physiol A Mol Integr Physiol 135:25-38. 2003..We conclude that the chronic physiological effects of Cu and apparent endocrine disrupting effects of Cu are two sides of the same toxicological process... - A proposal for the use of biomarkers for the assessment of chronic pollution and in regulatory toxicologyRichard D Handy
Plymouth Environmental Research Centre, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK
Ecotoxicology 12:331-43. 2003..We propose a regulatory framework for biomarkers based on a weight of evidence approach that can integrate biomarkers in risk assessment and long-term monitoring programmes... - Toxicity of titanium dioxide nanoparticles to rainbow trout (Oncorhynchus mykiss): gill injury, oxidative stress, and other physiological effectsGillian Federici
Ecotoxicology and Stress Biology Research Group, School of Biological Sciences, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK
Aquat Toxicol 84:415-30. 2007..Respiratory distress is a concern and sub-lethal toxicity involves oxidative stress, organ pathologies, and the induction of anti-oxidant defences, such as glutathione... - Dietary exposure to titanium dioxide nanoparticles in rainbow trout, (Oncorhynchus mykiss): no effect on growth, but subtle biochemical disturbances in the brainChristopher S Ramsden
Ecotoxicology and Stress Biology Research Group, School of Biological Sciences, University of Plymouth, Drake Circus, Plymouth, PL4 8AA, UK
Ecotoxicology 18:939-51. 2009.... - Dietary copper exposure and recovery in Nile tilapia, Oreochromis niloticusBenjamin J Shaw
School of Biological Sciences, University of Plymouth, Drake Circus, UK
Aquat Toxicol 76:111-21. 2006..However, the liver of the Cu-fed fish showed a further 1.7-fold rise in Cu content and marked hepatic lipidosis (increased intracellular fat stores) post-exposure, suggesting redistribution of Cu to the liver and delayed hepatotoxicity... - Subtle alterations in swimming speed distributions of rainbow trout exposed to titanium dioxide nanoparticles are associated with gill rather than brain injuryDavid Boyle
Ecotoxicology Research and Innovation Centre, School of Biomedical and Biological Sciences, University of Plymouth, Devon, UK
Aquat Toxicol 126:116-27. 2013..Whole brain homogenates showed a statistically significant increase in oxidative stress defences such as the total glutathione pool, but without loss of Na(+)K(+)-ATPase or acetylcholinesterase activities... - Toxicity of single walled carbon nanotubes to rainbow trout, (Oncorhynchus mykiss): respiratory toxicity, organ pathologies, and other physiological effectsCatherine J Smith
Ecotoxicology and Stress Biology Research Group, School of Biological Sciences, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK
Aquat Toxicol 82:94-109. 2007.... - Dietary toxicity of single-walled carbon nanotubes and fullerenes (C60) in rainbow trout (Oncorhynchus mykiss)Thomas W K Fraser
School of Biomedical and Biological Sciences, University of Plymouth, Devon, UK
Nanotoxicology 5:98-108. 2011..28 ± 0.56 nmol mg(-1) protein). No other significant treatment-related differences were observed. Results indicate that dietary exposure to SWCNTs and C(60) in rainbow trout did not result in overt toxicity... - Histopathological effects of waterborne copper nanoparticles and copper sulphate on the organs of rainbow trout (Oncorhynchus mykiss)Genan A Al-Bairuty
Ecotoxicology Research and Innovation Centre, School of Biomedical and Biological Sciences, University of Plymouth, UK
Aquat Toxicol 126:104-15. 2013.... - Effects of waterborne copper nanoparticles and copper sulphate on rainbow trout, (Oncorhynchus mykiss): physiology and accumulationBenjamin J Shaw
School of Biomedical and Biological Sciences, Plymouth University, Drake Circus, Plymouth PL4 8AA, UK
Aquat Toxicol 116:90-101. 2012..Overall, these data show that Cu-NPs have similar types of toxic effects to CuSO₄, which can occur at lower tissue Cu concentrations than expected for the dissolved metal... - Physiological effects of nanoparticles on fish: a comparison of nanometals versus metal ionsBenjamin J Shaw
Ecotoxicology Research and Innovation Centre, School of Biomedical and Biological Sciences, University of Plymouth, Drake Circus, Plymouth, UK
Environ Int 37:1083-97. 2011..We conclude that nanometals do have adverse physiological effects on fish, and the hazard for some metal NPs will be different to the traditional dissolved forms of metals... - Differentiating copper and arsenic toxicity using biochemical biomarkers in Asellus aquaticus and Dreissena polymorphaNicolas J Bouskill
Plymouth Environmental Research Centre and School of Biological Sciences, University of Plymouth, Drakes Circus, Plymouth PL4 8AA, UK
Ecotoxicol Environ Saf 65:342-9. 2006..aquaticus, 1.1 micromol Pi/mg/h, and for D. polymorpha, 0.38 micromol Pi/mg/h, are probably the first reported for these species... - Ingestion of metal-nanoparticle contaminated food disrupts endogenous microbiota in zebrafish (Danio rerio)Daniel L Merrifield
School of Biomedical and Biological Sciences, Plymouth University, 401 Davy Building, Drake Circus, Plymouth PL4 8AA, Devon, UK
Environ Pollut 174:157-63. 2013..Unique changes in zebrafish microbiome caused by exposure to Ag-NP and Cu-NP indicate that NP ingestion could affect digestive system function and organism health... - Tissue injury and cellular immune responses to mercuric chloride exposure in the common mussel Mytilus edulis: modulation by lipopolysaccharideSherin K Sheir
School of Biomedical and Biological Science, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK
Ecotoxicol Environ Saf 73:1338-44. 2010..We conclude that Hg can cause inflammation in mussels in vivo, and that stimulation with LPS can greatly increase Hg-dependent immunotoxicity... - Effects of nitrate and atrazine on larval development and sexual differentiation in the northern leopard frog Rana pipiensFrances Orton
School of Biological Sciences, University of Plymouth, Plymouth, Devon PL4 8AA, United Kingdom
Environ Toxicol Chem 25:65-71. 2006..Histological evidence suggests that premature maturation of gonad may occur as a result of nitrate and/or atrazine exposure during larval development... - Effect of low salinity on cadmium accumulation and calcium homeostasis in the shore crab (Carcinus maenas) at fixed free Cd2+ concentrationsJonathan Burke
School of Biological Sciences, University of Plymouth, Drake Circus, Plymouth PL4 8AA, United Kingdom
Environ Toxicol Chem 22:2761-7. 2003..Physiological responses are therefore important during low-level Cd exposure in dilute seawater... - Quantification of changing Pseudomonas aeruginosa sodA, htpX and mt gene abundance in response to trace metal toxicity: a potential in situ biomarker of environmental healthNicolas J Bouskill
Department of Microbiology, Montana State University, Bozeman, MT 59717, USA
FEMS Microbiol Ecol 60:276-86. 2007..The development of rapid microbial biomarker tools represents a significant advance in the field of environmental biomonitoring and the prediction of metal bioavailability... - Assessing the sensitivity of Atlantic salmon (Salmo salar) to dietary endosulfan exposure using tissue biochemistry and histologyChris N Glover
National Institute of Nutrition and Seafood Research NIFES, Bergen, Norway
Aquat Toxicol 84:346-55. 2007.... - Ecotoxicity test methods and environmental hazard assessment for engineered nanoparticlesMark Crane
WCA Environment Limited, 23 London Street, Faringdon, Oxfordshire SN7 7AG, UK
Ecotoxicology 17:421-37. 2008.... - Chronic dietary mercury exposure causes oxidative stress, brain lesions, and altered behaviour in Atlantic salmon (Salmo salar) parrMarc H G Berntssen
National Institute for Nutrition and Seafood Research, P O Box 176, N 5804 Bergen, Norway
Aquat Toxicol 65:55-72. 2003..However, above a threshold of 10 mg kg(-1) methylmercury these defences are overcome and lipid peroxidative injury (TBARS) as well as severe pathological damage and adverse behaviour become apparent...