A M Hanby
Affiliation: University of Leeds
- Male breast carcinoma: increased awareness neededJonathan White
Department of Surgery, Leeds General Infi rmary, Great George Street, Leeds LS1 3EX, UK
Breast Cancer Res 13:219. 2011..The clinical management of male breast carcinoma is considered, in particular the potential role of aromatase inhibitors and fulvestrant and targeting pathways involving prolactin and androgen receptor...
- Response to mTOR inhibition: activity of eIF4E predicts sensitivity in cell lines and acquired changes in eIF4E regulation in breast cancerSampoorna Satheesha
Leeds Institute of Molecular Medicine, St, James s University Hospital, Leeds University, UK
Mol Cancer 10:19. 2011..In an alternative approach we estimated eIF4E activity, a key effector of mTOR function, and tested the hypothesis that eIF4E activity predicts sensitivity to mTOR inhibition in cell lines and in breast tumours...
- Basal-like grade III invasive ductal carcinoma of the breast: patterns of metastasis and long-term survivalLaura G Fulford
Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK
Breast Cancer Res 9:R4. 2007..Previous studies have suggested that expression of such 'basal' markers predicts different biological behaviour, with more frequent lung and brain metastases and poorer prognosis than other carcinomas...
- In situ and invasive lobular neoplasia of the breastA M Hanby
Leeds Institute of Molecular Medicine, Yorkshire Cancer Research and Liz Dawn Pathology and Translational Sciences Centre, St James s University Hospital, Leeds, UK
Histopathology 52:58-66. 2008..For invasive carcinoma, molecular studies will allow refinement of therapy and the possibility of novel targeted therapies, for example directed against fibroblast growth factor receptor 1...
- Systematic review and meta-analysis of cytokeratin 19-based one-step nucleic acid amplification versus histopathology for sentinel lymph node assessment in breast cancerJ P Tiernan
Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK Department of Surgery, St James s University Hospital, Leeds, UK
Br J Surg 101:298-306. 2014..The aim of this systematic review and meta-analysis was to determine whether intraoperative OSNA for lymph node assessment is comparable to routine histopathology in the detection of clinically relevant metastases...
- Combined analysis of eIF4E and 4E-binding protein expression predicts breast cancer survival and estimates eIF4E activityL J Coleman
Leeds Institute of Molecular Medicine, Leeds University, Leeds LS9 7TF, UK
Br J Cancer 100:1393-9. 2009..We conclude that eIF4E's influence on cancer survival is modulated substantially by 4E-BPs, and that combined pathway analyses can estimate functional eIF4E...
- Adverse effects of dyes used in sentinel node biopsy on immunocytochemical determination of hormone receptors in breast cancer cellsY A Masannat
Department of General Surgery, The Leeds Teaching Hospitals NHS Trust, Leeds General Infirmary, Leeds, UK
J Clin Pathol 60:730-2. 2007
- The prognostic significance of tumour-stroma ratio in oestrogen receptor-positive breast cancerC L Downey
Leeds Institute of Cancer and Pathology, University of Leeds, St James s University Hospital, Leeds LS9 7TF, UK
Br J Cancer 110:1744-7. 2014..We determined the prognostic significance of tumour-stroma ratio (TSR) in oestrogen receptor (ER)-positive male and female breast carcinomas...
- Lymphangiogenesis in abdominal aortic aneurysmD J A Scott
Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics, and Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, UK
Br J Surg 100:895-903. 2013..The aim was to determine the presence of lymphangiogenesis and to delineate the relationship between inflammation and neovascularization in AAA tissue...
- Angiogenesis in breast cancer: how should we measure this? (Review)M J K Pollitt
Molecular Medicine Unit, University of Leeds, Clinical Sciences Building, St James s University Hospital, Leeds LS9 7TF, UK
Oncol Rep 13:931-6. 2005..Here we review the pros and cons of current methods of assessing angiogenesis, both clinical and in the laboratory, and discuss with respect to breast cancer...
- Aspects of molecular phenotype and its correlations with breast cancer behaviour and taxonomyA M Hanby
Academic Unit of Pathology, Leeds University, c o Department of Histopathology, St James s University Hospital, Beckett Street, Leeds LS9 7TF, UK
Br J Cancer 92:613-7. 2005..The tumour morphology reflects the molecular profile that produced it and consequently each can be predictive of the other...
- Testing for HER2 in breast cancerF Lewis
Academic Unit of Pathology, University of Leeds, Leeds, UK
Histopathology 45:207-17. 2004..In the future rapid throughput techniques such as real-time quantitative polymerase chain reaction (rqPCR), tissue microarrays or both should bring significant economies of cost and scale...
- Agreement between preoperative core needle biopsy and postoperative invasive breast cancer histopathology is not dependent on the amount of clinical material obtainedR O'Leary
School of Medicine, University of Leeds, Leeds, LS2 9NL, UK
J Clin Pathol 57:193-5. 2004..To establish the relation between the amount of breast core needle biopsy (CNB) material examined and agreement between preoperative and postoperative histopathology parameters in invasive breast cancer...
- Tumour-promoting activity of altered WWP1 expression in breast cancer and its utility as a prognostic indicatorN S Nguyen Huu
University of Manchester, Faculty of Life Sciences, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
J Pathol 216:93-102. 2008..Thus, WWP1 is a prognostic marker and may be a potential therapeutic target for a subset of breast tumours...
- Small is beautiful: microRNAs and breast cancer-where are we now?E T Verghese
Leeds Teaching Hospital NHS Trust, UK
J Pathol 215:214-21. 2008..Here we present an overview of our current understanding of miRNA in breast cancer...
- A comprehensive genetic profile of phyllodes tumours of the breast detects important mutations, intra-tumoral genetic heterogeneity and new genetic changes on recurrenceA M Jones
Molecular and Population Genetics Laboratory, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
J Pathol 214:533-44. 2008..We believe it likely that unfavourable sub-clones not easily identified by histology account for the unpredictable clinical behaviour of these tumours...
- Correlation of energy dispersive diffraction signatures and microCT of small breast tissue samples with pathological analysisJ A Griffiths
Department of Medical Physics and Bioengineering, University College London, Gower Street, London, UK
Phys Med Biol 52:6151-64. 2007..X-ray diffraction signatures generated from the measured data were categorized and analysed, with a t-test indicating that they have the potential for use in tissue type identification...
- Retention of the expression of E-cadherin and catenins is associated with shorter survival in grade III ductal carcinoma of the breastC E Gillett
Hedley Atkins ICRF Breast Pathology Laboratory, Guy s Hospital, London SE1 9RT, UK
J Pathol 193:433-41. 2001..Taken together, these findings suggest that a conserved E-cadherin/catenin axis may play a part in determining adverse outcome in grade III breast carcinoma...
- The pattern of expression of the microtubule-binding protein RHAMM/IHABP in mammary carcinoma suggests a role in the invasive behaviour of tumour cellsV Assmann
Richard Dimbleby Department of Cancer Research/Imperial Cancer Research Fund Laboratory, St. Thomas' Hospital, London SE1 7EH, UK
J Pathol 195:191-6. 2001..017). These results suggest that RHAMM/IHABP expression may contribute to the motility and invasiveness of a tumour cell sub-population in breast cancers...
- Mitotic counts provide additional prognostic information in grade II mammary carcinomaJ Lynch
Guy s, Kings and St Thomas School of Medicine, Guy s Hospital, St Thomas Street, London SE1 9RT, UK
J Pathol 196:275-9. 2002..It is proposed that MC, used once to establish grade, could be used again amongst the grade II tumours to improve the accuracy of prognosis and thus influence treatment strategies with minimal additional effort or expense...
- BAG-i expression in human breast cancer: interrelationship between BAG-1 RNA, protein, HSC70 expression and clinico-pathological dataP A Townsend
Cancer Sciences Division, School of Medicine, University of Southampton, Southampton General Hospital, UK
J Pathol 197:51-9. 2002..These results are consistent with the hypothesis that BAG-1 plays an important but variable role in breast cancers developing in pre-menopausal and post-menopausal women...
- Tissue microarrays--big potential from small samples (review)A Waterworth
Breast Unit, Leeds General Infirmary, Leeds LS1 3EX, UK
Int J Oncol 25:167-71. 2004..This area of histological study has been revolutionised by the development of tissue microarrays (TMAs). This review describes the development and use of TMAs and discusses their possible applications to clinical oncological practice...
- The pathology of breast cancer and the role of the histopathology laboratoryA M Hanby
Academic Unit of Pathology, Leeds University
Clin Oncol (R Coll Radiol) 17:234-9. 2005..With the rise of modern molecular techniques, the demise of diagnostic histopathology has been predicted, but, for now and the intermediate future, the histopathologist remains a key element of the integrated breast-care team...
- An alternative method of dissecting mastectomy specimensC D'Arrigo
Histopathology 48:608-9. 2006
- HER2 testing in the UK: consensus from a national consultationMitch Dowsett
The Royal Marsden NHS Trust, Fulham Road, London SW3 6JJ, UK
J Clin Pathol 60:685-9. 2007..To gain an understanding of current attitudes among oncologists and pathologists to prospective HER2 testing in breast cancer and to gauge whether a national consensus exists regarding extent and quality of testing...
- An inbred colony of oncogene transgenic mice: diversity of tumours and potential as a therapeutic modelH Thomas
ICRF Biological Therapies Laboratory, London, UK
Br J Cancer 73:65-72. 1996..However, further genetic and environmental manipulations are required to increase tumour incidence and decrease age of onset...