A M Hanby

Summary

Affiliation: University of Leeds
Country: UK

Publications

  1. pmc Male breast carcinoma: increased awareness needed
    Jonathan White
    Department of Surgery, Leeds General Infi rmary, Great George Street, Leeds LS1 3EX, UK
    Breast Cancer Res 13:219. 2011
  2. pmc Response to mTOR inhibition: activity of eIF4E predicts sensitivity in cell lines and acquired changes in eIF4E regulation in breast cancer
    Sampoorna Satheesha
    Leeds Institute of Molecular Medicine, St, James s University Hospital, Leeds University, UK
    Mol Cancer 10:19. 2011
  3. pmc Basal-like grade III invasive ductal carcinoma of the breast: patterns of metastasis and long-term survival
    Laura G Fulford
    Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK
    Breast Cancer Res 9:R4. 2007
  4. doi request reprint In situ and invasive lobular neoplasia of the breast
    A M Hanby
    Leeds Institute of Molecular Medicine, Yorkshire Cancer Research and Liz Dawn Pathology and Translational Sciences Centre, St James s University Hospital, Leeds, UK
    Histopathology 52:58-66. 2008
  5. ncbi request reprint Systematic review and meta-analysis of cytokeratin 19-based one-step nucleic acid amplification versus histopathology for sentinel lymph node assessment in breast cancer
    J P Tiernan
    Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK Department of Surgery, St James s University Hospital, Leeds, UK
    Br J Surg 101:298-306. 2014
  6. pmc Combined analysis of eIF4E and 4E-binding protein expression predicts breast cancer survival and estimates eIF4E activity
    L J Coleman
    Leeds Institute of Molecular Medicine, Leeds University, Leeds LS9 7TF, UK
    Br J Cancer 100:1393-9. 2009
  7. pmc Adverse effects of dyes used in sentinel node biopsy on immunocytochemical determination of hormone receptors in breast cancer cells
    Y A Masannat
    Department of General Surgery, The Leeds Teaching Hospitals NHS Trust, Leeds General Infirmary, Leeds, UK
    J Clin Pathol 60:730-2. 2007
  8. pmc The prognostic significance of tumour-stroma ratio in oestrogen receptor-positive breast cancer
    C L Downey
    Leeds Institute of Cancer and Pathology, University of Leeds, St James s University Hospital, Leeds LS9 7TF, UK
    Br J Cancer 110:1744-7. 2014
  9. doi request reprint Lymphangiogenesis in abdominal aortic aneurysm
    D J A Scott
    Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics, and Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, UK
    Br J Surg 100:895-903. 2013
  10. ncbi request reprint Angiogenesis in breast cancer: how should we measure this? (Review)
    M J K Pollitt
    Molecular Medicine Unit, University of Leeds, Clinical Sciences Building, St James s University Hospital, Leeds LS9 7TF, UK
    Oncol Rep 13:931-6. 2005

Collaborators

  • V Speirs
  • Ashutosh Nerurkar
  • M Dowsett
  • A S Waterworth
  • E T Verghese
  • C E Gillett
  • K Horgan
  • J White
  • J P Tiernan
  • C L Downey
  • K Ryder
  • D J A Scott
  • Jonathan White
  • Sampoorna Satheesha
  • R Poulsom
  • L J Coleman
  • P F Jones
  • T A Hughes
  • A M Shaaban
  • A M Jones
  • N S Nguyen Huu
  • D M Barnes
  • Y A Masannat
  • J A Griffiths
  • Laura G Fulford
  • C D'Arrigo
  • G Coast
  • P Jackson
  • M J K Pollitt
  • R O'Leary
  • F Lewis
  • R J Springall
  • S S Rajan
  • B Kim
  • J Lynch
  • S Pollock
  • J L Jones
  • H H Thygesen
  • P A Townsend
  • S Pathak
  • A Nair
  • S A Simpkins
  • J Kulka
  • D L Holliday
  • L B Jordan
  • H Thygesen
  • I R Hart
  • C J Allen
  • A B Johnson
  • C Hammond
  • S L Perry
  • C A Honstvet
  • V Assmann
  • E Jane Macaskill
  • Brijesh Madhok
  • Kieran Horgan
  • Thomas A Hughes
  • Louise J Coleman
  • Charlotte A B Suleman
  • Olive Kearins
  • Victoria J Cookson
  • David Dodwell
  • Jim N McElwaine
  • John M S Bartlett
  • J Michael Dixon
  • Nicola Ingram
  • Vicky S Sabine
  • L Smith
  • M B Peter
  • R A Brannan
  • H Honarpisheh
  • T J Teall
  • J N McElwaine
  • Sally Hales
  • Rosemary Walker
  • Puay Hoon Tan
  • Christopher Smith
  • Rashida Goderya
  • E J Sawyer
  • Paul Cane
  • E Winter
  • R Springall
  • David Green
  • R S Camplejohn
  • T Graham
  • M Chiu
  • R B Clarke
  • Fiona MacNeill
  • David Rowlands
  • N Zeps

Detail Information

Publications26

  1. pmc Male breast carcinoma: increased awareness needed
    Jonathan White
    Department of Surgery, Leeds General Infi rmary, Great George Street, Leeds LS1 3EX, UK
    Breast Cancer Res 13:219. 2011
    ..The clinical management of male breast carcinoma is considered, in particular the potential role of aromatase inhibitors and fulvestrant and targeting pathways involving prolactin and androgen receptor...
  2. pmc Response to mTOR inhibition: activity of eIF4E predicts sensitivity in cell lines and acquired changes in eIF4E regulation in breast cancer
    Sampoorna Satheesha
    Leeds Institute of Molecular Medicine, St, James s University Hospital, Leeds University, UK
    Mol Cancer 10:19. 2011
    ..In an alternative approach we estimated eIF4E activity, a key effector of mTOR function, and tested the hypothesis that eIF4E activity predicts sensitivity to mTOR inhibition in cell lines and in breast tumours...
  3. pmc Basal-like grade III invasive ductal carcinoma of the breast: patterns of metastasis and long-term survival
    Laura G Fulford
    Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK
    Breast Cancer Res 9:R4. 2007
    ..Previous studies have suggested that expression of such 'basal' markers predicts different biological behaviour, with more frequent lung and brain metastases and poorer prognosis than other carcinomas...
  4. doi request reprint In situ and invasive lobular neoplasia of the breast
    A M Hanby
    Leeds Institute of Molecular Medicine, Yorkshire Cancer Research and Liz Dawn Pathology and Translational Sciences Centre, St James s University Hospital, Leeds, UK
    Histopathology 52:58-66. 2008
    ..For invasive carcinoma, molecular studies will allow refinement of therapy and the possibility of novel targeted therapies, for example directed against fibroblast growth factor receptor 1...
  5. ncbi request reprint Systematic review and meta-analysis of cytokeratin 19-based one-step nucleic acid amplification versus histopathology for sentinel lymph node assessment in breast cancer
    J P Tiernan
    Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK Department of Surgery, St James s University Hospital, Leeds, UK
    Br J Surg 101:298-306. 2014
    ..The aim of this systematic review and meta-analysis was to determine whether intraoperative OSNA for lymph node assessment is comparable to routine histopathology in the detection of clinically relevant metastases...
  6. pmc Combined analysis of eIF4E and 4E-binding protein expression predicts breast cancer survival and estimates eIF4E activity
    L J Coleman
    Leeds Institute of Molecular Medicine, Leeds University, Leeds LS9 7TF, UK
    Br J Cancer 100:1393-9. 2009
    ..We conclude that eIF4E's influence on cancer survival is modulated substantially by 4E-BPs, and that combined pathway analyses can estimate functional eIF4E...
  7. pmc Adverse effects of dyes used in sentinel node biopsy on immunocytochemical determination of hormone receptors in breast cancer cells
    Y A Masannat
    Department of General Surgery, The Leeds Teaching Hospitals NHS Trust, Leeds General Infirmary, Leeds, UK
    J Clin Pathol 60:730-2. 2007
  8. pmc The prognostic significance of tumour-stroma ratio in oestrogen receptor-positive breast cancer
    C L Downey
    Leeds Institute of Cancer and Pathology, University of Leeds, St James s University Hospital, Leeds LS9 7TF, UK
    Br J Cancer 110:1744-7. 2014
    ..We determined the prognostic significance of tumour-stroma ratio (TSR) in oestrogen receptor (ER)-positive male and female breast carcinomas...
  9. doi request reprint Lymphangiogenesis in abdominal aortic aneurysm
    D J A Scott
    Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics, and Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, UK
    Br J Surg 100:895-903. 2013
    ..The aim was to determine the presence of lymphangiogenesis and to delineate the relationship between inflammation and neovascularization in AAA tissue...
  10. ncbi request reprint Angiogenesis in breast cancer: how should we measure this? (Review)
    M J K Pollitt
    Molecular Medicine Unit, University of Leeds, Clinical Sciences Building, St James s University Hospital, Leeds LS9 7TF, UK
    Oncol Rep 13:931-6. 2005
    ..Here we review the pros and cons of current methods of assessing angiogenesis, both clinical and in the laboratory, and discuss with respect to breast cancer...
  11. pmc Aspects of molecular phenotype and its correlations with breast cancer behaviour and taxonomy
    A M Hanby
    Academic Unit of Pathology, Leeds University, c o Department of Histopathology, St James s University Hospital, Beckett Street, Leeds LS9 7TF, UK
    Br J Cancer 92:613-7. 2005
    ..The tumour morphology reflects the molecular profile that produced it and consequently each can be predictive of the other...
  12. ncbi request reprint Testing for HER2 in breast cancer
    F Lewis
    Academic Unit of Pathology, University of Leeds, Leeds, UK
    Histopathology 45:207-17. 2004
    ..In the future rapid throughput techniques such as real-time quantitative polymerase chain reaction (rqPCR), tissue microarrays or both should bring significant economies of cost and scale...
  13. pmc Agreement between preoperative core needle biopsy and postoperative invasive breast cancer histopathology is not dependent on the amount of clinical material obtained
    R O'Leary
    School of Medicine, University of Leeds, Leeds, LS2 9NL, UK
    J Clin Pathol 57:193-5. 2004
    ..To establish the relation between the amount of breast core needle biopsy (CNB) material examined and agreement between preoperative and postoperative histopathology parameters in invasive breast cancer...
  14. doi request reprint Tumour-promoting activity of altered WWP1 expression in breast cancer and its utility as a prognostic indicator
    N S Nguyen Huu
    University of Manchester, Faculty of Life Sciences, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    J Pathol 216:93-102. 2008
    ..Thus, WWP1 is a prognostic marker and may be a potential therapeutic target for a subset of breast tumours...
  15. ncbi request reprint Small is beautiful: microRNAs and breast cancer-where are we now?
    E T Verghese
    Leeds Teaching Hospital NHS Trust, UK
    J Pathol 215:214-21. 2008
    ..Here we present an overview of our current understanding of miRNA in breast cancer...
  16. doi request reprint A comprehensive genetic profile of phyllodes tumours of the breast detects important mutations, intra-tumoral genetic heterogeneity and new genetic changes on recurrence
    A M Jones
    Molecular and Population Genetics Laboratory, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    J Pathol 214:533-44. 2008
    ..We believe it likely that unfavourable sub-clones not easily identified by histology account for the unpredictable clinical behaviour of these tumours...
  17. ncbi request reprint Correlation of energy dispersive diffraction signatures and microCT of small breast tissue samples with pathological analysis
    J A Griffiths
    Department of Medical Physics and Bioengineering, University College London, Gower Street, London, UK
    Phys Med Biol 52:6151-64. 2007
    ..X-ray diffraction signatures generated from the measured data were categorized and analysed, with a t-test indicating that they have the potential for use in tissue type identification...
  18. ncbi request reprint Retention of the expression of E-cadherin and catenins is associated with shorter survival in grade III ductal carcinoma of the breast
    C E Gillett
    Hedley Atkins ICRF Breast Pathology Laboratory, Guy s Hospital, London SE1 9RT, UK
    J Pathol 193:433-41. 2001
    ..Taken together, these findings suggest that a conserved E-cadherin/catenin axis may play a part in determining adverse outcome in grade III breast carcinoma...
  19. ncbi request reprint The pattern of expression of the microtubule-binding protein RHAMM/IHABP in mammary carcinoma suggests a role in the invasive behaviour of tumour cells
    V Assmann
    Richard Dimbleby Department of Cancer Research/Imperial Cancer Research Fund Laboratory, St. Thomas' Hospital, London SE1 7EH, UK
    J Pathol 195:191-6. 2001
    ..017). These results suggest that RHAMM/IHABP expression may contribute to the motility and invasiveness of a tumour cell sub-population in breast cancers...
  20. ncbi request reprint Mitotic counts provide additional prognostic information in grade II mammary carcinoma
    J Lynch
    Guy s, Kings and St Thomas School of Medicine, Guy s Hospital, St Thomas Street, London SE1 9RT, UK
    J Pathol 196:275-9. 2002
    ..It is proposed that MC, used once to establish grade, could be used again amongst the grade II tumours to improve the accuracy of prognosis and thus influence treatment strategies with minimal additional effort or expense...
  21. ncbi request reprint BAG-i expression in human breast cancer: interrelationship between BAG-1 RNA, protein, HSC70 expression and clinico-pathological data
    P A Townsend
    Cancer Sciences Division, School of Medicine, University of Southampton, Southampton General Hospital, UK
    J Pathol 197:51-9. 2002
    ..These results are consistent with the hypothesis that BAG-1 plays an important but variable role in breast cancers developing in pre-menopausal and post-menopausal women...
  22. ncbi request reprint Tissue microarrays--big potential from small samples (review)
    A Waterworth
    Breast Unit, Leeds General Infirmary, Leeds LS1 3EX, UK
    Int J Oncol 25:167-71. 2004
    ..This area of histological study has been revolutionised by the development of tissue microarrays (TMAs). This review describes the development and use of TMAs and discusses their possible applications to clinical oncological practice...
  23. ncbi request reprint The pathology of breast cancer and the role of the histopathology laboratory
    A M Hanby
    Academic Unit of Pathology, Leeds University
    Clin Oncol (R Coll Radiol) 17:234-9. 2005
    ..With the rise of modern molecular techniques, the demise of diagnostic histopathology has been predicted, but, for now and the intermediate future, the histopathologist remains a key element of the integrated breast-care team...
  24. ncbi request reprint An alternative method of dissecting mastectomy specimens
    C D'Arrigo
    Histopathology 48:608-9. 2006
  25. pmc HER2 testing in the UK: consensus from a national consultation
    Mitch Dowsett
    The Royal Marsden NHS Trust, Fulham Road, London SW3 6JJ, UK
    J Clin Pathol 60:685-9. 2007
    ..To gain an understanding of current attitudes among oncologists and pathologists to prospective HER2 testing in breast cancer and to gauge whether a national consensus exists regarding extent and quality of testing...
  26. pmc An inbred colony of oncogene transgenic mice: diversity of tumours and potential as a therapeutic model
    H Thomas
    ICRF Biological Therapies Laboratory, London, UK
    Br J Cancer 73:65-72. 1996
    ..However, further genetic and environmental manipulations are required to increase tumour incidence and decrease age of onset...