D Lee Hamilton
Affiliation: University of Stirling
Hamilton D, Beall C, Jeromson S, Chevtzoff C, Cuthbertson D, Ashford M. Kv1.3 inhibitors have differential effects on glucose uptake and AMPK activity in skeletal muscle cell lines and mouse ex vivo skeletal muscle. J Physiol Sci. 2014;64:13-20 pubmed publisher
..In conclusion, AMPK does not mediate the effects of Kv1.3 inhibitors and they display differential effects in different skeletal muscle cell lines without impairing mitochondrial function. ..
Jeromson S, Gallagher I, Galloway S, Hamilton D. Omega-3 Fatty Acids and Skeletal Muscle Health. Mar Drugs. 2015;13:6977-7004 pubmed publisher
..Finally, we suggest some avenues for further research to clarify how omega-3 fatty acids may be exerting their biological action in skeletal muscle. ..
Haythorne E, Hamilton D, Findlay J, Beall C, McCrimmon R, Ashford M. Chronic exposure to KATP channel openers results in attenuated glucose sensing in hypothalamic GT1-7 neurons. Neuropharmacology. 2016;111:212-222 pubmed publisher
Hamilton D, Philp A, Mackenzie M, Patton A, Towler M, Gallagher I, et al
. Molecular brakes regulating mTORC1 activation in skeletal muscle following synergist ablation. Am J Physiol Endocrinol Metab. 2014;307:E365-73 pubmed publisher
..These data suggest that during supraphysiological muscle loading at least three potential molecular brakes engage to downregulate mTORC1. ..
Shaw A, Jeromson S, Watterson K, Pediani J, Gallagher I, Whalley T, et al
. Multiple AMPK activators inhibit l-carnitine uptake in C2C12 skeletal muscle myotubes. Am J Physiol Cell Physiol. 2017;312:C689-C696 pubmed publisher
..However, caffeine likely inhibits l-carnitine uptake by alternative mechanisms independently of calcium release. PKA activation or direct interference with transporter function may play a role. ..
Jeromson S, Mackenzie I, Doherty M, Whitfield P, Bell G, Dick J, et al
. Lipid remodelling and an altered membrane proteome may drive the effects of EPA and DHA treatment on skeletal muscle glucose uptake and protein accretion. Am J Physiol Endocrinol Metab. 2017;:ajpendo.00438.2015 pubmed publisher