Steve Halligan

..Studies are poorly reported, however, and the authors propose a minimum data set for study reporting...

..Computed tomographic colonography (CTC) might be a more sensitive and acceptable alternative. We aimed to compare CTC and BE for diagnosis of colorectal cancer or large polyps in symptomatic patients in clinical practice...

..To externally validate a computer-assisted detection (CAD) system for computed tomography (CT) colonography, using data from a single centre uninvolved with the software development...

..Whether offering CT colonography as an alternative to competing strategies will genuinely enhance compliance also needs further and more detailed attention...

..They also explain how systematic review can help guide methodologic development for future research...

..To quantify the changes in reader performance levels, if any, during interpretation of computed tomographic (CT) colonographic data when a computer-aided detection (CAD) system is used as a second or concurrent reader...

..However, the unavoidable interaction between CAD and the reader has not been addressed...

..e. large polyps misclassified as medium). Caution should be exercised for polyps whose colonographic diameter is below but close to the 1-cm boundary threshold in order to avoid potential miscategorisation of advanced adenomas...

..1% and 88.5% with and without local colonic collapse. Moreover, it improves an existing surface-based registration algorithm, decreasing mean registration error from 9.7mm to 7.7mm in cases exhibiting collapse...

..To determine patient acceptability of barium enema (BE) or CT colonography (CTC)...

..To use a randomized design to compare patients' short- and longer-term experiences after computed tomographic (CT) colonography or colonoscopy...

..To determine mural perfusion dynamics in Crohn disease by using dynamic contrast material-enhanced magnetic resonance (MR) imaging and to correlate these with histopathologic markers of inflammation and angiogenesis...

..Reduced preparation was tolerated better than full endoscopic preparation by 61%. Reduced-laxative CTC with three doses of 20 ml 40% barium sulphate is as effective as more complex regimens, retaining adequate diagnostic accuracy...

..The objective of our study was to investigate whether an increasing number of computer-aided detection (CAD) false-positives decreases reader sensitivity, specificity, and confidence for nonexpert readers of CT colonography (CTC)...

..8% for polyps 6 mm or more when used at a sphericity setting of 0.3. Higher sphericity settings increased specificity while reducing sensitivity. The bowel preparation used significantly impacts on specificity...

..There was consensus that polyps 4 mm or less could be ignored assuming agreement from local gastroenterological colleagues. There is increasing consensus amongst European experts as to the current best practice in CTC...

..To compare quantified terminal ileal (TI) motility during MR enterography (MRE) with histopathological severity of acute inflammation in Crohn's disease...

..To investigate how the histological scoring of microvessel density affects correlations between integrated (18)F-FDG-PET/perfusion CT parameters and CD105 microvessel density...

..To retrospectively describe the characteristics of polyps incorrectly dismissed by radiologists despite appropriate computer-aided detection (CAD) prompting during computed tomographic (CT) colonography...

..To prospectively investigate the relative accuracy and reproducibility of manual and automated computer software measurements by using polyps of known size in a human colectomy specimen...

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..We aimed to compare rates of additional colonic investigation after CTC or colonoscopy for detection of colorectal cancer or large (≥10 mm) polyps in symptomatic patients in clinical practice...

..CONCLUSION: Polyp conspicuity and measurement in tagged data sets were optimized at 700 HU with bone viewing windows. At less than 300 HU, conspicuity improved with abdominal viewing windows...

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..At all settings, >96.1% of CAD true positives were classified as focal. CAD may be effective for the detection of morphologically flat cancer, although minimally raised laterally spreading tumors remain problematic...

..This review will discuss the clinical relevance of flat colonic neoplasia, describe some of the challenges facing CAD detection algorithms, and review the current CAD literature on this topic...

..To develop and validate a qualitative scoring system for enteric Crohn's disease activity using MR enterography (MRE)...

..To examine public perceptions of and preferences for colonoscopy vs. CT colonography (CTC) as technologies for colorectal cancer (CRC) screening...

..03. Wide-angle (140-degree) CTC can reduce both numbers of missed areas and review times. However, this may be at the expense of polyp conspicuity...

..87 mm, Whiting span: 2.18 mm). CONCLUSION: Fully automated measurement of polyp diameter and volume is technically feasible and results in superior inter- and intraobserver agreement...

..The authors present a novel approach to automatically establish spatial correspondence between prone and supine endoluminal colonic surfaces after surface parameterization, even in the case of local colon collapse...

..Untrained reader performance is variable but generally poor. Most missed polyps are due perceptual error rather than characterization, suggesting basic training should focus heavily on lesion detection...

..To determine objectively the current standard of reporting for studies of computer-aided detection (CAD) for computed tomographic (CT) colonography by systematically reviewing published articles...

..The method was validated on twelve clinical cases and demonstrated promising registration results over the majority of the colon surface...

..The purpose of this review is to bring the reader up-to-date with the latest developments in CT colonography, in particular, those of the last year...

..The purpose was to prospectively test the technical feasibility and acceptability of combined nonlaxative PET/CT colonography in patients at higher risk of colorectal neoplasia and to provide pilot data on diagnostic performance...

..To derive an MRI score for assessing severity, therapeutic response and prognosis in acute severe inflammatory colitis...

..To investigate the effect of colonic distension on polyp measurement accuracy and reader agreement...

..To explore information needs and preferences on diagnostic bowel tests and elicit preferences for CT colonography (CTC) vs. colonoscopy (CC)...

..Technicians who report more slowly are more accurate. All groups reported faster as the study period progressed...

..In particular, those which modify or conceal sample characteristics (e.g. disease prevalence or reporting intensity) or research setting ("laboratory" versus "field"). We also investigated recall bias...

..3). CONCLUSION: Potentially serious adverse events related to CT colonography occurred in 0.08% of symptomatic patients...

..Future directions for virtual colonoscopy are explored, including advances toward prepless examinations and automated interpretation...

..With the recent introduction of PET/MRI, we investigated whether diffusion-weighted imaging (DWI) can complement PET for predicting local treatment response in Hodgkin lymphoma...

..The aim of this study was to assess the in vivo flow-metabolic phenotype in primary colorectal cancer with integrated (18)F-FDG PET/perfusion CT and its relationship to gold standard histopathologic assessment of angiogenesis and hypoxia...

..To validate proposed magnetic resonance (MR) imaging features of Crohn disease activity against a histopathologic reference...

..Hydrogen peroxide improved conspicuity of some tracks and internal openings and so may be helpful in difficult cases, although no overall diagnostic benefit was demonstrated...

..Most important, the authors describe how the radiologist is well placed to answer the surgical riddles that must be solved for treatment to be effective...

..To compare the cardiovascular effects of computed tomographic (CT) colonography and conventional endoscopy in a group of patients undergoing both procedures...

..There is considerable variation in the ability to report CT colonography. Prior experience in gastrointestinal radiology is a distinct advantage. Competence cannot be assumed even after directed training via a database of 50 cases...

..Although already widely disseminated, important future developments, such as prepless bowel cleansing (laxative free) and computer-aided diagnosis, may establish CT colonography as the preferred first-line, whole-colon investigation...

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..2 is sensitive for polyp detection, with a clinically acceptable false-positive rate. ColonCAR version 1.2 has a synergistic effect to the reviewer alone, and its standalone performance may exceed even that of experts...

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..Polyps smaller than 5 mm, however, may be poorly depicted with use of these settings in the transverse colon...

..While MR imaging remains superior in all respects, endosonography is a viable alternative for identification of the internal opening...

..CONCLUSIONS: Scan acquisitions of 45 seconds are too short for reliable permeability measurement in the abdomen. Longer acquisition times are required...

..CONCLUSION: There is greater inter- than intraobserver agreement for CT vascular perfusion measurements of primary colorectal cancer, which must be addressed for reliable clinical application in therapeutic monitoring...

..Benefit is greatest in the left colon, particularly when the patient is supine. Patient acceptance is similar to that for manual insufflation...

..CONCLUSION: Hyoscine butylbromide improves colonic distention during CT colonography and should be routinely administered where it is available. Use of a thin rectal tube for insufflation is adequate...

..Although 3D visualization display is commonly used for polyp detection, it should not be used for measurement...

..02 (-1.40, 1.43), 6.60 (-11.2, 24.3), -3.76 (-16.87, 9.35), and 1.30 (-4.68, 7.28), respectively. CONCLUSION: Quantitative perfusion measurements are reproducible. Measurements from tumor are less variable than from skeletal muscle...

..To assess the methods and reporting of systematic reviews of diagnostic tests...

..To prospectively determine the level of agreement between tumor blood volume and permeability measurements obtained with two commercially available perfusion computed tomographic (CT) software packages...

..To prospectively determine whether position and size of tumor region of interest (ROI) influence estimates of colorectal cancer vascular parameters at computed tomography (CT)...

..In patients expressing a preference, CT colonography was the preferred follow-up investigation...